BG51252A3 - Method for netylmycin preparation - Google Patents

Method for netylmycin preparation Download PDF

Info

Publication number: BG51252A3
Authority: BG; Bulgaria
Prior art keywords: netilmycin; reduced; anhydrous conditions; under anhydrous; acetaldehyde
Prior art date: 1985-10-15

Application number

BG080149A

Other languages

Bulgarian (bg)

English (en)

Inventor

Chou-Hong Tann

John Chiu

Cesar Colon

Tiruvettipuram Thiruvengadam

Original Assignee

Schering Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-15

Filing date

1987-06-12

Publication date

1993-03-15

1987-06-12 Application filed by Schering Corporation filed Critical Schering Corporation

1993-03-15 Publication of BG51252A3 publication Critical patent/BG51252A3/xx

Links

IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 abstract 4
ZBGPYVZLYBDXKO-HILBYHGXSA-N netilmycin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@]([C@H](NC)[C@@H](O)CO1)(C)O)NCC)[C@H]1OC(CN)=CC[C@H]1N ZBGPYVZLYBDXKO-HILBYHGXSA-N 0.000 abstract 2
QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical group CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 abstract 1
URWAJWIAIPFPJE-UHFFFAOYSA-N Rickamicin Natural products O1CC(O)(C)C(NC)C(O)C1OC1C(O)C(OC2C(CC=C(CN)O2)N)C(N)CC1N URWAJWIAIPFPJE-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
239000006227 byproduct Substances 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
229910052987 metal hydride Inorganic materials 0.000 abstract 1
150000004681 metal hydrides Chemical class 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
URWAJWIAIPFPJE-YFMIWBNJSA-N sisomycin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N URWAJWIAIPFPJE-YFMIWBNJSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BG080149A 1985-10-15 1987-06-12 Method for netylmycin preparation BG51252A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78719385A	1985-10-15	1985-10-15
PCT/US1986/002122 WO1987002365A2 (en)	1985-10-15	1986-10-14	Process for preparing netilmicin

Publications (1)

Publication Number	Publication Date
BG51252A3 true BG51252A3 (en)	1993-03-15

Family

ID=25140700

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG080149A BG51252A3 (en)	1985-10-15	1987-06-12	Method for netylmycin preparation

Country Status (21)

Country	Link
EP (2)	EP0242385B1 (xx)
JP (2)	JPH0649716B2 (xx)
KR (1)	KR930003493B1 (xx)
AR (1)	AR242396A1 (xx)
AU (1)	AU597285B2 (xx)
BG (1)	BG51252A3 (xx)
CA (1)	CA1290751C (xx)
DK (1)	DK169343B1 (xx)
ES (1)	ES2030395T3 (xx)
FI (1)	FI84486C (xx)
GR (1)	GR3002670T3 (xx)
HU (1)	HU199498B (xx)
IE (1)	IE59481B1 (xx)
IL (1)	IL80299A (xx)
NZ (1)	NZ217918A (xx)
PH (1)	PH24737A (xx)
PL (1)	PL149511B1 (xx)
PT (1)	PT83533B (xx)
SU (1)	SU1630614A3 (xx)
WO (1)	WO1987002365A2 (xx)
ZA (1)	ZA867785B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0139021B1 (ko) *	1995-02-09	1998-04-30	김은영	1-엔(n)-에틸시소마이신의 제조방법
GB2478990A (en)	2010-03-26	2011-09-28	E2V Tech	Magnetron with high gfrequency cathode heater power supply
CN102796150A (zh) *	2012-08-31	2012-11-28	无锡福祈制药有限公司	一种高纯度西索霉素的分离纯化方法
CN105503972B (zh) *	2015-12-09	2018-05-29	无锡济民可信山禾药业股份有限公司	一种以杂多酸为催化剂合成1-N-乙基庆大霉素C1a的方法
CN106866756A (zh) *	2017-01-10	2017-06-20	苏利制药科技江阴有限公司	一种合成1‑n‑乙基西索米星的方法
CN110885350A (zh) *	2019-08-28	2020-03-17	山东安信制药有限公司	一种普拉佐米星的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1034573A (en) *	1974-08-01	1978-07-11	Peter J.L. Daniels	Preparation of 1-n-substituted 4,6-di-(aminoglycosyl)-1,3-diaminocyclitols
US4230847A (en) *	1976-06-17	1980-10-28	Schering Corporation	Aminoglycoside antibiotic compounds
DE2712160A1 (de) *	1977-03-19	1978-09-28	Bayer Ag	Pseudotrisaccharide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2924659A1 (de) *	1979-06-19	1981-01-22	Bayer Ag	Pseudotrisaccharide, ihre herstellung und verwendung als arzneimittel

1986
- 1986-10-14 KR KR1019870700501A patent/KR930003493B1/ko not_active IP Right Cessation
- 1986-10-14 PL PL1986261846A patent/PL149511B1/pl unknown
- 1986-10-14 AR AR86305570A patent/AR242396A1/es active
- 1986-10-14 JP JP61505496A patent/JPH0649716B2/ja not_active Expired - Fee Related
- 1986-10-14 IL IL80299A patent/IL80299A/xx not_active IP Right Cessation
- 1986-10-14 IE IE270686A patent/IE59481B1/en not_active IP Right Cessation
- 1986-10-14 WO PCT/US1986/002122 patent/WO1987002365A2/en active IP Right Grant
- 1986-10-14 EP EP86906216A patent/EP0242385B1/en not_active Expired - Lifetime
- 1986-10-14 HU HU865468A patent/HU199498B/hu not_active IP Right Cessation
- 1986-10-14 CA CA000520424A patent/CA1290751C/en not_active Expired - Fee Related
- 1986-10-14 ES ES198686906216T patent/ES2030395T3/es not_active Expired - Lifetime
- 1986-10-14 PH PH34364A patent/PH24737A/en unknown
- 1986-10-14 AU AU64744/86A patent/AU597285B2/en not_active Ceased
- 1986-10-14 ZA ZA867785A patent/ZA867785B/xx unknown
- 1986-10-14 NZ NZ217918A patent/NZ217918A/en unknown
- 1986-10-14 PT PT83533A patent/PT83533B/pt not_active IP Right Cessation
- 1986-10-14 EP EP86114196A patent/EP0219093A3/en active Pending
1987
- 1987-06-12 FI FI872621A patent/FI84486C/fi active IP Right Grant
- 1987-06-12 SU SU874202675A patent/SU1630614A3/ru active
- 1987-06-12 DK DK299587A patent/DK169343B1/da not_active IP Right Cessation
- 1987-06-12 BG BG080149A patent/BG51252A3/xx unknown
1991
- 1991-09-10 GR GR91401281T patent/GR3002670T3/el unknown
1993
- 1993-12-09 JP JP5309048A patent/JPH0735394B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
GR3002670T3 (en)	1993-01-25
PL149511B1 (en)	1990-02-28
SU1630614A3 (ru)	1991-02-23
ES2030395T3 (es)	1992-11-01
FI84486C (fi)	1991-12-10
FI872621A0 (fi)	1987-06-12
JPS63501079A (ja)	1988-04-21
EP0242385A1 (en)	1987-10-28
DK299587D0 (da)	1987-06-12
EP0242385B1 (en)	1991-06-12
PT83533B (pt)	1989-05-31
FI84486B (fi)	1991-08-30
EP0219093A3 (en)	1987-11-25
KR870700632A (ko)	1987-12-30
ZA867785B (en)	1988-05-25
AU597285B2 (en)	1990-05-31
IE862706L (en)	1987-04-15
HU199498B (en)	1990-02-28
FI872621A (fi)	1987-06-12
EP0219093A2 (en)	1987-04-22
WO1987002365A2 (en)	1987-04-23
AU6474486A (en)	1987-05-05
JPH0735394B2 (ja)	1995-04-19
DK169343B1 (da)	1994-10-10
PT83533A (en)	1986-11-01
NZ217918A (en)	1990-11-27
DK299587A (da)	1987-06-12
HUT43613A (en)	1987-11-30
PL261846A1 (en)	1988-06-23
WO1987002365A3 (en)	1987-08-27
JPH06316589A (ja)	1994-11-15
IE59481B1 (en)	1994-03-09
CA1290751C (en)	1991-10-15
AR242396A1 (es)	1994-08-31
KR930003493B1 (ko)	1993-05-01
JPH0649716B2 (ja)	1994-06-29
IL80299A0 (en)	1987-01-30
IL80299A (en)	1991-06-10
PH24737A (en)	1990-10-01

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