BE1003436A3 - CYCLIC DERIVATIVES AND THEIR METABOLITES, THEIR PREPARATION AND THEIR USE AS MEDICINES. - Google Patents

CYCLIC DERIVATIVES AND THEIR METABOLITES, THEIR PREPARATION AND THEIR USE AS MEDICINES. Download PDF

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Publication number
BE1003436A3
BE1003436A3 BE8901266A BE8901266A BE1003436A3 BE 1003436 A3 BE1003436 A3 BE 1003436A3 BE 8901266 A BE8901266 A BE 8901266A BE 8901266 A BE8901266 A BE 8901266A BE 1003436 A3 BE1003436 A3 BE 1003436A3
Authority
BE
Belgium
Prior art keywords
metabolites
medicines
preparation
cyclic derivatives
compounds
Prior art date
Application number
BE8901266A
Other languages
French (fr)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1003436A3 publication Critical patent/BE1003436A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention a pour objet les composés de formule I dans laquelle R1, R2 et X ont des significations variées, et quatre métabolites de structure non connue, désignés métabolites A, B, C et D. Ces composés peuvent être obtenus par synthèse et par fermentation de souches de Streptomyces par exemple la souche Spreptomyces tsukubaensis Nr. 9993. L'invention concerne également l'utilisation de ces composés comme médicamants.The subject of the present invention is the compounds of formula I in which R1, R2 and X have various meanings, and four metabolites of unknown structure, designated metabolites A, B, C and D. These compounds can be obtained by synthesis and by fermentation of strains of Streptomyces, for example the strain Spreptomyces tsukubaensis Nr. 9993. The invention also relates to the use of these compounds as medicaments.

BE8901266A 1988-11-29 1989-11-27 CYCLIC DERIVATIVES AND THEIR METABOLITES, THEIR PREPARATION AND THEIR USE AS MEDICINES. BE1003436A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3840185 1988-11-29
DE3917779 1989-05-31

Publications (1)

Publication Number Publication Date
BE1003436A3 true BE1003436A3 (en) 1992-03-24

Family

ID=25874647

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8901266A BE1003436A3 (en) 1988-11-29 1989-11-27 CYCLIC DERIVATIVES AND THEIR METABOLITES, THEIR PREPARATION AND THEIR USE AS MEDICINES.

Country Status (6)

Country Link
JP (1) JPH02275884A (en)
BE (1) BE1003436A3 (en)
CH (1) CH678855A5 (en)
FR (1) FR2639637A1 (en)
GB (1) GB2225576B (en)
IT (1) IT1237429B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2245891A (en) * 1990-07-09 1992-01-15 Fujisawa Pharmaceutical Co Tricyclo compounds
GB2246350A (en) * 1990-07-23 1992-01-29 Fujisawa Pharmaceutical Co Tricyclo compounds
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
CA2051872A1 (en) * 1990-09-24 1992-03-25 Kevin M. Byrne Directed biosynthesis process for prolyl-immunomycin
US5527820A (en) * 1992-06-23 1996-06-18 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Antibiotics having immunosuppressive activity, delaminomycins and processes for the production of the same
AU670597B2 (en) * 1992-06-24 1996-07-25 Ferring B.V. Novel benzodiazepine derivative
EP1474404A4 (en) 2002-02-13 2006-01-11 Biogal Gyogyszergyar Method for extracting a macrolide from biomatter
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0184162A2 (en) * 1984-12-03 1986-06-11 Fujisawa Pharmaceutical Co., Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
EP0323042A1 (en) * 1987-12-09 1989-07-05 FISONS plc Process to macrocyclic compounds
EP0349049A2 (en) * 1988-06-29 1990-01-03 Merck & Co. Inc. Immunosuppressant compound
EP0349061A2 (en) * 1988-06-29 1990-01-03 Merck & Co. Inc. Immunosuppressant agent
EP0353678A2 (en) * 1988-08-01 1990-02-07 Fujisawa Pharmaceutical Co., Ltd. FR-901154 and FR-901155 substances, a process for their production
EP0358508A2 (en) * 1988-09-08 1990-03-14 Merck & Co. Inc. Novel immunosuppressant compound

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0184162A2 (en) * 1984-12-03 1986-06-11 Fujisawa Pharmaceutical Co., Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
EP0323042A1 (en) * 1987-12-09 1989-07-05 FISONS plc Process to macrocyclic compounds
EP0349049A2 (en) * 1988-06-29 1990-01-03 Merck & Co. Inc. Immunosuppressant compound
EP0349061A2 (en) * 1988-06-29 1990-01-03 Merck & Co. Inc. Immunosuppressant agent
EP0353678A2 (en) * 1988-08-01 1990-02-07 Fujisawa Pharmaceutical Co., Ltd. FR-901154 and FR-901155 substances, a process for their production
EP0358508A2 (en) * 1988-09-08 1990-03-14 Merck & Co. Inc. Novel immunosuppressant compound

Also Published As

Publication number Publication date
GB2225576B (en) 1992-07-01
JPH02275884A (en) 1990-11-09
IT1237429B (en) 1993-06-04
GB8926787D0 (en) 1990-01-17
FR2639637A1 (en) 1990-06-01
IT8948610A0 (en) 1989-11-29
GB2225576A (en) 1990-06-06
FR2639637B1 (en) 1994-08-19
CH678855A5 (en) 1991-11-15

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: S.A. SANDOZ

Effective date: 19951130