BR0209114A - Terapia de combinação usando agentes antiangiogênicos e tnfalfa - Google Patents
Terapia de combinação usando agentes antiangiogênicos e tnfalfaInfo
- Publication number
- BR0209114A BR0209114A BR0209114-3A BR0209114A BR0209114A BR 0209114 A BR0209114 A BR 0209114A BR 0209114 A BR0209114 A BR 0209114A BR 0209114 A BR0209114 A BR 0209114A
- Authority
- BR
- Brazil
- Prior art keywords
- agents
- combination therapy
- antiangiogenic agents
- administration
- tfalphal
- Prior art date
Links
- 239000004037 angiogenesis inhibitor Substances 0.000 title abstract 3
- 238000002648 combination therapy Methods 0.000 title abstract 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 2
- 229940127089 cytotoxic agent Drugs 0.000 abstract 2
- 102000006992 Interferon-alpha Human genes 0.000 abstract 1
- 108010047761 Interferon-alpha Proteins 0.000 abstract 1
- 102000008070 Interferon-gamma Human genes 0.000 abstract 1
- 108010074328 Interferon-gamma Proteins 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229960003130 interferon gamma Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
"TERAPIA DE COMBINAçãO USANDO AGENTES ANTIANGIOGêNICOS E TNFalfa". A presente invenção refere-se a uma terapia de combinação para o tratamento de metástases de tumores, compreendendo a administração de agentes antiangiogênicos e fator de necrose tumoral alfa (TNFa), opcionalmente juntos com outros agentes citotóxicos, tais como o interferon gama (IFN~ <SYM>~), ou agentes quimioterapêuticos, tais como os anticorpos anti-EGFR. O método e as composições farmacêuticas compreendendo os ditos agentes podem resultar em uma potenciação sinérgica do efeito de inibição da proliferação das células de tumor de cada agente terapêutico individual, produzindo um tratamento mais eficaz do que verificado por administração de um componente individual sozinho.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01109981 | 2001-04-24 | ||
PCT/EP2002/004298 WO2002085405A2 (en) | 2001-04-24 | 2002-04-18 | COMBINATION THERAPY USING ANTI-ANGIOGENIC AGENTS AND TNF$g(a) |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0209114A true BR0209114A (pt) | 2004-07-13 |
Family
ID=8177227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0209114-3A BR0209114A (pt) | 2001-04-24 | 2002-04-18 | Terapia de combinação usando agentes antiangiogênicos e tnfalfa |
Country Status (20)
Country | Link |
---|---|
US (3) | US20040136949A1 (pt) |
EP (2) | EP1381384B1 (pt) |
JP (2) | JP4660067B2 (pt) |
KR (1) | KR100861466B1 (pt) |
CN (1) | CN1247258C (pt) |
AT (1) | ATE510557T1 (pt) |
AU (1) | AU2002316855B2 (pt) |
BR (1) | BR0209114A (pt) |
CA (1) | CA2444821C (pt) |
CZ (1) | CZ20033119A3 (pt) |
DK (1) | DK1381384T3 (pt) |
ES (1) | ES2366775T3 (pt) |
HU (1) | HUP0303927A3 (pt) |
MX (1) | MXPA03009683A (pt) |
PL (1) | PL363311A1 (pt) |
PT (1) | PT1381384E (pt) |
RU (1) | RU2316337C2 (pt) |
SK (1) | SK14272003A3 (pt) |
WO (1) | WO2002085405A2 (pt) |
ZA (1) | ZA200309060B (pt) |
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PT1381384E (pt) * | 2001-04-24 | 2011-09-01 | Merck Patent Gmbh | Terapia de combinação usando agentes anti-angiogénicos e tnfa |
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ATE546157T1 (de) | 2003-11-13 | 2012-03-15 | Sutter West Bay Hospitals | Anti-pecam-therapie zur unterdrückung von metastasen |
WO2005089443A2 (en) * | 2004-03-19 | 2005-09-29 | The Penn State Research Foundation | Combinatorial methods and compositions for treatment of melanoma |
DK1819358T3 (da) * | 2004-11-18 | 2014-10-27 | Imclone Llc | Antistoffer mod vaskulær endothel-vækstfaktor-receptor-1 |
CA2593964A1 (en) | 2004-12-23 | 2006-06-29 | Molmed Spa | Conjugation product |
WO2006074370A2 (en) * | 2005-01-07 | 2006-07-13 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Agonists and antagonists of tnfrii/cd120b for treatment of immune-related diseases |
US20110165150A1 (en) * | 2006-01-18 | 2011-07-07 | Merck Patent Gmbh | Isolated organ perfusion combination therapy of cancer |
BRPI0806596A2 (pt) * | 2007-01-18 | 2013-07-23 | Merck Patent Ges Mit Berchraenkter Haftung | medicamento e terapia especÍfica usando-se ligantes de integrina para o tratamento de cÂncer |
WO2008103301A2 (en) * | 2007-02-16 | 2008-08-28 | President And Fellows Of Harvard College | Treatment of the eye using macrophages and/or agents able to affect blood vessel morphology |
MX2010010026A (es) | 2008-03-13 | 2011-03-21 | Biotest Ag | Agente para tratar enfermedad. |
SG190627A1 (en) | 2008-03-13 | 2013-06-28 | Biotest Ag | Agent for treating disease |
US8293714B2 (en) * | 2008-05-05 | 2012-10-23 | Covx Technology Ireland, Ltd. | Anti-angiogenic compounds |
WO2009140661A1 (en) * | 2008-05-16 | 2009-11-19 | Corthera, Inc. | Method of preventing premature delivery |
FR2931677B1 (fr) * | 2008-06-02 | 2010-08-20 | Sanofi Aventis | Association d'un agoniste partiel des recepteurs nicotiniques et d'un inhibiteur d'acetylcholinesterase, composition la contenant et son utilisation dans le traitement des troubles cognitifs |
SG194362A1 (en) * | 2008-09-29 | 2013-11-29 | Biotest Ag | Composition for treating disease |
AU2009305893B2 (en) * | 2008-10-23 | 2014-03-27 | Steba Biotech S.A. | RGD-containing peptidomimetics and uses thereof |
GB0920944D0 (en) | 2009-11-30 | 2010-01-13 | Biotest Ag | Agents for treating disease |
JP5212849B2 (ja) | 2010-01-14 | 2013-06-19 | 株式会社三和化学研究所 | 眼内血管新生及び/又は眼内血管透過性亢進を伴う疾患の予防又は治療のための医薬 |
WO2011103583A2 (en) * | 2010-02-22 | 2011-08-25 | University Of Chicago | Methods and compositions related to anti-angiogenic peptides |
WO2012054717A2 (en) * | 2010-10-21 | 2012-04-26 | The Johns Hopkins University | Detecting and treating solid tumors through selective disruption of tumor vasculature |
WO2012105610A1 (ja) | 2011-02-02 | 2012-08-09 | 公立大学法人名古屋市立大学 | 眼内血管新生及び/又は眼内血管透過性亢進を伴う疾患の予防又は治療のための医薬 |
RU2530592C2 (ru) * | 2012-07-20 | 2014-10-10 | Федеральное государственное бюджетное учреждение науки Институт теоретической и экспериментальной биофизики Российской академии наук (ИТЭБ РАН) | Способ подавления роста опухолей |
CN111868237A (zh) | 2017-10-05 | 2020-10-30 | 弗尔康医疗公司 | P38抑制剂降低dux4表达的用途 |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
CN112569358B (zh) * | 2019-09-30 | 2022-06-28 | 上海生物制品研究所有限责任公司 | 培干扰素和原癌基因产物靶向抑制剂在协同抑制肿瘤中的应用 |
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EA002822B1 (ru) | 1997-12-17 | 2002-10-31 | Мерк Энд Ко., Инк. | Антагонисты рецептора интегрина |
US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
AU736026B2 (en) | 1997-12-17 | 2001-07-26 | Merck & Co., Inc. | Integrin receptor antagonists |
US6017926A (en) | 1997-12-17 | 2000-01-25 | Merck & Co., Inc. | Integrin receptor antagonists |
EP1044001B1 (en) | 1997-12-17 | 2005-07-06 | Merck & Co., Inc. | Integrin receptor antagonists |
CA2319160A1 (en) | 1998-01-23 | 1999-07-29 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Monoclonal antibody anti .alpha.v-integrin and its use to inhibit .alpha.v.beta.6-integrin attachment to fibronectin |
CA2338275A1 (en) | 1998-07-29 | 2000-02-10 | Merck & Co., Inc. | Integrin receptor antagonists |
WO2000009503A1 (en) | 1998-08-13 | 2000-02-24 | Merck & Co., Inc. | Integrin receptor antagonists |
US6235877B1 (en) * | 1999-08-04 | 2001-05-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors |
JP2002533387A (ja) | 1998-12-23 | 2002-10-08 | ジー.ディー.サール & カンパニー | 腫瘍治療の複合療法としてインテグリン拮抗物質と一つ以上の抗腫瘍剤を使用する方法 |
TR200103431T2 (tr) | 1999-06-02 | 2002-06-21 | Merck & Co.,Inc. | Alfa V integrin reseptör antagonistleri. |
KR20090126330A (ko) * | 1999-08-27 | 2009-12-08 | 제넨테크, 인크. | 항-ErbB2 항체 투여 치료 방법 |
PT1381384E (pt) * | 2001-04-24 | 2011-09-01 | Merck Patent Gmbh | Terapia de combinação usando agentes anti-angiogénicos e tnfa |
-
2002
- 2002-04-18 PT PT02745238T patent/PT1381384E/pt unknown
- 2002-04-18 AT AT02745238T patent/ATE510557T1/de active
- 2002-04-18 KR KR1020037013956A patent/KR100861466B1/ko not_active IP Right Cessation
- 2002-04-18 US US10/475,713 patent/US20040136949A1/en not_active Abandoned
- 2002-04-18 DK DK02745238.2T patent/DK1381384T3/da active
- 2002-04-18 CN CNB02808876XA patent/CN1247258C/zh not_active Expired - Fee Related
- 2002-04-18 JP JP2002582978A patent/JP4660067B2/ja not_active Expired - Fee Related
- 2002-04-18 EP EP02745238A patent/EP1381384B1/en not_active Expired - Lifetime
- 2002-04-18 WO PCT/EP2002/004298 patent/WO2002085405A2/en active Application Filing
- 2002-04-18 SK SK1427-2003A patent/SK14272003A3/sk not_active Application Discontinuation
- 2002-04-18 AU AU2002316855A patent/AU2002316855B2/en not_active Ceased
- 2002-04-18 HU HU0303927A patent/HUP0303927A3/hu unknown
- 2002-04-18 PL PL02363311A patent/PL363311A1/xx not_active Application Discontinuation
- 2002-04-18 ES ES02745238T patent/ES2366775T3/es not_active Expired - Lifetime
- 2002-04-18 CA CA2444821A patent/CA2444821C/en not_active Expired - Fee Related
- 2002-04-18 EP EP10010393A patent/EP2292251A1/en not_active Withdrawn
- 2002-04-18 RU RU2003132431/15A patent/RU2316337C2/ru not_active IP Right Cessation
- 2002-04-18 CZ CZ20033119A patent/CZ20033119A3/cs unknown
- 2002-04-18 BR BR0209114-3A patent/BR0209114A/pt not_active IP Right Cessation
- 2002-04-18 MX MXPA03009683A patent/MXPA03009683A/es active IP Right Grant
-
2003
- 2003-11-20 ZA ZA200309060A patent/ZA200309060B/en unknown
-
2007
- 2007-09-04 US US11/849,685 patent/US20090035270A1/en not_active Abandoned
-
2009
- 2009-08-04 JP JP2009181445A patent/JP5178663B2/ja not_active Expired - Fee Related
-
2011
- 2011-03-21 US US13/052,496 patent/US20110177027A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2003132431A (ru) | 2005-04-10 |
EP2292251A1 (en) | 2011-03-09 |
CA2444821A1 (en) | 2002-10-31 |
HUP0303927A2 (hu) | 2004-03-01 |
RU2316337C2 (ru) | 2008-02-10 |
EP1381384A2 (en) | 2004-01-21 |
JP4660067B2 (ja) | 2011-03-30 |
WO2002085405A2 (en) | 2002-10-31 |
WO2002085405A3 (en) | 2003-10-02 |
SK14272003A3 (sk) | 2004-04-06 |
ES2366775T3 (es) | 2011-10-25 |
CA2444821C (en) | 2012-07-10 |
PL363311A1 (en) | 2004-11-15 |
AU2002316855B2 (en) | 2008-03-13 |
PT1381384E (pt) | 2011-09-01 |
KR100861466B1 (ko) | 2008-10-02 |
CN1505527A (zh) | 2004-06-16 |
US20040136949A1 (en) | 2004-07-15 |
JP2009256373A (ja) | 2009-11-05 |
EP1381384B1 (en) | 2011-05-25 |
CN1247258C (zh) | 2006-03-29 |
ZA200309060B (en) | 2005-02-21 |
MXPA03009683A (es) | 2004-02-12 |
DK1381384T3 (da) | 2011-07-25 |
CZ20033119A3 (cs) | 2005-01-12 |
KR20040030595A (ko) | 2004-04-09 |
JP2004529149A (ja) | 2004-09-24 |
ATE510557T1 (de) | 2011-06-15 |
JP5178663B2 (ja) | 2013-04-10 |
US20090035270A1 (en) | 2009-02-05 |
HUP0303927A3 (en) | 2006-03-28 |
US20110177027A1 (en) | 2011-07-21 |
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