BR0112338A - Composto, composição farmacêutica, e, uso de um composto - Google Patents

Composto, composição farmacêutica, e, uso de um composto

Info

Publication number
BR0112338A
BR0112338A BR0112338-6A BR0112338A BR0112338A BR 0112338 A BR0112338 A BR 0112338A BR 0112338 A BR0112338 A BR 0112338A BR 0112338 A BR0112338 A BR 0112338A
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
thrombin
cyclohexyl
cyclopentyl
Prior art date
Application number
BR0112338-6A
Other languages
English (en)
Inventor
Johannes Bernardus Ma Rewinkel
Cornelis Marius Timmers
Paolo Giovanni Martino Conti
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of BR0112338A publication Critical patent/BR0112338A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, USO DE UM COMPOSTO". A invenção refere-se a um composto tendo a fórmula (I) em que R~ 1~ é ciclopentila, ciclo-hexila ou uma alquila (3-4C) ramificada; R~ 2~ é ciclo-hexila ou fenila; R~ 3~ é H ou metila; e A é um anel de 4,5 ou 6 membros saturado, não substituído; ou um sal farmaceuticamente aceitável do mesmo. Os compostos da invenção tem atividade anticoagulante e podem ser usados no tratamento ou prevenção de doenças mediadas por trombina e associadas com trombina.
BR0112338-6A 2000-07-12 2001-07-09 Composto, composição farmacêutica, e, uso de um composto BR0112338A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00202491 2000-07-12
PCT/EP2001/007887 WO2002004423A1 (en) 2000-07-12 2001-07-09 Thrombin inhibitors comprising an aminoisoquinoline group

Publications (1)

Publication Number Publication Date
BR0112338A true BR0112338A (pt) 2003-07-22

Family

ID=8171793

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0112338-6A BR0112338A (pt) 2000-07-12 2001-07-09 Composto, composição farmacêutica, e, uso de um composto

Country Status (23)

Country Link
US (1) US6642253B2 (pt)
EP (1) EP1303491A1 (pt)
JP (1) JP2004502759A (pt)
KR (1) KR20030022270A (pt)
CN (1) CN1441784A (pt)
AR (1) AR029596A1 (pt)
AU (1) AU2001278476A1 (pt)
BR (1) BR0112338A (pt)
CA (1) CA2413035A1 (pt)
CZ (1) CZ200392A3 (pt)
EC (1) ECSP034422A (pt)
HR (1) HRP20030017A2 (pt)
HU (1) HUP0301258A2 (pt)
IL (1) IL153611A0 (pt)
MX (1) MXPA03000337A (pt)
NO (1) NO20030145L (pt)
NZ (1) NZ523553A (pt)
PE (1) PE20020209A1 (pt)
PL (1) PL359787A1 (pt)
RU (1) RU2003104017A (pt)
SK (1) SK322003A3 (pt)
WO (1) WO2002004423A1 (pt)
ZA (1) ZA200300080B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0400651A2 (hu) 2000-11-07 2004-06-28 Bristol-Myers Squibb Company Szerin proteáz inhibitorokként alkalmazható savszármazékok és ezeket tartalmazó gyógyszerkészítmények
US6906192B2 (en) 2000-11-07 2005-06-14 Bristol Myers Squibb Company Processes for the preparation of acid derivatives useful as serine protease inhibitors
TWI389899B (zh) * 2006-08-08 2013-03-21 Msd Oss Bv 具口服活性之凝血酶抑制劑
MY154767A (en) * 2006-12-27 2015-07-15 Sanofi Aventis Cycloalkyamine substituted isoquinoline and isoquinolinone derivatives
US7927378B2 (en) * 2007-03-05 2011-04-19 Scussel Sbj Systems, Llc Vacuum assisted prosthetic sleeve and socket
CN109810173B (zh) * 2017-11-21 2020-11-27 首都医科大学 二氢异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用
CN109810172B (zh) * 2017-11-21 2021-01-01 首都医科大学 异喹啉-3-甲酰-PARGD(aa)aa,其制备,抗静脉血栓活性和应用
CN109810174B (zh) * 2017-11-21 2021-01-01 首都医科大学 异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL123986A (en) * 1997-04-24 2011-10-31 Organon Nv Medicinal compounds

Also Published As

Publication number Publication date
ECSP034422A (es) 2003-03-10
US20030166579A1 (en) 2003-09-04
NO20030145D0 (no) 2003-01-10
US6642253B2 (en) 2003-11-04
HUP0301258A2 (hu) 2003-08-28
RU2003104017A (ru) 2004-08-20
JP2004502759A (ja) 2004-01-29
CZ200392A3 (cs) 2003-05-14
PE20020209A1 (es) 2002-03-19
SK322003A3 (en) 2003-06-03
WO2002004423A1 (en) 2002-01-17
NZ523553A (en) 2004-04-30
PL359787A1 (en) 2004-09-06
WO2002004423A9 (en) 2003-05-15
EP1303491A1 (en) 2003-04-23
CA2413035A1 (en) 2002-01-17
MXPA03000337A (es) 2004-04-05
AU2001278476A1 (en) 2002-01-21
KR20030022270A (ko) 2003-03-15
HRP20030017A2 (en) 2003-04-30
AR029596A1 (es) 2003-07-02
NO20030145L (no) 2003-01-10
ZA200300080B (en) 2004-04-05
IL153611A0 (en) 2003-07-06
WO2002004423A8 (en) 2003-03-06
CN1441784A (zh) 2003-09-10

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A E 7A ANUIDADE

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1963 DE 19.08.2008.