BE779522A - 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa - Google Patents
3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpaInfo
- Publication number
- BE779522A BE779522A BE779522A BE779522A BE779522A BE 779522 A BE779522 A BE 779522A BE 779522 A BE779522 A BE 779522A BE 779522 A BE779522 A BE 779522A BE 779522 A BE779522 A BE 779522A
- Authority
- BE
- Belgium
- Prior art keywords
- alkyl
- deriv
- substd
- hmpa
- dma
- Prior art date
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
Abstract
In a process for the prodn. of (I) (where X is Cl, Br or I; R is 1-6C alkyl, Z-CH- or Z-(CH2)m-A-(CH2)n-; Z is thineyl, furyl or Y is protected amino or hydroxy; Ais O, S or a bons; m is 0-4; n is 1-4; Q is H, F, Cl, Br, 1-6C alkyl, MeO, EtO, NO2 CN, OH or CF3; R1 is H, 1-6C alkyl, 1-6C haloalkyl, 3-8C alkenyl, 3-8C alkynyl, benzyl, methoxy benzyl, nitrobenzyl, Ph2CH, Ph3C, phthalimidomethyl, succinimidomethyl phenacyl or Me3Si, R2 is 1-6C alkyl, 2-6C alkyl (opt. substd. by OH, NO2, Di-(1-4C) alkylamino, CN or halo) 3-6C alkenyl, PhCH2, Ph pyridyl. thienyl,furyl, thiadiazyl, tetrazyl or CH2COR3; R3 is OR4 or N(R4)2, R4 is H or 1-4C alkyl and p is 0 or 1) the corresponding 3-halomethyl deriv. is reacted with R2SH at 0-50 degrees in the presence of DMF, DMA or HMPA. Thus (I, R = PhOCH2, R1 = p-nitrobenzyl and R2 = Me) is prepd. from the 3-bromomethyl deriv.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE779522A BE779522A (en) | 1972-02-18 | 1972-02-18 | 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE779522A BE779522A (en) | 1972-02-18 | 1972-02-18 | 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa |
Publications (1)
Publication Number | Publication Date |
---|---|
BE779522A true BE779522A (en) | 1972-08-18 |
Family
ID=3859275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE779522A BE779522A (en) | 1972-02-18 | 1972-02-18 | 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa |
Country Status (1)
Country | Link |
---|---|
BE (1) | BE779522A (en) |
-
1972
- 1972-02-18 BE BE779522A patent/BE779522A/en unknown
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