BR0110428A - Composto ou um seu sal farmacologicamente aceitável, composição farmacêutica, usos de um composto ou um seu sal farmacologicamente aceitável, de um modulador de ppar gama e de um antagonista parcial, agentes que inibe a diferenciação de adipócitos, que acentua ou recupera a função osteogênica, para tratamento ou prevenção de osteoporose, que tem atividade moduladora de ppar gama, diminuidor do açúcar no sangue, para tratamento ou prevenção de diabetes melito, e, para tratamento ou prevenção - Google Patents

Composto ou um seu sal farmacologicamente aceitável, composição farmacêutica, usos de um composto ou um seu sal farmacologicamente aceitável, de um modulador de ppar gama e de um antagonista parcial, agentes que inibe a diferenciação de adipócitos, que acentua ou recupera a função osteogênica, para tratamento ou prevenção de osteoporose, que tem atividade moduladora de ppar gama, diminuidor do açúcar no sangue, para tratamento ou prevenção de diabetes melito, e, para tratamento ou prevenção

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Publication number
BR0110428A
BR0110428A BR0110428-4A BR0110428A BR0110428A BR 0110428 A BR0110428 A BR 0110428A BR 0110428 A BR0110428 A BR 0110428A BR 0110428 A BR0110428 A BR 0110428A
Authority
BR
Brazil
Prior art keywords
prevention
treatment
acceptable salt
compound
pharmacologically acceptable
Prior art date
Application number
BR0110428-4A
Other languages
English (en)
Inventor
Yoshiya Amemiya
Kenji Wakabayashi
Sachiko Takaishi
Chie Fukuda
Original Assignee
Sankyo Co
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Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of BR0110428A publication Critical patent/BR0110428A/pt

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Abstract

"COMPOSTO OU UM SEU SAL FARMACOLOGICAMENTE ACEITáVEL, COMPOSIçãO FARMACêUTICA, USOS DE UM COMPOSTO OU UM SEU SAL FARMACOLOGICAMENTE ACEITáVEL, DE UM MODULADOR DE PPAR GAMA E DE UM ANTAGONISTA PARCIAL, AGENTES QUE INIBE A DIFERENCIAçãO DE ADIPóCITOS, QUE ACENTUA OU RECUPERA A FUNçãO OSTEOGêNICA, PARA TRATAMENTO OU PREVENçãO DE OSTEOPOROSE, QUE TEM ATIVIDADE MODULADORA DE PPAR GAMA, DIMINUIDOR DO AçúCAR NO SANGUE, PARA TRATAMENTO OU PREVENçãO DE DIABETE MELITO, E, PARA TRATAMENTO OU PREVENçãO DE DISTúRBIOS". Objeto A presente invenção tem a finalidade de proporcionar um modulador de PPAR <sym> que pode ser um agente terapêutico para osteoporose retrógrada em que a excessiva diferenciação de adipócitos foi inibida e a formação e diferenciação de osteoblastos de células-tronco é facilitada ou que para diabete melito sem características, como adipogênese excessiva, disfunção do fígado, distúrbios vasculares e análogos. Solução Composto de fórmula a seguir ou um seu sal farmacologicamente aceitável em que A representa um grupo fenila ou análogo, B representa um grupo arila ou análogo, X representa um átomo de oxigênio ou análogo, e n representa 0 ou 1.
BR0110428-4A 2000-04-28 2001-04-26 Composto ou um seu sal farmacologicamente aceitável, composição farmacêutica, usos de um composto ou um seu sal farmacologicamente aceitável, de um modulador de ppar gama e de um antagonista parcial, agentes que inibe a diferenciação de adipócitos, que acentua ou recupera a função osteogênica, para tratamento ou prevenção de osteoporose, que tem atividade moduladora de ppar gama, diminuidor do açúcar no sangue, para tratamento ou prevenção de diabetes melito, e, para tratamento ou prevenção BR0110428A (pt)

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JP2000129565 2000-04-28
JP2001060366 2001-03-05
PCT/JP2001/003655 WO2001083427A1 (fr) 2000-04-28 2001-04-26 MODULATEURS DE PPAR$g(g)

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Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041691B1 (en) 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
JP4083422B2 (ja) * 2000-12-22 2008-04-30 石原産業株式会社 アニリン誘導体またはその塩ならびにそれらを含有するサイトカイン産生抑制剤
CA2432713C (en) 2000-12-22 2009-10-27 Ishihara Sangyo Kaisha, Ltd. Aniline derivatives or salts thereof and cytokine production inhibitors containing the same
US20030144350A1 (en) * 2001-07-20 2003-07-31 Adipogenix, Inc. Fat accumulation-modulation compounds
MXPA04000615A (es) * 2001-07-20 2004-04-20 Juvantia Pharma Ltd Oy Compuestos utiles para el tratamiento o la prevencion de enfermedades mediadas por alfa-2b-adrenoceptor.
WO2003013516A1 (en) * 2001-08-10 2003-02-20 Adipogenix, Inc. Fat accumulation-modulating compounds
WO2003033494A1 (fr) * 2001-10-17 2003-04-24 Sankyo Company, Limited Derive de benzimidazole
WO2003035602A1 (fr) * 2001-10-25 2003-05-01 Sankyo Company, Limited Modulateurs lipidiques
EP1503986B1 (en) * 2001-12-21 2015-09-30 Cytokinetics, Inc. Compositions and methods for treating heart failure
EP1388341A1 (en) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
DK1539724T3 (da) * 2002-08-07 2008-02-11 Neuraxon Inc Aminobenzothiazolforbindelser med NOS-inhiberende aktivitet
US7338956B2 (en) 2002-08-07 2008-03-04 Sanofi-Aventis Deutschland Gmbh Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
JP2005104951A (ja) * 2003-01-17 2005-04-21 Kirin Brewery Co Ltd 血圧降下用組成物および血管柔軟性改善用組成物並びにこれらの機能が付与された食品
WO2004067521A1 (en) * 2003-01-27 2004-08-12 Astellas Pharma Inc. Thiazole derivatives and their use as vap-1 inhibitors
AU2004240885A1 (en) * 2003-05-21 2004-12-02 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type I
US7173030B2 (en) 2003-05-21 2007-02-06 Biovitrum Ab Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
DE602004012858T2 (de) * 2003-06-20 2009-05-14 F. Hoffmann-La Roche Ag 2-aminobenzothiazole als cb1 rezeptor inverse agonisten
CA2533594C (en) * 2003-07-23 2013-04-02 Synta Pharmaceuticals, Corp. Compounds for inflammation and immune-related uses
FR2858321B1 (fr) * 2003-07-28 2006-01-20 Servier Lab Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2772017C (en) * 2003-08-29 2016-05-31 Mitsui Chemicals, Inc. Agricultural/horticultural insecticide and method for using the same
PT1535612E (pt) * 2003-11-28 2006-12-29 Merck Sante Sas Tratamento da hiperuricemia
ATE384058T1 (de) * 2003-12-08 2008-02-15 Hoffmann La Roche Thiazolderivate
WO2005063678A1 (ja) * 2003-12-26 2005-07-14 Daiichi Pharmaceutical Co., Ltd フェニル酢酸誘導体の製造方法
CA2554437C (en) * 2004-01-28 2011-06-21 Mitsui Chemicals, Inc. Amide derivatives, process for preparation thereof and use thereof as insecticide
JP4884963B2 (ja) * 2004-03-10 2012-02-29 財団法人乙卯研究所 記憶固定促進剤
US20070208068A1 (en) * 2004-03-18 2007-09-06 R-Tech Ueno, Ltd. & Astellas Pharma Inc. Aqueous Composition Comprising Thiazole Derivative
UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
MX2007003321A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
CN101084212A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
EP2289510A1 (en) 2004-09-20 2011-03-02 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
US7592343B2 (en) 2004-09-20 2009-09-22 Xenon Pharmaceuticals Inc. Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors
EP2316458A1 (en) 2004-09-20 2011-05-04 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
WO2006034440A2 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
GB0421908D0 (en) * 2004-10-01 2004-11-03 Angeletti P Ist Richerche Bio New uses
JP2008019169A (ja) * 2004-10-25 2008-01-31 Osaka Univ 新規ｐｐａｒ調節剤およびそのスクリーニング方法
JP4221383B2 (ja) * 2005-02-10 2009-02-12 独立行政法人科学技術振興機構 神経因性疼痛治療剤
WO2006096398A2 (en) * 2005-03-03 2006-09-14 Smithkline Beecham Corporation Medicaments
AU2006223000B2 (en) * 2005-03-14 2011-06-30 Center For Molecular Medicine And Immunology Methods of treating cancer using PPAR-gamma antagonists
CN101208089A (zh) 2005-06-03 2008-06-25 泽农医药公司 氨基噻唑衍生物作为人硬酯酰-CoA去饱和酶抑制剂
ZA200800608B (en) 2005-06-21 2009-06-24 Mitsui Chemicals Inc Amide derivative and insecticide containing the same
AU2006299087A1 (en) 2005-10-06 2007-04-12 Sanofi-Aventis Cyclic N-[1 ,3,4]-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals
KR20080050468A (ko) 2005-10-06 2008-06-05 사노피-아벤티스 Ｎ-[1,3,4]-티아디아졸-2-일-벤젠 설폰아미드, 이의 제조방법 및 약제로서의 이의 용도
ATE513829T1 (de) * 2005-10-06 2011-07-15 Sanofi Aventis Bicyclische arylsulfonsäureä1,3,4ü-thiadiazol-2- yl-amide, verfahren zu ihrer herstellung und ihre verwendung als pharmazeutika
RU2442773C2 (ru) * 2005-12-09 2012-02-20 Зольвай Фармасьютиклз Гмбх Новые n-сульфамоилпиперидинамиды, предназначенные для профилактики или лечения ожирения и родственных патологических состояний
CN101096363B (zh) * 2006-06-27 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
US7994338B2 (en) 2006-08-16 2011-08-09 The J. David Gladstone Institutes Small molecule inhibitors of kynurenine-3-monooxygenase
EP2054056A4 (en) * 2006-08-16 2010-08-25 J David Gladstone Inst A Testa SMALL MOLECULAR INHIBITORS OF KYNURENINE-3-MONOOXYGENASE
WO2008044700A1 (fr) * 2006-10-11 2008-04-17 Takeda Pharmaceutical Company Limited INHIBITEUR DE LA GSK-3β
TW200906826A (en) * 2007-06-12 2009-02-16 Genelabs Tech Inc Anti-viral inhibitors and methods of use
RU2518892C2 (ru) * 2008-09-23 2014-06-10 Виста Лабораториз Лтд. Лиганды для агрегированных молекул тау-белка
DE102008049675A1 (de) 2008-09-30 2010-04-01 Markus Dr. Heinrich Verfahren zur Herstellung von 3-Aminobiphenylen
GB0907601D0 (en) * 2009-05-01 2009-06-10 Equateq Ltd Novel methods
TW201103904A (en) * 2009-06-11 2011-02-01 Hoffmann La Roche Janus kinase inhibitor compounds and methods
CA2808841A1 (en) * 2010-08-24 2012-03-01 Brigham Young University Antimetastatic compounds
EP2610249B1 (en) 2010-08-26 2017-10-11 Kyoto University Pluripotent stem cell cardiomyocyte differentiation-promoting agent
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
JPWO2012121168A1 (ja) * 2011-03-04 2014-07-17 国立大学法人京都大学 キナーゼ阻害剤
KR101996343B1 (ko) 2012-01-27 2019-07-05 고쿠리츠 다이가쿠 호진 교토 다이가쿠 전능성 줄기세포의 심근분화 유도방법
WO2014136519A1 (ja) 2013-03-08 2014-09-12 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
JP6651218B2 (ja) 2014-05-30 2020-02-19 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
EA201791982A1 (ru) 2015-03-09 2020-02-17 Интекрин Терапьютикс, Инк. Способы лечения неалкогольной жировой болезни печени и/или липодистрофии
TW201643143A (zh) * 2015-03-13 2016-12-16 國立大學法人北海道大學 抑制氧化壓迫引發的神經細胞死亡之化合物
KR101815193B1 (ko) * 2015-12-29 2018-01-30 (주)스파크바이오파마 PPARγ 인산화 저해제 및 이를 포함하는 약학적 조성물
AU2017313842A1 (en) * 2016-08-18 2019-03-07 Intekrin Therapeutics, Inc. PPARgamma AGONIST FOR TREATMENT OF BONE DISORDERS
CA3058806A1 (en) 2017-04-03 2018-10-11 Coherus Biosciences Inc. Ppar.gamma. agonist for treatment of progressive supranuclear palsy
EP3498694A1 (en) * 2017-12-12 2019-06-19 Medibiofarma, S.L. New benzamide derivatives as ppar-gamma modulators
CN114105902B (zh) * 2018-12-28 2023-11-03 中山大学 噻唑苯甲酰胺衍生物及其在制备抗骨质疏松药物中的应用
CN110156729B (zh) * 2019-05-14 2022-12-06 浙江大学 一种苯基哌嗪类ube2f小分子抑制剂及其合成方法
EP4039676A4 (en) * 2019-10-02 2024-04-03 Klotho Sciences COMPOUND INTENDED TO INDUCE THE EXPRESSION OF AN ANTI-AGING KLOTHO GENE AND USE THEREOF
CN112812077B (zh) * 2019-11-18 2023-08-22 中国科学院上海药物研究所 苯甲酰胺类化合物及其制备方法、药物组合物和用途
CN113831301B (zh) 2020-06-08 2023-06-06 沈阳药科大学 苯并噻唑类衍生物及其用途
AU2022248891A1 (en) * 2021-04-01 2023-10-26 Klotho Sciences Composition for preventing or treating chronic kidney disease, comprising compound that induces expression of anti-aging gene klotho
WO2022217276A1 (en) * 2021-04-09 2022-10-13 Nimbus Clio, Inc. Cbl-b modulators and uses thereof
CN115232030A (zh) * 2021-04-23 2022-10-25 中国医学科学院药物研究所 芳基脲类化合物及其制法和药物用途
WO2023172845A1 (en) * 2022-03-08 2023-09-14 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof
WO2023172846A1 (en) * 2022-03-08 2023-09-14 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof
CN115093389A (zh) * 2022-05-31 2022-09-23 广州医科大学 6-酰胺色满-3-甲酰胺衍生物及其制备方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2754209A (en) * 1952-06-10 1956-07-10 Azoplate Corp Light-sensitive para quinone diazides for making printing plates
DE1642224B2 (de) * 1967-04-28 1976-04-29 Basf Ag, 6700 Ludwigshafen Verwendung von substituierten benzoesaeureaniliden zur bekaempfung von pilzen aus der klasse der basidiomyceten
US5449691A (en) * 1991-12-31 1995-09-12 Sterling Winthrop Inc. 3,4-disubstituted anilines-immunomodulating agents
US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US7115728B1 (en) * 1995-01-30 2006-10-03 Ligand Pharmaceutical Incorporated Human peroxisome proliferator activated receptor γ
WO1996029405A2 (en) * 1995-03-20 1996-09-26 Ligand Pharmaceuticals Incorporated MODULATORS OF ob GENE AND SCREENING METHODS THEREFOR
US5939442A (en) * 1995-06-07 1999-08-17 The Salk Institute For Biological Studies Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof
CA2204616C (en) * 1995-09-18 2002-12-17 Ranjan Mukherjee Ppar gamma antagonists for treating obesity
WO1998005331A2 (en) * 1996-08-02 1998-02-12 Ligand Pharmaceuticals Incorporated Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators
CA2279331C (en) * 1997-02-07 2010-04-20 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6200995B1 (en) * 1998-01-29 2001-03-13 Tularik Inc. PPAR-γ modulators
ATE212552T1 (de) * 1998-04-17 2002-02-15 Tufts College Map kinase-inhibitoren zur behandlung von durch tnf-alpha induzierte lipolyse- verursachte krankheiten
AU4713499A (en) * 1998-06-27 2000-01-17 Photogenesis, Inc. Ophthalmic uses of ppargamma agonists and ppargamma antagonists
GB9824614D0 (en) * 1998-11-11 1999-01-06 Glaxo Group Ltd Chemical compounds
WO2000055118A1 (en) * 1999-03-16 2000-09-21 Glaxo Group Limited Nuclear receptor arylating compounds

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WO2001083427A1 (fr) 2001-11-08
HUP0301146A3 (en) 2004-08-30
KR20020089493A (ko) 2002-11-29
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AU2001252612A1 (en) 2001-11-12
CZ20023562A3 (cs) 2003-03-12
RU2002128733A (ru) 2004-03-10
CA2407587A1 (en) 2001-11-08
HUP0301146A2 (hu) 2003-08-28
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