BR0213398A - Sal de alendronato, alendronato monossódico, processos para a produção dos mesmos, composição farmacêutica, e, método para inibição da ressorção óssea em um paciente - Google Patents
Sal de alendronato, alendronato monossódico, processos para a produção dos mesmos, composição farmacêutica, e, método para inibição da ressorção óssea em um pacienteInfo
- Publication number
- BR0213398A BR0213398A BR0213398-9A BR0213398A BR0213398A BR 0213398 A BR0213398 A BR 0213398A BR 0213398 A BR0213398 A BR 0213398A BR 0213398 A BR0213398 A BR 0213398A
- Authority
- BR
- Brazil
- Prior art keywords
- alendronate
- patient
- processes
- production
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical class NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 2
- 208000006386 Bone Resorption Diseases 0.000 title 1
- 230000024279 bone resorption Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- CAKRAHQRJGUPIG-UHFFFAOYSA-M sodium;[4-azaniumyl-1-hydroxy-1-[hydroxy(oxido)phosphoryl]butyl]-hydroxyphosphinate Chemical compound [Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O CAKRAHQRJGUPIG-UHFFFAOYSA-M 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
"SAL DE ALENDRONATO, ALENDRONATO MONOSSóDICO, PROCESSOS PARA A PRODUçãO DOS MESMOS, COMPOSIçãO FARMACêUTICA, E, MéTODO PARA INIBIçãO DA RESSORçãO óSSEA EM UM PACIENTE". Um sal de alendronato farmaceuticamente aceitável em uma forma amorfa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0125081A GB2383042A (en) | 2001-10-18 | 2001-10-18 | Amorphous alendronate sodium |
PCT/GB2002/004730 WO2003033508A1 (en) | 2001-10-18 | 2002-10-18 | Pharmaceutically acceptable alendronate salts in amorphous form |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0213398A true BR0213398A (pt) | 2005-01-11 |
Family
ID=9924125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0213398-9A Withdrawn BR0213398A (pt) | 2001-10-18 | 2002-10-18 | Sal de alendronato, alendronato monossódico, processos para a produção dos mesmos, composição farmacêutica, e, método para inibição da ressorção óssea em um paciente |
Country Status (22)
Country | Link |
---|---|
US (1) | US7112577B2 (pt) |
EP (1) | EP1436303B1 (pt) |
JP (1) | JP4490100B2 (pt) |
KR (1) | KR20040053186A (pt) |
AT (1) | ATE338761T1 (pt) |
AU (1) | AU2002334200B2 (pt) |
BR (1) | BR0213398A (pt) |
CA (1) | CA2463815C (pt) |
CL (1) | CL2004001372A1 (pt) |
DE (1) | DE60214576T2 (pt) |
EC (1) | ECSP045067A (pt) |
ES (1) | ES2271375T3 (pt) |
GB (1) | GB2383042A (pt) |
HK (1) | HK1066011A1 (pt) |
IL (1) | IL161360A0 (pt) |
MX (1) | MXPA04003549A (pt) |
NZ (1) | NZ532292A (pt) |
PT (1) | PT1436303E (pt) |
RU (1) | RU2334751C2 (pt) |
TN (1) | TNSN04067A1 (pt) |
WO (1) | WO2003033508A1 (pt) |
ZA (1) | ZA200403024B (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003057136A2 (en) * | 2001-12-24 | 2003-07-17 | Teva Pharmaceutical Industries Ltd. | Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it |
US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
ITMI20020146A1 (it) * | 2002-01-29 | 2003-07-29 | Lyogen Ltd | Alendronato monosodico amorfo e processo per la sua preparazione |
EP1723157B2 (en) † | 2004-02-26 | 2017-02-08 | Zentiva, k.s. | Amorphous forms of risedronate monosodium |
DE602005001873T2 (de) | 2004-03-03 | 2008-04-24 | Chemi S.P.A., Cinisello Balsamo | Amorphe 3-Pyridyl-1-Hydroxyethyliden-1,1-Bisphosphonsäure Mononatriumsalz und Verfahren zu deren Herstellung |
CZ297262B6 (cs) * | 2004-12-28 | 2006-10-11 | Zentiva, A. S. | Trisodná sul kyseliny 4-amino-1-hydroxybutyliden-1,1-bisfosfonové |
US20090118238A1 (en) * | 2007-09-17 | 2009-05-07 | Protia, Llc | Deuterium-enriched alendronate |
AU2013315619B2 (en) * | 2012-09-11 | 2018-02-08 | Astellas Pharma Inc. | Formulations of enzalutamide |
US20150239848A1 (en) * | 2012-09-11 | 2015-08-27 | Dr. Reddy's Laboratories Limited | Enzalutamide polymorphic forms and its preparation |
MX2018013742A (es) * | 2016-05-09 | 2019-08-01 | Anacor Pharmaceuticals Inc | Formas cristalinas de crisaborol en forma libre, metodo de preparacion y uso de las mismas. |
US11447506B2 (en) | 2016-05-09 | 2022-09-20 | Anacor Pharmaceuticals, Inc. | Crystal forms of crisaborole in free form and preparation method and use thereof |
WO2017218957A1 (en) * | 2016-06-16 | 2017-12-21 | Teva Pharmaceuticals International Gmbh | Solid state forms of spiro-oxindole compounds |
EP3510021A1 (en) * | 2016-09-06 | 2019-07-17 | Indena S.p.A. | Solid forms of ingenol 3-(3,5-diethylisoxazole-4-carboxylate) and method for preparing the same |
DK3512863T3 (da) | 2016-09-07 | 2022-03-07 | Atea Pharmaceuticals Inc | 2¿-substituerede-N6-substituerede purinnukleotider til behandling af RNA-virus |
US11369579B2 (en) | 2016-10-24 | 2022-06-28 | Syneurx International (Taiwan) Corp. | Polymorphic forms of sodium benzoate and uses thereof |
US10336679B2 (en) * | 2016-10-24 | 2019-07-02 | Syneurx International (Taiwan) Corp. | Polymorphic forms of sodium benzoate and uses thereof |
KR102592899B1 (ko) * | 2017-02-01 | 2023-10-24 | 아테아 파마슈티컬즈, 인크. | C형 간염 바이러스를 치료하기 위한 뉴클레오티드 헤미-술페이트 염 |
MX2019011649A (es) * | 2017-03-30 | 2019-12-19 | Merck Patent Gmbh | Forma solida de (s)-[2-cloro-4-fluoro-5-(7-morfolin-4-il-quinazoli n-4-il)fenil]-(6-metoxi-piridazin-3-il)-metanol. |
WO2019104134A1 (en) * | 2017-11-22 | 2019-05-31 | Agios Pharmaceuticals, Inc. | Crystalline forms of n-(4-(4-(cyclopropylmethyl) piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide |
JP2021521118A (ja) | 2018-04-10 | 2021-08-26 | アテア ファーマシューティカルズ, インコーポレイテッド | 肝硬変を伴うhcv感染患者の治療 |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
WO2022176017A1 (ja) * | 2021-02-16 | 2022-08-25 | 大塚製薬株式会社 | 非晶質体及び当該非晶質体を含む組成物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4304734A (en) * | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
DK0833643T3 (da) * | 1995-06-06 | 2005-05-30 | Merck & Co Inc | Formuleringer af vandfrit mononatriumsalt af alendronat og deres anvendelse til behandling af knoglesygdomme |
US5853759A (en) * | 1996-05-17 | 1998-12-29 | Merck & Co.. Inc. | Effervescent alendronate formulation |
PL346347A1 (en) | 1998-08-27 | 2002-02-11 | Teva Pharma | Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof |
US6160165A (en) * | 1998-12-10 | 2000-12-12 | Aesgen, Inc. | Method for preparation of disodium pamidronate |
ATE238315T1 (de) | 1998-12-10 | 2003-05-15 | Aesgen Inc | Verfahren zur herstellung von dinatriumpamidronat |
AU7902800A (en) | 1999-10-26 | 2001-05-08 | A/S Gea Farmaceutisk Fabrik | Novel salts of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid, their preparation and use |
-
2001
- 2001-10-18 GB GB0125081A patent/GB2383042A/en not_active Withdrawn
-
2002
- 2002-10-18 DE DE60214576T patent/DE60214576T2/de not_active Expired - Lifetime
- 2002-10-18 KR KR10-2004-7005768A patent/KR20040053186A/ko not_active Application Discontinuation
- 2002-10-18 ES ES02801429T patent/ES2271375T3/es not_active Expired - Lifetime
- 2002-10-18 EP EP02801429A patent/EP1436303B1/en not_active Expired - Lifetime
- 2002-10-18 RU RU2004113306/04A patent/RU2334751C2/ru not_active IP Right Cessation
- 2002-10-18 US US10/492,977 patent/US7112577B2/en not_active Expired - Fee Related
- 2002-10-18 BR BR0213398-9A patent/BR0213398A/pt not_active Withdrawn
- 2002-10-18 PT PT02801429T patent/PT1436303E/pt unknown
- 2002-10-18 WO PCT/GB2002/004730 patent/WO2003033508A1/en active IP Right Grant
- 2002-10-18 AT AT02801429T patent/ATE338761T1/de not_active IP Right Cessation
- 2002-10-18 JP JP2003536247A patent/JP4490100B2/ja not_active Expired - Fee Related
- 2002-10-18 IL IL16136002A patent/IL161360A0/xx not_active IP Right Cessation
- 2002-10-18 MX MXPA04003549A patent/MXPA04003549A/es active IP Right Grant
- 2002-10-18 AU AU2002334200A patent/AU2002334200B2/en not_active Ceased
- 2002-10-18 NZ NZ532292A patent/NZ532292A/en not_active IP Right Cessation
- 2002-10-18 CA CA002463815A patent/CA2463815C/en not_active Expired - Fee Related
-
2004
- 2004-04-16 TN TNP2004000067A patent/TNSN04067A1/en unknown
- 2004-04-16 EC EC2004005067A patent/ECSP045067A/es unknown
- 2004-04-21 ZA ZA200403024A patent/ZA200403024B/xx unknown
- 2004-06-04 CL CL200401372A patent/CL2004001372A1/es unknown
- 2004-11-09 HK HK04108787A patent/HK1066011A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU2002334200B2 (en) | 2008-04-03 |
MXPA04003549A (es) | 2004-07-22 |
HK1066011A1 (en) | 2005-03-11 |
PT1436303E (pt) | 2006-12-29 |
ES2271375T3 (es) | 2007-04-16 |
JP4490100B2 (ja) | 2010-06-23 |
JP2005521636A (ja) | 2005-07-21 |
DE60214576T2 (de) | 2007-08-30 |
US20040259846A1 (en) | 2004-12-23 |
KR20040053186A (ko) | 2004-06-23 |
RU2334751C2 (ru) | 2008-09-27 |
CA2463815A1 (en) | 2003-04-24 |
EP1436303B1 (en) | 2006-09-06 |
WO2003033508A1 (en) | 2003-04-24 |
ATE338761T1 (de) | 2006-09-15 |
TNSN04067A1 (en) | 2006-06-01 |
EP1436303A1 (en) | 2004-07-14 |
GB0125081D0 (en) | 2001-12-12 |
ECSP045067A (es) | 2004-07-23 |
DE60214576D1 (de) | 2006-10-19 |
CL2004001372A1 (es) | 2005-05-06 |
RU2004113306A (ru) | 2005-10-10 |
US7112577B2 (en) | 2006-09-26 |
GB2383042A (en) | 2003-06-18 |
IL161360A0 (en) | 2004-09-27 |
CA2463815C (en) | 2009-04-07 |
ZA200403024B (en) | 2005-03-30 |
NZ532292A (en) | 2005-07-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 4A., 5A., 6A. E 7A. ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2034 DE 29/12/2009. |