BG106080A - Cyclothiocarbamate derivatives as progesterone receptor modulators - Google Patents
Cyclothiocarbamate derivatives as progesterone receptor modulatorsInfo
- Publication number
- BG106080A BG106080A BG106080A BG10608001A BG106080A BG 106080 A BG106080 A BG 106080A BG 106080 A BG106080 A BG 106080A BG 10608001 A BG10608001 A BG 10608001A BG 106080 A BG106080 A BG 106080A
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- optionally substituted
- aryl
- ring
- groups
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
The present invention provides compounds which are agonists of the progesterone receptor and have structures or wherein R1 and R2 are independent substituents selected from the group of H, optionally substituted C1 to C6 alkyl, alkenyl, alkynyl, or alkynyl groups C3 to C8 cycloalkyl, aryl, substituted aryl, or heterocyclic groups, or CORA or NRBCORA; or R1 and R2 are fused to form an optionally substituted 3 to 8 membered Spiro alkyl or alkenyl ring, or a Spiro cyclic ring containing one to three heteroatoms selected from O, S and N; RA is selected from H, amino, or optionally substituted C1 to C3 alkyl, aryl, C1 to C3 alkoxy, or C1 to C3 aminoalkyl groups; RB is H, C1 to C3 alkyl, or substituted C1 to C3 alkyl; R3 is H, OH, NH2 CORC, or optionally substituted C1 to C6 alkyl, C3 to C6 alkenyl, or alkynyl groups; RC is selected from H or optionally substituted C1 to C3 alkyl, aryl, C1 to C3 alkoxy, or C1 to C3 aminoalkyl groups; Q1 is S, NR7, or CR8R9, R5 is an optionally trisubstituted benzene ring or an optionally substituted five or six membered heterocyclic ring with 1, 2 or 3 ring heteroatoms selected from the group of O, S, SO, SO2 or NR6; or a pharmaceutically acceptable salt thereof. As well as methods of using these compounds for contraception and the treatment of progesterone-related maladies. 13 claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18301399P | 1999-05-04 | 1999-05-04 | |
| US09/552,354 US6436929B1 (en) | 1999-05-04 | 2000-04-19 | Cyclothiocarbamate derivatives as progesterone receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG106080A true BG106080A (en) | 2002-05-31 |
| BG65277B1 BG65277B1 (en) | 2007-11-30 |
Family
ID=26878649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG106080A BG65277B1 (en) | 1999-05-04 | 2001-11-02 | Cyclothiocarbamate derivatives as modulators of progesterone receptors |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1175411B1 (en) |
| JP (2) | JP4958338B2 (en) |
| KR (1) | KR100732692B1 (en) |
| CN (1) | CN1131856C (en) |
| AT (1) | ATE386729T1 (en) |
| AU (1) | AU766801B2 (en) |
| BG (1) | BG65277B1 (en) |
| BR (1) | BR0010214A (en) |
| CA (1) | CA2371712C (en) |
| CZ (1) | CZ20013952A3 (en) |
| DE (1) | DE60038108T2 (en) |
| DK (1) | DK1175411T3 (en) |
| EA (1) | EA004511B1 (en) |
| ES (1) | ES2301482T3 (en) |
| GE (1) | GEP20043181B (en) |
| HU (1) | HUP0203332A3 (en) |
| IL (1) | IL146298A0 (en) |
| MX (1) | MXPA01011287A (en) |
| NO (1) | NO321370B1 (en) |
| NZ (1) | NZ515353A (en) |
| PL (1) | PL351083A1 (en) |
| SG (1) | SG120970A1 (en) |
| SK (1) | SK15922001A3 (en) |
| TR (1) | TR200103285T2 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| JP4958338B2 (en) * | 1999-05-04 | 2012-06-20 | ワイス・エルエルシー | Cyclothiocarbamate derivatives as progesterone receptor modulators |
| ATE413398T1 (en) * | 2004-04-08 | 2008-11-15 | Wyeth Corp | THIOAMIDE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS |
| BRPI0509213A (en) * | 2004-04-08 | 2007-08-28 | Wyeth Corp | method for preventing, reducing or minimizing the formation of thioamide impurities during thionation of a carbonyl compound, product, and use of an extractor |
| US7582755B2 (en) * | 2004-04-27 | 2009-09-01 | Wyeth | Cyanopyrrole-containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same |
| CN1953967B (en) | 2004-04-27 | 2013-03-13 | 惠氏公司 | Purification of progesterone receptor modulators |
| JP5288796B2 (en) * | 2004-07-07 | 2013-09-11 | ワイス・エルエルシー | Periodic progestin regimens and kits |
| PT1778710E (en) * | 2004-08-13 | 2012-04-12 | Wyeth Llc | Tanaproget derivatives, metabolites, and uses thereof |
| ES2340518T3 (en) * | 2005-04-28 | 2010-06-04 | Wyeth Llc | MICRONIZED TANAPROGET AND COMPOSITIONS THAT CONTAIN IT. |
| AU2006287925B2 (en) | 2005-04-28 | 2012-03-01 | Wyeth | Compositions containing micronized tanaproget |
| CN101166532B (en) | 2005-04-28 | 2011-06-22 | 惠氏公司 | Micronized tanaproget, compositions, and methods of preparing the same |
| CN101184738B (en) * | 2005-04-28 | 2012-05-23 | 惠氏公司 | Purified form of tanaproget |
| MX2007013469A (en) * | 2005-04-28 | 2008-01-22 | Wyeth Corp | Polymorph form ii of tanaproget. |
| MX2007015571A (en) * | 2005-06-09 | 2008-03-06 | Wyeth Corp | Tanaproget compositions containing ethinyl estradiol. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0510235A1 (en) * | 1991-04-26 | 1992-10-28 | Dong-A Pharm. Co., Ltd. | Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same |
| JPH0510235A (en) * | 1991-07-05 | 1993-01-19 | Nippondenso Co Ltd | Ignition timing controller for internal combustion engine |
| WO1995020389A1 (en) * | 1994-01-28 | 1995-08-03 | Merck & Co., Inc. | Benzoxazinones as inhibitors of hiv reverse transcriptase |
| US5693646A (en) * | 1994-12-22 | 1997-12-02 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
| NZ300739A (en) * | 1994-12-22 | 2000-05-26 | Ligand Pharm Inc | Steroid receptor modulator compounds |
| CA2268953A1 (en) * | 1996-10-02 | 1998-04-09 | Du Pont Pharmaceuticals Company | 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same |
| JP4958338B2 (en) * | 1999-05-04 | 2012-06-20 | ワイス・エルエルシー | Cyclothiocarbamate derivatives as progesterone receptor modulators |
| ES2340518T3 (en) * | 2005-04-28 | 2010-06-04 | Wyeth Llc | MICRONIZED TANAPROGET AND COMPOSITIONS THAT CONTAIN IT. |
| MX2007015571A (en) * | 2005-06-09 | 2008-03-06 | Wyeth Corp | Tanaproget compositions containing ethinyl estradiol. |
-
2000
- 2000-05-01 JP JP2000615600A patent/JP4958338B2/en not_active Expired - Fee Related
- 2000-05-01 SK SK1592-2001A patent/SK15922001A3/en unknown
- 2000-05-01 AU AU48119/00A patent/AU766801B2/en not_active Ceased
- 2000-05-01 EA EA200101181A patent/EA004511B1/en not_active IP Right Cessation
- 2000-05-01 DK DK00930266T patent/DK1175411T3/en active
- 2000-05-01 MX MXPA01011287A patent/MXPA01011287A/en active IP Right Grant
- 2000-05-01 KR KR1020017014085A patent/KR100732692B1/en not_active IP Right Cessation
- 2000-05-01 CZ CZ20013952A patent/CZ20013952A3/en unknown
- 2000-05-01 DE DE60038108T patent/DE60038108T2/en not_active Expired - Lifetime
- 2000-05-01 AT AT00930266T patent/ATE386729T1/en not_active IP Right Cessation
- 2000-05-01 NZ NZ515353A patent/NZ515353A/en unknown
- 2000-05-01 ES ES00930266T patent/ES2301482T3/en not_active Expired - Lifetime
- 2000-05-01 IL IL14629800A patent/IL146298A0/en unknown
- 2000-05-01 PL PL00351083A patent/PL351083A1/en not_active Application Discontinuation
- 2000-05-01 BR BR0010214-8A patent/BR0010214A/en active Search and Examination
- 2000-05-01 CN CN008070997A patent/CN1131856C/en not_active Expired - Fee Related
- 2000-05-01 TR TR2001/03285T patent/TR200103285T2/en unknown
- 2000-05-01 SG SG200400081A patent/SG120970A1/en unknown
- 2000-05-01 CA CA002371712A patent/CA2371712C/en not_active Expired - Fee Related
- 2000-05-01 EP EP00930266A patent/EP1175411B1/en not_active Expired - Lifetime
- 2000-05-01 GE GEAP20006120A patent/GEP20043181B/en unknown
- 2000-05-01 HU HU0203332A patent/HUP0203332A3/en unknown
-
2001
- 2001-11-02 BG BG106080A patent/BG65277B1/en unknown
- 2001-11-02 NO NO20015381A patent/NO321370B1/en unknown
-
2011
- 2011-11-14 JP JP2011249051A patent/JP5523430B2/en not_active Expired - Fee Related
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