GEP20043221B - Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators, Pharmaceutical Composition Containing Them and Use Thereof for Treatment Progesterone-Related Maladies. - Google Patents

Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators, Pharmaceutical Composition Containing Them and Use Thereof for Treatment Progesterone-Related Maladies.

Info

Publication number
GEP20043221B
GEP20043221B GEAP20006119A GEAP2000006119A GEP20043221B GE P20043221 B GEP20043221 B GE P20043221B GE AP20006119 A GEAP20006119 A GE AP20006119A GE AP2000006119 A GEAP2000006119 A GE AP2000006119A GE P20043221 B GEP20043221 B GE P20043221B
Authority
GE
Georgia
Prior art keywords
substituted
alkyl
progesterone
alkoxy
aminoalkyl
Prior art date
Application number
GEAP20006119A
Inventor
Christopher M Tegley
Lin Zhi
Horace Fletcher Iii
Eugene A Terefenko
James P Edwards
Todd K Jones
Jay E Wrobel
Andrew Fensome
Puwen Zhang
Original Assignee
Ligand Pharmaceuticals Inc Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharmaceuticals Inc Us filed Critical Ligand Pharmaceuticals Inc Us
Publication of GEP20043221B publication Critical patent/GEP20043221B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

1. Technical Result Increase in efficiency of treatment of progesterone-related maladies. 2. Essence This invention provides compounds of Formula wherein R1 and R2 may be single substituents or fused to form spirocyclic or heterospirocyclic rings; R3 is H, OH, NH2, C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C6 alkenyl, substituted C1 to C6 alkenyl, alkynyl, or substituted alkynyl, CORc; Rc is H, C1 to C3 alkyl, substituted C1 to C3 alkyl, aryl, substituted aryl, C1 to C3 alkoxy , substituted C1 to C3 alkoxy, C1 to C3 aminoalkyl, or substituted C1 to C3 aminoalkyl; R4 is H, halogen, CN, NO2, C1 to C6 alkyl, substituted C1 to C6 alkyl, alkynyl, or substituted alkynyl, C1 to C6 alkoxy, substituted C1 to C6 alkoxy, substituted C1 to C6 alkoxy, amino, C1 to C6 aminoalkyl, or substituted C1 to C6 aminoalkyl; and R5 is selected from a trisubstituted benzene ring of a five or six membered ring with 1, 2, or 3 heteroatoms from the group including O, S, SO, SO2 or NR6 and containing one or two independent substituents from the group including H, halogen, CN, NO2, amino, and C1 to C3 alkyl, C1 to C3 alkoxy, C1 to C3 aminoalkyl, CORF, or NRGCORF; and pharmaceutical compositions containing them for treatment progesterone-related maladies. 3. Field of Application Medicine.
GEAP20006119A 1999-05-04 2000-05-01 Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators, Pharmaceutical Composition Containing Them and Use Thereof for Treatment Progesterone-Related Maladies. GEP20043221B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18301299P 1999-05-04 1999-05-04
US55263399A 1999-05-04 1999-05-04

Publications (1)

Publication Number Publication Date
GEP20043221B true GEP20043221B (en) 2004-04-26

Family

ID=82308717

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP20006119A GEP20043221B (en) 1999-05-04 2000-05-01 Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators, Pharmaceutical Composition Containing Them and Use Thereof for Treatment Progesterone-Related Maladies.

Country Status (1)

Country Link
GE (1) GEP20043221B (en)

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