AU2002352447A1 - N-aroyl cyclic amine derivatives as orexin receptor antagonists - Google Patents
N-aroyl cyclic amine derivatives as orexin receptor antagonistsInfo
- Publication number
- AU2002352447A1 AU2002352447A1 AU2002352447A AU2002352447A AU2002352447A1 AU 2002352447 A1 AU2002352447 A1 AU 2002352447A1 AU 2002352447 A AU2002352447 A AU 2002352447A AU 2002352447 A AU2002352447 A AU 2002352447A AU 2002352447 A1 AU2002352447 A1 AU 2002352447A1
- Authority
- AU
- Australia
- Prior art keywords
- receptor antagonists
- cyclic amine
- amine derivatives
- orexin receptor
- aroyl cyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0130335.3 | 2001-12-19 | ||
| GB0130335A GB0130335D0 (en) | 2001-12-19 | 2001-12-19 | Compounds |
| PCT/GB2002/005773 WO2003051368A1 (en) | 2001-12-19 | 2002-12-18 | N-aroyl cyclic amine derivatives as orexin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2002352447A1 true AU2002352447A1 (en) | 2003-06-30 |
Family
ID=9927918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002352447A Abandoned AU2002352447A1 (en) | 2001-12-19 | 2002-12-18 | N-aroyl cyclic amine derivatives as orexin receptor antagonists |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2002352447A1 (en) |
| GB (1) | GB0130335D0 (en) |
| WO (1) | WO2003051368A1 (en) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60108420T2 (en) * | 2000-11-28 | 2005-12-22 | Smithkline Beecham P.L.C., Brentford | MORPHOLIN DERIVATIVES AS ANTAGONISTS OF OREXIN RECEPTORS |
| CA2498091C (en) | 2002-10-11 | 2011-03-22 | Actelion Pharmaceuticals Ltd. | Sulfonylamino-acetic acid derivatives |
| GB0225944D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| ES2533389T3 (en) | 2004-03-01 | 2015-04-09 | Actelion Pharmaceuticals Ltd. | 1,2,3,4-tetrahydroisoquinoline derivatives substituted |
| US7501395B2 (en) | 2005-04-25 | 2009-03-10 | Eisai R & D Management Co., Ltd. | Method of screening for antianxiety drugs |
| WO2008038251A2 (en) * | 2006-09-29 | 2008-04-03 | Actelion Pharmaceuticals Ltd | 3-aza-bicyclo[3.1.0]hexane derivatives |
| ES2357992T3 (en) | 2006-12-01 | 2011-05-04 | Actelion Pharmaceuticals Ltd. | DERIVATIVES OF 3-HETEROARIL (AMINO OR AMIDO) -1- (BIFENIL OR PHENYLTIAZOLIL) CARBONYLPIPERIDINE AS INHIBITORS OF THE OREXINE RECEIVER. |
| PE20081229A1 (en) | 2006-12-01 | 2008-08-28 | Merck & Co Inc | DIAZEPAM OREXIN RECEPTOR ANTAGONISTS REPLACED |
| CL2007003827A1 (en) * | 2006-12-28 | 2008-09-26 | Actelion Pharmaceuticals Ltd | COMPOUNDS DERIVED FROM N- (2-AZA-BICYCLE (3.1.0) HEX-3-ILMETIL) AMIDA; AND ITS USE TO PREVENT OR TREAT DEPRESSION, NEUROSIS, SCHIZOPHRENIA, ANXIETY, ADDICTIONS, EPILEPSY, PAIN, HEART DISEASES, AMONG OTHERS. |
| WO2008087611A2 (en) * | 2007-01-19 | 2008-07-24 | Actelion Pharmaceuticals Ltd | Pyrrolidine- and piperidine- bis-amide derivatives |
| CL2008000836A1 (en) | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Thiazolidine derivative compounds, orexin receptor antagonists; pharmaceutical composition that includes them; and its use in the treatment of emotional neurosis, severe depression, psychotic disorders, Alzheimer's, parkinson's, pain, among others. |
| DE602008002934D1 (en) * | 2007-05-14 | 2010-11-18 | Actelion Pharmaceuticals Ltd | 2-CYCLOPROPYLTHIAZOLDERIVATE |
| CA2688776A1 (en) | 2007-05-18 | 2008-11-27 | Merck & Co., Inc. | Oxo bridged diazepan orexin receptor antagonists |
| AU2008260647A1 (en) | 2007-05-23 | 2008-12-11 | Merck Sharp & Dohme Corp. | Cyclopropyl pyrrolidine orexin receptor antagonists |
| PL2152690T3 (en) | 2007-05-23 | 2012-06-29 | Merck Sharp & Dohme | Pyridyl piperidine orexin receptor antagonists |
| AR067665A1 (en) | 2007-07-27 | 2009-10-21 | Actelion Pharmaceuticals Ltd | DERIVATIVES OF TRANS-3- AZA-BICYCLE (3.1.0) HEXANO |
| ATE493386T1 (en) * | 2007-07-27 | 2011-01-15 | Actelion Pharmaceuticals Ltd | TRANS-3-AZA-BICYCLO-Ä3.1.0Ü-HEXANE DERIVATIVES |
| JP2010534647A (en) | 2007-07-27 | 2010-11-11 | アクテリオン ファーマシューティカルズ リミテッド | 2-Aza-bicyclo [3.3.0] octane derivatives |
| US8288411B2 (en) | 2007-09-24 | 2012-10-16 | Actelion Pharmaceuticals Ltd. | Pyrrolidines and piperidines as orexin receptor antagonists |
| AU2009215243A1 (en) * | 2008-02-21 | 2009-08-27 | Actelion Pharmaceuticals Ltd. | 2-aza-bicyclo[2.2.1]heptane derivatives |
| CN102459229A (en) * | 2009-04-24 | 2012-05-16 | 葛兰素集团有限公司 | 3-azabicyclo [4.1.0] heptanes used as orexin antagonists |
| AR088352A1 (en) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | ANTAGONISTS OF THE RECEIVER OF 2-PIRIDILOXI-4-NITRILE OREXINE |
| US9150566B2 (en) * | 2011-11-08 | 2015-10-06 | Actelion Pharmaceuticals Ltd. | 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-YL)picolinamide derivatives as orexin receptor antagonists |
| AU2013217323A1 (en) | 2012-02-07 | 2014-08-28 | Eolas Therapeutics, Inc. | Substituted prolines / piperidines as orexin receptor antagonists |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| ITMI20120424A1 (en) | 2012-03-19 | 2013-09-20 | Rottapharm Spa | CHEMICAL COMPOUNDS |
| EP2855453B1 (en) | 2012-06-04 | 2016-12-07 | Actelion Pharmaceuticals Ltd. | Benzimidazole-proline derivatives |
| CA2885180C (en) | 2012-10-10 | 2021-03-02 | Actelion Pharmaceuticals Ltd | Orexin receptor antagonists which are [ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives |
| CA2902135A1 (en) | 2013-03-12 | 2014-09-18 | Actelion Pharmaceuticals Ltd | Azetidine amide derivatives as orexin receptor antagonists |
| UA119151C2 (en) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | Crystalline salt form of (s)-(2-(6-chloro-7-methyl-1 h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone as orexin receptor antagonist |
| JP6496733B2 (en) | 2013-12-03 | 2019-04-03 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | (S)-(2- (6-Chloro-7-methyl-1H-benzo [D] imidazol-2-yl) -2-methylpyrrolidin-1-yl) (5-methoxy-2- (2H-1, Crystalline form of 2,3-triazol-2-yl) phenyl) methanone and its use as an orexin receptor antagonist |
| TR201815342T4 (en) | 2013-12-04 | 2018-11-21 | Idorsia Pharmaceuticals Ltd | Use of benzimidazole-proline derivatives. |
| US10221170B2 (en) | 2014-08-13 | 2019-03-05 | Eolas Therapeutics, Inc. | Difluoropyrrolidines as orexin receptor modulators |
| CR20180429A (en) | 2016-02-12 | 2018-12-05 | Astrazeneca Ab | PIPERIDINS REPLACED WITH HALO AS MODULATORS OF THE OREXINE RECEIVER |
| WO2017194548A1 (en) | 2016-05-10 | 2017-11-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
| WO2020007964A1 (en) | 2018-07-05 | 2020-01-09 | Idorsia Pharmaceuticals Ltd | 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives |
| WO2020099511A1 (en) | 2018-11-14 | 2020-05-22 | Idorsia Pharmaceuticals Ltd | Benzimidazole-2-methyl-morpholine derivatives |
| WO2023218023A1 (en) | 2022-05-13 | 2023-11-16 | Idorsia Pharmaceuticals Ltd | Thiazoloaryl-methyl substituted cyclic hydrazine-n-carboxamide derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1075478B1 (en) * | 1998-05-08 | 2003-04-16 | SmithKline Beecham plc | Phenylurea and phenylthio urea derivatives |
| CA2450922C (en) * | 2000-06-16 | 2010-02-16 | Clive Leslie Branch | Piperidines for use as orexin receptor antagonists |
| DE60108420T2 (en) * | 2000-11-28 | 2005-12-22 | Smithkline Beecham P.L.C., Brentford | MORPHOLIN DERIVATIVES AS ANTAGONISTS OF OREXIN RECEPTORS |
| IL158463A0 (en) * | 2001-05-05 | 2004-05-12 | Smithkline Beecham Plc | N-aroyl cyclic amines |
| JP2004534026A (en) * | 2001-05-05 | 2004-11-11 | スミスクライン ビーチャム パブリック リミテッド カンパニー | N-aroyl cyclic amine derivatives as orexin receptor antagonists |
-
2001
- 2001-12-19 GB GB0130335A patent/GB0130335D0/en not_active Ceased
-
2002
- 2002-12-18 WO PCT/GB2002/005773 patent/WO2003051368A1/en not_active Application Discontinuation
- 2002-12-18 AU AU2002352447A patent/AU2002352447A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| GB0130335D0 (en) | 2002-02-06 |
| WO2003051368A1 (en) | 2003-06-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2002341123A1 (en) | N-aroyl cyclic amine derivatives as orexin receptor antagonists | |
| AU2002352447A1 (en) | N-aroyl cyclic amine derivatives as orexin receptor antagonists | |
| IL159041A0 (en) | N-aroyl cyclic amine derivatives as orexin receptor antagonists | |
| WO2003002559A3 (en) | Piperidine compounds for use as orexin receptor antagonist | |
| AU2003285319A1 (en) | N-aryl acetyl cyclic amine derivatives as orexin antagonists | |
| PL356034A1 (en) | Cyclic amine compounds as ccr5 antagonists | |
| IL158463A0 (en) | N-aroyl cyclic amines | |
| AU2001280187A1 (en) | Cyclic amine derivatives | |
| AU2003241836A1 (en) | Lpa receptor antagonists | |
| HUP0301665A3 (en) | Novel benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists | |
| ZA200408335B (en) | Pyrrolidinium derivatives as antagonists of M3 muscarinic receptors. | |
| AU2003301851A1 (en) | Azacyclic compounds as orexin receptor antagonist | |
| IL160060A0 (en) | Piperidine derivatives useful as ccr5 antagonists | |
| AU2002366320A1 (en) | Lactams as tachykinin antagonists | |
| HK1073312A1 (en) | Cyclic amine compound | |
| IL137936A0 (en) | 2-arylethyl- (piperidin-4-ylmethyl) amine derivatives as muscarinic receptor antagonists | |
| PL370765A1 (en) | 4-piperidinyl alkylamine derivatives as muscarinic receptor antagonists | |
| AU2003236247A1 (en) | Bombesin antagonists | |
| PL370799A1 (en) | Aminotetralin derivatives as muscarinic receptor antagonists | |
| AU2002356369A1 (en) | Xanthine derivatives as muscarinic receptor antagonists | |
| AU2002347552A1 (en) | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists | |
| AU2002352388A1 (en) | N-aroyl cyclic amine derivatives and their use as orxin receptor antagonist | |
| EP1538142A4 (en) | Amine derivative | |
| AU2002334100A1 (en) | Azabicyclic amine derivatives as nk-1 receptor antagonists | |
| AU2002351806A1 (en) | Benzamide derivatives as antagonists of orexin receptors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |