BR0112962B1 - Composições farmacêuticas compreendendo ácido hialurônico, ácido glicirretínico e polivinilpirrolidona, e uso desses compostos na preparação de medicamentos - Google Patents

Composições farmacêuticas compreendendo ácido hialurônico, ácido glicirretínico e polivinilpirrolidona, e uso desses compostos na preparação de medicamentos

Info

Publication number
BR0112962B1
BR0112962B1 BRPI0112962-7B1A BR0112962A BR0112962B1 BR 0112962 B1 BR0112962 B1 BR 0112962B1 BR 0112962 A BR0112962 A BR 0112962A BR 0112962 B1 BR0112962 B1 BR 0112962B1
Authority
BR
Brazil
Prior art keywords
acid
medicaments
polyvinylpyrrolidone
preparation
pharmaceutical compositions
Prior art date
Application number
BRPI0112962-7B1A
Other languages
English (en)
Other versions
BR0112962A (pt
BRPI0112962B8 (pt
Inventor
Marco Mastrodonato
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR0112962A publication Critical patent/BR0112962A/pt
Publication of BR0112962B1 publication Critical patent/BR0112962B1/pt
Publication of BRPI0112962B8 publication Critical patent/BRPI0112962B8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015Drug-containing film-forming compositions, e.g. spray-on
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/785Polymers containing nitrogen
    • A61K31/787Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A61K31/79Polymers of vinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BRPI0112962A 2000-07-28 2001-07-18 composições farmacêuticas compreendendo ácido hialurônico, ácido glicirretínico e polivinilpirrolidona, e uso desses compostos na preparação de medicamentos BRPI0112962B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI001732A IT1318649B1 (it) 2000-07-28 2000-07-28 Composizioni farmaceutiche per il trattamento di mucositi e stomatiti.
PCT/EP2001/008303 WO2002009637A2 (en) 2000-07-28 2001-07-18 Pharmaceutical compositions for the treatment of mucositis, stomatitis and behcet's syndrome

Publications (3)

Publication Number Publication Date
BR0112962A BR0112962A (pt) 2003-06-24
BR0112962B1 true BR0112962B1 (pt) 2013-12-31
BRPI0112962B8 BRPI0112962B8 (pt) 2021-05-25

Family

ID=11445589

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0112962A BRPI0112962B8 (pt) 2000-07-28 2001-07-18 composições farmacêuticas compreendendo ácido hialurônico, ácido glicirretínico e polivinilpirrolidona, e uso desses compostos na preparação de medicamentos

Country Status (26)

Country Link
US (1) US20020173485A1 (pt)
EP (1) EP1313489B1 (pt)
JP (1) JP2004505028A (pt)
KR (1) KR100761051B1 (pt)
CN (1) CN1198625C (pt)
AR (1) AR030068A1 (pt)
AT (1) ATE289512T1 (pt)
AU (2) AU1211302A (pt)
BR (1) BRPI0112962B8 (pt)
CA (1) CA2424346C (pt)
CZ (1) CZ301461B6 (pt)
DE (1) DE60109044T2 (pt)
ES (1) ES2236324T3 (pt)
HK (1) HK1059215A1 (pt)
HR (1) HRP20030046B1 (pt)
IT (1) IT1318649B1 (pt)
MX (1) MXPA03000712A (pt)
MY (1) MY130477A (pt)
NO (1) NO329574B1 (pt)
NZ (1) NZ523832A (pt)
PL (1) PL204397B1 (pt)
PT (1) PT1313489E (pt)
RU (1) RU2272636C2 (pt)
UA (1) UA79075C2 (pt)
WO (1) WO2002009637A2 (pt)
ZA (1) ZA200300712B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2314049T3 (es) 2001-02-15 2009-03-16 Access Pharmaceuticals, Inc. Formulaciones liquidas para la prevencion y el tratamiento de enfermedades y trastornos de la mucosa.
US7544348B2 (en) 2001-02-15 2009-06-09 Access Pharmaceuticals, Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
US6585997B2 (en) 2001-08-16 2003-07-01 Access Pharmaceuticals, Inc. Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
KR100518152B1 (ko) 2002-05-09 2005-09-29 메디제네스(주) 혈장 또는 혈청을 함유한 창상 치료용 약학 조성물
WO2004064850A1 (en) * 2003-01-23 2004-08-05 Ml Laboratories Plc Antiviral composition comprising a sulphated glucose polymer and a bacteriostatic agent
GB0312485D0 (en) * 2003-05-30 2003-07-09 Dodson & Horrell Horse food composition
ITMI20031291A1 (it) 2003-06-25 2004-12-26 Ricerfarma Srl Uso di acido ialuronico per la preparazione di composizioni per il trattamento di afte del cavo orale.
WO2005027939A1 (en) * 2003-08-21 2005-03-31 Access Pharmaceuticals, Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8377468B2 (en) 2006-08-28 2013-02-19 Rexaderm, Inc. Dry wound dressing and drug delivery system
KR100758636B1 (ko) * 2006-12-19 2007-09-13 고려대학교 산학협력단 생체 점막 점착성 고분자 접합체 및 이의 제조방법
SI3354276T1 (sl) 2007-11-13 2020-09-30 Meritage Pharma, Inc. Sestavki za zdravljenje gastrointestinalnega vnetja
US8865692B2 (en) 2007-11-13 2014-10-21 Meritage Pharma, Inc Compositions for the treatment of gastrointestinal inflammation
US20090264392A1 (en) * 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
GB0813589D0 (en) * 2008-07-24 2008-09-03 Sinclair Pharmaceuticals Ltd Composition
ES2428337T3 (es) * 2009-05-25 2013-11-07 Sofar Swiss Sa Uso de una combinación fija de glucosaminoglucanos y composición masticable que comprende dicha combinación fija
JP6306349B2 (ja) 2010-04-14 2018-04-04 アルトリア クライアント サービシーズ リミテッド ライアビリティ カンパニー 予成形無煙タバコ製品
SG189434A1 (en) 2010-11-12 2013-06-28 Colgate Palmolive Co Oral care product and methods of use and manufacture thereof
ES2388281B1 (es) 2010-12-27 2013-10-01 Laboratorios Viñas S.A. Composición farmacéutica que comprende ácido hialurónico y un compuesto de zinc y pastilla con palito y procedimiento para preparación correspondientes
ITMI20110954A1 (it) * 2011-05-26 2012-11-27 Professional Dietetics Srl Combinazioni per il trattamento delle mucositi vaginali o rettali
US10799548B2 (en) * 2013-03-15 2020-10-13 Altria Client Services Llc Modifying taste and sensory irritation of smokeless tobacco and non-tobacco products
CA2964064C (en) * 2013-10-16 2022-07-05 Orahealth Corporation Treating mucosal lesions with hyaluronan delivered from an adhering troche
CN105342987A (zh) * 2015-12-04 2016-02-24 亚飞(上海)生物医药科技有限公司 一种凝胶及其制备方法和应用
ITUA20161822A1 (it) * 2016-03-18 2017-09-18 Indena Spa Composizioni utili nella prevenzione e/o nel trattamento di patologie del cavo orale, delle prime vie aeree e dell’esofago
JP6281968B1 (ja) * 2016-07-27 2018-02-21 株式会社リタファーマ 口腔粘膜貼付材及びその製造方法
IT201600079773A1 (it) * 2016-07-29 2018-01-29 Matteo Bevilacqua Composizioni contenenti oligosaccaridi di acido ialuronico (HA4), condroitin solfato (CS2-4) ed eparan solfato (HS2-4), triterpeni pentaciclici e derivati per uso medico curativo e metodo per la preparazione di tali composizioni.
CN106176863A (zh) * 2016-08-04 2016-12-07 陈广圣 一种医用抗菌剂
CN107802641A (zh) * 2016-09-09 2018-03-16 李明典 口腔软组织(牙龈、粘膜)抗发炎酸痛剂
EP3459368A1 (en) * 2017-09-20 2019-03-27 Geophyt S.r.L. Food integrator for antineoplastic therapies
CN109331023A (zh) * 2018-11-12 2019-02-15 沈阳药科大学 甘草次酸的医药用途
KR102475125B1 (ko) 2019-08-07 2022-12-07 고려대학교 산학협력단 일산화질소 복합체를 포함하는 구강 점막염 치료용 조성물 및 구강 점막염 치료제
JP2022553412A (ja) * 2019-10-25 2022-12-22 ムココルト アクチエボラグ 粘膜又は皮膚における炎症状態の治療
IT202100011879A1 (it) * 2021-05-10 2022-11-10 Aurora Biofarma S R L Composizione orale per il trattamento delle esofagiti

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2092442B (en) 1981-02-06 1984-02-08 Biorex Laboratories Ltd Pharmaceutical composition for treating diseases of the oral cavity containing glycyrrhetinic acid or a derivative thereof
ZA82361B (en) * 1981-02-06 1982-12-29 Biorex Laboratories Ltd Pharmaceutical composition for treating diseases of the oral cavity
JPS6117510A (ja) * 1984-07-03 1986-01-25 Toyobo Co Ltd 口腔粘膜適用徐放性ニフエジピン製剤
JPS6440423A (en) * 1987-08-05 1989-02-10 Kyukyu Yakuhin Kogyo Kk Patch for mucosa in oral cavity
US4965253A (en) * 1987-10-14 1990-10-23 University Of Florida Viscoelastic material for ophthalmic surgery
IT1240316B (it) * 1990-02-21 1993-12-07 Ricerca Di Schiena Del Dr. Michele G. Di Schiema & C. Composizioni a base di acido ialuronico ad alto peso molecolare somministrabili per via topica per il trattamento di infiammazioni del cavo orale ,per la cosmetica e l'igiene del cavo orale
JPH09169652A (ja) * 1995-12-18 1997-06-30 Lion Corp 水性液状組成物
JPH10182390A (ja) * 1996-12-25 1998-07-07 Lion Corp 口腔用組成物
JP2000178185A (ja) * 1998-12-18 2000-06-27 Lion Corp 口腔粘膜付着型徐放性錠剤

Also Published As

Publication number Publication date
CA2424346C (en) 2010-03-09
ZA200300712B (en) 2004-02-09
ITMI20001732A0 (it) 2000-07-28
KR100761051B1 (ko) 2007-10-04
HRP20030046A2 (en) 2004-04-30
HRP20030046B1 (en) 2011-08-31
MY130477A (en) 2007-06-29
KR20030069979A (ko) 2003-08-27
EP1313489A2 (en) 2003-05-28
ITMI20001732A1 (it) 2002-01-28
EP1313489B1 (en) 2005-02-23
CN1474700A (zh) 2004-02-11
UA79075C2 (uk) 2007-05-25
CZ301461B6 (cs) 2010-03-10
NO20030411L (no) 2003-01-27
DE60109044T2 (de) 2005-07-21
NO20030411D0 (no) 2003-01-27
NZ523832A (en) 2003-09-26
WO2002009637A2 (en) 2002-02-07
HK1059215A1 (en) 2004-06-25
RU2272636C2 (ru) 2006-03-27
PL362921A1 (en) 2004-11-02
JP2004505028A (ja) 2004-02-19
AR030068A1 (es) 2003-08-13
AU2002212113B2 (en) 2006-01-12
BR0112962A (pt) 2003-06-24
CN1198625C (zh) 2005-04-27
DE60109044D1 (de) 2005-03-31
BRPI0112962B8 (pt) 2021-05-25
ATE289512T1 (de) 2005-03-15
IT1318649B1 (it) 2003-08-27
WO2002009637A3 (en) 2002-12-05
CA2424346A1 (en) 2002-02-07
MXPA03000712A (es) 2004-11-01
US20020173485A1 (en) 2002-11-21
ES2236324T3 (es) 2005-07-16
NO329574B1 (no) 2010-11-15
AU1211302A (en) 2002-02-13
PL204397B1 (pl) 2010-01-29
PT1313489E (pt) 2005-05-31

Similar Documents

Publication Publication Date Title
BR0112962B1 (pt) Composições farmacêuticas compreendendo ácido hialurônico, ácido glicirretínico e polivinilpirrolidona, e uso desses compostos na preparação de medicamentos
IL154965A0 (en) Sulfonamide derivatives, their preparation and pharmaceutical compositions containing them
EE200100684A (et) Indalüülasendatud benseenkarboksamiidid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE201300011A (et) Ksantiini derivaadid, nende valmistamine ja kasutamine ravimina
DK1263720T3 (da) Azetidinderivater, fremstilling deraf samt farmaceutiske sammensætninger, der indeholder samme
HUP0400837A3 (en) 2-phenyl-thiazole derivatives, their use and pharmaceutical compositions containing them
HUP0204474A3 (en) 1h-imidazopyridine derivatives, pharmaceutical compositions containing them and their use
HUP0402497A3 (en) Pharmaceutical compositions containing two activ ingredients and their uses
IL163894A (en) 2-hydroxy-3-heteroarylindole derivatives, pharmaceutical compositions comprising them and their uses in the preparation of medicaments
HUP0301573A3 (en) Substituted arylpyrazines, pharmaceutical compositions containing them and their use
HUP0200308A2 (en) Quinolinecarboxamides as antiviral agents, pharmaceutical compositions containing them and their use
HUP0400467A3 (en) 2-iminopyrrolidine derivatives, pharmaceutical compositions containing them and their use
IL151209A0 (en) Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation
HUP0301722A3 (en) Pyrimidine derivatives, pharmaceutical compositions containing them and their use
AU2001279905A2 (en) Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents
AU2001279905A1 (en) Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents
HUP0200859A3 (en) Cyclo-alkyl substituted benzimidazoles, pharmaceutical compositions containing them, their preparation and their use
IL161623A (en) Nicotin-or isonicotin benzothiazole derivatives, their preparation and pharmaceutical compositions comprising them
FR2811552B1 (fr) Composition notamment cosmetique ou pharmaceutique se presentant sous forme solide
IL204947A0 (en) Phenylacetamido-thiazole derivatives, process for their preparation and their use in the manufacture of medicaments, pharmaceutical compositions and kits comprising them
HUP0400967A3 (en) Substituted 2-anilino-benzimidazoles, their use and pharmaceutical compositions containing them
HUP0500024A3 (en) 6-aminomorphinane derivatives, their use and pharmaceutical compositions containing them
IL151912A0 (en) Pyrolidine derivatives, their preparation and pharmaceutical compositions containing them
BR0208566B1 (pt) Derivados de Beta-Carbolina, Seu Uso, e composição Farmacêutica
BR0012184B1 (pt) compostos derivados de indol, formulação farmacêutica, e, composição e uso dos compostos na fabricação de medicamentos

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT. CL: A61K 31/79

Ipc: A61K 31/19 (2010.01), A61K 31/728 (2010.01), A61K

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 31/12/2013, OBSERVADAS AS CONDICOES LEGAIS.

B25A Requested transfer of rights approved
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/07/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B21H Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2679, DE 10/05/2022, EM VIRTUDE DO DESPACHO DE RETIFICACAO DA CARTA PATENTE PUBLICADO NA RPI 2629, DE 25/05/2021, REFERENTE A VIGENCIA DA PATENTE EM TELA, ALTERANDO-A PARA 20 ANOS CONTADOS DA DATA DE DEPOSITO, FAZENDO COM QUE NAO SEJA DEVIDO O PAGAMENTO DA 21A ANUIDADE.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 18/07/2021