BG100883A - Тропан-2-алдоксинови производни като невротрансмитерни инхибитори на обратното поемане (реъптейк) - Google Patents

Тропан-2-алдоксинови производни като невротрансмитерни инхибитори на обратното поемане (реъптейк)

Info

Publication number
BG100883A
BG100883A BG100883A BG10088396A BG100883A BG 100883 A BG100883 A BG 100883A BG 100883 A BG100883 A BG 100883A BG 10088396 A BG10088396 A BG 10088396A BG 100883 A BG100883 A BG 100883A
Authority
BG
Bulgaria
Prior art keywords
cycloalkyl
alkyl
alkynyl
alkenyl
cycloalkoxy
Prior art date
Application number
BG100883A
Other languages
English (en)
Other versions
BG63259B1 (bg
Inventor
Peter Moldt
Frank Waetjen
Jorgen Scheel-Krueger
Original Assignee
Neurosearch A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch A/S filed Critical Neurosearch A/S
Publication of BG100883A publication Critical patent/BG100883A/bg
Publication of BG63259B1 publication Critical patent/BG63259B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Изобретението се отнася до съединения с формула или до каквато и да е смес, или тяхна фармацевтичноприемлива сол, в които формули R е водород, алкил, алкенил, алкинил, циклоалкил, циклоалкилалкил или 2-хидроксиетил, R3 e CH=NOR', като R' е водород или алкенил, алкинил, циклоалкил, циклоалкилалкил,арил или алкил, като всеки от тях може да бъде земестен с СООН, СОО-алкил, СОО-циклоалкил или фенил, които могат да бъдат заместени един или повече пъти със заместители от група, състояща се от халоген, СF3, CN, алкокси, циклоалкокси, алкил, циклоалкил, алкенил, алкинил, амино и нитро, R4 означава фенил, който може да бъде заместен един или няколко пъти със заместители, избрани от групата, съдържаща халоген, CF3, CN, алкокси, циклоалкокси, алкил, циклоалкил, алкенил, алкинил, амино, нитро, хетероарил и арил, 3,4-метилендиоксифенил, бензил, който може да бъде заместен един или няколко пъти съсзаместители, избрани от групата, състояща се от халоген, CF3, CN, алкокси, циклоалкокси, алкил, циклоалкил, алкенил, алкинил, амино, нитро, хетероарил и арил, хетероарил, който може да бъде заместен един или няколко пъти със заместители, избрани от групата, състояща се от халоген, CF3, CN, алкокси,циклоалкокси, алкил, циклоалкил, алкенил, алкинил, амино, нитро, хетероарил и арил, или нафтил, който може да бъде заместен един или няколко пъти съсзаместители от група, състояща се от халоген, CF3, CN, алкокси, циклоалкокси, алкил, циклоалкил, алкенил, алкинил, амино, нитро, хет
BG100883A 1994-04-19 1996-10-02 Тропан-2-алдоксинови производни като невротрансмитерни инхибитори на обратното поемане (реъптейк) BG63259B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK44794 1994-04-19
DK133894 1994-11-24
PCT/EP1995/001358 WO1995028401A1 (en) 1994-04-19 1995-04-12 Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors

Publications (2)

Publication Number Publication Date
BG100883A true BG100883A (bg) 1998-03-31
BG63259B1 BG63259B1 (bg) 2001-07-31

Family

ID=26064021

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100883A BG63259B1 (bg) 1994-04-19 1996-10-02 Тропан-2-алдоксинови производни като невротрансмитерни инхибитори на обратното поемане (реъптейк)

Country Status (25)

Country Link
US (1) US5736556A (bg)
EP (1) EP0756596B1 (bg)
JP (1) JP2899418B2 (bg)
KR (1) KR100210417B1 (bg)
CN (1) CN1043763C (bg)
AT (1) ATE222587T1 (bg)
AU (1) AU690257B2 (bg)
BG (1) BG63259B1 (bg)
BR (1) BR9507489A (bg)
CA (1) CA2187309C (bg)
CZ (1) CZ284379B6 (bg)
DE (1) DE69527839T2 (bg)
DK (1) DK0756596T3 (bg)
EE (1) EE03877B1 (bg)
FI (1) FI965074A (bg)
GE (1) GEP19991749B (bg)
HU (1) HU215830B (bg)
LV (1) LV11738B (bg)
NO (1) NO964180L (bg)
NZ (1) NZ284075A (bg)
PL (1) PL183025B1 (bg)
RU (1) RU2134264C1 (bg)
SK (1) SK280875B6 (bg)
UA (1) UA49801C2 (bg)
WO (1) WO1995028401A1 (bg)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0859777B1 (en) * 1995-10-13 2007-05-23 Neurosearch A/S 8-azabicyclo(3.2.1)oct-2-ene derivatives, their preparation and use
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
TR199800780T2 (xx) * 1995-11-02 1998-07-21 Neurosearch A/S Kayna�m�� tropan t�revleri, haz�rlan��lar� ve kullan�mlar�.
US5948933A (en) * 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
DK0885220T3 (da) * 1996-02-22 2001-10-15 Neurosearch As Tropanderivater, deres fresmtilling og anvendelse
US6232326B1 (en) 1998-07-14 2001-05-15 Jodi A. Nelson Treatment for schizophrenia and other dopamine system dysfunctions
US20040229908A1 (en) * 1999-07-13 2004-11-18 Jodi Nelson Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias
US6417177B1 (en) 1999-07-13 2002-07-09 Alpha Research Group, Llc Chloroquine derivatives for the treatment of Parkinson's disease
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
CZ299102B6 (cs) * 2000-05-26 2008-04-23 Pfizer Inc. Tropanový derivát, zpusoby a meziprodukty pro jeho výrobu, léciva a lécivové kombinace s jeho obsahem
WO2002102801A1 (en) * 2001-05-23 2002-12-27 Neurosearch A/S Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US6610849B2 (en) * 2001-06-28 2003-08-26 Boehringer Ingelheim Pharma Kg Process for the manufacture of tropenol
WO2003045388A1 (en) * 2001-11-30 2003-06-05 Neurosearch A/S Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
EP1483237A4 (en) * 2002-03-28 2006-07-05 Harvard College TROPANE COMPOUNDS
US7309790B2 (en) 2003-10-03 2007-12-18 Pfizer Inc Chemical compounds
JP2007508336A (ja) * 2003-10-16 2007-04-05 ニューロサーチ、アクティーゼルスカブ モノアミン神経伝達物質再取り込みインヒビター及びアセチルコリンエステラーゼインヒビターを含む医薬組成物
WO2005070427A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Compounds for the sustained reduction of body weight
CA2554617A1 (en) * 2004-01-22 2005-08-04 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist
RU2352332C1 (ru) * 2005-01-14 2009-04-20 Частное Предприятие "Славянская Клиника" Применение местного анестетика для коррекции пищевого поведения человека и способ применения
EP1779851A1 (en) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Treatment of diabetes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds

Also Published As

Publication number Publication date
SK280875B6 (sk) 2000-08-14
CZ298296A3 (en) 1997-06-11
DE69527839D1 (en) 2002-09-26
CA2187309A1 (en) 1995-10-26
EP0756596B1 (en) 2002-08-21
RU2134264C1 (ru) 1999-08-10
CN1148854A (zh) 1997-04-30
EE03877B1 (et) 2002-10-15
HUT75865A (en) 1997-05-28
BR9507489A (pt) 1997-08-12
DE69527839T2 (de) 2003-01-02
AU690257B2 (en) 1998-04-23
ATE222587T1 (de) 2002-09-15
HU215830B (hu) 2001-05-28
NZ284075A (en) 1998-01-26
LV11738B (en) 1997-12-20
JPH09505607A (ja) 1997-06-03
BG63259B1 (bg) 2001-07-31
NO964180L (no) 1996-12-16
CA2187309C (en) 2000-11-21
FI965074A0 (fi) 1996-12-17
FI965074A (fi) 1996-12-17
HU9602707D0 (en) 1996-11-28
NO964180D0 (no) 1996-10-02
CN1043763C (zh) 1999-06-23
DK0756596T3 (da) 2002-12-23
GEP19991749B (en) 1999-09-10
MX9604966A (es) 1998-05-31
PL183025B1 (pl) 2002-05-31
CZ284379B6 (cs) 1998-11-11
UA49801C2 (uk) 2002-10-15
AU2257595A (en) 1995-11-10
KR100210417B1 (ko) 1999-07-15
JP2899418B2 (ja) 1999-06-02
LV11738A (lv) 1997-04-20
SK128896A3 (en) 1997-04-09
WO1995028401A1 (en) 1995-10-26
EP0756596A1 (en) 1997-02-05
US5736556A (en) 1998-04-07
PL316876A1 (en) 1997-02-17
EE9600132A (et) 1997-04-15

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