AU2965989A - Renin inhibitors - Google Patents

Renin inhibitors

Info

Publication number
AU2965989A
AU2965989A AU29659/89A AU2965989A AU2965989A AU 2965989 A AU2965989 A AU 2965989A AU 29659/89 A AU29659/89 A AU 29659/89A AU 2965989 A AU2965989 A AU 2965989A AU 2965989 A AU2965989 A AU 2965989A
Authority
AU
Australia
Prior art keywords
renin inhibitors
renin
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU29659/89A
Other versions
AU615516B2 (en
Inventor
Joachim Dr. Gante
Gunter Dr. Holzemann
Alfred Dr. Jonczyk
Dr. Klaus-Otto Minck
Peter Dr. Raddatz
Claus Jochen Dr. Schmitges
Johannes Dr. Sombroek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3803584A external-priority patent/DE3803584A1/en
Priority claimed from DE19883819263 external-priority patent/DE3819263A1/en
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2965989A publication Critical patent/AU2965989A/en
Application granted granted Critical
Publication of AU615516B2 publication Critical patent/AU615516B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
AU29659/89A 1988-02-06 1989-02-06 Renin inhibitors Ceased AU615516B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3803584 1988-02-06
DE3803584A DE3803584A1 (en) 1988-02-06 1988-02-06 Amino acid derivatives
DE3819263 1988-06-07
DE19883819263 DE3819263A1 (en) 1988-06-07 1988-06-07 Amino-acid derivatives

Publications (2)

Publication Number Publication Date
AU2965989A true AU2965989A (en) 1989-08-10
AU615516B2 AU615516B2 (en) 1991-10-03

Family

ID=25864616

Family Applications (1)

Application Number Title Priority Date Filing Date
AU29659/89A Ceased AU615516B2 (en) 1988-02-06 1989-02-06 Renin inhibitors

Country Status (5)

Country Link
EP (1) EP0327877A3 (en)
JP (1) JPH021445A (en)
KR (1) KR890013058A (en)
AU (1) AU615516B2 (en)
HU (1) HU203249B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU624114B2 (en) * 1988-03-04 1992-06-04 Merck Patent Gesellschaft Mit Beschrankter Haftung Renin inhibitors

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931585A1 (en) * 1989-09-22 1991-04-04 Merck Patent Gmbh AMINOSAEUREDERIVATE
EP1330430A2 (en) 2000-08-18 2003-07-30 Genentech, Inc. Integrin receptor inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0249096B1 (en) * 1986-06-10 1995-01-11 Merck Patent Gmbh Renin-inhibiting amino acid derivatives.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU624114B2 (en) * 1988-03-04 1992-06-04 Merck Patent Gesellschaft Mit Beschrankter Haftung Renin inhibitors

Also Published As

Publication number Publication date
EP0327877A2 (en) 1989-08-16
JPH021445A (en) 1990-01-05
HU203249B (en) 1991-06-28
EP0327877A3 (en) 1991-08-14
KR890013058A (en) 1989-09-21
AU615516B2 (en) 1991-10-03
HUT52523A (en) 1990-07-28

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