ITMI20022292A1 - 9a-azalidi ad attivita' antiinfiammatoria. - Google Patents

9a-azalidi ad attivita' antiinfiammatoria.

Info

Publication number
ITMI20022292A1
ITMI20022292A1 IT002292A ITMI20022292A ITMI20022292A1 IT MI20022292 A1 ITMI20022292 A1 IT MI20022292A1 IT 002292 A IT002292 A IT 002292A IT MI20022292 A ITMI20022292 A IT MI20022292A IT MI20022292 A1 ITMI20022292 A1 IT MI20022292A1
Authority
IT
Italy
Prior art keywords
inflammatory activity
azalids
azalides
cladinose
macrolides
Prior art date
Application number
IT002292A
Other languages
English (en)
Inventor
Gabriele Morazzoni
Ermanno Moriggi
Mauro Napoletano
Fernando Ornaghi
Franco Pellacini
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Priority to IT002292A priority Critical patent/ITMI20022292A1/it
Priority to EP03809747A priority patent/EP1556397B1/en
Priority to US10/531,462 priority patent/US7419961B2/en
Priority to CA2502347A priority patent/CA2502347C/en
Priority to CNB2003801023509A priority patent/CN100486985C/zh
Priority to PCT/EP2003/012071 priority patent/WO2004039821A1/en
Priority to AU2003276214A priority patent/AU2003276214B2/en
Priority to DE60303967T priority patent/DE60303967D1/de
Priority to RU2005116248/04A priority patent/RU2320668C2/ru
Priority to JP2004547618A priority patent/JP4536516B2/ja
Priority to AT03809747T priority patent/ATE319729T1/de
Publication of ITMI20022292A1 publication Critical patent/ITMI20022292A1/it
Priority to IL167882A priority patent/IL167882A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IT002292A 2002-10-29 2002-10-29 9a-azalidi ad attivita' antiinfiammatoria. ITMI20022292A1 (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT002292A ITMI20022292A1 (it) 2002-10-29 2002-10-29 9a-azalidi ad attivita' antiinfiammatoria.
PCT/EP2003/012071 WO2004039821A1 (en) 2002-10-29 2003-10-28 9a-azalides with anti-inflammatory activity
US10/531,462 US7419961B2 (en) 2002-10-29 2003-10-28 9a-azalides with anti-inflammatory activity
CA2502347A CA2502347C (en) 2002-10-29 2003-10-28 9a-azalides with anti-inflammatory activity
CNB2003801023509A CN100486985C (zh) 2002-10-29 2003-10-28 具有抗炎活性的9a-氮杂内酯类
EP03809747A EP1556397B1 (en) 2002-10-29 2003-10-28 9a-azalides with anti-inflammatory activity
AU2003276214A AU2003276214B2 (en) 2002-10-29 2003-10-28 9a-azalides with anti-inflammatory activity
DE60303967T DE60303967D1 (de) 2002-10-29 2003-10-28 9a-azalide mit entzündungshemmender wirkung
RU2005116248/04A RU2320668C2 (ru) 2002-10-29 2003-10-28 9а-азалиды с противовоспалительной активностью
JP2004547618A JP4536516B2 (ja) 2002-10-29 2003-10-28 抗炎症性活性を有する９ａ−アザライド
AT03809747T ATE319729T1 (de) 2002-10-29 2003-10-28 9a-azalide mit entzündungshemmender wirkung
IL167882A IL167882A (en) 2002-10-29 2005-04-06 9a-AZALIDES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002292A ITMI20022292A1 (it) 2002-10-29 2002-10-29 9a-azalidi ad attivita' antiinfiammatoria.

Publications (1)

Publication Number Publication Date
ITMI20022292A1 true ITMI20022292A1 (it) 2004-04-30

Family

ID=32211389

Family Applications (1)

Application Number Title Priority Date Filing Date
IT002292A ITMI20022292A1 (it) 2002-10-29 2002-10-29 9a-azalidi ad attivita' antiinfiammatoria.

Country Status (12)

Country Link
US (1) US7419961B2 (it)
EP (1) EP1556397B1 (it)
JP (1) JP4536516B2 (it)
CN (1) CN100486985C (it)
AT (1) ATE319729T1 (it)
AU (1) AU2003276214B2 (it)
CA (1) CA2502347C (it)
DE (1) DE60303967D1 (it)
IL (1) IL167882A (it)
IT (1) ITMI20022292A1 (it)
RU (1) RU2320668C2 (it)
WO (1) WO2004039821A1 (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20021726A1 (it) * 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
EP2772254A3 (en) 2003-03-10 2015-03-11 Optimer Pharmaceuticals, Inc. Novel Antibacterial Agents
ATE419261T1 (de) 2005-01-13 2009-01-15 Glaxosmithkline Zagreb Decladinosyl-macrolide mit entzündungshemmender wirkung
US20080200403A1 (en) * 2005-01-14 2008-08-21 Glaxosmithkline 9A-Carbamoyl and Thiocarbamoyl Azalides with Anti-Inflammatory Activity
JP2009535395A (ja) * 2006-05-03 2009-10-01 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ ９ａ−置換アザリド
CN101917850B (zh) * 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
CN102245195B (zh) 2008-10-24 2016-01-13 森普拉制药公司 使用含***的大环内酯的生物防御
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
CN108570083A (zh) 2010-03-22 2018-09-25 森普拉制药公司 大环内脂的结晶形式及其用途
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
AU2013239696C1 (en) 2012-03-27 2018-11-29 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
EP2968801B1 (en) 2013-03-14 2018-09-26 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
EP2968384A4 (en) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
US20160031925A1 (en) * 2013-04-10 2016-02-04 Probiotic Pharmaceuticals Aps Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
GB201520419D0 (en) * 2015-11-19 2016-01-06 Epi Endo Pharmaceuticals Ehf Compounds
KR20210072026A (ko) 2018-10-02 2021-06-16 루넬라 바이오테크 인코포레이티드 세놀리틱 약물로서 아지트로마이신 및 록시스로마이신 유도체

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1100504A (en) 1967-08-16 1968-01-24 Pliva Pharm & Chem Works Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US3928387A (en) 1974-02-04 1975-12-23 Hoffmann La Roche Antibiotic 1745A/X and methods for the production thereof
SI7910768A8 (en) 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4464527A (en) 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
EP0283055B1 (en) * 1987-09-03 1990-08-29 SOUR PLIVA farmaceutska, Kemijska prehrambena i kozmeticka industrija, n.sol.o. 10-dihydro-10-deoxo-11-azaerythronolide-a-compounds, methods and intermediates for the manufacture thereof and their use in pharmaceuticals and in the manufacture thereof
SI9011409A (en) 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
WO1992016226A1 (en) 1991-03-19 1992-10-01 Smithkline Beecham Corporation Il-1 inhibitors
FR2691464B1 (fr) * 1992-05-21 1995-06-02 Roussel Uclaf Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
CN1159756A (zh) 1994-08-12 1997-09-17 大正制药株式会社 抑制白细胞介素5的产生的抑制剂
EP0771564A4 (en) 1994-08-12 1998-05-06 Taisho Pharmaceutical Co Ltd INTERLEUKIN-5 PRODUCTION INHIBITOR
AU7961498A (en) * 1997-06-26 1999-01-19 Merck & Co., Inc. 9a-azalides, compositions containing such compounds and methods of treatment
KR100554549B1 (ko) * 1997-10-16 2006-03-03 플리바 파마세우츠카 인두스트리야, 디오닉코, 드러스트보 9ａ-아잘리드류로부터 유래한 신규한 3,6-헤미케탈
ATE275151T1 (de) * 1998-03-03 2004-09-15 Pfizer Prod Inc 3,6-ketal-makrolidantibiotika
US6262030B1 (en) * 1998-11-03 2001-07-17 Pfizer Inc. Erythromycin derivatives
IT1306205B1 (it) 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.

Also Published As

Publication number Publication date
IL167882A (en) 2010-06-30
AU2003276214B2 (en) 2009-05-28
CA2502347C (en) 2011-06-28
CN1708507A (zh) 2005-12-14
ATE319729T1 (de) 2006-03-15
CA2502347A1 (en) 2004-05-13
JP2006513157A (ja) 2006-04-20
DE60303967D1 (de) 2006-05-04
CN100486985C (zh) 2009-05-13
EP1556397A1 (en) 2005-07-27
EP1556397B1 (en) 2006-03-08
RU2005116248A (ru) 2006-01-20
JP4536516B2 (ja) 2010-09-01
US20060166904A1 (en) 2006-07-27
RU2320668C2 (ru) 2008-03-27
US7419961B2 (en) 2008-09-02
AU2003276214A1 (en) 2004-05-25
WO2004039821A1 (en) 2004-05-13

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