AU2424499A - Heterocyclic amidines as callicrein protease inhibitors - Google Patents
Heterocyclic amidines as callicrein protease inhibitorsInfo
- Publication number
- AU2424499A AU2424499A AU24244/99A AU2424499A AU2424499A AU 2424499 A AU2424499 A AU 2424499A AU 24244/99 A AU24244/99 A AU 24244/99A AU 2424499 A AU2424499 A AU 2424499A AU 2424499 A AU2424499 A AU 2424499A
- Authority
- AU
- Australia
- Prior art keywords
- callicrein
- protease inhibitors
- heterocyclic amidines
- amidines
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19802802 | 1998-01-26 | ||
DE19802802 | 1998-01-26 | ||
PCT/EP1999/000435 WO1999037611A1 (en) | 1998-01-26 | 1999-01-23 | Heterocyclic amidines as callicrein protease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2424499A true AU2424499A (en) | 1999-08-09 |
Family
ID=7855661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU24244/99A Abandoned AU2424499A (en) | 1998-01-26 | 1999-01-23 | Heterocyclic amidines as callicrein protease inhibitors |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1049673A1 (en) |
JP (1) | JP2002501044A (en) |
AU (1) | AU2424499A (en) |
WO (1) | WO1999037611A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU765417B2 (en) * | 1998-12-29 | 2003-09-18 | Lg Life Sciences Ltd. | Thrombin inhibitors |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1054886B1 (en) * | 1998-02-09 | 2002-09-04 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines as protease inhibitors, in particular as urokinase inhibitors |
EA200100882A1 (en) * | 1999-02-09 | 2002-04-25 | 3-Дименшенл Фамэсьютикэлс, Инк. | AMETHINE, METHYLAMIDINE AND GUANIDA HEAT HYDROARIAL PRODUCTS (OPTIONS) MATERIALS (OPTIONS), PHARMACEUTICAL COMPOSITION (OPTIONS), METHOD FOR INHIBING PROTEASE (OPTIONS) AND SPODA SPEEDS (OPTIONS), SPEED INHIBITION (OPTIONS) AND SPODA PRODUCTS (OPTIONS); |
JP4489976B2 (en) * | 1999-04-09 | 2010-06-23 | ビーエーエスエフ ソシエタス・ヨーロピア | Small molecule inhibitors of complement protease |
BR0009674A (en) * | 1999-04-09 | 2002-01-15 | Basf Ag | Compound, drug and compound use |
AR023510A1 (en) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | A TEAM OF PARTS, PHARMACEUTICAL FORMULATION AND USE OF A THROMBIN INHIBITOR. |
US20050154229A1 (en) * | 2002-03-22 | 2005-07-14 | Aeri Kim | Maleic acid salt of(2s)-n-{5-[amino(imino)methy]-2-thienyl}methyl-1-{(2r)-2-[(carboxymethyl)amino]-3,3-diphenylpropanoyl}-2-pyrrolidine carboxamide and a process for |
EP1487826A4 (en) * | 2002-03-22 | 2005-06-29 | Lg Life Sciences Ltd | NEW CRYSTALLINE FORMS OF (2S)-N-5-(AMINO(IMINO)METHYL)-2-THIENYLMETHYL-1-(2R)-2-((CARBOXYMETHYL)AMINO)-3,3-DIPHENYLPROPANOYL-2-PYRROLIDINECARBOXAMIDE.nH2O |
WO2004002985A1 (en) * | 2002-06-27 | 2004-01-08 | Lg Life Sciences Ltd. | Peptidic thrombin inhibitor compound |
JP4775259B2 (en) | 2004-03-31 | 2011-09-21 | 味の素株式会社 | Aniline derivative |
DE102005035250A1 (en) * | 2005-07-25 | 2007-02-01 | Archimica Gmbh | Process for the preparation of nitriles by elimination reactions |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9301916D0 (en) * | 1993-06-03 | 1993-06-03 | Ab Astra | NEW PEPTIDES DERIVATIVES |
IL112795A (en) * | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them |
DE19506610A1 (en) * | 1995-02-24 | 1996-08-29 | Basf Ag | New orally active thrombin inhibiting peptide cpds. |
DE19504504A1 (en) * | 1995-02-10 | 1996-08-14 | Basf Ag | New orally active thrombin inhibiting peptide cpds. |
NZ302649A (en) * | 1995-02-17 | 2000-01-28 | Basf Ag | Dipeptide amidine derivatives, preparation and pharmaceutical compositions thereof |
DE19632773A1 (en) * | 1996-08-14 | 1998-02-19 | Basf Ag | New thrombin inhibitors |
-
1999
- 1999-01-23 WO PCT/EP1999/000435 patent/WO1999037611A1/en not_active Application Discontinuation
- 1999-01-23 AU AU24244/99A patent/AU2424499A/en not_active Abandoned
- 1999-01-23 EP EP99903676A patent/EP1049673A1/en not_active Withdrawn
- 1999-01-23 JP JP2000528535A patent/JP2002501044A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU765417B2 (en) * | 1998-12-29 | 2003-09-18 | Lg Life Sciences Ltd. | Thrombin inhibitors |
Also Published As
Publication number | Publication date |
---|---|
EP1049673A1 (en) | 2000-11-08 |
WO1999037611A1 (en) | 1999-07-29 |
JP2002501044A (en) | 2002-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |