BR0002655A - Corynebacteria produzindo l-lisina e processo para a preparação de l-lisina - Google Patents

Corynebacteria produzindo l-lisina e processo para a preparação de l-lisina

Info

Publication number
BR0002655A
BR0002655A BR0002655-7A BR0002655A BR0002655A BR 0002655 A BR0002655 A BR 0002655A BR 0002655 A BR0002655 A BR 0002655A BR 0002655 A BR0002655 A BR 0002655A
Authority
BR
Brazil
Prior art keywords
gene
lysine
corynebacteria
preparation
producing
Prior art date
Application number
BR0002655-7A
Other languages
English (en)
Other versions
BRPI0002655B1 (pt
Inventor
Bettina Moeckel
Walter Pfefferle
Caroline Kreutzer
Stephan Hans
Mechthild Rieping
Lothar Eggeling
Hermann Sahm
Miroslav Patek
Original Assignee
Degussa
Forschungszentrum Juelich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa, Forschungszentrum Juelich Gmbh filed Critical Degussa
Publication of BR0002655A publication Critical patent/BR0002655A/pt
Publication of BRPI0002655B1 publication Critical patent/BRPI0002655B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Patente de Invenção: <B>"CORYNEBACTERIA PRODUZINDO L-LISINA E PROCESSO PARA A PREPARAçãO DE L-LISINA"<D>. A invenção refere-se a produção de cepas de produção de L-lisina de corynebacteria com gene lysE amplificado (gene carreador de exportação de lisina), onde cepas de genes adicionais escolhidos do grupo compreendendo o gene dapA (gene diidro dipicolinato sintase), o gene lysC (gene aspartato cinase), o gene dapB (gene diidro dipicolinato redutase) e o gene pyc, mas especialmente o gene dapA e o gene lysC (gene aspartato cinase), são amplificados e, em particular, superexpressos, e a um processo para a preparação de L-lisina.
BRPI0002655A 1999-07-07 2000-07-07 "bactérias corineformes produtoras de l-lisina e processo para a produção de l-lisina em cultura por fermentação de bactérias corineformes" BRPI0002655B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19931317A DE19931317A1 (de) 1999-07-07 1999-07-07 L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von L-Lysin

Publications (2)

Publication Number Publication Date
BR0002655A true BR0002655A (pt) 2001-06-05
BRPI0002655B1 BRPI0002655B1 (pt) 2016-04-19

Family

ID=7913926

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0002655A BRPI0002655B1 (pt) 1999-07-07 2000-07-07 "bactérias corineformes produtoras de l-lisina e processo para a produção de l-lisina em cultura por fermentação de bactérias corineformes"

Country Status (17)

Country Link
US (1) US6200785B1 (pt)
EP (1) EP1067192B1 (pt)
JP (1) JP2001061485A (pt)
KR (1) KR100758831B1 (pt)
CN (2) CN1206342C (pt)
AT (1) ATE422548T1 (pt)
AU (1) AU4509900A (pt)
BR (1) BRPI0002655B1 (pt)
CA (1) CA2310870A1 (pt)
DE (2) DE19931317A1 (pt)
DK (1) DK1067192T3 (pt)
HU (1) HUP0002585A2 (pt)
ID (1) ID27720A (pt)
MX (1) MXPA00006643A (pt)
RU (1) RU2264461C2 (pt)
SK (1) SK10142000A3 (pt)
ZA (1) ZA200003402B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020086371A1 (en) * 1999-07-07 2002-07-04 Degussa-Huls Aktiengesellschaft L-lysine-producing corynebacteria and process for the preparation of L-lysine
US6861246B2 (en) * 1999-07-07 2005-03-01 Degussa Ag L-lysine-producing corynebacteria and process for the preparation of lysine
US6927046B1 (en) * 1999-12-30 2005-08-09 Archer-Daniels-Midland Company Increased lysine production by gene amplification using coryneform bacteria
BRPI0016995B1 (pt) * 2000-01-21 2016-03-08 Ajinomoto Kk bactéria escherichia coli geneticamente modificada, e, método para produzir l-lisina
AU2001282084A1 (en) * 2000-09-02 2002-03-13 Degussa A.G. Nucleotide sequences which code for the sigh gene
CN101126075B (zh) * 2001-08-06 2012-05-09 赢创德固赛有限公司 生产化合物ⅱ的棒状细菌
WO2003040373A2 (en) * 2001-08-06 2003-05-15 Degussa Ag Production of l-lysine by genetically modified corynebacterium glutamicum strains
US7160711B2 (en) * 2001-08-06 2007-01-09 Degussa Ag Coryneform bacteria which produce chemical compounds I
DE10210527A1 (de) * 2002-03-09 2003-09-18 Degussa Allele des aceA-Gens aus coryneformen Bakterien
DE10359594A1 (de) * 2003-12-18 2005-07-28 Basf Ag PEF-TU-Expressionseinheiten
DE102004035065A1 (de) * 2004-07-20 2006-02-16 Basf Ag P-ET-TS-Expressionseinheiten
KR100653742B1 (ko) * 2004-12-30 2006-12-05 씨제이 주식회사 신규한 ｌ-라이신-유도성 프로모터
DE102005047596A1 (de) * 2005-10-05 2007-04-12 Degussa Ag Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
US20070082031A1 (en) 2005-10-08 2007-04-12 Hermann Lotter L-lysine-containing feed additives
DE102006016158A1 (de) * 2005-10-08 2007-04-12 Degussa Ag L-Lysin enthaltende Futtermitteladditive
CN101573438B (zh) * 2006-09-15 2013-01-02 Cj第一制糖株式会社 具有增加的l-赖氨酸生产力的棒状杆菌和使用其生产l-赖氨酸的方法
DE102006048882A1 (de) * 2006-10-17 2008-04-24 Evonik Degussa Gmbh Allele des rel-Gens aus coryneformen Bakterien
KR100798118B1 (ko) * 2006-12-21 2008-01-28 씨제이제일제당 (주) 메틸말로네이트 세미알데하이드 디하이드로게나제 코딩유전자의 기능 결실에 의한 엘-라이신 생산능이 향상된코리네박테리아 및 이를 이용한 엘-라이신 생산 방법
KR100830826B1 (ko) * 2007-01-24 2008-05-19 씨제이제일제당 (주) 코리네박테리아를 이용하여 글리세롤을 포함한탄소원으로부터 발효산물을 생산하는 방법
DE102007005072A1 (de) * 2007-02-01 2008-08-07 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Cadaverin
KR100898246B1 (ko) * 2007-08-17 2009-05-18 씨제이제일제당 (주) 신규한 코리네박테리움 글루타미쿰 프로모터
PL2262894T3 (pl) * 2008-03-03 2015-02-27 Global Bio Chem Tech Group Company Limited Rekombinowany mikroorganizm i sposób wytwarzania l-lizyny
US8932861B2 (en) 2008-04-10 2015-01-13 Cj Cheiljedang Corporation Transformation vector comprising transposon, microorganisms transformed with the vector, and method for producing L-lysine using the microorganism
KR101126041B1 (ko) * 2008-04-10 2012-03-19 씨제이제일제당 (주) 트랜스포존을 이용한 형질전환용 벡터, 상기 벡터로형질전환된 미생물 및 이를 이용한 ｌ-라이신 생산방법
US8637295B1 (en) * 2009-02-20 2014-01-28 Evonik Degussa Gmbh Process for the production of L-lysine
ES2696173T3 (es) * 2011-12-21 2019-01-14 Cj Cheiljedang Corp Método para producir L-lisina usando microorganismos que tienen capacidad de producir L-lisina
WO2014145194A2 (en) 2013-03-15 2014-09-18 Kiverdi, Inc. Methods of using natural and engineered organisms to produce small molecules for industrial application
RU2549690C1 (ru) * 2013-10-08 2015-04-27 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") L-ЛИЗИН-ПРОДУЦИРУЮЩАЯ БАКТЕРИЯ Corynebacterium glutamicum ИЛИ Brevibacterium flavum, УСТОЙЧИВАЯ К ФУЗИДИНОВОЙ КИСЛОТЕ, И СПОСОБ МИКРОБИОЛОГИЧЕСКОГО СИНТЕЗА L-ЛИЗИНА С ЕЕ ИСПОЛЬЗОВАНИЕМ
CN103695454A (zh) * 2013-12-18 2014-04-02 山东寿光巨能金玉米开发有限公司 表达l-赖氨酸转运蛋白的重组质粒、工程菌及应用
WO2017085241A1 (en) * 2015-11-19 2017-05-26 Danmarks Tekniske Universitet A family of microbial lysine transporter polypeptides
RU2612159C1 (ru) * 2015-12-28 2017-03-02 Федеральное государственное бюджетное учреждение "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГБУ "ГосНИИгенетика") L-Лизин-продуцирующая коринеформная бактерия с мутантным геном fusA и способ получения L-лизина с использованием этой бактерии
KR101863456B1 (ko) * 2016-11-15 2018-06-01 씨제이제일제당 (주) L-라이신을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-라이신의 생산방법
CN111850010B (zh) * 2020-06-08 2021-04-09 黑龙江伊品生物科技有限公司 一种dapB基因改造的重组菌株及其构建方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3943117A1 (de) * 1989-12-27 1991-07-04 Forschungszentrum Juelich Gmbh Verfahren zur fermentativen herstellung von aminosaeure, insbesondere l-lysin, dafuer geeignete mikroorganismen und rekombinante dna
DE19548222A1 (de) * 1995-12-22 1997-06-26 Forschungszentrum Juelich Gmbh Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern
SK285201B6 (sk) * 1996-12-05 2006-08-03 Ajinomoto Co., Inc. Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7
SK284235B6 (en) * 1997-10-04 2004-11-03 Forschungszentrum Juelich Gmbh Method for microbial production of amino acids of the aspartate and/or glutamate family and agents which can be used in the said method
DE19831609B4 (de) * 1997-10-04 2009-11-12 Evonik Degussa Gmbh Verfahren zur Herstellung von Aminosäuren der Aspartat- und/oder Glutamatfamilie und im Verfahren einsetzbare Mittel

Also Published As

Publication number Publication date
DK1067192T3 (da) 2009-06-08
KR20010049729A (ko) 2001-06-15
DE19931317A1 (de) 2001-01-11
HUP0002585A2 (en) 2002-09-28
US6200785B1 (en) 2001-03-13
CN1706935A (zh) 2005-12-14
SK10142000A3 (sk) 2001-04-09
RU2264461C2 (ru) 2005-11-20
ZA200003402B (en) 2001-02-02
CN1280184A (zh) 2001-01-17
CN1206342C (zh) 2005-06-15
HU0002585D0 (en) 2000-09-28
CA2310870A1 (en) 2001-01-07
MXPA00006643A (es) 2002-04-30
EP1067192A1 (de) 2001-01-10
DE50015548D1 (de) 2009-03-26
ID27720A (id) 2001-04-26
EP1067192B1 (de) 2009-02-11
ATE422548T1 (de) 2009-02-15
CN100451108C (zh) 2009-01-14
AU4509900A (en) 2001-01-11
KR100758831B1 (ko) 2007-09-19
BRPI0002655B1 (pt) 2016-04-19
JP2001061485A (ja) 2001-03-13

Similar Documents

Publication Publication Date Title
BR0002655A (pt) Corynebacteria produzindo l-lisina e processo para a preparação de l-lisina
BR0002445A (pt) Corinebactérias produtos de l-lisina e processo para a preparação de lisina
EP2163629A3 (en) Methods and microorganisms for production of panto-compounds
Eot-Houllier et al. Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins
AU2003234196A1 (en) Functionalized nanoparticles and methods of use
WO2001049854A3 (en) Increased lysine production by gene amplification using coryneform bacteria
ATE346938T1 (de) Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen
EP2351839A3 (en) Antisense antibacterial method and compound
DK1155139T3 (da) Fremgangsmåde til mikrobiel fremstilling af L-valin
EP2084262A4 (en) HIGH-YIELD GLUTAMIC ACID-PRODUCING MICROORGANISM AND PROCESS FOR PRODUCING GLUTAMIC ACID THEREFOR
KR20130096163A (ko) 세포내의 신진대사 산물 감지용 센서
WO2008020333A3 (en) Nucleic acid encoding n-methylputrescine oxidase and uses thereof
EP1576160B8 (en) Borrelidin-derivatives and their use in medicine
ID29968A (id) Urutan nukleotida untuk gen tal
ID27760A (id) Poliketida-poliketida, pembuatannya, dan bahan-bahan untuk penggunaannya
WO2003046123A3 (de) Mutierte gene aus corynebacterium glutamicum
BR0010817A (pt) Processo para a preparação fermentativa de l-aminoácidos com amplificação do gene gnd
MY114645A (en) Cytochrome bd type quinol oxidase gene of brevibacterium lactofermentum
WO2002029064A3 (en) Method for establishing germ cell-specific gene expression
BR9915016A (pt) Cepas do grupo do bacillus subtilis para a fermentação de alimentos
Kitamatsu et al. Carrier PNA for shRNA delivery into cells
BR9800827A (pt) Dna codificando para uma proteìna, célula, e, proce.
Liaqat Artificial Evolution of Nucleic Acid Catalysts and their Use for Studying RNA
WO2003066871A3 (en) Compositions and methods for altering biosynthesis of taxanes and taxane-related compounds
Schmidtz et al. ARRANGEMENT AND TRANSCRIPTION OF EUKARYOTIC tRNA GENESl

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O C/C 13 DA LPI.

B25A Requested transfer of rights approved

Owner name: FORSCHUNGSZENTRUM JUELICH GMBH (DE) , DEGUSSA AG (

Free format text: TRANSFERIDO POR INCORPORACAO DE: DEGUSSA-HULS AKTIENGESELLSCHAFT

B25D Requested change of name of applicant approved

Owner name: FORSCHUNGSZENTRUM JUELICH GMBH (DE) , DEGUSSA GMBH

Free format text: NOME ALTERADO DE: DEGUSSA AG

B25D Requested change of name of applicant approved

Owner name: FORSCHUNGSZENTRUM JUELICH GMBH (DE) , EVONIK DEGUS

Free format text: NOME ALTERADO DE: DEGUSSA GMBH

B25G Requested change of headquarter approved

Owner name: FORSCHUNGSZENTRUM JUELICH GMBH (DE) , EVONIK DEGUS

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020100038204/RJ DE 30/04/2010.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/04/2016, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved