AU2016345668B2 - Identification of calibration deviations of pH-measuring devices - Google Patents

Identification of calibration deviations of pH-measuring devices Download PDF

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Publication number: AU2016345668B2
Authority: AU; Australia
Prior art keywords: medium; value; tank; measuring device; concentration
Prior art date: 2015-10-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

AU2016345668A

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English (en)

Other versions

AU2016345668A1 (en

Inventor

Detlef Eisenkraetzer

Katrin GREPPMAIR

Christian Klinger

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

F Hoffmann La Roche AG

Original Assignee

F Hoffmann La Roche AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-10-30

Filing date

2016-10-28

Publication date

2021-07-08

2016-10-28 Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG

2018-03-08 Publication of AU2016345668A1 publication Critical patent/AU2016345668A1/en

2021-07-08 Application granted granted Critical

2021-07-08 Publication of AU2016345668B2 publication Critical patent/AU2016345668B2/en

Status Active legal-status Critical Current

2036-10-28 Anticipated expiration legal-status Critical

Links

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Classifications

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- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
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- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D18/00—Testing or calibrating apparatus or arrangements provided for in groups G01D1/00 - G01D15/00
- G01D18/008—Testing or calibrating apparatus or arrangements provided for in groups G01D1/00 - G01D15/00 with calibration coefficients stored in memory
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/4163—Systems checking the operation of, or calibrating, the measuring apparatus
- G01N27/4165—Systems checking the operation of, or calibrating, the measuring apparatus for pH meters
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D21/00—Control of chemical or physico-chemical variables, e.g. pH value
- G05D21/02—Control of chemical or physico-chemical variables, e.g. pH value characterised by the use of electric means

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Sustainable Development (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
General Physics & Mathematics (AREA)
Physics & Mathematics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Electrochemistry (AREA)
Immunology (AREA)
Pathology (AREA)
Automation & Control Theory (AREA)
Computer Hardware Design (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Automatic Analysis And Handling Materials Therefor (AREA)
Testing Or Calibration Of Command Recording Devices (AREA)

AU2016345668A 2015-10-30 2016-10-28 Identification of calibration deviations of pH-measuring devices Active AU2016345668B2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP15192389		2015-10-30
EP15192389.3		2015-10-30
PCT/EP2016/076173 WO2017072346A1 (en)	2015-10-30	2016-10-28	Identification of calibration deviations of ph-measuring devices

Publications (2)

Publication Number	Publication Date
AU2016345668A1 AU2016345668A1 (en)	2018-03-08
AU2016345668B2 true AU2016345668B2 (en)	2021-07-08

Family

ID=54364192

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2016345668A Active AU2016345668B2 (en)	2015-10-30	2016-10-28	Identification of calibration deviations of pH-measuring devices

Country Status (16)

Country	Link
US (3)	US11371006B2 (zh)
EP (2)	EP3368653B1 (zh)
JP (1)	JP6893208B2 (zh)
KR (1)	KR102612135B1 (zh)
CN (1)	CN108368471B (zh)
AU (1)	AU2016345668B2 (zh)
BR (1)	BR112018003852B1 (zh)
CA (1)	CA2996468A1 (zh)
ES (2)	ES2808923T3 (zh)
HK (1)	HK1258706A1 (zh)
HR (2)	HRP20221081T1 (zh)
IL (1)	IL258080B (zh)
MX (1)	MX2018004248A (zh)
PL (2)	PL3368653T3 (zh)
SI (2)	SI3786278T1 (zh)
WO (1)	WO2017072346A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102019107625A1 (de) *	2018-12-20	2020-06-25	Endress+Hauser Conducta Gmbh+Co. Kg	Verfahren zur In-Prozess-Justage eines potentiometrischen Sensors einer Messanordnung
CN109856220B (zh) *	2019-03-07	2020-06-05	中南大学	一种pH值在线检测装置及其控制和校准预判方法
CN110057990B (zh) *	2019-03-08	2021-09-14	天津大学	一种多参数水质剖面仪的pH校正方法
US12031941B2 (en) *	2019-08-12	2024-07-09	Emd Millipore Corporation	Methods to automatically calibrate pH sensors without sampling
KR20230145343A (ko) *	2021-02-12	2023-10-17	바이엘 헬쓰케어 엘엘씨	세포 배양 배지의 pH를 조정하는 방법
WO2024094457A1 (en)	2022-11-02	2024-05-10	F. Hoffmann-La Roche Ag	Method for producing glycoprotein compositions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007085880A1 (en) *	2006-01-28	2007-08-02	Abb Research Ltd	A method for on-line prediction of future performance of a fermentation unit.
US20100120139A1 (en) *	2007-03-12	2010-05-13	Sanyo Electric Co., Ltd.	Incubation apparatus
US20130115588A1 (en) *	2010-04-15	2013-05-09	G & G Technologies, Inc.	Integrated bioreactor and separation system and methods of use therof
US20140141469A1 (en) *	2011-07-28	2014-05-22	Douglas P. Henderson	Methods of producing human hemoglobin in a bioreactor
US20140330398A1 (en) *	2011-10-28	2014-11-06	Siemens Aktiengesellschaft	Production Process Monitoring System And Control Method Therefor

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60141286A (ja)	1983-12-28	1985-07-26	Ajinomoto Co Inc	動物細胞の培養方法および装置
US4513280A (en)	1984-10-04	1985-04-23	The United States Of America As Represented By The Secretary Of The Navy	Method and apparatus for the detection of toxicants
JPH06174677A (ja) *	1992-12-08	1994-06-24	Meidensha Corp	酸−アルカリ滴定法におけるｐＨ計の誤差検出方法及び装置
AT401111B (de) *	1995-02-01	1996-06-25	Avl Verbrennungskraft Messtech	Verfahren zur kalibrierung eines ph-messelementes
US5578194A (en) *	1995-03-10	1996-11-26	Nova Biomedical Corporation	Calibration of electrodes
CH690251A5 (de) *	1995-11-10	2000-06-15	Hamilton Bonaduz Ag	Luftstabile pH-Standardlösungen.
EP0958499B1 (en) *	1997-01-17	2002-08-07	Metracor Technologies Inc	Method for calibrating sensors used in diagnostic testing
US6865407B2 (en)	2002-07-11	2005-03-08	Optical Sensors, Inc.	Calibration technique for non-invasive medical devices
DE10239610B3 (de) *	2002-08-29	2004-06-24	Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG	Verfahren zur Funktionsüberwachung von Sensoren
CN1238498C (zh)	2004-02-12	2006-01-25	陈志南	动物细胞无血清悬浮培养工艺过程控制参数的方法
US7771988B2 (en) *	2005-03-24	2010-08-10	Hitachi, Ltd.	Control device for fermenter
JP5136280B2 (ja) *	2007-08-24	2013-02-06	Ｔｏｔｏ株式会社	腸内状態測定装置および測定方法
US8178318B2 (en)	2008-08-06	2012-05-15	Praxair Technology, Inc.	Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield
US20120329151A1 (en) *	2009-07-06	2012-12-27	F. Hoffmann-La Roche Ag	Method of culturing eukaryotic cells
WO2012171030A2 (en) *	2011-06-10	2012-12-13	Biovest International, Inc.	Method and apparatus for antibody production and purification
JP5896105B2 (ja) *	2011-07-12	2016-03-30	横河電機株式会社	ｐＨ測定装置
WO2013041487A1 (en)	2011-09-21	2013-03-28	F. Hoffmann-La Roche Ag	Co2 profile cultivation
JP6164753B2 (ja) *	2015-03-30	2017-07-19	国立大学法人高知大学	被検溶液のｐＨ測定方法及びｐＨ測定装置

2016
- 2016-10-28 JP JP2018517832A patent/JP6893208B2/ja active Active
- 2016-10-28 CN CN201680058528.1A patent/CN108368471B/zh active Active
- 2016-10-28 CA CA2996468A patent/CA2996468A1/en active Pending
- 2016-10-28 US US15/765,222 patent/US11371006B2/en active Active
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007085880A1 (en) *	2006-01-28	2007-08-02	Abb Research Ltd	A method for on-line prediction of future performance of a fermentation unit.
US20100120139A1 (en) *	2007-03-12	2010-05-13	Sanyo Electric Co., Ltd.	Incubation apparatus
US20130115588A1 (en) *	2010-04-15	2013-05-09	G & G Technologies, Inc.	Integrated bioreactor and separation system and methods of use therof
US20140141469A1 (en) *	2011-07-28	2014-05-22	Douglas P. Henderson	Methods of producing human hemoglobin in a bioreactor
US20140330398A1 (en) *	2011-10-28	2014-11-06	Siemens Aktiengesellschaft	Production Process Monitoring System And Control Method Therefor

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MX2018004248A (es)	2018-05-15
EP3368653B1 (en)	2020-05-27
BR112018003852A2 (pt)	2018-10-02
PL3786278T3 (pl)	2022-09-19
IL258080B (en)	2021-05-31
IL258080A (en)	2018-05-31
ES2926594T3 (es)	2022-10-27
HRP20201130T1 (hr)	2020-10-30
CN108368471A (zh)	2018-08-03
EP3786278B1 (en)	2022-07-13
KR102612135B1 (ko)	2023-12-08
SI3368653T1 (sl)	2020-08-31
EP3368653A1 (en)	2018-09-05
US20180216059A1 (en)	2018-08-02
AU2016345668A1 (en)	2018-03-08
BR112018003852B1 (pt)	2021-12-14
ES2808923T3 (es)	2021-03-02
CN108368471B (zh)	2022-07-15
PL3368653T3 (pl)	2020-10-19
US20220325223A1 (en)	2022-10-13
HK1258706A1 (zh)	2019-11-15
CA2996468A1 (en)	2017-05-04
WO2017072346A1 (en)	2017-05-04
SI3786278T1 (sl)	2022-10-28
JP2018534560A (ja)	2018-11-22
US11866686B2 (en)	2024-01-09
US11371006B2 (en)	2022-06-28
JP6893208B2 (ja)	2021-06-23
EP3786278A1 (en)	2021-03-03
US20240132829A1 (en)	2024-04-25
HRP20221081T1 (hr)	2022-11-25
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Publication	Publication Date	Title
US11866686B2 (en)	2024-01-09	Identification of calibration deviations of pH-measuring devices
US11473042B2 (en)	2022-10-18	Monitoring state deviations in bioreactors
US10836991B2 (en)	2020-11-17	Systems and methods for producing bioproducts
US20220056398A1 (en)	2022-02-24	Perfusion bioreactor and related methods of use
Rhiel et al.	2002	Real‐time in situ monitoring of freely suspended and immobilized cell cultures based on mid‐infrared spectroscopic measurements
Bastidas-Oyanedel et al.	2010	Development of membrane inlet mass spectrometry for examination of fermentation processes
CN101498713B (zh)	2012-07-18	血液-气体反应监测与控制装置
US20150093775A1 (en)	2015-04-02	System and method for analyte sensing and monitoring
BR112012019814B1 (pt)	2019-09-03	método de determinação de um indicador da taxa metabólica de uma população celular
JP2010187594A (ja)	2010-09-02	培養モニタリング装置及び当該培養モニタリング装置を有する培養装置
Floris et al.	2020	Real-time characterization of mammalian cell culture bioprocesses by magnetic sector MS
Sigmon	2013	Development of High Cell Density 30 L Fed-Batch Pichia pastoris Fermentation and Optimization of in situ Methanol Probe Response for Automated Control of Recombinant Protein Expression.
CN118425257A (zh)	2024-08-02	测定厌氧发酵装置气液传质系数的方法及装置
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CN110551793A (zh)	2019-12-10	α-淀粉酶检测试剂及检测方法
Royce	1993	Structured monitoring of gas exchange in fermenters for control
Joeris et al.	2007	DEVELOPMENT OF A NEW PROBE FOR IN-SITU OXYGEN UPTAKE RATE (OUR) MEASUREMENT IN MAMMALIAN CELL CULTURE PROCESSES