AU2011235154B2 - Whole mouth malodor control by a combination of antibacterial and deodorizing agents - Google Patents

Whole mouth malodor control by a combination of antibacterial and deodorizing agents Download PDF

Info

Publication number: AU2011235154B2
Authority: AU; Australia
Prior art keywords: composition; odor; agent; phenyl; weight
Prior art date: 2010-04-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

AU2011235154A

Other languages

English (en)

Other versions

AU2011235154A1 (en

Inventor

Beverly D. Becker

Kristi Mckinney

Andrea L. Noland

Niranjan Ramji

Ann Gilligan Snider

Beth Hansell Statt

Lina Aurora Witte

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Procter and Gamble Co

Original Assignee

Procter and Gamble Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-04-01

Filing date

2011-03-31

Publication date

2014-06-05

2011-03-31 Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co

2012-10-25 Publication of AU2011235154A1 publication Critical patent/AU2011235154A1/en

2014-06-05 Application granted granted Critical

2014-06-05 Publication of AU2011235154B2 publication Critical patent/AU2011235154B2/en

Status Active legal-status Critical Current

2031-03-31 Anticipated expiration legal-status Critical

Links

230000001877 deodorizing effect Effects 0.000 title claims abstract description 34
230000000844 anti-bacterial effect Effects 0.000 title description 4
239000000203 mixture Substances 0.000 claims abstract description 220
239000003795 chemical substances by application Substances 0.000 claims abstract description 68
150000001875 compounds Chemical class 0.000 claims abstract description 43
239000003242 anti bacterial agent Substances 0.000 claims abstract description 25
-1 triclosan monophosphate Chemical class 0.000 claims description 86
ZRSNZINYAWTAHE-UHFFFAOYSA-N p-methoxybenzaldehyde Chemical compound COC1=CC=C(C=O)C=C1 ZRSNZINYAWTAHE-UHFFFAOYSA-N 0.000 claims description 66
WTWBUQJHJGUZCY-UHFFFAOYSA-N cuminaldehyde Chemical compound CC(C)C1=CC=C(C=O)C=C1 WTWBUQJHJGUZCY-UHFFFAOYSA-N 0.000 claims description 32
239000000796 flavoring agent Substances 0.000 claims description 32
239000000551 dentifrice Substances 0.000 claims description 31
239000002324 mouth wash Substances 0.000 claims description 30
235000019634 flavors Nutrition 0.000 claims description 24
239000004094 surface-active agent Substances 0.000 claims description 23
239000000463 material Substances 0.000 claims description 22
150000003839 salts Chemical class 0.000 claims description 21
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 20
229960001927 cetylpyridinium chloride Drugs 0.000 claims description 20
229960003500 triclosan Drugs 0.000 claims description 19
NTPLXRHDUXRPNE-UHFFFAOYSA-N 4-methoxyacetophenone Chemical compound COC1=CC=C(C(C)=O)C=C1 NTPLXRHDUXRPNE-UHFFFAOYSA-N 0.000 claims description 18
ISDBWOPVZKNQDW-UHFFFAOYSA-N 4-phenylbenzaldehyde Chemical compound C1=CC(C=O)=CC=C1C1=CC=CC=C1 ISDBWOPVZKNQDW-UHFFFAOYSA-N 0.000 claims description 18
ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 claims description 18
DDIZAANNODHTRB-UHFFFAOYSA-N methyl p-anisate Chemical compound COC(=O)C1=CC=C(OC)C=C1 DDIZAANNODHTRB-UHFFFAOYSA-N 0.000 claims description 18
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 17
XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 12
230000003472 neutralizing effect Effects 0.000 claims description 12
OJIYIVCMRYCWSE-UHFFFAOYSA-M Domiphen bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 OJIYIVCMRYCWSE-UHFFFAOYSA-M 0.000 claims description 11
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CHOMHKNFOBWRCW-UHFFFAOYSA-N 1-(4-methoxyphenyl)-2-methylpropan-1-one Chemical compound COC1=CC=C(C(=O)C(C)C)C=C1 CHOMHKNFOBWRCW-UHFFFAOYSA-N 0.000 claims description 9
JLCDSZXBELPBRD-UHFFFAOYSA-N 1-(4-methoxyphenyl)butan-1-one Chemical compound CCCC(=O)C1=CC=C(OC)C=C1 JLCDSZXBELPBRD-UHFFFAOYSA-N 0.000 claims description 9
ZEYHEAKUIGZSGI-UHFFFAOYSA-N 4-methoxybenzoic acid Chemical compound COC1=CC=C(C(O)=O)C=C1 ZEYHEAKUIGZSGI-UHFFFAOYSA-N 0.000 claims description 9
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YFVBASFBIJFBAI-UHFFFAOYSA-M 1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=CC=C1 YFVBASFBIJFBAI-UHFFFAOYSA-M 0.000 claims description 8
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IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 claims description 6
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235000019645 odor Nutrition 0.000 description 60
238000012360 testing method Methods 0.000 description 41
239000000047 product Substances 0.000 description 40
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AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
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KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 description 1
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239000004224 potassium gluconate Substances 0.000 description 1
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LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 description 1
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239000001476 sodium potassium tartrate Substances 0.000 description 1
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150000003462 sulfoxides Chemical class 0.000 description 1
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XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
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150000003512 tertiary amines Chemical class 0.000 description 1
RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
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CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
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XMLSXPIVAXONDL-UHFFFAOYSA-N trans-jasmone Natural products CCC=CCC1=C(C)CCC1=O XMLSXPIVAXONDL-UHFFFAOYSA-N 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
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235000019731 tricalcium phosphate Nutrition 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
OXAGUGIXGVHDGD-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;dihydrate Chemical compound O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O OXAGUGIXGVHDGD-UHFFFAOYSA-H 0.000 description 1
150000003672 ureas Chemical class 0.000 description 1
MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
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125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
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239000009637 wintergreen oil Substances 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000011667 zinc carbonate Substances 0.000 description 1
235000004416 zinc carbonate Nutrition 0.000 description 1
229910000010 zinc carbonate Inorganic materials 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
229960001939 zinc chloride Drugs 0.000 description 1
239000011746 zinc citrate Substances 0.000 description 1
235000006076 zinc citrate Nutrition 0.000 description 1
229940068475 zinc citrate Drugs 0.000 description 1
239000011670 zinc gluconate Substances 0.000 description 1
235000011478 zinc gluconate Nutrition 0.000 description 1
229960000306 zinc gluconate Drugs 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1
229960001296 zinc oxide Drugs 0.000 description 1
LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 description 1
229910000165 zinc phosphate Inorganic materials 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
229960001763 zinc sulfate Drugs 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1
VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 description 1
HZUKVFGMACOUEH-UHFFFAOYSA-L zinc;2-hydroxypropanoate;dihydrate Chemical compound O.O.[Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O HZUKVFGMACOUEH-UHFFFAOYSA-L 0.000 description 1
229930007845 β-thujaplicin Natural products 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Birds (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Oral & Maxillofacial Surgery (AREA)
Cosmetics (AREA)

AU2011235154A 2010-04-01 2011-03-31 Whole mouth malodor control by a combination of antibacterial and deodorizing agents Active AU2011235154B2 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US31989710P	2010-04-01	2010-04-01
US61/319,897		2010-04-01
US201161437815P	2011-01-31	2011-01-31
US61/437,815		2011-01-31
PCT/US2011/030665 WO2011123601A2 (en)	2010-04-01	2011-03-31	Whole mouth malodor control by a combination of antibacterial and deodorizing agents

Publications (2)

Publication Number	Publication Date
AU2011235154A1 AU2011235154A1 (en)	2012-10-25
AU2011235154B2 true AU2011235154B2 (en)	2014-06-05

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US (2)	US20110239736A1 (pt)
EP (1)	EP2553444B1 (pt)
CN (1)	CN103154726B (pt)
AU (1)	AU2011235154B2 (pt)
BR (1)	BR112012025099A2 (pt)
CA (1)	CA2795141C (pt)
ES (1)	ES2701018T3 (pt)
MX (1)	MX343550B (pt)
WO (1)	WO2011123601A2 (pt)

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Publication number	Priority date	Publication date	Assignee	Title
US8741275B2 (en)	2010-06-04	2014-06-03	Robetet, Inc.	Malodor neutralizing compositions comprising undecylenic acid or citric acid
US9200241B2 (en)	2011-01-27	2015-12-01	Robertet, Inc.	Malodor neutralizing compositions comprising bornyl acetate or isobornyl acetate
US9114180B2 (en) *	2012-03-30	2015-08-25	Robertet, Inc.	Malodor neutralizing compositions containing acids and alicyclic ketones
US20130315779A1 (en) *	2012-05-24	2013-11-28	Contact Marketing Solutions Innovative Technologies	Method for controlling odors associated with animal and plant byproducts
WO2014098894A1 (en) *	2012-12-21	2014-06-26	Colgate-Palmolive Company	Method for testing oral malodor
WO2014098895A1 (en) *	2012-12-21	2014-06-26	Colgate-Palmolive Company	Method for testing oral malodor
US10195124B2 (en) *	2012-12-24	2019-02-05	Colgate-Palmolive Company	Oral care composition
CA2913688C (en)	2013-07-22	2021-07-06	Nestec S.A.	Compositions and methods using p-anisaldehyde
CN103869039B (zh) *	2014-04-08	2015-11-18	福建中烟工业有限责任公司	一种同时检测香精香料中七种禁用化合物的方法
CN107074714B (zh) *	2014-11-10	2020-11-06	奇华顿股份有限公司	有机化合物中或与之相关的改进
MX2020004732A (es) *	2017-11-16	2020-08-13	Procter & Gamble	Dispositivo para demostracion de producto y metodo de este.
JP6981243B2 (ja) *	2017-12-27	2021-12-15	ライオン株式会社	歯磨剤組成物
WO2020117721A2 (en) *	2018-12-04	2020-06-11	The Procter & Gamble Company	Oral care compositions with improved tin compatability
US11857653B2 (en) *	2018-12-17	2024-01-02	Johnson & Johnson Consumer Inc.	Method of providing an oral care benefit using a poorly-soluble calcium compound and fluoride
WO2022203614A1 (en) *	2021-03-25	2022-09-29	Kwok Wannarat	Natural multifunction coenzyme q10 liquid toothpaste with antimicrobial efficacy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008005548A2 (en) *	2006-07-07	2008-01-10	The Procter & Gamble Company	Flavors for oral compositions

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3070510A (en)	1959-11-03	1962-12-25	Procter & Gamble	Dentifrice containing resinous cleaning agents
US3492131A (en)	1966-04-18	1970-01-27	Searle & Co	Peptide sweetening agents
US3538230A (en)	1966-12-05	1970-11-03	Lever Brothers Ltd	Oral compositions containing silica xerogels as cleaning and polishing agents
US3678154A (en)	1968-07-01	1972-07-18	Procter & Gamble	Oral compositions for calculus retardation
US3535421A (en)	1968-07-11	1970-10-20	Procter & Gamble	Oral compositions for calculus retardation
DE1801411A1 (de)	1968-10-05	1970-05-21	Hoechst Ag	Gerueststoffe fuer Wasch- und Reinigungsmittel
US4150052A (en)	1971-02-04	1979-04-17	Wilkinson Sword Limited	N-substituted paramenthane carboxamides
US4136163A (en)	1971-02-04	1979-01-23	Wilkinson Sword Limited	P-menthane carboxamides having a physiological cooling effect
US4178459A (en)	1971-02-04	1979-12-11	Wilkinson Sword Limited	N-Substituted paramenthane carboxamides
US4157384A (en)	1972-01-28	1979-06-05	Wilkinson Sword Limited	Compositions having a physiological cooling effect
GB1421743A (en)	1972-04-18	1976-01-21	Wilkinson Sword Ltd	Ingestible topical and other compositions
US4153679A (en)	1972-04-18	1979-05-08	Wilkinson Sword Limited	Acyclic carboxamides having a physiological cooling effect
US3959458A (en)	1973-02-09	1976-05-25	The Procter & Gamble Company	Oral compositions for calculus retardation
US3862307A (en)	1973-04-09	1975-01-21	Procter & Gamble	Dentifrices containing a cationic therapeutic agent and improved silica abrasive
US3988433A (en)	1973-08-10	1976-10-26	The Procter & Gamble Company	Oral compositions for preventing or removing stains from teeth
US4022880A (en)	1973-09-26	1977-05-10	Lever Brothers Company	Anticalculus composition
US4083955A (en)	1975-04-02	1978-04-11	The Procter & Gamble Company	Processes and compositions for remineralization of dental enamel
US4206215A (en)	1976-02-25	1980-06-03	Sterling Drug Inc.	Antimicrobial bis-[4-(substituted-amino)-1-pyridinium]alkanes
US4138477A (en)	1976-05-28	1979-02-06	Colgate Palmolive Company	Composition to control mouth odor
US4183914A (en)	1977-12-19	1980-01-15	Abdul Gaffar	Magnesium polycarboxylate complexes and anticalculus agents
US4340583A (en)	1979-05-23	1982-07-20	J. M. Huber Corporation	High fluoride compatibility dentifrice abrasives and compositions
JPS5888334A (ja)	1981-11-20	1983-05-26	Takasago Corp	３−ｌ−メントキシプロパン−１、２−ジオ−ル
US4528180A (en)	1983-03-01	1985-07-09	Schaeffer Hans A	Dental preparation, article and method for storage and delivery thereof
US4849213A (en)	1983-03-01	1989-07-18	Schaeffer Hans A	Dental preparation, article and method for storage and delivery therof
DE3418496A1 (de)	1984-05-18	1985-11-21	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von mischpolymerisaten aus vinylphosphonsaeure und (meth-)acrylsaeure in waessriger loesung und ihre verwendung
US5011913A (en)	1985-06-28	1991-04-30	The Procter & Gamble Company	Diphosphonate-derivatized macromolecules
US4627977A (en)	1985-09-13	1986-12-09	Colgate-Palmolive Company	Anticalculus oral composition
US4939284A (en)	1985-11-04	1990-07-03	The Procter & Gamble Company	Process for the manufacture of tetraalkyl ethenylidenebisphosphonate esters
US4894220A (en)	1987-01-30	1990-01-16	Colgate-Palmolive Company	Antibacterial antiplaque oral composition
US5004597A (en)	1987-09-14	1991-04-02	The Procter & Gamble Company	Oral compositions comprising stannous flouride and stannous gluconate
US4877603A (en)	1987-12-18	1989-10-31	The Procter & Gamble Company	Oral compositions
US5198220A (en)	1989-11-17	1993-03-30	The Procter & Gamble Company	Sustained release compositions for treating periodontal disease
US5009882A (en)	1990-05-21	1991-04-23	The Proctor & Gamble Company	Use of a carboxy starch polymer to inhibit plaque without tooth staining
US5292501A (en)	1990-06-25	1994-03-08	Degenhardt Charles R	Use of a carboxy-substituted polymer to inhibit plaque formation without tooth staining
US5093170A (en)	1990-06-25	1992-03-03	The Procter & Gamble Co.	Use of a carboxy-substituted polymer to inhibit plaque formation without tooth staining
US5015466A (en)	1990-06-26	1991-05-14	The Procter & Gamble Company	Anticalculus compositions using tartrate-succinates
US5213789A (en)	1990-08-02	1993-05-25	The Procter & Gamble Company	Use of a carboxy-containing copolymer to inhibit plaque formation without tooth staining
US5180577A (en)	1990-10-09	1993-01-19	Colgate-Palmolive	Stabilized bis biguanide/anionic active ingredient compositions
US5145666A (en)	1991-10-23	1992-09-08	The Proctor & Gamble Co.	Methods of reducing plaque and gingivitis with reduced staining
US5213790A (en)	1991-10-23	1993-05-25	The Procter & Gamble Co.	Methods of reducing plaque and gingivitis with reduced staining
US5281410A (en)	1991-10-23	1994-01-25	The Proctor & Gamble Company	Methods of reducing plaque and gingivitis with reduced staining
US5242910A (en)	1992-10-13	1993-09-07	The Procter & Gamble Company	Sustained release compositions for treating periodontal disease
US5603920A (en)	1994-09-26	1997-02-18	The Proctor & Gamble Company	Dentifrice compositions
US5534243A (en)	1994-09-26	1996-07-09	The Procter & Gamble Company	Aqueous oral compositions
US5578293A (en)	1994-12-06	1996-11-26	Colgate Palmolive Company	Oral compositions containing stabilized stannous compounds having antiplaque and antitartar efficacy
US5589160A (en)	1995-05-02	1996-12-31	The Procter & Gamble Company	Dentifrice compositions
US5658553A (en)	1995-05-02	1997-08-19	The Procter & Gamble Company	Dentifrice compositions
US5651958A (en)	1995-05-02	1997-07-29	The Procter & Gamble Company	Dentifrice compositions
EP0780406A3 (en)	1995-12-21	1997-08-20	Albright & Wilson Uk Ltd	Phosphonic acid polymers
GB9703951D0 (en)	1997-02-26	1997-04-16	Albright & Wilson Uk Ltd	Novel phosphino derivatives
DE60229745D1 (de)	2001-06-25	2008-12-18	Procter & Gamble	Mundpflegezusammensetzungen
US6723305B2 (en) *	2002-03-04	2004-04-20	Colgate Palmolive Company	Anti-microbial breath freshening mouthrinse
GB0303677D0 (en) *	2003-02-18	2003-03-19	Quest Int	Flavoured products
JP4786544B2 (ja)	2003-11-21	2011-10-05	ジボダンエスエー	Ｎ置換ｐ−メンタンカルボキサミド類
US20080085246A1 (en) *	2004-03-29	2008-04-10	Symrise Gmbh & Co. Kg	Use of Eugenol Acetate as an Agent Against Bad Breath
GB0517573D0 (en) *	2005-08-30	2005-10-05	Givaudan Sa	Compositions and methods to counteract oral malodour
US20080253976A1 (en)	2007-04-16	2008-10-16	Douglas Craig Scott	Personal Care Compositions Comprising An Antimicrobial Blend of Essential Oils or Constituents Thereof
BR112013016214A2 (pt) *	2010-12-23	2018-05-15	Colgate Palmolive Co	sistemas de polímero

2011
- 2011-03-31 CA CA2795141A patent/CA2795141C/en active Active
- 2011-03-31 AU AU2011235154A patent/AU2011235154B2/en active Active
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- 2011-03-31 US US13/076,802 patent/US20110239736A1/en not_active Abandoned
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2022
- 2022-04-25 US US17/728,246 patent/US20220257484A1/en active Pending

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2008005548A2 (en) *	2006-07-07	2008-01-10	The Procter & Gamble Company	Flavors for oral compositions

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EP2553444A2 (en)	2013-02-06
CA2795141C (en)	2017-08-22
MX2012011181A (es)	2012-11-06
MX343550B (es)	2016-11-08
WO2011123601A3 (en)	2013-05-16
WO2011123601A2 (en)	2011-10-06
EP2553444B1 (en)	2018-09-26
ES2701018T3 (es)	2019-02-20
CN103154726B (zh)	2015-12-09
CN103154726A (zh)	2013-06-12
BR112012025099A2 (pt)	2016-06-21
CA2795141A1 (en)	2011-10-06
AU2011235154A1 (en)	2012-10-25
US20110239736A1 (en)	2011-10-06
US20220257484A1 (en)	2022-08-18

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US11253451B2 (en)	2022-02-22	Reduction of tooth staining derived from cationic antibacterials
CA2657047C (en)	2013-11-12	Flavor oils with reduced sulfur content and use in oral care compositions
US11826452B2 (en)	2023-11-28	Reduction of tooth staining derived from cationic antimicrobials
AU2013201477B2 (en)	2015-06-18	Flavor oils with reduced sulfur content and use in oral care compositions
AU2013201769B2 (en)	2015-08-20	Flavor oils with reduced sulfur content and use in oral care compositions
AU2013201768B2 (en)	2014-10-30	Flavors for oral compositions