BE779522A - 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa - Google Patents

3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa

Info

Publication number
BE779522A
BE779522A BE779522A BE779522A BE779522A BE 779522 A BE779522 A BE 779522A BE 779522 A BE779522 A BE 779522A BE 779522 A BE779522 A BE 779522A BE 779522 A BE779522 A BE 779522A
Authority
BE
Belgium
Prior art keywords
alkyl
deriv
substd
hmpa
dma
Prior art date
Application number
BE779522A
Other languages
French (fr)
Inventor
C F Murphy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to BE779522A priority Critical patent/BE779522A/en
Publication of BE779522A publication Critical patent/BE779522A/en

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)

Abstract

In a process for the prodn. of (I) (where X is Cl, Br or I; R is 1-6C alkyl, Z-CH- or Z-(CH2)m-A-(CH2)n-; Z is thineyl, furyl or Y is protected amino or hydroxy; Ais O, S or a bons; m is 0-4; n is 1-4; Q is H, F, Cl, Br, 1-6C alkyl, MeO, EtO, NO2 CN, OH or CF3; R1 is H, 1-6C alkyl, 1-6C haloalkyl, 3-8C alkenyl, 3-8C alkynyl, benzyl, methoxy benzyl, nitrobenzyl, Ph2CH, Ph3C, phthalimidomethyl, succinimidomethyl phenacyl or Me3Si, R2 is 1-6C alkyl, 2-6C alkyl (opt. substd. by OH, NO2, Di-(1-4C) alkylamino, CN or halo) 3-6C alkenyl, PhCH2, Ph pyridyl. thienyl,furyl, thiadiazyl, tetrazyl or CH2COR3; R3 is OR4 or N(R4)2, R4 is H or 1-4C alkyl and p is 0 or 1) the corresponding 3-halomethyl deriv. is reacted with R2SH at 0-50 degrees in the presence of DMF, DMA or HMPA. Thus (I, R = PhOCH2, R1 = p-nitrobenzyl and R2 = Me) is prepd. from the 3-bromomethyl deriv.
BE779522A 1972-02-18 1972-02-18 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa BE779522A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BE779522A BE779522A (en) 1972-02-18 1972-02-18 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE779522A BE779522A (en) 1972-02-18 1972-02-18 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa

Publications (1)

Publication Number Publication Date
BE779522A true BE779522A (en) 1972-08-18

Family

ID=3859275

Family Applications (1)

Application Number Title Priority Date Filing Date
BE779522A BE779522A (en) 1972-02-18 1972-02-18 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa

Country Status (1)

Country Link
BE (1) BE779522A (en)

Similar Documents

Publication Publication Date Title
ECSP941099A (en) IMPROVEMENTS RELATED TO A CEPHALOSPORIN ANTIBIOTIC
HK39083A (en) 7-(alpha-oximino-alpha-(2-aminothiazol-4-yl) acetamido) cephalosporanic acid derivatives
PH19251A (en) Process for producing novel cephalosporin
AU3282378A (en) Process for producing 7-(substituted)amino-3-substituted thiomethyl cephalosporins
PT68511A (en) Process for the preparation of a d-alpha-amino- (p-hydroxyphenyl)-acetamido group containing penicillanic acid and cephalosporanic acid derivatives.
ES467601A1 (en) 7[(2-Amino-thiazol-4-yl)glyoxylamido]-cephem derivatives and processes for their preparation
FR2171990A1 (en) 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa
NL7202648A (en) 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa
BE779522A (en) 3-substd methylthiocephalosporin - from 3-halo deriv and a mercaptan in dmf,dma or hmpa
PH17085A (en) Heterocyclyl derivatives of oxyimino substituted cephalosporins
FR2336232A1 (en) METHOD FOR PRODUCING ARTIFICIAL INTRAOCULAR LENSES
IL50498A0 (en) Process for cephalosporin antibiotic intermeidates
PL232568A1 (en) Process for preparing novel derivatives of cephalosporin
JPS5214790A (en) Process for preparing cephem or penam compounds
AU5122673A (en) Process for preparing primary 3 carbamoyloxymethyl cephalosporins
ES8502697A1 (en) Process for producing 2-(2-aminothiazol-4-yl)glyoxylic acid derivative or a salt thereof, and intermediates therefor and process for producing the intermediates
PL233143A1 (en) Process for preparing novel derivatives of cephalosporins
FI891191A (en) FOERFARANDE FOER FRAMSTAELLNING AV 3-EXOMETYLEN-KEFAM-DERIVAT.
GB1325846A (en) Process for the preparation of a 3-thiomethyl cephalosporin
YU22580A (en) Process for obtaining penicillin or cephalosporin imino halides
JPS56127389A (en) 7-((2-amino-4-thiazolyl)(carboxy(alkylthio) alkoxyimino)acetamido)cephalosporins
YU204877A (en) Process for producing cephalosporin derivatives
GB1447959A (en) Process for preparing cephem aldehyde derivatives
GB1539053A (en) Process for the preparation of alpha-(2-oxoimidazolidinyl carbonylamino)-acetamido cephalosporins
IE811763L (en) Cephalosporins