BE903846A - COMPOUNDS DERIVED FROM INDOLE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION. - Google Patents

COMPOUNDS DERIVED FROM INDOLE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION.

Info

Publication number
BE903846A
BE903846A BE0/216004A BE216004A BE903846A BE 903846 A BE903846 A BE 903846A BE 0/216004 A BE0/216004 A BE 0/216004A BE 216004 A BE216004 A BE 216004A BE 903846 A BE903846 A BE 903846A
Authority
BE
Belgium
Prior art keywords
group
alkyl group
indole
preparation
represent
Prior art date
Application number
BE0/216004A
Other languages
French (fr)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BE903846A publication Critical patent/BE903846A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Dérivés d'indole de formule générale (1) ou R1 représente un atome d'hydrogène, un groupe alcoyle en C1 à C6, cycloalcoyle en C3 à C7 ou alcényle en C3 à C6, un groupe phényle ou phénylalcoyle en C1 à C4 substitué ou non substitué choisis entre alcoxy en C1 à C3,hydroxy, halogène, un groupe R5 R6 NCO- où R5 et R6 représentent chacun un atome d'hydrogène ou un groupe alcoyle en C1 à C3 ou un groupe R7 R8N-, où R7 et R8 représentent un atome d'hydrogène, un groupe alcoyle en C1 à C3, ou R7 R8N-représente un noyau monocyclique à 5 à 7 chainons saturé; R2 représente un hydrogène, un groupe alcoyle en C1 à C6; ou R1 et R2 ensemble avec l'atome d'azote auquel ils sont attachés forment un noyau monocyclique à 5 à 7 chainons saturé; R3 et R4 représentent un d'hydrogène, un groupe alcoyle en C1 à C3, ou un groupe 2-propényle; et n est un nombre entier allant de 2 à 5.Indole derivatives of general formula (1) where R1 represents a hydrogen atom, a C1 to C6 alkyl group, C3 to C7 cycloalkyl or C3 to C6 alkenyl, a substituted phenyl or C1 to C4 phenylalkyl group or unsubstituted chosen between C1 to C3 alkoxy, hydroxy, halogen, a group R5 R6 NCO- where R5 and R6 each represent a hydrogen atom or a C1 to C3 alkyl group or a group R7 R8N-, where R7 and R8 represent a hydrogen atom, a C1 to C3 alkyl group, or R7 R8N-represents a saturated 5- to 7-membered monocyclic ring; R2 represents hydrogen, a C1 to C6 alkyl group; or R1 and R2 together with the nitrogen atom to which they are attached form a saturated 5- to 7-membered monocyclic ring; R3 and R4 represent a hydrogen, a C1 to C3 alkyl group, or a 2-propenyl group; and n is an integer ranging from 2 to 5.

BE0/216004A 1984-12-13 1985-12-12 COMPOUNDS DERIVED FROM INDOLE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION. BE903846A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848431426A GB8431426D0 (en) 1984-12-13 1984-12-13 Chemical compounds

Publications (1)

Publication Number Publication Date
BE903846A true BE903846A (en) 1986-06-12

Family

ID=10571103

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216004A BE903846A (en) 1984-12-13 1985-12-12 COMPOUNDS DERIVED FROM INDOLE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION.

Country Status (11)

Country Link
JP (1) JPS61151172A (en)
AU (1) AU579687B2 (en)
BE (1) BE903846A (en)
CH (1) CH667454A5 (en)
DE (1) DE3543982A1 (en)
FR (1) FR2574793B1 (en)
GB (2) GB8431426D0 (en)
IT (1) IT1182089B (en)
NL (1) NL8503424A (en)
SE (1) SE8505887L (en)
ZA (1) ZA859520B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
GB8614287D0 (en) * 1986-06-12 1986-07-16 Glaxo Group Ltd Chemical compounds
US4894386A (en) * 1987-04-15 1990-01-16 Ici Americas Inc. Aliphatic carboxamides
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
WO1991018897A1 (en) * 1990-06-07 1991-12-12 The Wellcome Foundation Limited Therapeutic heterocyclic compounds
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9216009D0 (en) * 1992-07-28 1992-09-09 Almirall Lab New indol derivatives
ES2056025B1 (en) * 1992-10-08 1995-05-01 Almirall Lab NEW DERIVATIVES OF INDOL.
FR2707639B1 (en) * 1993-06-30 1995-10-13 Pf Medicament New indole compounds derived from arylamines as selective ligands for the 5HT1D and 5HT1B receptors.
CN1729174B (en) * 2002-12-20 2015-10-21 西巴特殊化学品控股有限公司 The synthesis of amine and the intermediate for the synthesis of amine
WO2005118551A2 (en) 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
AU2005299720B2 (en) * 2004-10-25 2010-02-04 Ligand Pharmaceuticals Incorporated Thrombopoietin activity modulating compounds and methods
MX2009010302A (en) 2007-03-29 2009-10-16 Asubio Pharma Co Ltd Indole derivative having cpla2 inhibitory activity, use of the same and method for producing the same.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
GB2082175B (en) * 1980-08-12 1984-05-02 Glaxo Group Ltd Heterocyclic compounds
FR2574077A1 (en) * 1984-12-04 1986-06-06 Glaxo Group Ltd INDOLE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds

Also Published As

Publication number Publication date
NL8503424A (en) 1986-07-01
CH667454A5 (en) 1988-10-14
SE8505887L (en) 1986-06-14
AU579687B2 (en) 1988-12-01
AU5115185A (en) 1986-06-19
DE3543982A1 (en) 1986-06-19
GB2168347A (en) 1986-06-18
JPS61151172A (en) 1986-07-09
ZA859520B (en) 1986-08-27
FR2574793B1 (en) 1988-10-14
IT8548921A0 (en) 1985-12-12
IT1182089B (en) 1987-09-30
GB8530591D0 (en) 1986-01-22
GB8431426D0 (en) 1985-01-23
GB2168347B (en) 1988-02-03
FR2574793A1 (en) 1986-06-20
SE8505887D0 (en) 1985-12-12

Similar Documents

Publication Publication Date Title
BE903846A (en) COMPOUNDS DERIVED FROM INDOLE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION.
FR2416012A1 (en) DERIVATIVES OF IMIDAZOLE AND MEDICINAL PRODUCTS CONTAINING THESE SUBSTANCES
ES8308312A1 (en) Benzazepines, process for their preparation and their application as pharmaceutical preparations.
FR2453854A1 (en) NOVEL O- (4-DIPHENYLMETHYLPIPERIDINO) -1-PHENYLALCANOLS DERIVATIVES, ESPECIALLY USEFUL AS ANTIHISTAMINS, AND THEIR PREPARATION PROCESS
FR2416234A1 (en) METRONIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING
BE902953A (en) 5H-2,3-BENZODIAZEPINE DERIVATIVES PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
BE904796A (en) NOVEL MORPHINANE AND MORPHINE DERIVATIVES, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2401914A1 (en) NEW HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICINAL COMPOSITIONS CONTAINING THE SAID COMPOUNDS
FR2392027A1 (en) NEW MORPHOLINE-CARBOXYLIC ACIDS, THEIR SYNTHESIS AND MEDICINAL PRODUCTS CONTAINING THEM
ES8107201A1 (en) Morpholine derivatives, pharmaceutical compositions containing them and processes for their preparation.
CA2013324A1 (en) Pteridin-4(3h)-ones, process for their preparation and drugs containing them
FR2397403A1 (en) NEW DERIVATIVES OF 1-ACYL 2-CYANO-AZIRIDINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
FR2370744A1 (en) NEW AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
FR2354766A1 (en) INDOLE N-AMINOALKYL DERIVATIVES AND METHODS FOR PREPARING THEM
BE1000338A4 (en) INDOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND PROCESS FOR THEIR PREPARATION.
FR2361346A1 (en) DIPEPTIDES USEFUL AS MEDICINAL PRODUCTS
EP0262053A3 (en) Amino-acid derivatives, their preparation and pharmaceutical compositions containing them
FR2707089B1 (en) New phosphonic acid derivatives, process for their preparation and pharmaceutical compositions containing them.
FR2446829A1 (en) POLYMETHYLENE DERIVATIVES DISUBSTITUTED IN ALPHA, OMEGA, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2399998A1 (en) PRODUCT DERIVED FROM DIPHENOXY-1,3 PROPANONE-2, PROCESS FOR ITS PREPARATION AND ITS APPLICATION TO THE REALIZATION OF A MEDICINAL PRODUCT
BE903376A (en) VITAMIN D DERIVATIVES AND PRECURSORS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
BE904865A (en) PHENANTHRENE DERIVATIVES, THEIR PREPARATION METHOD AND FUNGICIDAL COMPOSITIONS CONTAINING THEM.
BE901278A (en) 4,5,6,7-TETRAHYDROTHIAZOLO [5,4-C] PYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM
BE904588A (en) (-) - 1Beta-ETHYL-1ALPHA-HYDROXYMETHYL-1,2,3,4,6,7,12,12beta alpha-OCTAHYDROINDOLO (2,3-a) QUINOLIZINE, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME .
FR2359154A1 (en) PEPTIDIC DERIVATIVES USEFUL AS MEDICINAL PRODUCTS AND PROCESS FOR THEIR PREPARATION

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GLAXO GROUP LTD

Effective date: 19921231