BR0208939A - Método e agente para tratamento oftálmikco tópico de doenças inflamatórias oculares - Google Patents
Método e agente para tratamento oftálmikco tópico de doenças inflamatórias ocularesInfo
- Publication number
- BR0208939A BR0208939A BR0208939-4A BR0208939A BR0208939A BR 0208939 A BR0208939 A BR 0208939A BR 0208939 A BR0208939 A BR 0208939A BR 0208939 A BR0208939 A BR 0208939A
- Authority
- BR
- Brazil
- Prior art keywords
- agent
- inflammatory
- present
- topical ophthalmic
- ophthalmic treatment
- Prior art date
Links
- 208000030533 eye disease Diseases 0.000 title abstract 4
- 230000002757 inflammatory effect Effects 0.000 title abstract 4
- 230000000699 topical effect Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 7
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- 108010036941 Cyclosporins Proteins 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229930182912 cyclosporin Natural products 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000007803 itching Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"MéTODO E AGENTE PARA TRATAMENTO OFTáLMICO TóPICO DE DOENçAS INFLAMATóRIAS OCULARES". A presente invenção prove um agente para tratamento oftálmico tópico de um humano para doenças inflamatórias oculares, contendo um triciclo composto como mostrado pela fórmula geral (I) ou seu sal farmaceuticamente aceitável como o ingrediente ativo na concentração de 0,01%-0,1%. O presente agente para tratamento oftálmico tópico mostra continuamente superiores efeitos anti-inflamatórios oculares administrando-o topicamente em uma dose pequena ao olho do humano tendo as doenças inflamatórias oculares. O presente agente é efetivo para sintomas causados pelas doenças inflamatórias oculares tais como coceira, cintilação, edema, úlcera, etc. O presente agente também é efetivo para um sujeito no qual agentes anti-inflamatórios convencionais não mostram efeito de melhoria (p. e., esteróide e ciclosporinas). O presente agente também é efetivo para um sujeito para o qual outros agentes anti-inflamatórios não podem ser usados (p. e., contra-indicação a esteróide). O presente agente é muito útil especialmente pela razão que ele mostra efeitos suficientes administrando-o topicamente ao olho por uma a quatro vezes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28316901P | 2001-04-12 | 2001-04-12 | |
| PCT/JP2002/003664 WO2002085359A1 (en) | 2001-04-12 | 2002-04-12 | Agent for topical ophthalmic treatment of ocular inflammatory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0208939A true BR0208939A (pt) | 2004-04-20 |
Family
ID=23084835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0208939-4A BR0208939A (pt) | 2001-04-12 | 2002-04-12 | Método e agente para tratamento oftálmikco tópico de doenças inflamatórias oculares |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20020187998A1 (pt) |
| EP (1) | EP1379247A1 (pt) |
| JP (1) | JP2004529928A (pt) |
| KR (1) | KR20040007494A (pt) |
| CN (1) | CN1503671A (pt) |
| AR (1) | AR033151A1 (pt) |
| BR (1) | BR0208939A (pt) |
| CA (1) | CA2445508A1 (pt) |
| MX (1) | MXPA03009273A (pt) |
| NO (1) | NO20034560L (pt) |
| NZ (1) | NZ529255A (pt) |
| WO (1) | WO2002085359A1 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2452372A1 (en) | 2001-07-06 | 2003-01-16 | Sucampo Ag | Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent |
| EP1754482A1 (en) * | 2001-11-19 | 2007-02-21 | Novartis AG | Use of an ascomycin for the treatment of blepharitis |
| US20050239813A1 (en) * | 2002-08-09 | 2005-10-27 | Sucampo Pharmaceuticals Inc. | Pharmaceutical compositions comprising fk506 derivatives and their use for the treatment of allergic diseases |
| US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| WO2004062669A1 (en) * | 2003-01-16 | 2004-07-29 | Sucampo Ag | Use of a macrolide compound for treating dry eye |
| US7220422B2 (en) * | 2003-05-20 | 2007-05-22 | Allergan, Inc. | Methods and compositions for treating eye disorders |
| US7083802B2 (en) | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| US7087237B2 (en) | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| US7083803B2 (en) | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
| US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| US20060258698A1 (en) | 2005-02-09 | 2006-11-16 | Sreenivasu Mudumba | Liquid formulations for treatment of diseases or conditions |
| US8492400B2 (en) | 2006-02-09 | 2013-07-23 | Santen Pharmaceutical Co., Ltd. | Stable formulations, and methods of their preparation and use |
| JP5506378B2 (ja) | 2006-03-23 | 2014-05-28 | 参天製薬株式会社 | 血管透過性に関連する疾患または病気のための製剤および方法 |
| US8536190B2 (en) * | 2007-01-30 | 2013-09-17 | Allergan, Inc. | Treating unwanted ocular conditions using an ascomycin macrolactam |
| US20170198026A1 (en) * | 2014-06-06 | 2017-07-13 | The Schepens Eye Research Institute, Inc. | Compositions And Methods For Treating Tumors And Immune Based Inflammatory Diseases |
| ES2966595T3 (es) * | 2015-01-26 | 2024-04-23 | Bausch & Lomb | Composición de suspensión oftálmica |
| KR101710412B1 (ko) | 2015-09-15 | 2017-02-27 | 인제대학교 산학협력단 | Ycg063을 유효성분으로 함유하는 염증성 안구질환 예방 또는 치료용 약학조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| DK0406791T3 (da) * | 1989-07-05 | 1995-03-27 | Fujisawa Pharmaceutical Co | Vandigt flydende præparat til ekstern anvendelse |
| DE69021833T2 (de) * | 1989-11-09 | 1996-03-21 | Sandoz Ag | Heteroatome enthaltende tricyclische Verbindungen. |
| IE65341B1 (en) * | 1990-11-08 | 1995-10-18 | Fujisawa Pharmaceutical Co | Suspensions containing tricyclic compounds |
| ATE198708T1 (de) * | 1991-04-26 | 2001-02-15 | Fujisawa Pharmaceutical Co | Verwendung von makrolid-verbindungen gegen augenerkrankungen |
| AR004480A1 (es) * | 1995-04-06 | 1998-12-16 | Amico Derin C D | Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen |
-
2002
- 2002-04-11 AR ARP020101334A patent/AR033151A1/es not_active Application Discontinuation
- 2002-04-12 US US10/120,515 patent/US20020187998A1/en not_active Abandoned
- 2002-04-12 CN CNA028082001A patent/CN1503671A/zh active Pending
- 2002-04-12 KR KR10-2003-7013323A patent/KR20040007494A/ko not_active Application Discontinuation
- 2002-04-12 BR BR0208939-4A patent/BR0208939A/pt not_active IP Right Cessation
- 2002-04-12 CA CA002445508A patent/CA2445508A1/en not_active Abandoned
- 2002-04-12 NZ NZ529255A patent/NZ529255A/en unknown
- 2002-04-12 MX MXPA03009273A patent/MXPA03009273A/es unknown
- 2002-04-12 EP EP02717124A patent/EP1379247A1/en not_active Withdrawn
- 2002-04-12 JP JP2002582932A patent/JP2004529928A/ja not_active Abandoned
- 2002-04-12 WO PCT/JP2002/003664 patent/WO2002085359A1/en not_active Application Discontinuation
-
2003
- 2003-10-10 NO NO20034560A patent/NO20034560L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03009273A (es) | 2004-02-12 |
| NO20034560L (no) | 2003-12-09 |
| NO20034560D0 (no) | 2003-10-10 |
| KR20040007494A (ko) | 2004-01-24 |
| JP2004529928A (ja) | 2004-09-30 |
| WO2002085359A1 (en) | 2002-10-31 |
| CA2445508A1 (en) | 2002-10-31 |
| US20020187998A1 (en) | 2002-12-12 |
| AR033151A1 (es) | 2003-12-03 |
| EP1379247A1 (en) | 2004-01-14 |
| CN1503671A (zh) | 2004-06-09 |
| NZ529255A (en) | 2006-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 5A., 6A., 7A. E 8A. ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010. |