BE2015C053I2 - - Google Patents

Download PDF

Info

Publication number
BE2015C053I2
BE2015C053I2 BE2015C053C BE2015C053C BE2015C053I2 BE 2015C053 I2 BE2015C053 I2 BE 2015C053I2 BE 2015C053 C BE2015C053 C BE 2015C053C BE 2015C053 C BE2015C053 C BE 2015C053C BE 2015C053 I2 BE2015C053 I2 BE 2015C053I2
Authority
BE
Belgium
Application number
BE2015C053C
Original Assignee
Janssen Sciences Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34280181&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2015C053(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Sciences Ireland Unlimited Co filed Critical Janssen Sciences Ireland Unlimited Co
Publication of BE2015C053I2 publication Critical patent/BE2015C053I2/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
BE2015C053C 2003-09-03 2015-10-21 BE2015C053I2 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US49977103P 2003-09-03 2003-09-03
EP03103275 2003-09-03
EP03103319 2003-09-08
EP03103335 2003-09-10
EP03103668 2003-10-02
US50848603P 2003-10-03 2003-10-03
EP04787096.9A EP1663240B2 (fr) 2003-09-03 2004-09-03 Combinaison d'un inhibiteur non-nucleosidique de la transcriptase inverse (nnrti) contenant une pyrimidine avec un inhibiteur nucleosidique de la transcriptase inverse (nrti)
PCT/EP2004/052028 WO2005021001A1 (fr) 2003-09-03 2004-09-03 Combinaisons d'une pyrimidine renfermant nnrti avec des inhibiteurs de rt

Publications (1)

Publication Number Publication Date
BE2015C053I2 true BE2015C053I2 (fr) 2023-12-14

Family

ID=34280181

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2015C053C BE2015C053I2 (fr) 2003-09-03 2015-10-21

Country Status (25)

Country Link
US (9) US20080200435A1 (fr)
EP (1) EP1663240B2 (fr)
JP (3) JP5507791B2 (fr)
KR (1) KR20060090658A (fr)
CN (1) CN101060844B (fr)
AP (1) AP2109A (fr)
AU (5) AU2004268390B2 (fr)
BE (1) BE2015C053I2 (fr)
CA (1) CA2537095C (fr)
CY (5) CY2015038I2 (fr)
FI (1) FI1663240T4 (fr)
FR (3) FR15C0072I2 (fr)
HK (1) HK1092698A1 (fr)
HR (1) HRP20150798T4 (fr)
HU (5) HUS1500052I1 (fr)
IL (2) IL173438A (fr)
LT (2) LTC1663240I2 (fr)
LU (3) LU92853I2 (fr)
MX (1) MXPA06002437A (fr)
MY (1) MY169670A (fr)
NL (2) NL300781I2 (fr)
NO (5) NO334877B1 (fr)
NZ (1) NZ545306A (fr)
PL (1) PL1663240T5 (fr)
WO (1) WO2005021001A1 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
CN100554245C (zh) 2002-08-09 2009-10-28 詹森药业有限公司 制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法
CN105596356A (zh) 2003-01-14 2016-05-25 吉里德科学公司 用于联合抗病毒治疗的组合物和方法
UA92467C2 (ru) * 2004-09-02 2010-11-10 Янссен Фармацевтика Н.В. Гидрохлорид 4-[[4-[[4-(2-цианоэтенил)-2,6-диметилфенил]амино]-2-пиримидинил]амино]бензонитрила
SI1789139T1 (sl) * 2004-09-02 2012-08-31 Janssen Pharmaceutica Nv Fumarat 4-((4-((4-(2-cianoetenil)-2,6-dimetifenil amino-2-pirimidinil amino benzonitrila
PT1632232E (pt) * 2004-09-02 2011-08-02 Janssen Pharmaceutica Nv Sal de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]amino]- 2-pirimidinil]amino]benzonitrilo
AU2005279158C1 (en) * 2004-09-02 2010-12-16 Janssen Pharmaceutica N.V. Hydrochloride of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl] amino]benzonitrile
WO2006024667A1 (fr) * 2004-09-02 2006-03-09 Janssen Pharmaceutica N.V. Furamate de 4- ( (4- ( (4- (2-cyanoethenyl) -2, 6-dimethylphenyl) amino) -2-pyrimidinyl) amino) benzonitrile
TWI457136B (zh) * 2005-04-04 2014-10-21 Tibotec Pharm Ltd Hiv-感染之預防
TWI471145B (zh) * 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
KR20080091767A (ko) * 2005-12-14 2008-10-14 씨아이피엘에이 엘티디. (테노포비어 및 라미뷰딘과 같은) 뉴클레오티드 역전사효소억제제 및 뉴클레오시드 역전사효소 억제제를 투여 단위의상이한 부분에 포함하는 약제학적 조합물
AP2936A (en) * 2006-01-20 2014-07-31 Tibotec Pharm Ltd Long term treatment of HIV-infection with TMC278
US9044509B2 (en) 2006-02-03 2015-06-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibition of HIV infection through chemoprophylaxis
FR2903312B1 (fr) 2006-07-05 2008-09-26 Univ Aix Marseille Ii Utilisation d'inhibiteurs d'hmg-coa reductase et de farnesyl-pyrophosphate synthase dans la preparation d'un medicament
CL2008000746A1 (es) * 2007-03-14 2008-09-22 Tibotec Pharm Ltd Composicion farmaceutica en solucion que comprende tmc278 y un polimero soluble en agua; proceso de preparacion de dicha composicion; y uso de un polvo que comprende tmc278 para tratar sida.
DK2234620T3 (en) 2008-01-03 2016-06-06 Université D'aix-Marseille Triple therapy used for treatment of an hiv-infected patient
WO2010072844A1 (fr) * 2008-12-24 2010-07-01 Tibotec Pharmaceuticals Dispositifs implantables pour le traitement du vih
JP5950825B2 (ja) 2009-12-21 2016-07-13 ヤンセン・サイエンシズ・アイルランド・ユーシー 活性化合物の持続放出のための分解性の取り外し可能なインプラント
UA105556C2 (uk) 2010-01-27 2014-05-26 Віів Гелскер Компані Комбінація сполук, що містить інгібітори віл інтегрази з іншими терапевтичними агентами
BR112013012245B1 (pt) * 2010-11-19 2022-09-27 Janssen Sciences Ireland Uc Comprimido compreendendo hcl de rilpivirina e fumarato de tenofovir disoproxila seu uso no tratamento profilático ou terapêutico de uma infecção por hiv
WO2012125993A1 (fr) 2011-03-17 2012-09-20 Teva Pharmaceutical Industries Ltd. Formes à l'état solide de base rilpivirine et sels de rilpivirine
EP2755959B1 (fr) * 2011-09-16 2018-05-16 Hetero Research Foundation Chlorhydrate de rilpivirine
NZ718708A (en) 2012-12-21 2018-11-30 Gilead Sciences Inc Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
KR102606625B1 (ko) 2015-11-09 2023-11-27 길리애드 사이언시즈, 인코포레이티드 인간 면역결핍 바이러스의 치료를 위한 치료 조성물
JP7197474B2 (ja) 2016-10-24 2022-12-27 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 分散性組成物
WO2018119371A1 (fr) * 2016-12-23 2018-06-28 Temple University - Of The Commonwealth System Of Higher Education Activité anti-flaviviridae d'inhibiteurs de la transcriptase inverse nucléosidiques et non nucléosidiques anti-rétroviraux (nnrtis)
CA3060222A1 (fr) * 2017-04-18 2018-10-25 Cipla Limited Polytherapie destinee a etre utilisee dans le traitement d'infections retrovirales
WO2019021319A1 (fr) * 2017-07-27 2019-01-31 Cipla Limited Compositions pharmaceutiques
KR20220109389A (ko) 2019-11-29 2022-08-04 스키피오 라이프 사이언스 리미티드 릴피비린을 포함하는 조성물 및 종양 또는 암 치료를 위한 이의 용도

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182111A (en) 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5047407A (en) 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
GB8815265D0 (en) 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
US5368864A (en) 1988-11-25 1994-11-29 Henning Berlin Gmbh Chemie- Und Pharmawerk Formulation of oxypurinol and/or its alkali and alkaline earth salts
MY104575A (en) 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
DK0489181T3 (da) 1990-07-19 1996-11-18 Otsuka Pharma Co Ltd Fast præparat
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
CA2121129A1 (fr) 1991-10-29 1993-05-13 Patrick Soon-Shiong Polysaccharides pouvant etre reticules, polycations et lipides, utiles pour l'encapsulation et la liberation controlee de medicaments
AU4079593A (en) 1992-05-13 1993-12-13 Wellcome Foundation Limited, The Therapeutic combinations
JPH06316524A (ja) 1992-09-11 1994-11-15 Naoyuki Inoue 抗エイズウイルス剤
TW401303B (en) * 1994-07-01 2000-08-11 Janssen Pharmaceutica Nv Anti-HIV triple combination
IT1281502B1 (it) * 1995-06-13 1998-02-18 Sardinian Antiviral Research C Impiego di un inibitore non nucleosidico della trascrittasi inversa in associazione con inibitori nucleosidici per il trattamento della
US6045829A (en) 1997-02-13 2000-04-04 Elan Pharma International Limited Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers
KR100801588B1 (ko) 1999-09-21 2008-02-05 스키에파마 캐나다 인코포레이티드 생물학적 유효 물질의 표면 변형된 미립자 조성물
US6743446B2 (en) 1999-12-15 2004-06-01 The Ohio State University Research Foundation Methods for stabilizing biologically active agents encapsulated in biodegradable controlled-release polymers
TW200800298A (en) 2000-01-27 2008-01-01 Zentaris Ag Compressed microparticles for dry injection
US7135465B2 (en) 2000-03-30 2006-11-14 Bristol-Myers Squibb Company Sustained release beadlets containing stavudine
US20040115268A1 (en) 2000-04-26 2004-06-17 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
DE10050199A1 (de) 2000-10-11 2002-04-25 Ethicon Gmbh Flächiges Implantat mit im Ultraschall detektierbaren Elementen
CA2431319A1 (fr) 2000-12-11 2002-06-20 Hiroto Bando Composition medicinale dont la solubilite dans l'eau est amelioree
ES2333645T3 (es) 2001-06-22 2010-02-25 Bend Research, Inc. Composiciones farmaceuticas de dispersiones de medicamentos y polimeros neutros.
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
US20030166509A1 (en) 2001-11-20 2003-09-04 Advanced Inhalation Research, Inc. Compositions for sustained action product delivery and methods of use thereof
CN100554245C (zh) 2002-08-09 2009-10-28 詹森药业有限公司 制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法
AU2003278766A1 (en) 2002-09-04 2004-03-29 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
AU2003291457A1 (en) 2002-11-08 2004-06-03 Glaxo Group Limited Pharmaceutical antiviral compositions
AP1927A (en) 2002-11-15 2008-12-10 Tibotec Pharm Ltd Substituted indolepyridinium as anti-infective compounds
WO2004050068A1 (fr) 2002-11-29 2004-06-17 Janssen Pharmaceutica N.V. Compositions pharmaceutiques comprenant un compose medicamenteux respectivement basique, tensioactif et base respectivement acide hydrosoluble et tolerable physiologiquement
JP5602333B2 (ja) 2003-02-07 2014-10-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Hiv感染の予防のためのピリミジン誘導体
KR100629771B1 (ko) 2004-01-27 2006-09-28 씨제이 주식회사 결정성이 감소되거나 무정형화된 올티프라즈의 제조방법
RU2373923C2 (ru) 2004-06-08 2009-11-27 Вертекс Фармасьютикалз Инкорпорейтед Фармацевтические композиции
MY191349A (en) 2004-08-27 2022-06-17 Bayer Pharmaceuticals Corp New pharmaceutical compositions for the treatment of hyper-proliferative disorders
PT1632232E (pt) 2004-09-02 2011-08-02 Janssen Pharmaceutica Nv Sal de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]amino]- 2-pirimidinil]amino]benzonitrilo
AU2005279158C1 (en) 2004-09-02 2010-12-16 Janssen Pharmaceutica N.V. Hydrochloride of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl] amino]benzonitrile
EP2623095A1 (fr) 2004-11-16 2013-08-07 Elan Pharma International Limited Formulations injectables de nanoparticules d'olanzapine
TWI457136B (zh) 2005-04-04 2014-10-21 Tibotec Pharm Ltd Hiv-感染之預防
AR056652A1 (es) 2005-04-11 2007-10-17 Tibotec Pharm Ltd Derivados de (1,10-b dihidro-2-(aminoalquil-fenil) -5h-pirazolo (1,5-c) (1,3)benzoxazin-5-il) fenilmetanona y su uso en la fabricacion de un medicamento
WO2006110889A2 (fr) 2005-04-11 2006-10-19 The Board Of Trustees Of The Leland Stanford Junior University Structure multicouche possedant une configuration predeterminee comprenant un agent
US20090142401A1 (en) 2005-06-07 2009-06-04 Leah Elizabeth Appel Multiparticulates comprising low-solubility drugs and carriers that result in rapid drug release
JP5243247B2 (ja) 2005-07-28 2013-07-24 アイエスピー インヴェストメンツ インコーポレイテッド スプレー乾燥された粉体及び粒状化された材料の特性の改良方法、並びにそれによって製造した製品
AP2936A (en) 2006-01-20 2014-07-31 Tibotec Pharm Ltd Long term treatment of HIV-infection with TMC278
PL2040671T3 (pl) 2006-06-23 2018-08-31 Janssen Sciences Ireland Uc Wodne zawiesiny TMC278
WO2008060360A2 (fr) 2006-09-28 2008-05-22 Surmodics, Inc. Dispositif médical implantable pourvu d'ouvertures pour administrer des agents bioactifs
CL2008000746A1 (es) 2007-03-14 2008-09-22 Tibotec Pharm Ltd Composicion farmaceutica en solucion que comprende tmc278 y un polimero soluble en agua; proceso de preparacion de dicha composicion; y uso de un polvo que comprende tmc278 para tratar sida.
AU2008274185B2 (en) 2007-07-12 2014-07-03 Janssen Sciences Ireland Uc Crystalline form of (E) 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2 pyrimidinyl]amino]benzonitrile
WO2009046299A2 (fr) 2007-10-04 2009-04-09 Boston Scientific Scimed, Inc Forme retard implantable pour un système antidouleur d'administration de médicament intrarachidien
WO2010047819A1 (fr) 2008-10-24 2010-04-29 Concert Pharmaceuticals, Inc. Dérivés d'hydroxyéthylaminosulfonamide

Also Published As

Publication number Publication date
AU2016210733A1 (en) 2016-08-25
LU92853I2 (fr) 2015-12-21
AP2006003551A0 (en) 2006-04-30
NO20061374L (no) 2006-03-27
CN101060844A (zh) 2007-10-24
NO2014031I1 (no) 2015-01-05
US20170100398A1 (en) 2017-04-13
HUS1600058I1 (hu) 2017-02-28
NO2014032I2 (no) 2014-12-18
JP2015044839A (ja) 2015-03-12
AP2109A (en) 2010-02-26
HK1092698A1 (en) 2007-02-16
CA2537095A1 (fr) 2005-03-10
CN101060844B (zh) 2012-01-04
CY2016048I1 (el) 2017-07-12
LTC1663240I2 (lt) 2022-05-25
JP2012051915A (ja) 2012-03-15
PL1663240T3 (pl) 2015-10-30
HUS1500052I1 (hu) 2016-03-29
NO2014030I1 (no) 2015-01-05
CY2015039I2 (el) 2016-08-31
NZ545306A (en) 2009-11-27
EP1663240B1 (fr) 2015-04-22
JP2007520443A (ja) 2007-07-26
JP5507791B2 (ja) 2014-05-28
NO2014031I2 (no) 2014-12-18
EP1663240B2 (fr) 2023-03-01
LU92854I2 (fr) 2015-12-21
US8841310B2 (en) 2014-09-23
AU2016210733B2 (en) 2018-11-08
CA2537095C (fr) 2012-05-29
NO2014030I2 (no) 2014-12-18
NO2016025I1 (fr) 2016-12-20
LTPA2016045I1 (lt) 2017-01-10
AU2019200813A1 (en) 2019-02-28
US20150283135A1 (en) 2015-10-08
EP1663240A1 (fr) 2006-06-07
LU92855I2 (fr) 2015-12-21
NO2014032I1 (no) 2015-01-05
FR15C0072I1 (fr) 2015-04-12
NO334877B1 (no) 2014-06-23
KR20060090658A (ko) 2006-08-14
CY2016048I2 (el) 2017-07-12
AU2014203484A1 (en) 2014-07-17
CY2015038I1 (el) 2016-08-31
US20140349971A1 (en) 2014-11-27
HUS1500054I1 (hu) 2016-03-29
AU2011201123B2 (en) 2013-10-10
US20100029591A1 (en) 2010-02-04
LTPA2016044I1 (lt) 2017-01-10
IL173438A0 (en) 2006-06-11
AU2011201123A1 (en) 2011-04-07
FR15C0073I2 (fr) 2016-02-12
FR15C0072I2 (fr) 2019-05-17
CY2015039I1 (el) 2016-08-31
FR15C0071I1 (fr) 2015-04-12
MY169670A (en) 2019-05-08
FR15C0071I2 (fr) 2016-02-12
WO2005021001A1 (fr) 2005-03-10
US20220008417A1 (en) 2022-01-13
AU2014203484B2 (en) 2016-09-29
AU2004268390B2 (en) 2011-03-31
IL213104A0 (en) 2011-07-31
IL213104A (en) 2016-02-29
HUS1600059I1 (hu) 2017-02-28
MXPA06002437A (es) 2006-06-20
HRP20150798T1 (hr) 2015-09-11
PL1663240T5 (pl) 2024-02-26
FI1663240T4 (fi) 2023-04-25
US20190216807A1 (en) 2019-07-18
HUS1500053I1 (hu) 2016-03-29
CY2015038I2 (el) 2016-08-31
CY2016049I2 (el) 2017-07-12
CY2015040I2 (el) 2016-08-31
CY2015040I1 (el) 2016-08-31
CY2016049I1 (el) 2017-07-12
HRP20150798T4 (hr) 2023-06-09
IL173438A (en) 2012-03-29
NL300781I1 (fr) 2016-04-19
AU2004268390A1 (en) 2005-03-10
NL300781I2 (fr) 2016-04-19
US20080200435A1 (en) 2008-08-21
US20200171027A1 (en) 2020-06-04
NL300768I2 (nl) 2023-08-09
NL300768I1 (fr) 2015-12-16
JP5820045B2 (ja) 2015-11-24
US20180228800A1 (en) 2018-08-16
FR15C0073I1 (fr) 2015-04-12

Similar Documents

Publication Publication Date Title
NO2016025I1 (fr)
BE2015C007I2 (fr)
BE2014C055I2 (fr)
BE2014C027I2 (fr)
BE2014C003I2 (fr)
BE2013C075I2 (fr)
BE2013C070I2 (fr)
BE2013C067I2 (fr)
BE2013C038I2 (fr)
BE2013C036I2 (fr)
BE2011C030I2 (fr)
JP2004032725A5 (fr)
JP2004003080A5 (fr)
JP2004001496A5 (fr)
JP2004005486A5 (fr)
JP2004032700A5 (fr)
JP2004227558A5 (fr)
BE2015C005I2 (fr)
JP2004002666A5 (fr)
JP2004160186A5 (fr)
JP2004164542A5 (fr)
JP2004088759A5 (fr)
JP2004035109A5 (fr)
JP2003337765A5 (fr)
JP2004006886A5 (fr)