BE899963A - 6-desoxyanthracyclines et procede pour les preparer. - Google Patents
6-desoxyanthracyclines et procede pour les preparer.Info
- Publication number
- BE899963A BE899963A BE0/213174A BE213174A BE899963A BE 899963 A BE899963 A BE 899963A BE 0/213174 A BE0/213174 A BE 0/213174A BE 213174 A BE213174 A BE 213174A BE 899963 A BE899963 A BE 899963A
- Authority
- BE
- Belgium
- Prior art keywords
- desoxyanthracyclines
- preparing
- deoxyanthracyclinones
- tetrahydrophthalate
- describes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Ce procédé est une synthèse totale des 6-désoxyanthracyclinones de formule générale (I) à l'aide de 1,2,3,6-tétrahydrophtalate comme matière de départ, dans laquelle R représente un atome d'hydrogène. L'invention décrit aussi la préparation de glycosides d'anthracyclines ayant des propriétés anti-tumorales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838317037A GB8317037D0 (en) | 1983-06-23 | 1983-06-23 | 6-deoxyanthracyclines |
Publications (1)
Publication Number | Publication Date |
---|---|
BE899963A true BE899963A (fr) | 1984-12-20 |
Family
ID=10544662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/213174A BE899963A (fr) | 1983-06-23 | 1984-06-20 | 6-desoxyanthracyclines et procede pour les preparer. |
Country Status (20)
Country | Link |
---|---|
US (2) | US4939282A (fr) |
JP (2) | JPS6013735A (fr) |
AT (1) | AT390252B (fr) |
AU (2) | AU561456B2 (fr) |
BE (1) | BE899963A (fr) |
CA (1) | CA1234104A (fr) |
CH (2) | CH665422A5 (fr) |
CS (2) | CS243500B2 (fr) |
DK (2) | DK306484A (fr) |
FI (1) | FI842505A (fr) |
FR (1) | FR2549046B1 (fr) |
GB (1) | GB8317037D0 (fr) |
GR (1) | GR82130B (fr) |
HU (2) | HU194902B (fr) |
IL (1) | IL72168A (fr) |
IT (1) | IT1212101B (fr) |
NL (1) | NL8401957A (fr) |
SE (2) | SE8403353L (fr) |
SU (2) | SU1561821A3 (fr) |
ZA (1) | ZA844719B (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8317037D0 (en) * | 1983-06-23 | 1983-07-27 | Erba Farmitalia | 6-deoxyanthracyclines |
GB2182926B (en) * | 1985-11-19 | 1989-10-04 | Erba Farmitalia | Nitro anthracyclines, process for their preparation and use thereof |
GB8803301D0 (en) * | 1988-02-12 | 1988-03-09 | Erba Carlo Spa | Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin |
IT1275953B1 (it) * | 1995-03-22 | 1997-10-24 | Sicor Spa | Procedimento per la preparazione di antibiotici della classe delle antracicline |
US5948896A (en) * | 1997-08-13 | 1999-09-07 | Gem Pharmaceuticals | Processes for preparing 13-deoxy anthracycline derivatives |
US5942605A (en) * | 1998-03-03 | 1999-08-24 | Gem Pharmaceuticals, Inc. | 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them |
JP4455643B2 (ja) | 2007-10-30 | 2010-04-21 | 東洋エンジニアリング株式会社 | 造粒装置及びそれを用いる造粒方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3803124A (en) * | 1968-04-12 | 1974-04-09 | Farmaceutici It Soc | Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives |
GB1467383A (en) * | 1974-06-12 | 1977-03-16 | Farmaceutici Italia | Daunomycin analogues |
GB1509875A (en) * | 1976-06-14 | 1978-05-04 | Farmaceutici Italia | Optically active anthracyclinones and anthracycline glycosides |
GB1567456A (en) * | 1976-11-16 | 1980-05-14 | Farmaceutici Italia | Daunomycin derivatives |
GB1573037A (en) * | 1977-05-05 | 1980-08-13 | Farmaceutici Italia | Anthracyclines |
GB1573036A (en) * | 1977-05-05 | 1980-08-13 | Farmaceutici Italia | Anthracyclines |
GB1567457A (en) * | 1977-11-11 | 1980-05-14 | Farmaceutici Italia | Daunomycinone derivatives |
US4370476A (en) * | 1979-07-17 | 1983-01-25 | Usher Thomas C | Dextran polycarboxylic acids, ferric hydroxide complexes |
US4348388A (en) * | 1980-04-02 | 1982-09-07 | G.D. Searle & Co. | 11-Amino-11-deoxydaunorubicin and analogs |
US4374979A (en) * | 1981-04-27 | 1983-02-22 | The University Of Kansas Endowment Association | Regiospecific synthesis of anthracyclinone compounds such as daunomycinone |
GB8317037D0 (en) * | 1983-06-23 | 1983-07-27 | Erba Farmitalia | 6-deoxyanthracyclines |
IT1210476B (it) * | 1981-05-28 | 1989-09-14 | Erba Farmitalia | Antracicline. |
EP0087807B1 (fr) * | 1982-03-02 | 1985-11-27 | Sumitomo Chemical Company, Limited | Préparation de dérivés de la 4-déméthoxydaunomycinone optiquement actifs |
BE896743A (fr) * | 1982-08-13 | 1983-09-16 | Erba Farmitalia | Synthese de naphtacenequinone. |
-
1983
- 1983-06-23 GB GB838317037A patent/GB8317037D0/en active Pending
-
1984
- 1984-06-19 US US06/622,177 patent/US4939282A/en not_active Expired - Fee Related
- 1984-06-19 AT AT0199684A patent/AT390252B/de not_active IP Right Cessation
- 1984-06-19 AU AU29524/84A patent/AU561456B2/en not_active Ceased
- 1984-06-20 NL NL8401957A patent/NL8401957A/xx not_active Application Discontinuation
- 1984-06-20 IL IL72168A patent/IL72168A/xx unknown
- 1984-06-20 BE BE0/213174A patent/BE899963A/fr not_active IP Right Cessation
- 1984-06-20 FI FI842505A patent/FI842505A/fi not_active Application Discontinuation
- 1984-06-20 FR FR8409680A patent/FR2549046B1/fr not_active Expired
- 1984-06-20 GR GR75063A patent/GR82130B/el unknown
- 1984-06-21 JP JP59126567A patent/JPS6013735A/ja active Granted
- 1984-06-21 CH CH3510/86A patent/CH665422A5/it not_active IP Right Cessation
- 1984-06-21 CS CS841254A patent/CS243500B2/cs unknown
- 1984-06-21 ZA ZA844719A patent/ZA844719B/xx unknown
- 1984-06-21 IT IT8421522A patent/IT1212101B/it active
- 1984-06-21 CS CS844740A patent/CS243490B2/cs unknown
- 1984-06-21 SU SU843753950A patent/SU1561821A3/ru active
- 1984-06-21 CH CH3007/84A patent/CH661922A5/it not_active IP Right Cessation
- 1984-06-21 SE SE8403353A patent/SE8403353L/xx not_active Application Discontinuation
- 1984-06-22 HU HU842436A patent/HU194902B/hu not_active IP Right Cessation
- 1984-06-22 HU HU843650A patent/HU196821B/hu not_active IP Right Cessation
- 1984-06-22 DK DK306484A patent/DK306484A/da not_active Application Discontinuation
- 1984-06-22 CA CA000457254A patent/CA1234104A/fr not_active Expired
- 1984-12-13 SU SU843823254A patent/SU1429935A3/ru active
-
1987
- 1987-02-11 AU AU68818/87A patent/AU574599B2/en not_active Ceased
-
1989
- 1989-05-02 SE SE8901572A patent/SE8901572D0/xx not_active Application Discontinuation
-
1990
- 1990-02-13 DK DK037890A patent/DK37890A/da not_active Application Discontinuation
- 1990-03-28 US US07/501,869 patent/US5037970A/en not_active Expired - Fee Related
-
1992
- 1992-08-19 JP JP4220019A patent/JPH0735392B2/ja not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: FARMITALIA CARLO ERBA S.P.A. Effective date: 19900630 |