BE1003254A5 - Derives de furanne. - Google Patents
Derives de furanne. Download PDFInfo
- Publication number
- BE1003254A5 BE1003254A5 BE8900773A BE8900773A BE1003254A5 BE 1003254 A5 BE1003254 A5 BE 1003254A5 BE 8900773 A BE8900773 A BE 8900773A BE 8900773 A BE8900773 A BE 8900773A BE 1003254 A5 BE1003254 A5 BE 1003254A5
- Authority
- BE
- Belgium
- Prior art keywords
- salts
- ranitidine
- well
- furanne
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention a pour objet des sels de ranitidine avec un complexe bismuth/acide carboxylique et des produits solvatisés de tels sels. Les exemples d'acides carboxyliques appropriés sont les acides citrique, tartrique et agaricique. Les sels sont efficaces pour le traitement des troubles gastro-intestinaux, en particulier des troubles gastroduodénaux. Les sels font preuve d'une activité d'anti-sécrétion associée à la ranitidine, ainsi qu'une activité antibactérienne contre Campylobacter pylori, ainsi que des propriétés cytoprotectrices.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888817098A GB8817098D0 (en) | 1988-07-18 | 1988-07-18 | Chemical compounds |
GB898904686A GB8904686D0 (en) | 1989-03-01 | 1989-03-01 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BE1003254A5 true BE1003254A5 (fr) | 1992-02-11 |
Family
ID=26294175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE8900773A BE1003254A5 (fr) | 1988-07-18 | 1989-07-17 | Derives de furanne. |
Country Status (35)
Country | Link |
---|---|
US (1) | US5008256A (fr) |
JP (1) | JP2523185B2 (fr) |
KR (1) | KR0122598B1 (fr) |
CN (1) | CN1022626C (fr) |
AT (1) | AT398200B (fr) |
AU (1) | AU632052B2 (fr) |
BE (1) | BE1003254A5 (fr) |
CA (1) | CA1332610C (fr) |
CH (1) | CH679582A5 (fr) |
CY (1) | CY1650A (fr) |
DE (1) | DE3923638C2 (fr) |
DK (1) | DK168381B1 (fr) |
EG (1) | EG19368A (fr) |
ES (1) | ES2014175A6 (fr) |
FI (1) | FI90538C (fr) |
FR (1) | FR2634122B1 (fr) |
GB (1) | GB2220937B (fr) |
GR (1) | GR1000431B (fr) |
HK (1) | HK61392A (fr) |
HU (2) | HU206104B (fr) |
IE (1) | IE61076B1 (fr) |
IL (1) | IL91005A (fr) |
IT (1) | IT1231481B (fr) |
LU (2) | LU88722I2 (fr) |
MX (1) | MX174145B (fr) |
MY (1) | MY104055A (fr) |
NL (2) | NL192604C (fr) |
NO (2) | NO176319C (fr) |
NZ (1) | NZ229958A (fr) |
PL (1) | PL162391B1 (fr) |
PT (1) | PT91188B (fr) |
SE (1) | SE468715B (fr) |
SG (1) | SG51992G (fr) |
YU (1) | YU47021B (fr) |
ZW (1) | ZW8689A1 (fr) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0282132B1 (fr) * | 1987-03-09 | 1992-09-30 | The Procter & Gamble Company | Compositions et leur utilisation dans le traitement d'affections gastrointestinales |
IL85472A (en) * | 1987-03-09 | 1991-06-30 | Procter & Gamble | Pharmaceutical compositions for treating gastrointestinal disorders |
AU641903B2 (en) * | 1988-10-26 | 1993-10-07 | Glaxo Group Limited | Carboxylic acid derivatives |
GB9004328D0 (en) * | 1990-02-27 | 1990-04-25 | Glaxo Group Ltd | Chemical compounds |
GB9009240D0 (en) * | 1990-04-25 | 1990-06-20 | Glaxo Group Ltd | Chemical compounds |
GB9009437D0 (en) * | 1990-04-26 | 1990-06-20 | Glaxo Group Ltd | Chemical compounds |
HUT64080A (en) * | 1990-07-20 | 1993-11-29 | Slagel David | Process for produicng bismuth-polyacrylate complexes and pharmaceutical compositions comprising same as active ingredient |
GB9019875D0 (en) * | 1990-09-11 | 1990-10-24 | Glaxo Group Ltd | Pharmaceutical compositions |
US5192752A (en) * | 1991-01-14 | 1993-03-09 | The Procter & Gamble Company | Swallowable pharmaceutical compositions containing colloidal bismuth subcitrate |
US5128140A (en) * | 1991-01-14 | 1992-07-07 | The Procter & Gamble Company | Swallowable pharmaceutical compositions |
GB9120131D0 (en) * | 1991-09-20 | 1991-11-06 | Glaxo Group Ltd | Medicaments |
DK0550083T3 (da) * | 1991-12-06 | 1999-10-11 | Glaxo Group Ltd | Lægemidler til behandling af inflammatoriske tilstande eller til analgesi og indeholdende et NSAID og ranitidinbismuthcitra |
AU1671295A (en) * | 1994-12-19 | 1996-07-10 | Lauteral Limited | Combinations of ranitidine hydrochloride-form 1 and bismuth compounds |
GB9501560D0 (en) | 1995-01-26 | 1995-03-15 | Nycomed Imaging As | Contrast agents |
HUP9900428A2 (hu) * | 1995-01-26 | 1999-06-28 | Nycomed Imaging A/S | Bizmutvegyületek, ezeket tartalmazó diagnosztikai kontrasztanyag, ennek alkalmazása és ezt tartalmazó gyógyászati készítmény |
EP1035192A1 (fr) * | 1999-01-26 | 2000-09-13 | Stefan Graichen | Additif pur un réfrigérant lubrifiant |
CN1102585C (zh) * | 1999-04-28 | 2003-03-05 | 常州兰陵制药有限公司 | 雷尼替丁枸橼酸铋盐的制备方法 |
US20060100271A1 (en) * | 2004-11-08 | 2006-05-11 | Keith Whitehead | Stabilized aqueous ranitidine compositions |
CN100402514C (zh) * | 2006-08-01 | 2008-07-16 | 丽珠医药集团股份有限公司 | 一种制备枸橼酸铋雷尼替丁的方法 |
CN101484132A (zh) * | 2007-07-09 | 2009-07-15 | 柏树制药公司 | 具有合意口味的雷尼替丁制剂 |
CN102408398B (zh) * | 2011-09-20 | 2012-12-05 | 江苏汉斯通药业有限公司 | 枸橼酸铋雷尼替丁的制备方法 |
US9731999B2 (en) | 2011-09-23 | 2017-08-15 | Iqbal Gill | Chemical admixtures for hydraulic cements |
ES2426539B1 (es) * | 2012-04-18 | 2014-09-09 | Dr Healthcare España, S. L. | Uso de la diaminooxidasa para el tratamiento o la prevención del trastorno por deficit de atencion con hiperactividad (adhd) |
CN103896888B (zh) * | 2014-03-28 | 2015-11-18 | 常州兰陵制药有限公司 | 枸橼酸铋雷尼替丁的制备方法 |
EP2929884A1 (fr) | 2014-04-11 | 2015-10-14 | Sanovel Ilac Sanayi ve Ticaret A.S. | Combinaisons pharmaceutiques de dabigatran et antagonistes du récepteur de h2 |
EP2942058A1 (fr) | 2014-05-09 | 2015-11-11 | Sanovel Ilac Sanayi ve Ticaret A.S. | Combinaisons pharmaceutiques de rivaroxaban et des antagonistes du récepteur d'histamine H2 |
CN107382921A (zh) * | 2017-07-28 | 2017-11-24 | 常州兰陵制药有限公司 | 制备枸橼酸铋雷尼替丁的方法 |
EP4196793A1 (fr) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | Bloqueurs de h2 ciblant des macrophages du foie pour la prévention et le traitement d'une maladie du foie et du cancer |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1565967A (en) * | 1976-08-04 | 1980-04-23 | Allen & Hanburys Ltd | Aminoalkyl furan derivatives |
BE905235A (fr) * | 1986-08-05 | 1986-12-01 | Hasunor Ag | Ascorbates antagonistes des recepteurs h2 et leur procede de preparation. |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2531706A1 (fr) * | 1982-08-13 | 1984-02-17 | Sanofi Sa | Benzamides, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant |
IT1215325B (it) * | 1987-01-07 | 1990-02-08 | Barisintex Sa | Composti antagonisti di recettori -h2 e procedimento per la loro preparazione. |
EP0282132B1 (fr) * | 1987-03-09 | 1992-09-30 | The Procter & Gamble Company | Compositions et leur utilisation dans le traitement d'affections gastrointestinales |
IL85472A (en) * | 1987-03-09 | 1991-06-30 | Procter & Gamble | Pharmaceutical compositions for treating gastrointestinal disorders |
DE3710462A1 (de) * | 1987-03-30 | 1988-10-13 | Heumann Pharma Gmbh & Co | Pharmazeutische zubereitung zur behandlung von erkrankungen des magen-darm-traktes |
GB9004328D0 (en) * | 1990-02-27 | 1990-04-25 | Glaxo Group Ltd | Chemical compounds |
GB9009437D0 (en) * | 1990-04-26 | 1990-06-20 | Glaxo Group Ltd | Chemical compounds |
-
1989
- 1989-07-14 CH CH2647/89A patent/CH679582A5/fr not_active IP Right Cessation
- 1989-07-17 DE DE3923638A patent/DE3923638C2/de not_active Expired - Fee Related
- 1989-07-17 AU AU38178/89A patent/AU632052B2/en not_active Ceased
- 1989-07-17 YU YU142789A patent/YU47021B/sh unknown
- 1989-07-17 CN CN89104959A patent/CN1022626C/zh not_active Expired - Fee Related
- 1989-07-17 ES ES8902517A patent/ES2014175A6/es not_active Expired - Fee Related
- 1989-07-17 NL NL8901840A patent/NL192604C/nl not_active IP Right Cessation
- 1989-07-17 IT IT8948196A patent/IT1231481B/it active Protection Beyond IP Right Term
- 1989-07-17 EG EG34289A patent/EG19368A/xx active
- 1989-07-17 FR FR8909575A patent/FR2634122B1/fr not_active Expired - Fee Related
- 1989-07-17 IL IL9100589A patent/IL91005A/en not_active IP Right Cessation
- 1989-07-17 SE SE8902550A patent/SE468715B/sv not_active IP Right Cessation
- 1989-07-17 LU LU88722C patent/LU88722I2/fr unknown
- 1989-07-17 GR GR890100454A patent/GR1000431B/el not_active IP Right Cessation
- 1989-07-17 MX MX1682989A patent/MX174145B/es unknown
- 1989-07-17 CA CA000605843A patent/CA1332610C/fr not_active Expired - Fee Related
- 1989-07-17 PT PT91188A patent/PT91188B/pt not_active IP Right Cessation
- 1989-07-17 BE BE8900773A patent/BE1003254A5/fr not_active IP Right Cessation
- 1989-07-17 DK DK351789A patent/DK168381B1/da not_active IP Right Cessation
- 1989-07-17 NZ NZ229958A patent/NZ229958A/xx unknown
- 1989-07-17 HU HU893595A patent/HU206104B/hu unknown
- 1989-07-17 MY MYPI89000969A patent/MY104055A/en unknown
- 1989-07-17 ZW ZW86/89A patent/ZW8689A1/xx unknown
- 1989-07-17 JP JP1184402A patent/JP2523185B2/ja not_active Expired - Lifetime
- 1989-07-17 IE IE230989A patent/IE61076B1/en not_active IP Right Cessation
- 1989-07-17 NO NO892936A patent/NO176319C/no not_active IP Right Cessation
- 1989-07-17 PL PL28062889A patent/PL162391B1/pl unknown
- 1989-07-17 GB GB8916288A patent/GB2220937B/en not_active Expired - Lifetime
- 1989-07-17 US US07/380,378 patent/US5008256A/en not_active Expired - Lifetime
- 1989-07-17 LU LU87557A patent/LU87557A1/fr active Protection Beyond IP Right Term
- 1989-07-17 FI FI893448A patent/FI90538C/fi not_active IP Right Cessation
- 1989-07-17 AT AT0172889A patent/AT398200B/de not_active IP Right Cessation
- 1989-07-18 KR KR1019890010213A patent/KR0122598B1/ko not_active IP Right Cessation
-
1992
- 1992-05-09 SG SG519/92A patent/SG51992G/en unknown
- 1992-08-13 HK HK613/92A patent/HK61392A/xx not_active IP Right Cessation
- 1992-12-11 CY CY1650A patent/CY1650A/xx unknown
-
1995
- 1995-06-12 HU HU95P/P00186P patent/HU211173A9/hu unknown
-
1997
- 1997-12-18 NL NL970046C patent/NL970046I2/nl unknown
-
1998
- 1998-02-05 NO NO1998007C patent/NO1998007I1/no unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1565967A (en) * | 1976-08-04 | 1980-04-23 | Allen & Hanburys Ltd | Aminoalkyl furan derivatives |
BE905235A (fr) * | 1986-08-05 | 1986-12-01 | Hasunor Ag | Ascorbates antagonistes des recepteurs h2 et leur procede de preparation. |
Non-Patent Citations (1)
Title |
---|
CHEMICAL ABSTRACTS, vol. 108, no. 19, 9 mai 1988, page 47, colonne 1, abrégé no. 161242u, Columbus, Ohio, US; "G. BIANCHI PORRO et al.: "Why are nonsteroidal anti-inflammatory drugs important in peptic ulceration?", & ALIMENT. PHARMACOL. THER. 1987, 1(Suppl. 1), 540S-547S * |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Effective date: 20060731 |
|
CCRE | Expiry of a supplementary protection certificate |
Free format text: PRODUCT NAME: RANITIDINE BISMUTH CITRATE; NAT. REGISTRATION NO/DATE: 5505 IE 1 F 3 19960426; FIRST REGISTRATION: GB PL 14213/0001 19950714 Spc suppl protection certif: 96C0017 Filing date: 19960521 Expiry date: 20090717 Extension date: 20100714 Effective date: 20100714 |