BE877542R - Nouveaux 1,1-dioxydes de l'acide penicillanique et de ses esters utiles comme inhibiteurs de la b-lactamase - Google Patents

Nouveaux 1,1-dioxydes de l'acide penicillanique et de ses esters utiles comme inhibiteurs de la b-lactamase

Info

Publication number
BE877542R
BE877542R BE0/196180A BE196180A BE877542R BE 877542 R BE877542 R BE 877542R BE 0/196180 A BE0/196180 A BE 0/196180A BE 196180 A BE196180 A BE 196180A BE 877542 R BE877542 R BE 877542R
Authority
BE
Belgium
Prior art keywords
dioxides
novel
penicillanic acid
lactamase inhibitors
esters useful
Prior art date
Application number
BE0/196180A
Other languages
English (en)
Inventor
W Barth
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of BE877542R publication Critical patent/BE877542R/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE0/196180A 1977-06-07 1979-07-06 Nouveaux 1,1-dioxydes de l'acide penicillanique et de ses esters utiles comme inhibiteurs de la b-lactamase BE877542R (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US80432077A 1977-06-07 1977-06-07
US87938178A 1978-02-21 1978-02-21
US89045178A 1978-03-29 1978-03-29
US96376378A 1978-11-27 1978-11-27
US06/017,807 US4276285A (en) 1977-06-07 1979-03-05 Combinations of penicillanic acid 1,1-dioxide with 7-(D-2-[4-ethylpiperazin-2,3-dione-1-carboxamido]-2-[4-hydroxyphenyl]acetamido)-3-([1-methyl-5-tetrazolyl]thiomethyl)-3-desacetoxymethylcephalosporanic acid

Publications (1)

Publication Number Publication Date
BE877542R true BE877542R (fr) 1980-01-07

Family

ID=27533756

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/196180A BE877542R (fr) 1977-06-07 1979-07-06 Nouveaux 1,1-dioxydes de l'acide penicillanique et de ses esters utiles comme inhibiteurs de la b-lactamase

Country Status (5)

Country Link
US (1) US4276285A (fr)
JP (2) JPS6056160B2 (fr)
AU (2) AU514926B2 (fr)
BE (1) BE877542R (fr)
MX (1) MX9203747A (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5661386A (en) * 1979-10-11 1981-05-26 Leo Pharm Prod Ltd Manufacture of penicillanic acid derivative
US4361513A (en) * 1980-12-11 1982-11-30 Pfizer Inc. Esters of penicillanic acid sulfone
US4331599A (en) * 1981-02-02 1982-05-25 Pfizer Inc. Sparingly water-soluble salts of penicillanic acid 1,1-dioxide
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
US4351840A (en) * 1981-09-18 1982-09-28 Pfizer Inc. Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives
US4406887A (en) * 1981-10-13 1983-09-27 Bristol-Myers Company Method for treating resistant bacteria including anaerobes
US4428935A (en) * 1982-05-24 1984-01-31 Pfizer Inc. Penicillanic acid dioxide prodrug
JPS59104319A (ja) * 1982-12-06 1984-06-16 Chugai Pharmaceut Co Ltd 抗菌剤およびそのキツト
AT392903B (de) * 1987-10-08 1991-07-10 Hoechst Ag Pharmazeutische zubereitung enthaltend ein cephalosporin und ein penemantibiotikum
KR900006980B1 (ko) * 1988-07-08 1990-09-25 김영설 상승효과를 가지는 약학적 조성물
EP0606506A1 (fr) * 1993-01-12 1994-07-20 Yeong Sul Kim Composition antibactérienne résistante aux bêta-lactamases
JP3236261B2 (ja) 1998-04-09 2001-12-10 大塚化学株式会社 ハロゲン化β−ラクタム化合物の製造法
CN102952147B (zh) * 2011-08-16 2015-04-08 台州市信友医药化工有限公司 一种舒巴坦酸的合成方法
CN102702228A (zh) * 2012-06-26 2012-10-03 齐鲁天和惠世制药有限公司 一种舒巴坦制备方法
CN106699774A (zh) * 2016-12-30 2017-05-24 淄博鑫泉医药技术服务有限公司 舒巴坦钠的制备方法
KR102668212B1 (ko) * 2018-09-28 2024-05-23 삼성전자 주식회사 자동 초점 방법 및 이를 수행하는 전자 장치
CN111848645B (zh) * 2020-07-20 2024-03-08 青岛科技大学 一种制备舒巴坦酸的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197466A (en) * 1961-10-30 1965-07-27 Smith Kline French Lab Penicillin sulfoxides and process
BE648188A (fr) * 1963-05-29 1964-09-16
US3536698A (en) * 1968-02-27 1970-10-27 Lilly Co Eli Simplified method for esterification of antibiotics via carbonate anhydride intermediates

Also Published As

Publication number Publication date
AU514926B2 (en) 1981-03-05
AU522487B2 (en) 1982-06-10
AU6403080A (en) 1981-03-12
AU4846579A (en) 1980-05-29
JPS6056160B2 (ja) 1985-12-09
MX9203747A (es) 1992-09-01
JPS543094A (en) 1979-01-11
JPS5572115A (en) 1980-05-30
US4276285A (en) 1981-06-30

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: PFIZER INC.

Effective date: 19980606