BE800868A - OXAZOLO- AND THIAZOLOPYRIDINES - Google Patents

OXAZOLO- AND THIAZOLOPYRIDINES

Info

Publication number
BE800868A
BE800868A BE132231A BE132231A BE800868A BE 800868 A BE800868 A BE 800868A BE 132231 A BE132231 A BE 132231A BE 132231 A BE132231 A BE 132231A BE 800868 A BE800868 A BE 800868A
Authority
BE
Belgium
Prior art keywords
thiazolopyridines
oxazolo
Prior art date
Application number
BE132231A
Other languages
French (fr)
Inventor
T-Y Shen
R L Clark
A A Pessolano
B E Witzel
T J Lanza
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BE800868A publication Critical patent/BE800868A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE132231A 1972-06-14 1973-06-13 OXAZOLO- AND THIAZOLOPYRIDINES BE800868A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26289872A 1972-06-14 1972-06-14
BE147896A BE819177R (en) 1972-06-14 1974-08-26 OXAZOLO- AND THIAZOLOPYRIDINES

Publications (1)

Publication Number Publication Date
BE800868A true BE800868A (en) 1973-12-13

Family

ID=25648082

Family Applications (2)

Application Number Title Priority Date Filing Date
BE132231A BE800868A (en) 1972-06-14 1973-06-13 OXAZOLO- AND THIAZOLOPYRIDINES
BE147896A BE819177R (en) 1972-06-14 1974-08-26 OXAZOLO- AND THIAZOLOPYRIDINES

Family Applications After (1)

Application Number Title Priority Date Filing Date
BE147896A BE819177R (en) 1972-06-14 1974-08-26 OXAZOLO- AND THIAZOLOPYRIDINES

Country Status (17)

Country Link
JP (1) JPS5943475B2 (en)
AR (1) AR208500A1 (en)
AT (1) AT333277B (en)
AU (1) AU472528B2 (en)
BE (2) BE800868A (en)
CA (1) CA1019741A (en)
CS (1) CS178889B2 (en)
DD (1) DD105237A5 (en)
DE (1) DE2330109A1 (en)
DK (1) DK152050C (en)
FI (1) FI57417C (en)
FR (1) FR2187356B1 (en)
GB (1) GB1421619A (en)
LU (1) LU67786A1 (en)
NL (1) NL184836C (en)
SE (2) SE401675B (en)
ZA (1) ZA733760B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2527321A1 (en) * 1975-06-19 1976-12-23 Merck & Co Inc 2-(Substd phenyl) oxazolo (4,5-b) pyridines - topical anti-inflammatories with very low systemic activity
JPS527992A (en) * 1975-07-04 1977-01-21 Merck & Co Inc Oxazolo *4*55b* pyridines
NL187021C (en) * 1975-07-15 1991-05-01 Merck & Co Inc PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION WITH ANTI-INFLAMMATORY ACTION, AND A METHOD FOR PREPARING ANTI-INFLAMMATIC ACTIVITY 2-PHENYL-OXAZOLO-PID-BIDANE.
US4011326A (en) * 1975-07-29 1977-03-08 Merck & Co., Inc. 2-Substituted oxazolo[4,5-b]pyridine anti-inflammatory agents
US4753673A (en) * 1977-07-22 1988-06-28 The Dow Chemical Company Trifluoromethyl pyridinyloxyphenoxy and pyridinylthiophenoxy propanoic acids and propanols and derivatives thereof and methods of herbicidal use
DE2862490D1 (en) * 1977-08-12 1988-04-21 Ici Plc Phenoxypyridine compound
JPS5461182A (en) * 1977-10-20 1979-05-17 Ishihara Sangyo Kaisha Ltd 2-phenoxy-5-trifluoromethylpyridine compounds
JPS5461183A (en) * 1977-10-21 1979-05-17 Ishihara Sangyo Kaisha Ltd 2-substituted-5-trifluoromethyl pyridine compounds
EP0003877B1 (en) * 1978-02-15 1988-02-03 Imperial Chemical Industries Plc Herbicidal derivatives of 2-(4(2-pyridyloxy)phenoxy)propane, processes for preparing them, and herbicidal compositions containing them
JPS55130840U (en) * 1979-03-12 1980-09-16
JPS55124763A (en) * 1979-03-19 1980-09-26 Ishihara Sangyo Kaisha Ltd 5-trifluoromethyl-2-pyridone derivative
GB8333514D0 (en) * 1983-12-16 1984-01-25 Erba Farmitalia Tetrahydrothiazolo(5 4-c)pyridine derivatives
FR2652085A1 (en) * 1989-09-20 1991-03-22 Science Organisation NEW PROCESS FOR THE SYNTHESIS OF OXAZOLOPYRIDINE DERIVATIVES
DE59711147D1 (en) * 1996-11-11 2004-01-29 Altana Pharma Ag New imidazo- and oxazolopyridines as phosphodiesterase inhibitors.
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
TR200100189T2 (en) * 1998-06-04 2001-05-21 Abbott Laboratories Anti-inflammatory compounds against cell adhesion
EP1181296A1 (en) * 1999-06-03 2002-02-27 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
AU2002216649A1 (en) * 2000-10-31 2002-05-15 Lynn Bonham Benzoxazole lpaat- beta inhibitors and uses thereof
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7855289B2 (en) * 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
WO2007019416A1 (en) 2005-08-04 2007-02-15 Sirtris Pharmaceuticals, Inc. Benzimidazole derivatives as sirtuin modulators
CL2008001822A1 (en) 2007-06-20 2009-03-13 Sirtris Pharmaceuticals Inc Compounds derived from thiazolo [5,4-b] pyridine; pharmaceutical composition comprising said compounds; and use of the compound in the treatment of insulin resistance, metabolic syndrome, diabetes, among others.
US8795630B2 (en) * 2008-08-29 2014-08-05 Treventis Corporation Butyrylcholinesterase ligands as diagnostic tools and treatment for diseases of the nervous system
EA021424B1 (en) 2008-12-19 2015-06-30 Сертрис Фармасьютикалз, Инк. Thiazolopyridine sirtuin modulating compounds
AR078463A1 (en) * 2009-09-30 2011-11-09 Sumitomo Chemical Co COMPOSITION AND METHOD TO CONTROL PESTS OF ARTROPODES
MX2013003019A (en) 2010-09-15 2013-05-28 Hoffmann La Roche Azabenzothiazole compounds, compositions and methods of use.
KR20130140125A (en) 2010-12-24 2013-12-23 수미토모 케미칼 컴퍼니 리미티드 Fused heterocyclic compound and use for pest control thereof
US20170217941A1 (en) * 2014-06-25 2017-08-03 Epizyme, Inc. Substituted benzene and 6,5-fused bicyclic heteroaryl compounds
US10138254B2 (en) 2014-12-02 2018-11-27 Bayer Cropscience Aktiengesellschaft Bicyclic compounds as pest control agents
US10399966B2 (en) 2016-01-21 2019-09-03 University Of Washington Compounds for treatment of trypanosomes and neurological pathogens and uses thereof
EP3483148B1 (en) * 2016-07-07 2023-08-23 Hodogaya Chemical Co., Ltd. Compound having benzazole ring structure and organic electroluminescent element

Also Published As

Publication number Publication date
NL7307582A (en) 1973-12-18
DK152050B (en) 1988-01-25
FR2187356A1 (en) 1974-01-18
ATA508673A (en) 1976-03-15
NL184836B (en) 1989-06-16
NL184836C (en) 1989-11-16
CS178889B2 (en) 1977-10-31
FI57417B (en) 1980-04-30
JPS5943475B2 (en) 1984-10-22
AT333277B (en) 1976-11-10
SE401675B (en) 1978-05-22
DK152050C (en) 1988-07-18
LU67786A1 (en) 1973-08-16
GB1421619A (en) 1976-01-21
AU5651173A (en) 1974-12-05
SE432767B (en) 1984-04-16
CA1019741A (en) 1977-10-25
FI57417C (en) 1980-08-11
DE2330109A1 (en) 1974-01-03
BE819177R (en) 1975-02-26
AU472528B2 (en) 1976-05-27
FR2187356B1 (en) 1977-01-28
DD105237A5 (en) 1974-04-12
ZA733760B (en) 1975-01-29
JPS4961195A (en) 1974-06-13
AR208500A1 (en) 1977-02-15
SE7604385L (en) 1976-04-14

Similar Documents

Publication Publication Date Title
BE795162A (en) INJEKTIE-INRICHTING
BE793731A (en) ELECTROGENERATORS
BE819177R (en) OXAZOLO- AND THIAZOLOPYRIDINES
BE794087A (en) POLYEPOXYDES
BE793764A (en) INTEGREREND WEEGINRICHTING
AT324072B (en) WENDELBOHREB
AT353108B (en) SKIBOB
BE795790A (en) DIBENZO-TRIAZOLO-AZEPINE
BE790615A (en) HOUDERDRAGER
AT323930B (en) UNDERMATTRESS
FI54256B (en) TORKARANORDNING FOER STRAOLKASTARE
BE793718A (en) AMINOBENZIMIDAZOLES
BE793745A (en) ANTISTATISCHE POLYSTYREENCOMPOSITIES
BE795272A (en) BOORINRICHTING
BE791330A (en) HOUDERDRAGER
BE795808A (en) AMIDAZOLES POLYSUBSTITUES
FI55968C (en) ISBRYTNINGSANORDNING
BE796355A (en) DECALCOMANIES
AT335953B (en) LAUTERBODEN
AT322779B (en) BOOKBOARD
BE794891A (en) BIGOUDI
BE794421A (en) VERDUURZAAMDE SMEERVETDSAMENSTELLINGEN
BE793934A (en) 15-OXASTEROIDS
ATA324376A (en) MICROSCOPOCULAR
BE793926A (en) MENGSELSCHEIDING

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: MERCK & CO. INC.

Effective date: 19920630