BG49825A3 - Method for preparing of 10- dihydro- 10- deoxo- 11- asaeritronolides a - Google Patents

Method for preparing of 10- dihydro- 10- deoxo- 11- asaeritronolides a

Info

Publication number
BG49825A3
BG49825A3 BG083878A BG8387888A BG49825A3 BG 49825 A3 BG49825 A3 BG 49825A3 BG 083878 A BG083878 A BG 083878A BG 8387888 A BG8387888 A BG 8387888A BG 49825 A3 BG49825 A3 BG 49825A3
Authority
BG
Bulgaria
Prior art keywords
deoxo
dihydro
asaeritronolides
preparing
azaerythronolides
Prior art date
Application number
BG083878A
Other languages
Bulgarian (bg)
English (en)
Inventor
Slobodan Djokic
Nevenka Lopotar
Gabrijela Kobrehel
Hrvoje Krnjevic
Olga Carevic
Original Assignee
Sour Pliva Farmaceutska, Kemijska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from YU163187A external-priority patent/YU44641B/xx
Priority claimed from YU85/88A external-priority patent/YU45054B/xx
Application filed by Sour Pliva Farmaceutska, Kemijska filed Critical Sour Pliva Farmaceutska, Kemijska
Publication of BG49825A3 publication Critical patent/BG49825A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
BG083878A 1987-09-03 1988-04-26 Method for preparing of 10- dihydro- 10- deoxo- 11- asaeritronolides a BG49825A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
YU163187A YU44641B (en) 1987-09-03 1987-09-03 Process for preparing derivatives of 10-dihydro-10-deoxo-11-azaeritronolides
YU85/88A YU45054B (en) 1988-01-18 1988-01-18 Process for preparing derivative of 10-dihydro-10-deoxo-11-azaerithronolide a

Publications (1)

Publication Number Publication Date
BG49825A3 true BG49825A3 (en) 1992-02-14

Family

ID=27130708

Family Applications (1)

Application Number Title Priority Date Filing Date
BG083878A BG49825A3 (en) 1987-09-03 1988-04-26 Method for preparing of 10- dihydro- 10- deoxo- 11- asaeritronolides a

Country Status (12)

Country Link
US (1) US4886792A (ro)
EP (1) EP0283055B1 (ro)
JP (1) JPH01287076A (ro)
CN (1) CN1020452C (ro)
BG (1) BG49825A3 (ro)
CA (1) CA1296000C (ro)
CS (1) CS274462B2 (ro)
DE (1) DE3860503D1 (ro)
HU (1) HU198913B (ro)
PL (1) PL155159B1 (ro)
RO (1) RO105811B1 (ro)
RU (1) RU2007398C1 (ro)

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US5049557A (en) * 1986-05-13 1991-09-17 Chai-Tech Corporation Metallo-organic salt compounds and pharmaceutical uses thereof
EP0432975A1 (en) * 1989-12-08 1991-06-19 Merck & Co. Inc. Cyclic renin inhibitors
US5254682A (en) * 1989-12-08 1993-10-19 Merck & Co., Inc. Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs
US5194605A (en) * 1989-12-08 1993-03-16 Merck & Co., Inc. Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3S,4S)-5-cyclohexyl-3,4-di-hydroxy pentanoic acid or 2-substituted (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhexanoic acid or its analogs
YU45590A (sh) * 1990-03-07 1992-07-20 PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o. Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
FR2691464B1 (fr) * 1992-05-21 1995-06-02 Roussel Uclaf Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
US5185365A (en) * 1992-06-24 1993-02-09 Cornell Research Foundation, Inc. Insect deterrent azamcrolides
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
AU7961498A (en) * 1997-06-26 1999-01-19 Merck & Co., Inc. 9a-azalides, compositions containing such compounds and methods of treatment
WO1999000125A1 (en) * 1997-06-27 1999-01-07 Merck & Co., Inc. 9a-aza-3-ketolides, compositions containing such compounds and methods of treatment
HUP0004085A3 (en) * 1997-10-16 2003-05-28 Pliva Pharm & Chem Works Novel 3,6-hemiketals from the class of 9a-azalides
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
CA2373117C (en) * 1999-05-24 2006-02-28 Pfizer Products Inc. 13-methyl-erythromycin derivatives
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
US20030207819A1 (en) * 2002-05-02 2003-11-06 Moskowitz Roland W. Compositions and methods for treating inflammatory connective tissue diseases
CN100577681C (zh) * 2002-07-08 2010-01-06 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 用于治疗炎性疾病和病症的新化合物、组合物和方法
ES2325495T3 (es) 2002-07-08 2009-09-07 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Moleculas hibridas de macrolidos con moleculas anti-inflamatorias esteroideas y no esteroideas.
RU2342398C2 (ru) 2002-07-08 2008-12-27 Глаксосмитклайн Истраживацки Центар Загреб Д.О.О. Новые нестероидные противовоспалительные вещества, составы и способы их применения
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
HRP20030324A2 (en) * 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
ES2337915T3 (es) 2004-10-27 2010-04-30 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugados con adtividad antiinflamatoria.
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
JP2008526945A (ja) * 2005-01-14 2008-07-24 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗炎症活性を有する９ａ−カルバモイルおよびチオカルバモイルアザライド
CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
US20100031410A1 (en) * 2008-08-08 2010-02-11 Linda Clark Multi-Positionable Face Shield
ES2565083T3 (es) 2008-10-24 2016-03-31 Cempra Pharmaceuticals, Inc. Biodefensas usando macrólidos que contienen triazol
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN101619085B (zh) * 2009-08-11 2015-04-22 沈阳药科大学 红霉素衍生物及其作为肿瘤细胞增殖抑制剂的用途
CN102724874B (zh) 2009-09-10 2018-06-01 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES
KR20140139083A (ko) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. 마크롤라이드계 항생제를 투여하기 위한 비경구 제제
JP6426696B2 (ja) 2013-03-14 2018-11-21 センプラ ファーマシューティカルズ，インコーポレイテッド 呼吸器疾患の治療のための方法および製剤
WO2014145210A1 (en) 2013-03-15 2014-09-18 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
EP2984087A1 (en) 2013-04-10 2016-02-17 Probiotic Pharmaceuticals APS Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
GB201608236D0 (en) * 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
CN106478542A (zh) * 2016-10-17 2017-03-08 南开大学 一种大环内脂类衍生物盐、其制备方法及用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox

Also Published As

Publication number Publication date
EP0283055A3 (en) 1989-03-15
DE3860503D1 (de) 1990-10-04
EP0283055A2 (en) 1988-09-21
HUT47552A (en) 1989-03-28
PL272025A1 (en) 1989-03-06
RU2007398C1 (ru) 1994-02-15
JPH01287076A (ja) 1989-11-17
PL155159B1 (en) 1991-10-31
CN1020452C (zh) 1993-05-05
US4886792A (en) 1989-12-12
CA1296000C (en) 1992-02-18
CN1031703A (zh) 1989-03-15
CS253388A2 (en) 1990-09-12
HU198913B (en) 1989-12-28
CS274462B2 (en) 1991-04-11
EP0283055B1 (en) 1990-08-29
RO105811B1 (ro) 1992-12-30

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