BR0206436A - Composto, método de preparação do composto, e, agentes antidiabéticos orais - Google Patents
Composto, método de preparação do composto, e, agentes antidiabéticos oraisInfo
- Publication number
- BR0206436A BR0206436A BR0206436-7A BR0206436A BR0206436A BR 0206436 A BR0206436 A BR 0206436A BR 0206436 A BR0206436 A BR 0206436A BR 0206436 A BR0206436 A BR 0206436A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- antidiabetic agents
- oral antidiabetic
- lower alkyl
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"COMPOSTO, MéTODO DE PREPARAçãO DO COMPOSTO, E, AGENTES ANTIDIABéTICOS ORAIS". Derivado de isoquinuclidina representado pela fórmula geral (I) a seguir: (I) [em que A~ 1~ é metileno ou carbonila]; R~ 1~ é hidrogênio ou metila: R~ 2~ é -(CH~ 2~)~ n~-A~ 2~-Ph (n é um número inteiro de 0 a 3 e A~ 2~ é uma ligação simples ou -O-); e R~ 3~ é -COON, -COOR~ 4~, -COSR~ 4~ (R~ 4~ é alquila inferior, fenila insubstituído, ou fenila substituído com um grupo alquila inferior, alcóxi inferior, hidroxila 9 metoxicarbonila, etoxicarbonila, ou trifluorometanossulfonamida ou por um átomo de halogênio), etc.] ou um seu sal farmaceuticamente aceitável do composto. Proporciona-se também um remédio oral para diabete, que contém o composto e apresenta atividade hipoglicêmica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001088653 | 2001-03-26 | ||
PCT/JP2002/002847 WO2002076981A1 (fr) | 2001-03-26 | 2002-03-25 | Derives d'isoquinuclidine, methode de production et composition medicinale contenant ces derives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0206436A true BR0206436A (pt) | 2004-07-06 |
Family
ID=18943715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0206436-7A BR0206436A (pt) | 2001-03-26 | 2002-03-25 | Composto, método de preparação do composto, e, agentes antidiabéticos orais |
Country Status (10)
Country | Link |
---|---|
US (1) | US6903111B2 (pt) |
EP (1) | EP1375500A1 (pt) |
JP (1) | JPWO2002076981A1 (pt) |
KR (1) | KR20030083010A (pt) |
CN (1) | CN1218946C (pt) |
BR (1) | BR0206436A (pt) |
CA (1) | CA2441838A1 (pt) |
MX (1) | MXPA03008636A (pt) |
RU (1) | RU2003131329A (pt) |
WO (1) | WO2002076981A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101797519B (zh) * | 2010-03-19 | 2011-12-07 | 西南大学 | 氟代双苯磺酰亚胺作为氮杂Diels-Alder反应催化剂的应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH474519A (de) | 1966-07-12 | 1969-06-30 | Geigy Ag J R | Verfahren zur Herstellung von neuen N'- substituierten N-Arylsulfonylharnstoffen |
US4028364A (en) | 1976-07-06 | 1977-06-07 | G. D. Searle & Co. | 2-Azabicyclo[2.2.2.]octan-2-yl-diphenyl-alkanones and related compounds |
US4134890A (en) * | 1977-03-11 | 1979-01-16 | G. D. Searle & Co. | 2-Aryl-2-[ω-(diisopropylamino)alkyl]-ω-(azabicycloalkyl)alkanamides |
FR2619813B1 (fr) | 1987-08-28 | 1991-05-03 | Adir | Nouveaux derives de l'acide aza - 2 bicyclooctane carboxylique - 3, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
FR2635684A1 (fr) | 1988-08-24 | 1990-03-02 | Adir | Utilisation de derives de l'acide aza - 2 bicyclooctane (2.2.2) carboxylique - 3 pour l'obtention de medicaments destines au traitement des maladies consecutives a l'alteration de la paroi vasculaire ainsi qu'aux troubles de la microcirculation |
US5019580A (en) | 1989-12-19 | 1991-05-28 | Shaman Pharmaceuticals, Inc. | Dioscoretine and its use as a hypoglycemic agent |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
-
2002
- 2002-03-25 KR KR10-2003-7012428A patent/KR20030083010A/ko not_active Application Discontinuation
- 2002-03-25 JP JP2002576239A patent/JPWO2002076981A1/ja active Pending
- 2002-03-25 MX MXPA03008636A patent/MXPA03008636A/es not_active Application Discontinuation
- 2002-03-25 EP EP02708653A patent/EP1375500A1/en not_active Withdrawn
- 2002-03-25 WO PCT/JP2002/002847 patent/WO2002076981A1/ja not_active Application Discontinuation
- 2002-03-25 RU RU2003131329/04A patent/RU2003131329A/ru not_active Application Discontinuation
- 2002-03-25 CN CNB028072057A patent/CN1218946C/zh not_active Expired - Fee Related
- 2002-03-25 BR BR0206436-7A patent/BR0206436A/pt not_active IP Right Cessation
- 2002-03-25 US US10/467,719 patent/US6903111B2/en not_active Expired - Fee Related
- 2002-03-25 CA CA002441838A patent/CA2441838A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JPWO2002076981A1 (ja) | 2004-10-07 |
RU2003131329A (ru) | 2005-01-27 |
KR20030083010A (ko) | 2003-10-23 |
MXPA03008636A (es) | 2003-12-08 |
EP1375500A1 (en) | 2004-01-02 |
US6903111B2 (en) | 2005-06-07 |
CN1218946C (zh) | 2005-09-14 |
CA2441838A1 (en) | 2002-10-03 |
WO2002076981A1 (fr) | 2002-10-03 |
CN1500088A (zh) | 2004-05-26 |
US20040067911A1 (en) | 2004-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2025 DE 27/10/2009. |