BE875013A - Nouveaux derives de 2-hydroxymethyl-pyrazine, utiles notamment comme hypolipemiants, et leur procede de preparation - Google Patents

Nouveaux derives de 2-hydroxymethyl-pyrazine, utiles notamment comme hypolipemiants, et leur procede de preparation

Info

Publication number
BE875013A
BE875013A BE0/194146A BE194146A BE875013A BE 875013 A BE875013 A BE 875013A BE 0/194146 A BE0/194146 A BE 0/194146A BE 194146 A BE194146 A BE 194146A BE 875013 A BE875013 A BE 875013A
Authority
BE
Belgium
Prior art keywords
hypolipemiants
pyrazine
hydroxymethyl
useful
preparation process
Prior art date
Application number
BE0/194146A
Other languages
English (en)
Inventor
P Cozzi
O Magni
L Bertone
R Angelucci
P P Lovisolo
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE875013A publication Critical patent/BE875013A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/16—Halogen atoms; Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE0/194146A 1978-03-23 1979-03-22 Nouveaux derives de 2-hydroxymethyl-pyrazine, utiles notamment comme hypolipemiants, et leur procede de preparation BE875013A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21520/78A IT1094287B (it) 1978-03-23 1978-03-23 Derivati della 2-idrossimetil-pirazina aventi attivita' ipolipemizzante

Publications (1)

Publication Number Publication Date
BE875013A true BE875013A (fr) 1979-09-24

Family

ID=11183025

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/194146A BE875013A (fr) 1978-03-23 1979-03-22 Nouveaux derives de 2-hydroxymethyl-pyrazine, utiles notamment comme hypolipemiants, et leur procede de preparation

Country Status (13)

Country Link
US (1) US4267327A (fr)
JP (1) JPS5531063A (fr)
BE (1) BE875013A (fr)
CA (1) CA1146171A (fr)
CH (1) CH642639A5 (fr)
DE (1) DE2910824A1 (fr)
DK (1) DK151254C (fr)
FR (2) FR2448536A1 (fr)
GB (1) GB2017691B (fr)
IT (1) IT1094287B (fr)
NL (1) NL7902268A (fr)
SE (1) SE446338B (fr)
ZA (1) ZA791047B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4406901A (en) * 1980-02-06 1983-09-27 Farmitalia Carlo Erba S.P.A. Ethers of substituted hydroxymethylpyrazines
IL64267A (en) * 1980-12-09 1985-08-30 Erba Farmitalia Ethers of hydroxymethylpyrazin-n-oxides,their preparation and pharmaceutical compositions containing them
JPS59219269A (ja) * 1983-05-30 1984-12-10 Terumo Corp ピラジン誘導体を有効成分とする血小板凝集抑制剤
DE3433960A1 (de) * 1984-09-15 1986-03-27 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von 2-amino-3-cyano-5-dialkoxymehtyl-pyrazinen und zwischenprodukte fuer diese verfahren
JPS63135216U (fr) * 1987-02-27 1988-09-05
CN101684102B (zh) * 2008-09-28 2013-06-05 安徽省新星药物开发有限责任公司 苯氧乙酸吡嗪酯类衍生物及其制法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002750A (en) * 1972-04-28 1977-01-11 Carlo Erba S.P.A. Pyrazine 4-oxide derivatives and process for their preparation
GB1361967A (en) * 1972-04-28 1974-07-30 Erba Carlo Spa Pyrazine 4-oxide derivatives and process for their preparation
US4051245A (en) * 1972-04-28 1977-09-27 Carlo Erba, S.P.A. Pyrazine 4-oxide derivatives and process for their preparation

Also Published As

Publication number Publication date
NL7902268A (nl) 1979-09-25
CA1146171A (fr) 1983-05-10
CH642639A5 (de) 1984-04-30
DK151254B (da) 1987-11-16
SE7902661L (sv) 1979-09-24
SE446338B (sv) 1986-09-01
DK118879A (da) 1979-09-24
US4267327A (en) 1981-05-12
ZA791047B (en) 1980-03-26
JPS6310697B2 (fr) 1988-03-08
DE2910824A1 (de) 1979-09-27
GB2017691A (en) 1979-10-10
JPS5531063A (en) 1980-03-05
GB2017691B (en) 1982-06-16
FR2448536A1 (fr) 1980-09-05
FR2448536B1 (fr) 1983-01-28
DK151254C (da) 1988-07-04
IT7821520A0 (it) 1978-03-23
FR2445144B1 (fr) 1983-03-25
IT1094287B (it) 1985-07-26
FR2445144A1 (fr) 1980-07-25
DE2910824C2 (fr) 1989-06-22

Similar Documents

Publication Publication Date Title
FR2497203B1 (fr) Nouveaux 7-oxa-bicycloheptanes et -bicycloheptenes utiles notamment comme agents cardiovasculaires, et leur procede de preparation
BE847669A (fr) Nouveaux esters de (1-phenyl2-triazolylethyle), leur procede de preparation et leur application comme fongicides
FR2318153A1 (fr) Nouveaux ethers de 2',3,6'-trichloro-4-cyano-4'-benzoylureido-diphenyle, leur procede de preparation et leur application comme insecticides
LU80476A1 (fr) Nouvelles 4-quinolyl-guanidines,utiles notamment comme anti-inflammatoires,et leur procede de preparation
BE846569A (fr) Nouveaux derives phenylacetiques utiles notamment comme hypolipemiants et leur procede de preparation
BE853304A (fr) Nouveaux derives de 1,3,4,-thiadiazolyle, leur procede de preparation et leur application comme herbicides
FR2337719A1 (fr) Nouveaux triazolyl-o,n-acetals acyles, leur procede de preparation et leur application comme fongicides
FR2344538A1 (fr) Nouveaux derives de carbostyrile, utiles notamment comme b-bloquants cardio-selectifs, et leur procede de preparation
BE857522A (fr) Nouveaux derives de 1-azolyl-4-hydroxybutane, leur procede de preparation et leur application comme fongicides et bactericides
BE875013A (fr) Nouveaux derives de 2-hydroxymethyl-pyrazine, utiles notamment comme hypolipemiants, et leur procede de preparation
BE856464A (fr) Nouveaux derives 16-acythio de l'acide fusidique, utiles notamment comme antimicrobiens et leur procede de preparation
BE859480A (fr) Nouveaux derives de (1-phenyl-2-triazolyl-ethyl)-thioethers leur procede de preparation et leur application comme fongicides et substances de croissance
FR2320746A1 (fr) Nouveau thiopyranno(4,3-c)pyrasoles, utiles notamment comme anti-inflammatoires et leur procede de preparation
BE859971A (fr) Nouveaux esters de n-chloracetyl-n-phenyl-alanine leur procede de preparation et leur application comme fongicides
FR2337128A1 (fr) Nouveaux derives n-aminothio de n-methylcarbamates, leur procede de preparation et leur application comme pesticides
BE859629A (fr) Nouveaux derives 4,5-dichlorimidazoliques leur procede de preparation et leur application comme substances de croissance des plantes
BE853607A (fr) Nouveaux bis-penicillanoyloxyalcanes utiles notamment comme antibiotiques et leur procede de preparation
FR2303548A1 (fr) Nouveaux carbamates de 2-halogenoergolines et 2-halogenoergolenes, utiles notamment comme vasodilatateurs, et leur procede de preparation
BE873412A (fr) Nouveaux derives d'acides 1,5-cyclohexadienecarboxyliques substitues, utiles notamment comme antiepileptiques, et leur procede de preparation
BE874450A (fr) Derives d'acide 7-(2,3-dihydrobenzo-5-furannyl) acetamidocephalosporanique utiles notamment comme antibiotiques et leur procede de preparation
FR2285144A1 (fr) Derives n-acyles de l'orgoteine, utiles notamment comme anti-inflammatoires, et leur procede de preparation
BE866718A (fr) Nouveaux derives d'acides azolylalcane-carboxyliques, leur procede de preparation et leur application comme fongicides
BE873411A (fr) Nouveaux derives d'acides 1,4-cyclohexadienecarboxyliques substitues, utiles notamment comme antiepileptiques, et leur procede de preparation
FR2328463A1 (fr) Nouveaux derives de benzofuranne utiles notamment comme b-bloquants adrenergiques et leur procede de preparation
FR2283900A1 (fr) Nouveaux derives de dihydrotetrazolo(1,5-a)-quinazoline, leur procede de preparation et leur application comme pesticides

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A.

Effective date: 19920331