AU644621B2 - Pharmaceutical composition for treating or preventing retroviral infections - Google Patents

Pharmaceutical composition for treating or preventing retroviral infections

Info

Publication number
AU644621B2
AU644621B2 AU69755/91A AU6975590A AU644621B2 AU 644621 B2 AU644621 B2 AU 644621B2 AU 69755/91 A AU69755/91 A AU 69755/91A AU 6975590 A AU6975590 A AU 6975590A AU 644621 B2 AU644621 B2 AU 644621B2
Authority
AU
Australia
Prior art keywords
treating
pharmaceutical composition
retroviral infections
preventing retroviral
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU69755/91A
Inventor
Bruno Guy
Jean-Pierre Lecocq
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transgene SA
Original Assignee
Transgene SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9013102A external-priority patent/FR2668065B1/en
Application filed by Transgene SA filed Critical Transgene SA
Application granted granted Critical
Publication of AU644621B2 publication Critical patent/AU644621B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A pharmaceutical composition for treating or preventing retroviral diseases containing a thiol-protease inhibitor as an active principle. Thiol-protease inhibitors are known products such as cystatines and the derivatives thereof, antipaine [(S)-1-carboxy-2-phenyletyl]-carbamoyl-Arg-Val-Arg-al, E-64 (L-trans-epoxysuccinyl-leucylamide-(4-guanidino)-butane, N-[N-(L-3-transcarboxyirane-2-carbonyl)-L-leucyl]-agmatine, leupeptin, iodoacetic acid/iodoacetamide or N-Cbz-Phe-Ala-diazomethane.
AU69755/91A 1989-12-18 1990-12-18 Pharmaceutical composition for treating or preventing retroviral infections Ceased AU644621B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR8916726 1989-12-18
FR8916726 1989-12-18
FR9013102 1990-10-23
FR9013102A FR2668065B1 (en) 1990-10-23 1990-10-23 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND PREVENTION OF RETROVIRAL INFECTIONS.
PCT/FR1990/000921 WO1991008769A1 (en) 1989-12-18 1990-12-18 Pharmaceutical composition for treating or preventing retroviral infections

Publications (1)

Publication Number Publication Date
AU644621B2 true AU644621B2 (en) 1993-12-16

Family

ID=26227737

Family Applications (2)

Application Number Title Priority Date Filing Date
AU69755/91A Ceased AU644621B2 (en) 1989-12-18 1990-12-18 Pharmaceutical composition for treating or preventing retroviral infections
AU69755/91A Granted AU6975591A (en) 1989-12-18 1990-12-18 Pharmaceutical composition for treating or preventing retroviral infections

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU69755/91A Granted AU6975591A (en) 1989-12-18 1990-12-18 Pharmaceutical composition for treating or preventing retroviral infections

Country Status (8)

Country Link
EP (1) EP0506769B1 (en)
JP (1) JPH05502868A (en)
AT (1) ATE109006T1 (en)
AU (2) AU644621B2 (en)
CA (1) CA2071972A1 (en)
DE (1) DE69011130T2 (en)
DK (1) DK0506769T3 (en)
WO (1) WO1991008769A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993015730A1 (en) * 1992-02-07 1993-08-19 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Use of 5,5'-dithio-bis(2-nitrobenzoic acid) for inhibition of hiv protease
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
DE69333270T2 (en) 1992-03-11 2004-08-05 Narhex Ltd. AMINE DERIVATIVES OF OXO AND HYDROXY SUBSTITUTED CARBON HYDROGEN
RU2126794C1 (en) * 1992-03-11 1999-02-27 Нархекс Лимитед Amino-derivatives of oxo- or hydroxy-substituted hydrazines, method of their synthesis and pharmaceutical compositions for inhibition of retrovirus protease
JP3517238B2 (en) * 1992-09-09 2004-04-12 アムジェン インコーポレイテッド Inhibition of retroviral infection
FR2778851B1 (en) * 1998-05-19 2002-07-26 Aetsrn COMPOSITION BASED ON CYSTEINE PROTEASE INHIBITORS FOR DELAYING SENESCENCE, SELF-DESTRUCTION AND HEMOLYSIS OF ERYTHROCYTES
WO2005011649A2 (en) * 2003-05-19 2005-02-10 Vanderbilt University Methods of treating severe acute respiratory syndrome virus infections
US8232240B2 (en) 2005-02-23 2012-07-31 The Brigham And Women's Hospital, Inc. Inhibitors of enveloped virus infectivity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8510058A8 (en) * 1985-01-16 1996-04-30 Inst Jozef Stefan P O Process for insulation of poultry egg's cystatine from egg-white
EP0269311A3 (en) * 1986-11-17 1990-06-06 Merck & Co. Inc. Methods of treating bone diseases by administration of a cysteine proteinase inhibitor

Also Published As

Publication number Publication date
CA2071972A1 (en) 1991-06-19
JPH05502868A (en) 1993-05-20
EP0506769A1 (en) 1992-10-07
DK0506769T3 (en) 1994-11-28
ATE109006T1 (en) 1994-08-15
EP0506769B1 (en) 1994-07-27
AU6975591A (en) 1991-07-18
WO1991008769A1 (en) 1991-06-27
DE69011130D1 (en) 1994-09-01
DE69011130T2 (en) 1995-03-16

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