BG104222A - Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists - Google Patents
Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonistsInfo
- Publication number
- BG104222A BG104222A BG104222A BG10422200A BG104222A BG 104222 A BG104222 A BG 104222A BG 104222 A BG104222 A BG 104222A BG 10422200 A BG10422200 A BG 10422200A BG 104222 A BG104222 A BG 104222A
- Authority
- BG
- Bulgaria
- Prior art keywords
- carboxylic acid
- receptor antagonists
- acid derivatives
- production
- novel carboxylic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19738578A DE19738578A1 (de) | 1997-09-04 | 1997-09-04 | Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten |
DE1998111915 DE19811915A1 (de) | 1998-03-18 | 1998-03-18 | Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten |
PCT/EP1998/005354 WO1999011629A1 (de) | 1997-09-04 | 1998-08-24 | Neue carbonsäurederivate, ihre herstellung und verwendung als gemischte eta/etb-endothelin-rezeptorantagonisten |
Publications (1)
Publication Number | Publication Date |
---|---|
BG104222A true BG104222A (en) | 2001-02-28 |
Family
ID=26039663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG104222A BG104222A (en) | 1997-09-04 | 2000-03-06 | Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1009741A1 (ko) |
JP (1) | JP2001514254A (ko) |
KR (1) | KR20010023615A (ko) |
CN (1) | CN1269792A (ko) |
AR (1) | AR017052A1 (ko) |
AU (1) | AU748610B2 (ko) |
BG (1) | BG104222A (ko) |
BR (1) | BR9811631A (ko) |
CA (1) | CA2302350A1 (ko) |
CO (1) | CO4970738A1 (ko) |
HR (1) | HRP980484A2 (ko) |
HU (1) | HUP0004935A3 (ko) |
ID (1) | ID25620A (ko) |
IL (1) | IL134276A0 (ko) |
NO (1) | NO20001077D0 (ko) |
NZ (1) | NZ502660A (ko) |
PL (1) | PL338954A1 (ko) |
SK (1) | SK1522000A3 (ko) |
TR (1) | TR200000602T2 (ko) |
TW (1) | TW546295B (ko) |
WO (1) | WO1999011629A1 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19924892A1 (de) * | 1999-06-01 | 2000-12-07 | Basf Ag | Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten |
CA2652636A1 (en) * | 2006-05-29 | 2007-12-06 | Nicox S.A. | Nitrated heterocyclic compounds as endothelin receptor antagonist |
PL2268644T3 (pl) | 2008-03-05 | 2012-01-31 | Boehringer Ingelheim Int | Tricykliczne pochodne piperydyny, leki zawierające te związki, ich zastosowanie i sposoby ich wytwarzania |
EP2451786B1 (en) * | 2009-07-10 | 2014-01-22 | Cadila Healthcare Limited | Improved process for the preparation of ambrisentan and novel intermediates thereof |
SG183321A1 (en) | 2010-02-19 | 2012-09-27 | Boehringer Ingelheim Int | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
EP2760868B1 (en) | 2011-08-17 | 2018-04-25 | Boehringer Ingelheim International GmbH | Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4411225A1 (de) * | 1994-03-31 | 1995-10-05 | Basf Ag | Verwendung von Carbonsäurederivaten als Arzneimittel |
DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
JP2000504013A (ja) * | 1996-02-01 | 2000-04-04 | スミスクライン・ビーチャム・コーポレイション | エンドセリンレセプターアンタゴニスト |
DE19614542A1 (de) * | 1996-04-12 | 1997-10-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
DE19636046A1 (de) * | 1996-09-05 | 1998-03-12 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten |
-
1998
- 1998-08-24 KR KR1020007002264A patent/KR20010023615A/ko not_active Application Discontinuation
- 1998-08-24 BR BR9811631-2A patent/BR9811631A/pt not_active IP Right Cessation
- 1998-08-24 EP EP98948859A patent/EP1009741A1/de not_active Withdrawn
- 1998-08-24 WO PCT/EP1998/005354 patent/WO1999011629A1/de not_active Application Discontinuation
- 1998-08-24 IL IL13427698A patent/IL134276A0/xx unknown
- 1998-08-24 JP JP2000508669A patent/JP2001514254A/ja active Pending
- 1998-08-24 CN CN98808862A patent/CN1269792A/zh active Pending
- 1998-08-24 HU HU0004935A patent/HUP0004935A3/hu unknown
- 1998-08-24 PL PL98338954A patent/PL338954A1/xx unknown
- 1998-08-24 NZ NZ502660A patent/NZ502660A/en unknown
- 1998-08-24 CA CA002302350A patent/CA2302350A1/en not_active Abandoned
- 1998-08-24 AU AU95333/98A patent/AU748610B2/en not_active Ceased
- 1998-08-24 TR TR2000/00602T patent/TR200000602T2/xx unknown
- 1998-08-24 ID IDW20000386D patent/ID25620A/id unknown
- 1998-08-24 SK SK152-2000A patent/SK1522000A3/sk unknown
- 1998-09-02 HR HR19811915.1A patent/HRP980484A2/hr not_active Application Discontinuation
- 1998-09-03 CO CO98050561A patent/CO4970738A1/es unknown
- 1998-09-03 TW TW087114595A patent/TW546295B/zh active
- 1998-09-03 AR ARP980104402A patent/AR017052A1/es not_active Application Discontinuation
-
2000
- 2000-03-02 NO NO20001077A patent/NO20001077D0/no not_active Application Discontinuation
- 2000-03-06 BG BG104222A patent/BG104222A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL134276A0 (en) | 2001-04-30 |
BR9811631A (pt) | 2000-09-26 |
TR200000602T2 (tr) | 2000-12-21 |
JP2001514254A (ja) | 2001-09-11 |
SK1522000A3 (en) | 2000-08-14 |
TW546295B (en) | 2003-08-11 |
HUP0004935A2 (hu) | 2001-10-28 |
WO1999011629A1 (de) | 1999-03-11 |
CN1269792A (zh) | 2000-10-11 |
NZ502660A (en) | 2002-02-01 |
PL338954A1 (en) | 2000-12-04 |
EP1009741A1 (de) | 2000-06-21 |
HUP0004935A3 (en) | 2001-12-28 |
HRP980484A2 (en) | 1999-06-30 |
AR017052A1 (es) | 2001-08-22 |
CO4970738A1 (es) | 2000-11-07 |
CA2302350A1 (en) | 1999-03-11 |
KR20010023615A (ko) | 2001-03-26 |
NO20001077L (no) | 2000-03-02 |
AU9533398A (en) | 1999-03-22 |
AU748610B2 (en) | 2002-06-06 |
ID25620A (id) | 2000-10-19 |
NO20001077D0 (no) | 2000-03-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1129089A4 (en) | SPIRO-INDOLINS AS Y5 RECEPTOR ANTAGONISTS | |
BG105661A (en) | Hydroxy diphenylurea sulfonamides as il-8 receptor antagonists | |
MX9801987A (es) | Nuevos derivados de aminoacido, su obtencion y su uso. | |
AU4552497A (en) | Novel carboxylic acid derivatives, their preparation and use as mixed eta/etb receptor antagonists | |
MXPA03008811A (es) | Procedimiento para la preparacion de 4,6-diaminopirimido (5,4-d) pirimidinas. | |
ZA961364B (en) | 1-Aryl-2-acylamino-ethane compounds | |
MY120550A (en) | Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, processes for preparing them and their use as pharmaceutical compositions. | |
BG105847A (en) | Calcilytic compounds | |
BG104222A (en) | Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists | |
BG104022A (en) | New beta-amino and beta-azidocarboxylic acid derivatives, the production thereof and the use thereof as endothelin receptor antagonists | |
TR200001182T2 (tr) | Yeni karbonik asit türevleri, üretimleri ve kullanımları. | |
TR200001102T2 (tr) | İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları. | |
WO1999037291A3 (de) | Verwendung von substituierten sulfonamiden als antivirale mittel und neue stoffe | |
TR199901416T2 (xx) | Heterosiklik karbonikasit t�revleri. | |
MX9603045A (es) | Antagonistas de los receptores endoteliales. | |
MX9603199A (es) | Antagonistas de receptores a endotelina. | |
ZA983231B (en) | Substituted benzyloxyimino compounds. | |
MX9603087A (es) | Procedimiento para la obtencion de aminocarboniltriazolinonas substituidas. | |
BG106321A (en) | Novel carboxylic acid derivatives with 5,6- substituted pyrimidine ring, the production and utilization thereof as endothelin receptor antagonists | |
NZ516209A (en) | Indoloazepines as vasopressin receptor antagonists | |
BG105247A (en) | N-substituted azabicycloheptane derivatives, production and use thereof | |
DE50006244D1 (en) | Neue substituierte 3-phenoxy- und 3-phenylalkyloxy-2-phenyl-propylamine | |
BG106154A (en) | Carboxylic acid derivatives comprising aryl-substituted nitrogen heterocycles, methods for their production and their use as endothelin receptor antagonists | |
BG105618A (en) | Beta-amido and beta-sulphonamide derivatives of carboxylic acids, method for preparation and application as endothelin-receptor antagonists | |
BG105236A (en) | New carboxylic acid derivatives carrying keto side-chains, their production and use as endothelin-receptor antagonists |