BR0010381A - Método de tratamento da trombose em um mamìfero, e uso de uma combinação de (i) um inibidor do fator xa, e (ii) um composto selecionado do grupo que consiste em aspirina, tpa, um antagonista gpiib/iiia, heparina de baixo peso molecular e heparina - Google Patents
Método de tratamento da trombose em um mamìfero, e uso de uma combinação de (i) um inibidor do fator xa, e (ii) um composto selecionado do grupo que consiste em aspirina, tpa, um antagonista gpiib/iiia, heparina de baixo peso molecular e heparinaInfo
- Publication number
- BR0010381A BR0010381A BR0010381-0A BR0010381A BR0010381A BR 0010381 A BR0010381 A BR 0010381A BR 0010381 A BR0010381 A BR 0010381A BR 0010381 A BR0010381 A BR 0010381A
- Authority
- BR
- Brazil
- Prior art keywords
- heparin
- combination
- gpiib
- aspirin
- inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"MéTODO DE TRATAMENTO DA TROMBOSE EM UM MAMìFERO, E USO DE UMA COMBINAçãO DE (I) UM INIBIDOR DO FATOR XA, E (II) UM COMPOSTO SELECIONADO DO GRUPO QUE CONSISTE EM ASPIRINA, TPA, UM ANTAGONISTA GPIIB/IIIA, HEPARINA DE BAIXO PESO MOLECULAR E HEPARINA". Trata-se de um método de tratamento da trombose em mamíferos através da administração de quantidades terapeuticamente eficazes de uma combinação de (i) um inibidor do fator Xa, e (ii) um composto selecionado do grupo que consiste em aspirina, um antagonista GPIIb/IIIa, heparina de baixo peso molecular e heparina, sendo que a dose administrada para pelo menos um dentre (i) e (ii) é uma dose subterapêutica. Preferivelmente, a combinação de (i) e (ii) proporciona um efeito sinérgico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12381599P | 1999-03-11 | 1999-03-11 | |
PCT/US2000/006451 WO2000053264A1 (en) | 1999-03-11 | 2000-03-10 | Treatment of thrombosis by combined use of a factor xa inhibitor and aspirin, tissue plasminogen activator (tpa), a gpiib/iiia antagonist, low molecular weight heparin or heparin |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0010381A true BR0010381A (pt) | 2002-02-05 |
Family
ID=22411057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0010381-0A BR0010381A (pt) | 1999-03-11 | 2000-03-10 | Método de tratamento da trombose em um mamìfero, e uso de uma combinação de (i) um inibidor do fator xa, e (ii) um composto selecionado do grupo que consiste em aspirina, tpa, um antagonista gpiib/iiia, heparina de baixo peso molecular e heparina |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1161279A1 (pt) |
JP (1) | JP2002538226A (pt) |
KR (1) | KR20020005614A (pt) |
CN (1) | CN1346292A (pt) |
AU (1) | AU766089B2 (pt) |
BR (1) | BR0010381A (pt) |
CA (1) | CA2361650A1 (pt) |
EA (1) | EA200100966A1 (pt) |
IL (1) | IL144798A0 (pt) |
NZ (1) | NZ513217A (pt) |
WO (1) | WO2000053264A1 (pt) |
ZA (1) | ZA200106360B (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU760174B2 (en) | 1999-02-09 | 2003-05-08 | Bristol-Myers Squibb Company | Lactam inhibitors of FXa and method |
US6344450B1 (en) | 1999-02-09 | 2002-02-05 | Bristol-Myers Squibb Company | Lactam compounds and their use as inhibitors of serine proteases and method |
TWI290136B (en) * | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
JP2004501913A (ja) * | 2000-06-23 | 2004-01-22 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | ヘテロアリール−フェニル置換Xa因子阻害剤 |
US6511973B2 (en) | 2000-08-02 | 2003-01-28 | Bristol-Myers Squibb Co. | Lactam inhibitors of FXa and method |
EP1370570B1 (en) | 2001-02-28 | 2007-01-24 | John H. Griffin | Plasma glucosylceramide deficiency as risk factor for thrombosis and modulator of anticoagulant protein c |
SE0101932D0 (sv) * | 2001-05-31 | 2001-05-31 | Astrazeneca Ab | Pharmaceutical combinations |
DE10129725A1 (de) * | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
EP1455858A4 (en) | 2001-11-26 | 2006-02-15 | Genentech Inc | CATHETER COMPOSITION AND ITS USES |
CN100513398C (zh) | 2002-12-03 | 2009-07-15 | Axys药物公司 | 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物 |
CA2538366A1 (en) * | 2003-09-19 | 2005-03-31 | Kissei Pharmaceutical Co., Ltd. | Concurrent drugs |
MX2007008290A (es) | 2005-01-07 | 2008-02-15 | Synta Pharmaceuticals Corp | Compuestos para inflamacion y usos inmuno-relacionados. |
US8916148B2 (en) | 2006-11-07 | 2014-12-23 | Genentech, Inc. | Tissue plasminogen activator variant uses |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994012204A1 (en) * | 1992-12-01 | 1994-06-09 | Merck & Co., Inc. | Anticoagulant proteins |
HUT74690A (en) * | 1993-11-24 | 1997-01-28 | Du Pont Merck Pharma | Novel isoxazoline and isoxazole fibrinogen receptor antagonists process for producing them and pharmaceutical compositions containing them |
GB2299998B (en) * | 1995-03-31 | 1997-03-26 | Hamilton Civic Hospitals Res | Compositions for inhibiting thrombogenesis |
US5610308A (en) * | 1995-05-18 | 1997-03-11 | Bristol-Myers Squibb Company | Process for preparing intermediates for thrombin inhibitors |
US6069130A (en) * | 1995-06-07 | 2000-05-30 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
ATE443698T1 (de) * | 1996-12-23 | 2009-10-15 | Bristol Myers Squibb Pharma Co | Stickstoffhaltige heterocyclen als faktor xa- hemmer |
WO1999038827A1 (en) * | 1998-02-02 | 1999-08-05 | Merck & Co., Inc. | PLATELET AGGREGATION INHIBITION USING LOW MOLECULAR WEIGHT HEPARIN IN COMBINATION WITH A GP IIb/IIIa ANTAGONIST |
CA2322824A1 (en) * | 1998-03-13 | 1999-09-16 | Merck & Co., Inc. | Combination therapy and composition for acute coronary ischemic syndrome and related conditions |
DE19816983A1 (de) * | 1998-04-17 | 1999-10-21 | Boehringer Ingelheim Pharma | Bicyclen, deren Herstellung und deren Verwendung als Arzneimittel |
-
2000
- 2000-03-10 AU AU35254/00A patent/AU766089B2/en not_active Ceased
- 2000-03-10 BR BR0010381-0A patent/BR0010381A/pt not_active IP Right Cessation
- 2000-03-10 CA CA002361650A patent/CA2361650A1/en not_active Abandoned
- 2000-03-10 JP JP2000603752A patent/JP2002538226A/ja active Pending
- 2000-03-10 NZ NZ513217A patent/NZ513217A/en unknown
- 2000-03-10 IL IL14479800A patent/IL144798A0/xx unknown
- 2000-03-10 EA EA200100966A patent/EA200100966A1/ru unknown
- 2000-03-10 CN CN00804880A patent/CN1346292A/zh active Pending
- 2000-03-10 WO PCT/US2000/006451 patent/WO2000053264A1/en not_active Application Discontinuation
- 2000-03-10 KR KR1020017011454A patent/KR20020005614A/ko not_active Application Discontinuation
- 2000-03-10 EP EP00913894A patent/EP1161279A1/en not_active Withdrawn
-
2001
- 2001-08-02 ZA ZA200106360A patent/ZA200106360B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP1161279A1 (en) | 2001-12-12 |
NZ513217A (en) | 2003-11-28 |
CA2361650A1 (en) | 2000-09-14 |
CN1346292A (zh) | 2002-04-24 |
JP2002538226A (ja) | 2002-11-12 |
IL144798A0 (en) | 2002-06-30 |
ZA200106360B (en) | 2002-08-02 |
WO2000053264A1 (en) | 2000-09-14 |
AU766089B2 (en) | 2003-10-09 |
KR20020005614A (ko) | 2002-01-17 |
AU3525400A (en) | 2000-09-28 |
EA200100966A1 (ru) | 2002-02-28 |
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Legal Events
Date | Code | Title | Description |
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B25D | Requested change of name of applicant approved | ||
B25G | Requested change of headquarter approved | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008. |
|
B15K | Others concerning applications: alteration of classification |
Ipc: A61K 31/715 (2006.01), A61P 7/02 (2006.01), A61P 9 |