BG100883A - Тропан-2-алдоксинови производни като невротрансмитерни инхибитори на обратното поемане (реъптейк) - Google Patents
Тропан-2-алдоксинови производни като невротрансмитерни инхибитори на обратното поемане (реъптейк)Info
- Publication number
- BG100883A BG100883A BG100883A BG10088396A BG100883A BG 100883 A BG100883 A BG 100883A BG 100883 A BG100883 A BG 100883A BG 10088396 A BG10088396 A BG 10088396A BG 100883 A BG100883 A BG 100883A
- Authority
- BG
- Bulgaria
- Prior art keywords
- cycloalkyl
- alkyl
- alkynyl
- alkenyl
- cycloalkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Изобретението се отнася до съединения с формула или до каквато и да е смес, или тяхна фармацевтичноприемлива сол, в които формули R е водород, алкил, алкенил, алкинил, циклоалкил, циклоалкилалкил или 2-хидроксиетил, R3 e CH=NOR', като R' е водород или алкенил, алкинил, циклоалкил, циклоалкилалкил,арил или алкил, като всеки от тях може да бъде земестен с СООН, СОО-алкил, СОО-циклоалкил или фенил, които могат да бъдат заместени един или повече пъти със заместители от група, състояща се от халоген, СF3, CN, алкокси, циклоалкокси, алкил, циклоалкил, алкенил, алкинил, амино и нитро, R4 означава фенил, който може да бъде заместен един или няколко пъти със заместители, избрани от групата, съдържаща халоген, CF3, CN, алкокси, циклоалкокси, алкил, циклоалкил, алкенил, алкинил, амино, нитро, хетероарил и арил, 3,4-метилендиоксифенил, бензил, който може да бъде заместен един или няколко пъти съсзаместители, избрани от групата, състояща се от халоген, CF3, CN, алкокси, циклоалкокси, алкил, циклоалкил, алкенил, алкинил, амино, нитро, хетероарил и арил, хетероарил, който може да бъде заместен един или няколко пъти със заместители, избрани от групата, състояща се от халоген, CF3, CN, алкокси,циклоалкокси, алкил, циклоалкил, алкенил, алкинил, амино, нитро, хетероарил и арил, или нафтил, който може да бъде заместен един или няколко пъти съсзаместители от група, състояща се от халоген, CF3, CN, алкокси, циклоалкокси, алкил, циклоалкил, алкенил, алкинил, амино, нитро, хет
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK44794 | 1994-04-19 | ||
DK133894 | 1994-11-24 | ||
PCT/EP1995/001358 WO1995028401A1 (en) | 1994-04-19 | 1995-04-12 | Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
BG100883A true BG100883A (bg) | 1998-03-31 |
BG63259B1 BG63259B1 (bg) | 2001-07-31 |
Family
ID=26064021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG100883A BG63259B1 (bg) | 1994-04-19 | 1996-10-02 | Тропан-2-алдоксинови производни като невротрансмитерни инхибитори на обратното поемане (реъптейк) |
Country Status (25)
Country | Link |
---|---|
US (1) | US5736556A (bg) |
EP (1) | EP0756596B1 (bg) |
JP (1) | JP2899418B2 (bg) |
KR (1) | KR100210417B1 (bg) |
CN (1) | CN1043763C (bg) |
AT (1) | ATE222587T1 (bg) |
AU (1) | AU690257B2 (bg) |
BG (1) | BG63259B1 (bg) |
BR (1) | BR9507489A (bg) |
CA (1) | CA2187309C (bg) |
CZ (1) | CZ284379B6 (bg) |
DE (1) | DE69527839T2 (bg) |
DK (1) | DK0756596T3 (bg) |
EE (1) | EE03877B1 (bg) |
FI (1) | FI965074A (bg) |
GE (1) | GEP19991749B (bg) |
HU (1) | HU215830B (bg) |
LV (1) | LV11738B (bg) |
NO (1) | NO964180L (bg) |
NZ (1) | NZ284075A (bg) |
PL (1) | PL183025B1 (bg) |
RU (1) | RU2134264C1 (bg) |
SK (1) | SK280875B6 (bg) |
UA (1) | UA49801C2 (bg) |
WO (1) | WO1995028401A1 (bg) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0859777B1 (en) * | 1995-10-13 | 2007-05-23 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene derivatives, their preparation and use |
US6241963B1 (en) * | 1995-10-19 | 2001-06-05 | The Trustees Of The University Of Pennsylvania | Dopamine and serotonin transporter ligands and imaging agents |
TR199800780T2 (xx) * | 1995-11-02 | 1998-07-21 | Neurosearch A/S | Kayna�m�� tropan t�revleri, haz�rlan��lar� ve kullan�mlar�. |
US5948933A (en) * | 1997-07-11 | 1999-09-07 | Organix, Inc. | Tropane analogs and methods for inhibition of monoamine transport |
DK0885220T3 (da) * | 1996-02-22 | 2001-10-15 | Neurosearch As | Tropanderivater, deres fresmtilling og anvendelse |
US6232326B1 (en) | 1998-07-14 | 2001-05-15 | Jodi A. Nelson | Treatment for schizophrenia and other dopamine system dysfunctions |
US20040229908A1 (en) * | 1999-07-13 | 2004-11-18 | Jodi Nelson | Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias |
US6417177B1 (en) | 1999-07-13 | 2002-07-09 | Alpha Research Group, Llc | Chloroquine derivatives for the treatment of Parkinson's disease |
US6667314B2 (en) | 2000-05-26 | 2003-12-23 | Pfizer, Inc. | Tropane derivatives useful in therapy |
CZ299102B6 (cs) * | 2000-05-26 | 2008-04-23 | Pfizer Inc. | Tropanový derivát, zpusoby a meziprodukty pro jeho výrobu, léciva a lécivové kombinace s jeho obsahem |
WO2002102801A1 (en) * | 2001-05-23 | 2002-12-27 | Neurosearch A/S | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
US6610849B2 (en) * | 2001-06-28 | 2003-08-26 | Boehringer Ingelheim Pharma Kg | Process for the manufacture of tropenol |
WO2003045388A1 (en) * | 2001-11-30 | 2003-06-05 | Neurosearch A/S | Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases |
DE10200943A1 (de) * | 2002-01-12 | 2003-07-24 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Scopinestern |
EP1483237A4 (en) * | 2002-03-28 | 2006-07-05 | Harvard College | TROPANE COMPOUNDS |
US7309790B2 (en) | 2003-10-03 | 2007-12-18 | Pfizer Inc | Chemical compounds |
JP2007508336A (ja) * | 2003-10-16 | 2007-04-05 | ニューロサーチ、アクティーゼルスカブ | モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物 |
WO2005070427A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
CA2554617A1 (en) * | 2004-01-22 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
RU2352332C1 (ru) * | 2005-01-14 | 2009-04-20 | Частное Предприятие "Славянская Клиника" | Применение местного анестетика для коррекции пищевого поведения человека и способ применения |
EP1779851A1 (en) | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU671163B2 (en) * | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
-
1995
- 1995-04-12 DE DE69527839T patent/DE69527839T2/de not_active Expired - Lifetime
- 1995-04-12 DK DK95915869T patent/DK0756596T3/da active
- 1995-04-12 SK SK1288-96A patent/SK280875B6/sk unknown
- 1995-04-12 KR KR1019960705823A patent/KR100210417B1/ko not_active IP Right Cessation
- 1995-04-12 BR BR9507489A patent/BR9507489A/pt not_active Application Discontinuation
- 1995-04-12 RU RU96121937A patent/RU2134264C1/ru active
- 1995-04-12 HU HU9602707A patent/HU215830B/hu not_active IP Right Cessation
- 1995-04-12 EE EE9600132A patent/EE03877B1/xx not_active IP Right Cessation
- 1995-04-12 PL PL95316876A patent/PL183025B1/pl unknown
- 1995-04-12 CA CA002187309A patent/CA2187309C/en not_active Expired - Fee Related
- 1995-04-12 AU AU22575/95A patent/AU690257B2/en not_active Ceased
- 1995-04-12 CZ CZ962982A patent/CZ284379B6/cs not_active IP Right Cessation
- 1995-04-12 CN CN95193151A patent/CN1043763C/zh not_active Expired - Fee Related
- 1995-04-12 US US08/722,010 patent/US5736556A/en not_active Expired - Lifetime
- 1995-04-12 GE GEAP19953459A patent/GEP19991749B/en unknown
- 1995-04-12 JP JP7526700A patent/JP2899418B2/ja not_active Expired - Fee Related
- 1995-04-12 AT AT95915869T patent/ATE222587T1/de not_active IP Right Cessation
- 1995-04-12 EP EP95915869A patent/EP0756596B1/en not_active Expired - Lifetime
- 1995-04-12 UA UA96103884A patent/UA49801C2/uk unknown
- 1995-04-12 WO PCT/EP1995/001358 patent/WO1995028401A1/en active IP Right Grant
- 1995-04-12 NZ NZ284075A patent/NZ284075A/en unknown
-
1996
- 1996-10-02 NO NO964180A patent/NO964180L/no not_active Application Discontinuation
- 1996-10-02 BG BG100883A patent/BG63259B1/bg unknown
- 1996-11-11 LV LVP-96-428A patent/LV11738B/en unknown
- 1996-12-17 FI FI965074A patent/FI965074A/fi active IP Right Revival
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