AU2016304182B2 - Bicyclic heterocyclic derivatives - Google Patents
Bicyclic heterocyclic derivatives Download PDFInfo
- Publication number
- AU2016304182B2 AU2016304182B2 AU2016304182A AU2016304182A AU2016304182B2 AU 2016304182 B2 AU2016304182 B2 AU 2016304182B2 AU 2016304182 A AU2016304182 A AU 2016304182A AU 2016304182 A AU2016304182 A AU 2016304182A AU 2016304182 B2 AU2016304182 B2 AU 2016304182B2
- Authority
- AU
- Australia
- Prior art keywords
- methyl
- propan
- hydroxy
- trifluoro
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15179210 | 2015-07-31 | ||
EP15179210.8 | 2015-07-31 | ||
PCT/EP2016/001114 WO2017020981A1 (fr) | 2015-07-31 | 2016-06-30 | Dérivés hétérocycliques bicycliques |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2016304182A1 AU2016304182A1 (en) | 2018-03-15 |
AU2016304182B2 true AU2016304182B2 (en) | 2020-08-27 |
Family
ID=53765139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2016304182A Active AU2016304182B2 (en) | 2015-07-31 | 2016-06-30 | Bicyclic heterocyclic derivatives |
Country Status (9)
Country | Link |
---|---|
US (3) | US10526325B2 (fr) |
EP (1) | EP3328857B1 (fr) |
JP (1) | JP6847942B2 (fr) |
CN (1) | CN107849042B (fr) |
AU (1) | AU2016304182B2 (fr) |
CA (1) | CA2994027C (fr) |
ES (1) | ES2757052T3 (fr) |
IL (1) | IL256705B (fr) |
WO (1) | WO2017020981A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112020014177A2 (pt) * | 2018-02-01 | 2020-12-08 | Japan Tobacco, Inc. | Composto de amida heterocíclica nitrogenada, e uso do mesmo para finalidades médicas |
US20230025880A1 (en) * | 2020-03-04 | 2023-01-26 | Japan Tobacco Inc. | Fused tricyclic compound and medicinal use thereof |
TW202319051A (zh) * | 2021-09-01 | 2023-05-16 | 日商日本煙草產業股份有限公司 | 含氮三環性化合物及其醫藥用途 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015090496A1 (fr) * | 2013-12-17 | 2015-06-25 | Merck Patent Gmbh | Dérivés n1-(3,3,3-trifluoro-2-hydroxo-2-méthylpropionyl)-pipéridine en tant qu'inhibiteurs de pyruvate déshydrogénase kinase |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3423414A (en) | 1966-01-13 | 1969-01-21 | Ciba Geigy Corp | Pyrazolopyridines |
FR2748026B1 (fr) * | 1996-04-26 | 1998-06-05 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US6878712B1 (en) * | 1999-09-04 | 2005-04-12 | Astrazeneca Ab | Amides as inhibitors for pyruvate dehydrogenase |
CA2508947A1 (fr) * | 2002-12-20 | 2004-07-15 | Merck & Co., Inc. | Derives de 3-amino-4-phenylbutanoique acide utilises en tant qu'inhibiteurs de dipeptidyl peptidase pour le traitement ou la prevention du diabete |
AU2009248839B2 (en) | 2008-05-22 | 2014-04-17 | Amgen Inc. | Heterocycles as protein kinase inhibitors |
AR074797A1 (es) | 2008-10-10 | 2011-02-16 | Japan Tobacco Inc | Compuesto de fluoreno , composiciones farmaceuticas , inhibidores de pdhk y pdhk2 , metodos de tratamiento , usos de los mismos y kit comercial |
JP6062633B2 (ja) | 2009-01-28 | 2017-01-18 | カラ セラピューティクス インコーポレイテッド | 二環式ピラゾロ複素環類 |
UY32776A (es) | 2009-07-09 | 2011-02-28 | Irm Llc | Compuestos de imidazopirazinas sustituidas para el tratamiento de enfermedades parasitarias,composiciones farmacéuticas que los contienen y aplicación. |
US9556179B2 (en) | 2012-12-21 | 2017-01-31 | Bristol-Myers Squibb Company | Substituted imidazoles as casein kinase 1 D/E inhibitors |
TWI644671B (zh) * | 2013-03-14 | 2018-12-21 | 比利時商健生藥品公司 | P2x7調節劑 |
CN105916858B (zh) | 2013-12-20 | 2018-09-14 | 埃斯特韦制药股份公司 | 稠合咪唑基衍生物、其制备和作为药物的用途 |
-
2016
- 2016-06-30 US US15/748,786 patent/US10526325B2/en active Active
- 2016-06-30 ES ES16732946T patent/ES2757052T3/es active Active
- 2016-06-30 CN CN201680045062.1A patent/CN107849042B/zh active Active
- 2016-06-30 EP EP16732946.5A patent/EP3328857B1/fr active Active
- 2016-06-30 AU AU2016304182A patent/AU2016304182B2/en active Active
- 2016-06-30 CA CA2994027A patent/CA2994027C/fr active Active
- 2016-06-30 WO PCT/EP2016/001114 patent/WO2017020981A1/fr active Application Filing
- 2016-06-30 JP JP2018524530A patent/JP6847942B2/ja active Active
-
2018
- 2018-01-02 IL IL256705A patent/IL256705B/en active IP Right Grant
-
2019
- 2019-10-29 US US16/666,550 patent/US10829489B2/en active Active
-
2020
- 2020-09-17 US US17/023,782 patent/US11261185B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015090496A1 (fr) * | 2013-12-17 | 2015-06-25 | Merck Patent Gmbh | Dérivés n1-(3,3,3-trifluoro-2-hydroxo-2-méthylpropionyl)-pipéridine en tant qu'inhibiteurs de pyruvate déshydrogénase kinase |
Also Published As
Publication number | Publication date |
---|---|
US10829489B2 (en) | 2020-11-10 |
CA2994027A1 (fr) | 2017-02-09 |
IL256705A (en) | 2018-03-29 |
IL256705B (en) | 2020-01-30 |
CN107849042B (zh) | 2021-04-13 |
US20210002278A1 (en) | 2021-01-07 |
US20190010151A1 (en) | 2019-01-10 |
EP3328857B1 (fr) | 2019-08-14 |
US11261185B2 (en) | 2022-03-01 |
CA2994027C (fr) | 2023-10-10 |
CN107849042A (zh) | 2018-03-27 |
AU2016304182A1 (en) | 2018-03-15 |
JP2018522069A (ja) | 2018-08-09 |
JP6847942B2 (ja) | 2021-03-24 |
US20200062756A1 (en) | 2020-02-27 |
EP3328857A1 (fr) | 2018-06-06 |
US10526325B2 (en) | 2020-01-07 |
WO2017020981A1 (fr) | 2017-02-09 |
ES2757052T3 (es) | 2020-04-28 |
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AU2017242225B2 (en) | N1-(3,3,3-trifluoro-2-hydroxy-2-methylpropionyl)-piperidine derivatives as inhibitors of pyruvate dehydrogenase kinase | |
CA2933927C (fr) | Derives n1-(3,3,3-trifluoro-2-hydroxo-2-methylpropionyl)-piperidine en tant qu'inhibiteurs de pyruvate deshydrogenase kinase | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FGA | Letters patent sealed or granted (standard patent) |