BE903376A - Derives de la vitamine d et precurseurs de ceux-ci et compositions pharmaceutiques en contenant - Google Patents

Derives de la vitamine d et precurseurs de ceux-ci et compositions pharmaceutiques en contenant

Info

Publication number
BE903376A
BE903376A BE0/215682A BE215682A BE903376A BE 903376 A BE903376 A BE 903376A BE 0/215682 A BE0/215682 A BE 0/215682A BE 215682 A BE215682 A BE 215682A BE 903376 A BE903376 A BE 903376A
Authority
BE
Belgium
Prior art keywords
vitamin
precursors
derivatives
pharmaceutical compositions
compositions containing
Prior art date
Application number
BE0/215682A
Other languages
English (en)
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of BE903376A publication Critical patent/BE903376A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Des procédés pour les préparer et de nouveaux composés intermédiaires utiles à cette fin de formule (I) où R1, R2 et R3 représentent un atome d'hydrogène ou radical acyle en C 1-4 ou benzoyle et R4 et R5 représentent chacun un atome d'hydrogène ou pris ensemble forment une liaison carbone-carbone. Ces composés ont une activité vitaminoide D semblable à celle de 1a 1 alph, 25-dihydroxyvitamine D3.
BE0/215682A 1984-10-04 1985-10-04 Derives de la vitamine d et precurseurs de ceux-ci et compositions pharmaceutiques en contenant BE903376A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65754984A 1984-10-04 1984-10-04

Publications (1)

Publication Number Publication Date
BE903376A true BE903376A (fr) 1986-02-03

Family

ID=24637652

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215682A BE903376A (fr) 1984-10-04 1985-10-04 Derives de la vitamine d et precurseurs de ceux-ci et compositions pharmaceutiques en contenant

Country Status (13)

Country Link
EP (1) EP0197949A1 (fr)
JP (3) JPS62500301A (fr)
AU (2) AU582789B2 (fr)
BE (1) BE903376A (fr)
CH (1) CH672920A5 (fr)
DE (2) DE3590488T (fr)
DK (5) DK154290C (fr)
FR (1) FR2571369B1 (fr)
GB (2) GB2167070B (fr)
IE (1) IE58104B1 (fr)
IT (1) IT1190401B (fr)
NL (1) NL8520265A (fr)
WO (1) WO1986002078A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU614372B2 (en) * 1988-04-21 1991-08-29 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
RU2057117C1 (ru) * 1988-04-29 1996-03-27 Висконсин Алюмни Рисерч Фаундейшн ГОМОЛОГИ 1α - ГИДРОКСИВИТАМИНА D3 С НЕНАСЫЩЕННОЙ БОКОВОЙ ЦЕПЬЮ, КОМПОЗИЦИЯ, СПОСОБСТВУЮЩАЯ СТИМУЛЯЦИИ И УСИЛЕНИЮ ДИФФЕРЕНЦИАЦИИ ЗЛОКАЧЕСТВЕННЫХ КЛЕТОК ЛЕЙКЕМИИ ЧЕЛОВЕКА, СПОСОБ СТИМУЛЯЦИИ И УСИЛЕНИЯ ДИФФЕРЕНЦИАЦИИ ЗЛОКАЧЕСТВЕННЫХ КЛЕТОК ЛЕЙКЕМИИ ЧЕЛОВЕКА
GB2229921B (en) * 1989-04-05 1992-12-16 Chugai Pharmaceutical Co Ltd Treatment for hyperparathyroidism with use of vitamin d derivatives
DE3933034A1 (de) * 1989-10-02 1991-04-11 Schering Ag 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5891865A (en) * 1996-10-04 1999-04-06 Wisconsin Alumni Research Foundation Treatment of arthritic disease induced by infectious agents
WO2006051106A1 (fr) 2004-11-12 2006-05-18 Bioxell Spa Emploi combiné de dérivés de vitamine d et d'agents antiproliférants pour le traitement de cancers de la vessie

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833622A (en) * 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
AU527805B2 (en) * 1978-07-27 1983-03-24 Research Institute For Medicine And Chemistry Inc. 1alpha, 1beta dihydroxy steroid-5-enes
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
CH665834A5 (de) * 1983-05-09 1988-06-15 Wisconsin Alumni Res Found Verfahren zur herstellung von 1alpha,25-dihydroxyliertem vitamin d(2) und verwandten verbindungen.

Also Published As

Publication number Publication date
IT1190401B (it) 1988-02-16
JPH0569103B2 (fr) 1993-09-30
FR2571369A1 (fr) 1986-04-11
DK158989B (da) 1990-08-13
AU605007B2 (en) 1991-01-03
DK158991B (da) 1990-08-13
CH672920A5 (fr) 1990-01-15
EP0197949A1 (fr) 1986-10-22
DK177489D0 (da) 1989-04-13
DK260086D0 (da) 1986-06-03
GB8524479D0 (en) 1985-11-06
DK159389B (da) 1990-10-08
GB8709579D0 (en) 1987-05-28
DE3590488C2 (fr) 1992-10-01
GB2188932B (en) 1988-09-01
IE852443L (en) 1986-04-04
DK158989C (da) 1991-01-21
GB2167070B (en) 1988-09-01
JPH0689022B2 (ja) 1994-11-09
DK158990B (da) 1990-08-13
DK158991C (da) 1991-01-21
DK154290B (da) 1988-10-31
AU2761488A (en) 1989-06-08
FR2571369B1 (fr) 1987-12-04
DK159389C (da) 1991-03-11
JPH05178887A (ja) 1993-07-20
DK111188A (da) 1988-03-02
DK15390D0 (da) 1990-01-19
JPH0635475B2 (ja) 1994-05-11
DK15390A (da) 1990-01-19
JPS62500301A (ja) 1987-02-05
DK177489A (da) 1989-04-13
DK154290C (da) 1989-03-28
GB2167070A (en) 1986-05-21
GB2188932A (en) 1987-10-14
DE3590488T (de) 1986-10-09
IT8522359A0 (it) 1985-10-04
WO1986002078A1 (fr) 1986-04-10
AU582789B2 (en) 1989-04-13
DK15290A (da) 1990-01-19
NL8520265A (nl) 1986-09-01
DK15290D0 (da) 1990-01-19
DK158990C (da) 1991-01-21
JPH05222089A (ja) 1993-08-31
IE58104B1 (en) 1993-06-30
AU4776185A (en) 1986-04-17
DK260086A (da) 1986-06-03
DK111188D0 (da) 1988-03-02

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: WISCONSIN ALUMNI RESEARCH FOUNDATION

Effective date: 19981031