AU4918690A - Process for the preparation of aqueous mixed micelle solutions - Google Patents

Process for the preparation of aqueous mixed micelle solutions

Info

Publication number
AU4918690A
AU4918690A AU49186/90A AU4918690A AU4918690A AU 4918690 A AU4918690 A AU 4918690A AU 49186/90 A AU49186/90 A AU 49186/90A AU 4918690 A AU4918690 A AU 4918690A AU 4918690 A AU4918690 A AU 4918690A
Authority
AU
Australia
Prior art keywords
active substances
mixed micelle
lipoids
temperature
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU49186/90A
Other versions
AU636327B2 (en
Inventor
Detlef Goritz
Heinrich Dr Michel
Georg Dr Rossling
Johannes-Wilhelm Dr Tack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU4918690A publication Critical patent/AU4918690A/en
Application granted granted Critical
Publication of AU636327B2 publication Critical patent/AU636327B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Abstract

A process for producing aqueous mixed micelle solutions containing mixed micelles formed from lipoids and salts of bile acids, in which, if desired, active substances hardly soluble or insoluble in water are solubilized, is characterized in that the free bile acids are suspended in an aqueous solution possibly containing isotonizing additives and/or water-soluble active substances at a temperature of 40C to 100C, the lipoids are dispersed in this suspension at a temperature of 40C to 100C and the dispersion obtained is neutralized with bases at a temperature of 0C to 100C, provided that, if necessary, the active substances which are hardly soluble or insoluble in water are dispersed together with the lipoids or solubilized in the mixed micelle solution which does not contain these active substances.
AU49186/90A 1989-02-06 1990-02-06 Process for the preparation of aqueous mixed micelle solutions Ceased AU636327B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3903753 1989-02-06
DE3903753A DE3903753A1 (en) 1989-02-06 1989-02-06 METHOD FOR PRODUCING AQUEOUS MIXED MICRO SOLUTIONS

Publications (2)

Publication Number Publication Date
AU4918690A true AU4918690A (en) 1990-08-09
AU636327B2 AU636327B2 (en) 1993-04-29

Family

ID=6373663

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49186/90A Ceased AU636327B2 (en) 1989-02-06 1990-02-06 Process for the preparation of aqueous mixed micelle solutions

Country Status (15)

Country Link
EP (1) EP0409936B1 (en)
JP (1) JPH03503899A (en)
AT (1) ATE103803T1 (en)
AU (1) AU636327B2 (en)
CA (1) CA2009307A1 (en)
DD (1) DD291696A5 (en)
DE (2) DE3903753A1 (en)
DK (1) DK0409936T3 (en)
ES (1) ES2052246T3 (en)
FI (1) FI904892A0 (en)
GR (1) GR900100034A (en)
HU (1) HU206260B (en)
IE (1) IE65555B1 (en)
PT (1) PT93055B (en)
WO (1) WO1990008534A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU636947B2 (en) * 1990-01-24 1993-05-13 F. Hoffmann-La Roche Ag Pharmaceutical and cosmetic compositions

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA916314B (en) * 1990-08-17 1992-05-27 Hoffmann La Roche Use of mixed micelles
DE4120109A1 (en) * 1991-06-15 1992-12-17 Schering Ag 3-ARYL OR 3-HETARYL (BETA) CARBOLINES, THEIR PRODUCTION AND USE IN MEDICINAL PRODUCTS
JP2740153B2 (en) * 1995-03-07 1998-04-15 エフ・ホフマン−ラ ロシユ アーゲー Mixed micelle

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1202370B (en) * 1976-07-12 1989-02-09 Hoffmann La Roche INJECTABLE SOLUTIONS IN WHICH THE EMOLITHIC LIFE OF NATURAL MICELLES TRAINING AGENTS IS AVOIDED BY THE ADDITION OF LIPOIDS AND RELATED PRODUCTS
CA1319886C (en) * 1987-02-03 1993-07-06 Alberto Ferro Mixed micelle solutions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU636947B2 (en) * 1990-01-24 1993-05-13 F. Hoffmann-La Roche Ag Pharmaceutical and cosmetic compositions

Also Published As

Publication number Publication date
HUT55219A (en) 1991-05-28
PT93055A (en) 1990-08-31
DE3903753A1 (en) 1990-08-23
IE65555B1 (en) 1995-11-01
DD291696A5 (en) 1991-07-11
AU636327B2 (en) 1993-04-29
FI904892A0 (en) 1990-10-04
HU206260B (en) 1992-10-28
WO1990008534A1 (en) 1990-08-09
ATE103803T1 (en) 1994-04-15
DE59005243D1 (en) 1994-05-11
ES2052246T3 (en) 1994-07-01
JPH03503899A (en) 1991-08-29
HU901153D0 (en) 1991-03-28
IE900366L (en) 1990-08-06
CA2009307A1 (en) 1990-08-06
EP0409936A1 (en) 1991-01-30
PT93055B (en) 1995-12-29
GR900100034A (en) 1991-06-28
DK0409936T3 (en) 1994-07-18
EP0409936B1 (en) 1994-04-06

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired