BE885569A - Solvats d'ethers alicycliques et d'acide syn-7- (2-(2-amino-4-tiazolyl(-2-methoxyimino) acetamido-3-qacetoxymethyl-3-cephem-4-carboxylique, leur preparation et leur utilisation pour la preparation de l'acide libre et de ses sels - Google Patents

Solvats d'ethers alicycliques et d'acide syn-7- (2-(2-amino-4-tiazolyl(-2-methoxyimino) acetamido-3-qacetoxymethyl-3-cephem-4-carboxylique, leur preparation et leur utilisation pour la preparation de l'acide libre et de ses sels

Info

Publication number
BE885569A
BE885569A BE1/9975A BE1009975A BE885569A BE 885569 A BE885569 A BE 885569A BE 1/9975 A BE1/9975 A BE 1/9975A BE 1009975 A BE1009975 A BE 1009975A BE 885569 A BE885569 A BE 885569A
Authority
BE
Belgium
Prior art keywords
preparation
qacetoxymethyl
tiazolyl
cephem
methoxyimino
Prior art date
Application number
BE1/9975A
Other languages
English (en)
Inventor
B G Jackson
D Nezich Epouse Gardner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BE885569A publication Critical patent/BE885569A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE1/9975A 1979-10-09 1980-10-08 Solvats d'ethers alicycliques et d'acide syn-7- (2-(2-amino-4-tiazolyl(-2-methoxyimino) acetamido-3-qacetoxymethyl-3-cephem-4-carboxylique, leur preparation et leur utilisation pour la preparation de l'acide libre et de ses sels BE885569A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/082,822 US4252951A (en) 1979-10-09 1979-10-09 Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid

Publications (1)

Publication Number Publication Date
BE885569A true BE885569A (fr) 1981-04-08

Family

ID=22173679

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/9975A BE885569A (fr) 1979-10-09 1980-10-08 Solvats d'ethers alicycliques et d'acide syn-7- (2-(2-amino-4-tiazolyl(-2-methoxyimino) acetamido-3-qacetoxymethyl-3-cephem-4-carboxylique, leur preparation et leur utilisation pour la preparation de l'acide libre et de ses sels

Country Status (27)

Country Link
US (1) US4252951A (fr)
EP (1) EP0027050B1 (fr)
JP (1) JPS5661388A (fr)
KR (1) KR840000866B1 (fr)
AT (1) AT369008B (fr)
AU (1) AU6306180A (fr)
BE (1) BE885569A (fr)
CA (1) CA1146539A (fr)
CH (1) CH647523A5 (fr)
CS (1) CS215142B2 (fr)
DD (1) DD153375A5 (fr)
DE (1) DE3065181D1 (fr)
DK (1) DK424680A (fr)
ES (1) ES8201166A1 (fr)
FI (1) FI803200L (fr)
FR (1) FR2467211A1 (fr)
GB (1) GB2059966B (fr)
GR (1) GR70219B (fr)
HU (1) HU183230B (fr)
IE (1) IE50390B1 (fr)
IL (1) IL61227A (fr)
IT (1) IT1132926B (fr)
PH (1) PH15023A (fr)
PT (1) PT71886B (fr)
RO (1) RO80664B (fr)
YU (1) YU256480A (fr)
ZA (1) ZA806192B (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS588086A (ja) * 1981-07-07 1983-01-18 Takeda Chem Ind Ltd セフアロスポリン溶媒和物およびその製造法
JPH08831B2 (ja) * 1985-09-20 1996-01-10 富山化学工業株式会社 セファロスポリンの精製法
JPH07116200B2 (ja) * 1985-09-20 1995-12-13 富山化学工業株式会社 セファロスポリンの製造方法
PL350924A1 (en) * 1999-04-06 2003-02-10 Sepracor Inc Derivatives of venlafaxine and methods of preparing and using the same
US7576198B1 (en) * 1999-09-02 2009-08-18 Shionogi & Co., Ltd. Integrase inhibitors containing aromatic heterocycle derivatives
CA2284459C (fr) * 1999-10-04 2012-12-11 Neokimia Inc. Synthese combinatoire de bibliotheques de composes macrocycliques utiles pour la decouverte de medicaments
US7151191B2 (en) * 2000-01-13 2006-12-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
AU2002326375B2 (en) * 2001-03-08 2006-12-21 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers as anti-infective agents
NZ531139A (en) * 2001-08-29 2007-09-28 Neose Technologies Inc Synthetic ganglioside derivatives and compositions thereof
EP2617711A1 (fr) * 2002-09-19 2013-07-24 Kyorin Pharmaceutical Co., Ltd. Dérivés d'aminoalcool, leurs sels et des agents immunosuppresseurs
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
KR101241176B1 (ko) * 2003-03-17 2013-03-13 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 표면적으로 양쪽성인 중합체 및 올리고머 및 이의 용도
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
US20050203184A1 (en) * 2003-09-10 2005-09-15 Petasis Nicos A. Benzo lipoxin analogues
CN1922133A (zh) * 2004-01-23 2007-02-28 宾夕法尼亚州大学理事会 表面两亲性聚芳基和聚芳基炔基聚合物和低聚物及其用途
BRPI0510715A (pt) * 2004-05-06 2007-11-20 Univ California enaminonas substituìdas, seus derivados e usos destas
US7220742B2 (en) * 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
US20050255050A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Powder formulations for inhalation, comprising enantiomerically pure beta agonists
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
CA2599205A1 (fr) * 2005-02-25 2006-09-08 The Trustees Of The University Of Pennsylvania Polymeres et oligomeres a faces amphiphiles, composition a base de ceux-ci et, leur utilisation dans des procedes de traitement du cancer
JP5150807B2 (ja) * 2005-02-28 2013-02-27 株式会社明治 ハイドロキノン長鎖誘導体及び／又はフェノキシ長鎖誘導体及びこれらを含有する医薬
CA2619005A1 (fr) * 2005-08-10 2007-02-22 Johns Hopkins University Polyamines utiles en tant q'agents therapeutiques antiparasites et anticancereux et en tant qu'inhibiteurs de demethylase specifiques a la lysine
PL1917253T3 (pl) * 2005-08-15 2015-06-30 Boehringer Ingelheim Int Sposób wytwarzania betamimetyków
US8592433B2 (en) * 2005-10-28 2013-11-26 Advait Nagle Compounds and compositions as protein kinase inhibitors
EP1954259A2 (fr) * 2005-11-29 2008-08-13 Hammersmith Imanet, Ltd Derives d'amidines pour l'imagerie in vivo
ES2288107B1 (es) * 2006-01-27 2008-11-01 Fundacion Imabis Instituto Mediterraneo Para El Avance De La Biotecnologia Y La Investigacion Sanita Derivados aciclicos saturados e insaturados de cadena larga de sulfamidas como activadores especificos de receptores ppar-alfa.
US20090075935A1 (en) * 2006-07-03 2009-03-19 L'oreal Composition comprising at least one c-glycoside derivative and at least one hyaluronic acid and its cosmetic use
FR2902999B1 (fr) * 2006-07-03 2012-09-28 Oreal Utilisation de derives c-glycoside a titre d'actif prodesquamant
FR2903004B1 (fr) * 2006-07-03 2009-07-10 Oreal Utilisation en cosmetique d'un derive c-glycoside en association avec de l'acide ascorbique
FR2902996B1 (fr) * 2006-07-03 2008-09-26 Oreal Compositions cosmetiques associant un derive c-glycoside et un derive n-acylaminoamide
EA016820B1 (ru) * 2006-12-14 2012-07-30 Тева Фармасьютикал Индастриз, Лтд. Кристаллическое твердое основание разагилина
CN104844678B (zh) 2007-05-11 2018-02-09 香港科技大学 具有神经保护和增强记忆活性的受体调节剂
US7696383B2 (en) * 2007-06-26 2010-04-13 Solvay Pharmaceuticals B.V. N-oxides of venlafaxine and o-desmethylvenlafaxine as prodrugs
FR2920000B1 (fr) * 2007-08-13 2010-01-29 Oreal Composition cosmetique ou pharmaceutique contenant de l'acide hyaluronique, et procede cosmetique pour diminuer les signes du vieilissement
US8692017B2 (en) * 2007-10-19 2014-04-08 Janssen Pharmaceutica, N.V. Carbon linked modulators of gamma-secretase
CN101903347B (zh) * 2007-10-19 2013-03-27 詹森药业有限公司 带哌啶基和哌嗪基的γ-分泌酶调节剂
AU2008312371B2 (en) * 2007-10-19 2013-06-20 Janssen Pharmaceutica, N.V. Amine linked modulators of gamma-secretase
EP2093207A1 (fr) * 2008-02-06 2009-08-26 Julius-Maximilians-Universität Würzburg Composés anti-infectieux et anti-tumoraux isolés de lianes tropicales
US8063249B1 (en) * 2008-04-25 2011-11-22 Olema Pharmaceuticals, Inc. Substituted triphenyl butenes
WO2010017328A2 (fr) * 2008-08-06 2010-02-11 Rgo Biosciences Llc Conjugués de cyclodextrine
CA2740952C (fr) * 2008-10-22 2015-12-29 Ian L. Scott Composes de traitement de maladies et troubles ophtalmiques
FR2940610B1 (fr) * 2008-12-30 2011-05-06 Oreal Association de monosaccharides avec des derives c-glycosides et son utilisation en cosmetique
WO2010111530A1 (fr) 2009-03-25 2010-09-30 Seneb Biosciences, Inc. Glycolipides en tant que traitement de maladies
NZ596470A (en) * 2009-05-14 2014-04-30 Millennium Pharm Inc Hydrochloride salt of ((1s,2s,4r)-4-{ 4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl} -2-hydroxycyclopentyl)methyl sulfamate
US8962639B2 (en) * 2009-05-29 2015-02-24 Abbvie Inc. Potassium channel modulators
US8288592B2 (en) * 2009-09-22 2012-10-16 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
WO2012067824A1 (fr) 2010-11-16 2012-05-24 Abbott Laboratories Modulateurs des canaux potassiques
BR112014005234A2 (pt) * 2011-09-06 2017-04-11 Curna Inc tratamento de doenças relacionadas com subunididades alfa dos canais de sódio dependentes de voltagem (scnxa) com pequenas moléculas
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid

Also Published As

Publication number Publication date
GR70219B (fr) 1982-08-31
IL61227A0 (en) 1980-12-31
GB2059966A (en) 1981-04-29
KR830004314A (ko) 1983-07-09
DE3065181D1 (en) 1983-11-10
GB2059966B (en) 1983-09-01
PH15023A (en) 1982-05-13
IL61227A (en) 1983-07-31
CH647523A5 (fr) 1985-01-31
FR2467211A1 (fr) 1981-04-17
JPS5661388A (en) 1981-05-26
ZA806192B (en) 1982-05-26
YU256480A (en) 1983-02-28
ES495753A0 (es) 1981-12-01
FI803200L (fi) 1981-04-10
DD153375A5 (de) 1982-01-06
US4252951A (en) 1981-02-24
EP0027050B1 (fr) 1983-10-05
IE50390B1 (en) 1986-04-16
AU6306180A (en) 1981-04-16
PT71886B (en) 1981-08-13
IT8025200A0 (it) 1980-10-08
CA1146539A (fr) 1983-05-17
KR840000866B1 (ko) 1984-06-20
HU183230B (en) 1984-04-28
IE802086L (en) 1981-04-09
RO80664A (fr) 1983-02-15
DK424680A (da) 1981-04-10
PT71886A (en) 1980-11-01
FR2467211B1 (fr) 1983-06-10
IT1132926B (it) 1986-07-09
ES8201166A1 (es) 1981-12-01
RO80664B (ro) 1983-02-28
ATA498080A (de) 1982-04-15
CS215142B2 (en) 1982-07-30
AT369008B (de) 1982-11-25
EP0027050A1 (fr) 1981-04-15

Similar Documents

Publication Publication Date Title
BE885569A (fr) Solvats d'ethers alicycliques et d'acide syn-7- (2-(2-amino-4-tiazolyl(-2-methoxyimino) acetamido-3-qacetoxymethyl-3-cephem-4-carboxylique, leur preparation et leur utilisation pour la preparation de l'acide libre et de ses sels
BE883095A (fr) Dispositif perfectionne pour l'occlusion de canaux corporels
IT1163250B (it) Procedimento di misura optoelettronico e dispositivo per l'esecuzione del procedimento
FR2305192A1 (fr) Procede pour l'obtention de pancreatine pauvre en germes et exempte de fibres
BE866841A (fr) Procede de preparation d'imidazoazines et -diazines substituees et leur utilisation
BE887850A (fr) Sels internes d'hydroxydes de sulfooxytriazinium, sulfooxypyprimidium et sulfooxypyridinium, leur preparation et leur utilisation
BE882195A (fr) Derives d'acide 1,2,3-thiadiazole-5-carboxylique, leur procede de preparation et leur utilisation
BE867045A (fr) Catalyseur ameliore pour la preparation de l'oxyde d'ethylene
BE883097A (fr) Procede et dispositif pour la preparation d'oxydes azotiques
BE882067A (fr) Derives de l'acide d-2-hydroxy-4-methylmercaptobutyrique, procede pour leur preparation et utilisation de ces composes
BE882842A (fr) Formation d'image
IT7848882A0 (it) Sistema ottico per l'esame della retina
IT1121810B (it) Procedimento migliorate per la preparazione di viscosa e procedimento di filatura della viscosa cosi'ottenuta
IT1122388B (it) Procedimento per la preparazione di materiali biocompatibili tramite l'immobilizzazione superficiale di apirasi
BE858806A (fr) Procede pour la preparation de glycol-aldehyde et d'ethylene-glycol
AR222075A1 (es) Procedimiento de preparacion de 2',6'-dialquil-n-alcoximetil-2-cloro-acetanilida
IT1172894B (it) Procedimento per la produzione di polietilene alta densita'
PT69537A (fr) Procede pour la preparation d'etheres dibenziliques substitues therapeutiquement actifs
GB2017913B (en) Surveyor's staff
IT1134056B (it) Procedimento per misurare l'aumento di batteri
BE867414A (fr) Procede pour la preparation d'hydroxy-alpha-aminobenzylpenicillines
IT1127202B (it) Procedimento per preparare 2-(4'idrossiaril)-2-(4'amminoaril_-propani
IT1125604B (it) Procedimento per la preparazione di n-fenil-n'-alchilfenilendiammine
IT1157975B (it) Procedimento per la preparazione di dispersioni e sospensioni e dspositivo per l'attuazione del procedimento
BE876201A (fr) N-cyano-azomethines utilisables pour la preparation d'antihistaminiques et leur preparation

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: ELI LILLY AND CY

Effective date: 19871031