BR0012575A - Derivados de indol - Google Patents
Derivados de indolInfo
- Publication number
- BR0012575A BR0012575A BR0012575-0A BR0012575A BR0012575A BR 0012575 A BR0012575 A BR 0012575A BR 0012575 A BR0012575 A BR 0012575A BR 0012575 A BR0012575 A BR 0012575A
- Authority
- BR
- Brazil
- Prior art keywords
- disorders
- disease
- compounds
- indole derivatives
- compulsive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
"DERIVADOS DE INDOL". A invenção refere-se a compostos de fórmula (I), onde R^ 1^ e R^ 3^ têm o significado dado em reivindicação 1. Ditos compostos são antagonistas a 5-HT~ 2A~ potentes e são adequados para o tratamento de psicoses, esquizofrenia, depressão, distúrbios neurológicos, distúrbios de memória, mal de Parkinson, esclerose lateral amiotrófica, mal de Alzheimer, mal de Huntington, distúrbios de alimentação tais como bulimia e anorexia nervosa, síndrome pré-menstrual e/ou para positivamente influenciar comportamentos compulsivos (distúrbio obsessivo-compulsivo, OCD).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19934432A DE19934432A1 (de) | 1999-07-22 | 1999-07-22 | Indolderivate |
PCT/EP2000/006463 WO2001007434A2 (de) | 1999-07-22 | 2000-07-07 | Indolderivate und deren verwendung als 5ht2a liganden |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0012575A true BR0012575A (pt) | 2002-04-16 |
Family
ID=7915701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0012575-0A BR0012575A (pt) | 1999-07-22 | 2000-07-07 | Derivados de indol |
Country Status (26)
Country | Link |
---|---|
US (1) | US6723725B1 (pt) |
EP (1) | EP1228041B1 (pt) |
JP (1) | JP2003505457A (pt) |
KR (1) | KR100756506B1 (pt) |
CN (1) | CN1198801C (pt) |
AR (1) | AR024818A1 (pt) |
AT (1) | ATE252079T1 (pt) |
AU (1) | AU761166B2 (pt) |
BR (1) | BR0012575A (pt) |
CA (1) | CA2383769C (pt) |
CZ (1) | CZ200220A3 (pt) |
DE (2) | DE19934432A1 (pt) |
DK (1) | DK1228041T3 (pt) |
ES (1) | ES2204673T3 (pt) |
HK (1) | HK1049161B (pt) |
HU (1) | HUP0202479A3 (pt) |
MX (1) | MXPA02000731A (pt) |
MY (1) | MY123686A (pt) |
NO (1) | NO322152B1 (pt) |
PL (1) | PL197847B1 (pt) |
PT (1) | PT1228041E (pt) |
RU (1) | RU2256659C2 (pt) |
SK (1) | SK285893B6 (pt) |
UA (1) | UA73312C2 (pt) |
WO (1) | WO2001007434A2 (pt) |
ZA (1) | ZA200201483B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19934433A1 (de) * | 1999-07-22 | 2001-01-25 | Merck Patent Gmbh | N-(Indolcarbonyl-)piperazinderivate |
DE10157673A1 (de) * | 2001-11-24 | 2003-06-05 | Merck Patent Gmbh | Verwendung von N-(Indolcarbonyl-)piperazinderivaten |
GB0203811D0 (en) * | 2002-02-18 | 2002-04-03 | Glaxo Group Ltd | Compounds |
DE10217006A1 (de) * | 2002-04-16 | 2003-11-06 | Merck Patent Gmbh | Substituierte Indole |
DE50312523D1 (de) * | 2002-05-24 | 2010-04-29 | Carl-Fr Coester | Pharmazeutische wirkstoffkombination sowie deren verwendung |
JP2006523918A (ja) * | 2003-04-17 | 2006-10-19 | ハイドロジェニクス コーポレイション | 燃料電池試験システムのための警報リカバリシステム及び方法 |
SI1831159T1 (sl) * | 2004-12-21 | 2010-04-30 | Hoffmann La Roche | Derivati tetralina in indana ter njune uporabe |
AU2006267338B2 (en) * | 2005-07-13 | 2012-08-16 | Msd K.K. | Heterocycle-substituted benzimidazole derivative |
FR2941947B1 (fr) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique |
CA2935944A1 (en) | 2014-01-09 | 2015-07-16 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Substituted benzoxazine and related compounds |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA864772B (en) | 1985-07-02 | 1987-02-25 | Merrell Dow Pharma | Novel chemical compounds |
US5032598A (en) | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents |
US6004980A (en) | 1990-06-01 | 1999-12-21 | Merrell Pharmaceuticals, Inc. | (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
US5330986A (en) | 1992-11-24 | 1994-07-19 | Hoechst-Roussel Pharmaceuticals Inc. | Indole-7-carboxamide derivatives |
RU2124511C1 (ru) | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
US5618824A (en) | 1994-03-09 | 1997-04-08 | Merrell Pharmaceuticals Inc. | Treatment of obsessive-compulsive disorders with 5-HT2 antagonists |
GB9718712D0 (en) | 1997-09-03 | 1997-11-12 | Merck Sharp & Dohme | Theraputic Agents |
TWI249526B (en) | 1998-03-13 | 2006-02-21 | Aventis Pharma Inc | Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
DE19934433A1 (de) * | 1999-07-22 | 2001-01-25 | Merck Patent Gmbh | N-(Indolcarbonyl-)piperazinderivate |
-
1999
- 1999-07-22 DE DE19934432A patent/DE19934432A1/de not_active Withdrawn
-
2000
- 2000-07-07 DE DE50004104T patent/DE50004104D1/de not_active Expired - Lifetime
- 2000-07-07 HU HU0202479A patent/HUP0202479A3/hu unknown
- 2000-07-07 ES ES00954447T patent/ES2204673T3/es not_active Expired - Lifetime
- 2000-07-07 PL PL354971A patent/PL197847B1/pl unknown
- 2000-07-07 SK SK20-2002A patent/SK285893B6/sk unknown
- 2000-07-07 CZ CZ200220A patent/CZ200220A3/cs unknown
- 2000-07-07 MX MXPA02000731A patent/MXPA02000731A/es active IP Right Grant
- 2000-07-07 KR KR1020027000079A patent/KR100756506B1/ko not_active IP Right Cessation
- 2000-07-07 RU RU2002103301/04A patent/RU2256659C2/ru not_active IP Right Cessation
- 2000-07-07 PT PT00954447T patent/PT1228041E/pt unknown
- 2000-07-07 UA UA2002021353A patent/UA73312C2/uk unknown
- 2000-07-07 US US10/031,566 patent/US6723725B1/en not_active Expired - Fee Related
- 2000-07-07 CA CA002383769A patent/CA2383769C/en not_active Expired - Fee Related
- 2000-07-07 EP EP00954447A patent/EP1228041B1/de not_active Expired - Lifetime
- 2000-07-07 CN CNB00810638XA patent/CN1198801C/zh not_active Expired - Fee Related
- 2000-07-07 BR BR0012575-0A patent/BR0012575A/pt not_active Application Discontinuation
- 2000-07-07 DK DK00954447T patent/DK1228041T3/da active
- 2000-07-07 AU AU66901/00A patent/AU761166B2/en not_active Ceased
- 2000-07-07 WO PCT/EP2000/006463 patent/WO2001007434A2/de active IP Right Grant
- 2000-07-07 JP JP2001512518A patent/JP2003505457A/ja active Pending
- 2000-07-07 AT AT00954447T patent/ATE252079T1/de not_active IP Right Cessation
- 2000-07-20 MY MYPI20003321 patent/MY123686A/en unknown
- 2000-07-21 AR ARP000103774A patent/AR024818A1/es unknown
-
2002
- 2002-01-21 NO NO20020306A patent/NO322152B1/no unknown
- 2002-02-21 ZA ZA200201483A patent/ZA200201483B/en unknown
-
2003
- 2003-02-18 HK HK03101160.9A patent/HK1049161B/zh not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INT.CL: C07D 403/00 Ipc: C07D 403/00 (2010.01), A61K 31/404 (2010.01), A61K |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 13 E 25 DA LPI |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |