BG42189A3 - Method for preparing of ripe human leucocytic interferon - Google Patents

Method for preparing of ripe human leucocytic interferon

Info

Publication number: BG42189A3
Authority: BG; Bulgaria
Prior art keywords: human leukocyte; interferon; leukocyte interferon; coli; transformed
Prior art date: 1980-07-01

Application number

BG052673A

Other languages

Bulgarian (bg)

English (en)

Inventor

David Norman

Sidney Pestka

Original Assignee

F. Hoffmann - La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-07-01

Filing date

1981-06-29

Publication date

1987-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG42189(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1981-04-21 Priority claimed from US06/256,204 external-priority patent/US6610830B1/en

1981-06-29 Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag

1987-10-15 Publication of BG42189A3 publication Critical patent/BG42189A3/xx

Links

102000014150 Interferons Human genes 0.000 title abstract 2
108010050904 Interferons Proteins 0.000 title abstract 2
229940079322 interferon Drugs 0.000 title abstract 2
230000001527 leucocytic effect Effects 0.000 title 1
102000006992 Interferon-alpha Human genes 0.000 abstract 5
108010047761 Interferon-alpha Proteins 0.000 abstract 5
241000588724 Escherichia coli Species 0.000 abstract 4
108020004414 DNA Proteins 0.000 abstract 2
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 2
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 2
239000012634 fragment Substances 0.000 abstract 2
235000015097 nutrients Nutrition 0.000 abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
239000013604 expression vector Substances 0.000 abstract 1
230000034659 glycolysis Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

BG052673A 1980-07-01 1981-06-29 Method for preparing of ripe human leucocytic interferon BG42189A3 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US16498680A	1980-07-01	1980-07-01
US18490980A	1980-09-08	1980-09-08
US20557880A	1980-11-10	1980-11-10
US06/256,204 US6610830B1 (en)	1980-07-01	1981-04-21	Microbial production of mature human leukocyte interferons

Publications (1)

Publication Number	Publication Date
BG42189A3 true BG42189A3 (en)	1987-10-15

Family

ID=27496622

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG052673A BG42189A3 (en)	1980-07-01	1981-06-29	Method for preparing of ripe human leucocytic interferon

Country Status (36)

Country	Link
EP (2)	EP0211148B2 (xx)
AR (1)	AR242833A1 (xx)
AT (3)	AT380272B (xx)
AU (1)	AU552004B2 (xx)
BG (1)	BG42189A3 (xx)
BR (1)	BR8104189A (xx)
CH (2)	CH651308A5 (xx)
CS (1)	CS273152B2 (xx)
DD (3)	DD210304A5 (xx)
DE (3)	DE3125706C2 (xx)
DK (1)	DK173543B1 (xx)
DZ (1)	DZ312A1 (xx)
ES (1)	ES503528A0 (xx)
FI (1)	FI82712C (xx)
FR (1)	FR2486098B1 (xx)
GB (1)	GB2079291B (xx)
GE (1)	GEP19960519B (xx)
GR (1)	GR75714B (xx)
HK (1)	HK49285A (xx)
HU (1)	HU196457B (xx)
IE (1)	IE49255B1 (xx)
IT (1)	IT1137272B (xx)
KE (1)	KE3534A (xx)
LU (1)	LU83461A1 (xx)
MC (1)	MC1396A1 (xx)
MY (1)	MY8700711A (xx)
NL (1)	NL8103151A (xx)
NO (1)	NO159392C (xx)
NZ (1)	NZ197572A (xx)
PH (1)	PH18036A (xx)
PL (3)	PL148260B1 (xx)
PT (1)	PT73289B (xx)
RO (1)	RO87590A (xx)
SE (2)	SE465223C5 (xx)
SU (1)	SU1414319A3 (xx)
YU (1)	YU47700B (xx)

Families Citing this family (50)

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ZA811368B (en)	1980-03-24	1982-04-28	Genentech Inc	Bacterial polypedtide expression employing tryptophan promoter-operator
NZ196706A (en)	1980-04-03	1988-01-08	Biogen Nv	Dna sequences, recombinant dna molecules and processes for producing fibroblast interferon-like polypeptides; pharmaceutical and veterinary compositions
ATE25985T1 (de) *	1980-06-12	1987-04-15	Japan Found Cancer	Plasmid.
DK489481A (da) *	1980-11-10	1982-05-11	Searle & Co	Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) *	1981-02-25	1985-12-13	Genentech Inc	Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58501543A (ja) *	1981-08-14	1983-09-16	エイ／エス　アルフレツド　ベンツオン	ヒトインタ−フエロン蛋白とヒトインタ−フエロン蛋白に対する抗体に関する改良
JPS58110548A (ja) *	1981-12-24	1983-07-01	Asahi Chem Ind Co Ltd	新規な生理活性ペプチド
US4975276A (en) *	1982-01-15	1990-12-04	Cetus Corporation	Interferon-alpha 54
US5098703A (en) *	1982-01-15	1992-03-24	Cetus Corporation	Interferon-alpha 76
US4973479A (en) *	1982-01-15	1990-11-27	Cetus Corporation	Interferon-α61
US5827694A (en) *	1982-03-08	1998-10-27	Genentech, Inc.	DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6432677B1 (en)	1982-03-08	2002-08-13	Genentech, Inc.	Non-human animal interferons
US4775622A (en) *	1982-03-08	1988-10-04	Genentech, Inc.	Expression, processing and secretion of heterologous protein by yeast
IE54592B1 (en) *	1982-03-08	1989-12-06	Genentech Inc	Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
EP0088994B1 (en) *	1982-03-15	1991-06-19	Schering Corporation	Hybrid dna, binding composition prepared thereby and processes therefor
US4748233A (en) *	1982-03-23	1988-05-31	Bristol-Myers Company	Alpha-interferon Gx-1
US4695543A (en) *	1982-03-23	1987-09-22	Bristol-Myers Company	Alpha Interferon GX-1
CA1210714A (en) *	1982-03-23	1986-09-02	Alan Sloma	.alpha.-INTERFERON GX-1
US6936694B1 (en) *	1982-05-06	2005-08-30	Intermune, Inc.	Manufacture and expression of large structural genes
US5831023A (en) *	1982-11-01	1998-11-03	Genentech, Inc.	Recombinant animal interferon polypeptides
JPS60500574A (ja) *	1983-02-24	1985-04-25	インステイチユト　オルガニチエスコゴ　シンテザ　アカデミイ　ナウク　ラトビイスコイ　エスエスア−ル	ヒト白血球インタ−フェロンｎ及び細菌細胞におけるその製造方法
WO1985002862A1 (en) *	1983-12-23	1985-07-04	Monash University	PRODUCTION OF HUMAN INTERFERON-alpha
SU1364343A1 (ru) *	1984-07-13	1988-01-07	Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов	Способ получени человеческого лейкоцитарного интерферона альфа-2
IL76360A0 (en)	1984-09-26	1986-01-31	Takeda Chemical Industries Ltd	Mutual separation of proteins
WO1986002068A1 (en) *	1984-09-26	1986-04-10	Takeda Chemical Industries, Ltd.	Mutual separation of proteins
US5196323A (en) *	1985-04-27	1993-03-23	Boehringer Ingelheim International Gmbh	Process for preparing and purifying alpha-interferon
DE3515336C2 (de) *	1985-04-27	1994-01-20	Boehringer Ingelheim Int	Verfahren zur Herstellung und Reinigung von â-Interferon
JP2514950B2 (ja) *	1986-03-10	1996-07-10	エフ・ホフマン―ラロシユアーゲー	化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) *	1987-05-04	1989-03-09	Oncogen	Oncostatin m and novel composition having antitumor activity
CA1309044C (en) *	1987-11-09	1992-10-20	Toshiya Takano	Method of producing foreign gene products
GB8813032D0 (en) *	1988-06-02	1988-07-06	Boehringer Ingelheim Int	Antiviral pharmaceutical composition
WO1991003251A1 (en) *	1989-09-08	1991-03-21	California Institute Of Biological Research	Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) *	1989-09-28	1991-04-11	Boehringer Ingelheim Int	Verfahren zur reinigung von beta-interferon
DE69528751T2 (de) *	1994-03-07	2003-07-10	Imperial College Of Science, Technology & Medicine	Verwendung von Interferon-alpha 8 subtype zur Herstellung von Medikamenten zur Behandlung von Viralinfektionen der Leber
DK0679718T3 (da) *	1994-04-09	2001-10-22	Hoffmann La Roche	Fremgangsmåde til fremstilling af alfa-interferon
GB9609932D0 (en) *	1996-05-13	1996-07-17	Hoffmann La Roche	Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en)	1996-12-24	2003-10-09	Biogen, Inc.	Stable liquid interferon formulations
ZA9811070B (en)	1997-12-08	2000-07-03	Genentech Inc	Type I interferons.
CA2311681A1 (en)	1997-12-08	1999-06-17	Genentech, Inc.	Human interferon-epsilon: a type i interferon
US6783965B1 (en)	2000-02-10	2004-08-31	Mountain View Pharmaceuticals, Inc.	Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
CN1896231B (zh)	1998-08-06	2012-09-05	山景药品公司	分离四聚体尿酸氧化酶的方法
US6268178B1 (en)	1999-05-25	2001-07-31	Phage Biotechnology Corp.	Phage-dependent super-production of biologically active protein and peptides
WO2002036627A2 (en) *	2000-11-03	2002-05-10	Pbl Biomedical Laboratories	Interferons, uses and compositions related thereto
FR2822845B1 (fr)	2001-03-30	2003-12-12	Genodyssee	Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr)	2001-04-04	2003-12-12	Genodyssee	Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr)	2001-06-11	2004-09-24	Genodyssee	Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
JP2008535500A (ja)	2005-04-11	2008-09-04	サビエントファーマセウティカルズインク．	変異型尿酸オキシダーゼおよびその利用
US20110034672A1 (en) *	2008-01-18	2011-02-10	Roberto Falkenstein	Purification of not-glycosylated polypeptides
SG176897A1 (en)	2009-06-25	2012-01-30	Savient Pharmaceuticals Inc	Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
WO2018087345A1 (en)	2016-11-14	2018-05-17	F. Hoffmann-La Roche Ag	COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN150740B (xx) *	1978-11-24	1982-12-04	Hoffmann La Roche
FI77877C (fi) *	1979-04-20	1989-05-10	Technobiotic Ltd	Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
PT72322B (en) *	1980-01-08	1982-09-23	Biogen Nv	Process for preparation of recombinant dna molecules and of polipeptides similar to human interferon
DE3005897A1 (de) *	1980-02-16	1981-09-03	Hoechst Ag, 6000 Frankfurt	Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
ATE25985T1 (de) *	1980-06-12	1987-04-15	Japan Found Cancer	Plasmid.
ES8302778A1 (es) *	1980-11-10	1983-02-01	Genentech Inc	Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) *	1980-12-31	1984-01-10	Ilkka Antero Palva	Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
EP0062971B1 (en) *	1981-03-27	1990-03-07	Imperial Chemical Industries Plc	Genetically modified microorganisms

1981
- 1981-06-26 CH CH4244/81A patent/CH651308A5/de not_active IP Right Cessation
- 1981-06-26 CH CH1475/85A patent/CH657141A5/de not_active IP Right Cessation
- 1981-06-29 DZ DZ816241A patent/DZ312A1/fr active
- 1981-06-29 BG BG052673A patent/BG42189A3/xx unknown
- 1981-06-29 FR FR8112724A patent/FR2486098B1/fr not_active Expired
- 1981-06-29 MC MC811525A patent/MC1396A1/xx unknown
- 1981-06-29 HU HU811882A patent/HU196457B/hu unknown
- 1981-06-30 DK DK198102910A patent/DK173543B1/da not_active IP Right Cessation
- 1981-06-30 LU LU83461A patent/LU83461A1/de unknown
- 1981-06-30 PL PL1981231940A patent/PL148260B1/pl unknown
- 1981-06-30 EP EP86105365A patent/EP0211148B2/en not_active Expired - Lifetime
- 1981-06-30 ES ES503528A patent/ES503528A0/es active Granted
- 1981-06-30 DE DE3125706A patent/DE3125706C2/de not_active Expired - Lifetime
- 1981-06-30 GR GR65379A patent/GR75714B/el unknown
- 1981-06-30 SE SE8104093A patent/SE465223C5/xx not_active IP Right Cessation
- 1981-06-30 AT AT0290981A patent/AT380272B/de not_active IP Right Cessation
- 1981-06-30 AT AT86105365T patent/ATE79901T1/de not_active IP Right Cessation
- 1981-06-30 AR AR81285934A patent/AR242833A1/es active
- 1981-06-30 CS CS503781A patent/CS273152B2/cs unknown
- 1981-06-30 SU SU813302642A patent/SU1414319A3/ru active
- 1981-06-30 IE IE1463/81A patent/IE49255B1/en not_active IP Right Cessation
- 1981-06-30 EP EP81105067A patent/EP0043980B1/en not_active Expired
- 1981-06-30 NZ NZ197572A patent/NZ197572A/en unknown
- 1981-06-30 DE DE3177288T patent/DE3177288T3/de not_active Expired - Lifetime
- 1981-06-30 DE DE8181105067T patent/DE3176448D1/de not_active Expired
- 1981-06-30 PT PT73289A patent/PT73289B/pt unknown
- 1981-06-30 YU YU162281A patent/YU47700B/sh unknown
- 1981-06-30 AT AT81105067T patent/ATE29727T1/de not_active IP Right Cessation
- 1981-06-30 RO RO81104732A patent/RO87590A/ro unknown
- 1981-06-30 PL PL1981255773A patent/PL148261B1/pl unknown
- 1981-06-30 NO NO812247A patent/NO159392C/no not_active IP Right Cessation
- 1981-06-30 PL PL1981255774A patent/PL148276B1/pl unknown
- 1981-06-30 SE SE8104093D patent/SE8104093L/xx not_active Application Discontinuation
- 1981-06-30 NL NL8103151A patent/NL8103151A/nl not_active Application Discontinuation
- 1981-07-01 BR BR8104189A patent/BR8104189A/pt unknown
- 1981-07-01 GB GB8120279A patent/GB2079291B/en not_active Expired
- 1981-07-01 PH PH25843A patent/PH18036A/en unknown
- 1981-07-01 FI FI812067A patent/FI82712C/fi not_active IP Right Cessation
- 1981-07-01 IT IT22682/81A patent/IT1137272B/it active Protection Beyond IP Right Term
- 1981-07-01 DD DD81255299A patent/DD210304A5/de not_active IP Right Cessation
- 1981-07-01 DD DD81255300A patent/DD210305A5/de not_active IP Right Cessation
- 1981-07-01 DD DD81231371A patent/DD202307A5/de not_active IP Right Cessation
- 1981-07-01 AU AU72462/81A patent/AU552004B2/en not_active Expired
1985
- 1985-05-21 KE KE3534A patent/KE3534A/xx unknown
- 1985-06-27 HK HK492/85A patent/HK49285A/xx not_active IP Right Cessation
1987
- 1987-12-30 MY MY711/87A patent/MY8700711A/xx unknown
1993
- 1993-07-12 GE GEAP1993999A patent/GEP19960519B/en unknown

Also Published As

Publication number	Publication date
CS273152B2 (en)	1991-03-12
EP0043980A3 (en)	1982-09-15
FR2486098B1 (fr)	1985-12-27
CS503781A2 (en)	1990-07-12
ES8207514A1 (es)	1982-10-01
NO159392C (no)	1988-12-21
DD202307A5 (de)	1983-09-07
AT380272B (de)	1986-05-12
DE3176448D1 (en)	1987-10-22
PL148276B1 (en)	1989-09-30
PH18036A (en)	1985-03-06
CH651308A5 (de)	1985-09-13
FI82712B (fi)	1990-12-31
HU196457B (en)	1988-11-28
NZ197572A (en)	1985-07-31
AU552004B2 (en)	1986-05-22
ATA290981A (de)	1985-09-15
PL148260B1 (en)	1989-09-30
DE3177288T2 (de)	1992-12-10
DE3177288D1 (de)	1992-10-01
EP0043980A2 (en)	1982-01-20
ATE29727T1 (de)	1987-10-15
GB2079291B (en)	1984-06-13
CH657141A5 (de)	1986-08-15
PL231940A1 (en)	1983-07-18
EP0211148B1 (en)	1992-08-26
NL8103151A (nl)	1982-02-01
YU162281A (en)	1984-02-29
IE49255B1 (en)	1985-09-04
DE3125706A1 (de)	1982-04-15
FI812067L (fi)	1982-01-02
SE8104093L (sv)	1982-01-02
LU83461A1 (de)	1983-04-06
BR8104189A (pt)	1982-03-16
SU1414319A3 (ru)	1988-07-30
DE3177288T3 (de)	2000-03-16
NO159392B (no)	1988-09-12
ES503528A0 (es)	1982-10-01
ATE79901T1 (de)	1992-09-15
DD210304A5 (de)	1984-06-06
GB2079291A (en)	1982-01-20
IT8122682A0 (it)	1981-07-01
FR2486098A1 (fr)	1982-01-08
IE811463L (en)	1982-01-01
MY8700711A (en)	1987-12-31
GR75714B (xx)	1984-08-02
NO812247L (no)	1982-01-04
SE465223C5 (sv)	1998-02-10
EP0043980B1 (en)	1987-09-16
HK49285A (en)	1985-07-05
DE3125706C2 (de)	1995-05-24
DD210305A5 (de)	1984-06-06
DK291081A (da)	1982-01-02
DZ312A1 (fr)	2004-09-13
DK173543B1 (da)	2001-02-05
MC1396A1 (fr)	1982-04-27
PL148261B1 (en)	1989-09-30
PT73289A (en)	1981-07-01
GEP19960519B (en)	1996-07-02
SE465223B (sv)	1991-08-12
EP0211148B2 (en)	1999-11-24
KE3534A (en)	1985-06-07
RO87590A (ro)	1986-07-30
YU47700B (sh)	1996-01-08
AR242833A1 (es)	1993-05-31
PT73289B (en)	1983-05-11
FI82712C (fi)	1991-04-10
AU7246281A (en)	1982-01-07
IT1137272B (it)	1986-09-03
EP0211148A1 (en)	1987-02-25

Publication	Publication Date	Title
BG42189A3 (en)	1987-10-15	Method for preparing of ripe human leucocytic interferon
BG42526A3 (en)	1987-12-15	Method for preparing polypeptides by expression in bacteria of structural gene
BG43355A3 (en)	1988-05-16	Method for preparing of physiologically active polypeptide
ATE249476T1 (de)	2003-09-15	Cyclin d1 und seine cdna
MY104556A (en)	1994-06-30	Anoxic slaughtering of poultry
DE3175580D1 (en)	1987-01-02	Method for enhancing the growth rate of meat-producing animals and for improving the lean meat to fat ratio thereof
ATE67787T1 (de)	1991-10-15	Verfahren zur herstellung von proteinen mittels induzierbarer expressionssysteme in in-vivovermehrten, genetisch modifizierten eukaryotischen wirtszellen.
BG41137A3 (en)	1987-04-15	Method for preparing dna transfer vector for maintenance and replication of desoxynucleotide sequence coding human preproinsuline
King	1993	Potential fecundity of redclaw crayfish, Cherax quadricarinatus von Martens, in culture
RU94045882A (ru)	1996-09-10	Способ получения нового типа растений с азотфиксирующей способностью в листьях
Chennubhotla et al.	1986	Growth, reproduction and spore output in Gracilaria foliifera (Forsskal) boergesen and Gracilariopsis sjoestedtii (Kylin) Dawson around Mandapam
DK600386A (da)	1987-06-14	Proteinekspression
DeWitt et al.	1959	Reproduction in Physa pomilia and Helisoma duryi
Csatorday et al.	1977	Synchronization of Anacystis nidulans: oxygen evolution during the cell cycle
Porter et al.	2003	The use of additional lighting and artificial photoperiods to recondition early maturing Atlantic salmon (Salmo salar) in Tasmania
Keats et al.	1985	Aspects of the reproductive phenology of Saccorhiza dermatodea (Phaeophyta, Laminariales) in Newfoundland
SE8505777L (sv)	1986-06-14	Forfarande och anleggning for odling av akvakulturorganismer
Chakraborty	1995	Growth, mortality and yield per recruit of threadfin bream Nemipterus japonicus (Bloch) off Bombay
JPS6413928A (en)	1989-01-18	Method for rearing fry and young fishes
Zurlini et al.	1979	Growth of marine copepod populations in excess food supply
SU1658949A1 (ru)	1991-06-30	Способ селекции свиней
FR2444017A1 (fr)	1980-07-11	Adjuvant de croissance et de precocite pour champignons de couche, et procede pour sa fabrication
Fish	1952	Local hydrological conditions in Lake Victoria
SU886871A1 (ru)	1981-12-07	Способ разделени куколок тутового шелкопр да по полу
RU95113646A (ru)	1997-08-10	Способ приготовления рыбы горячего копчения