AU2002352388A1 - N-aroyl cyclic amine derivatives and their use as orxin receptor antagonist - Google Patents

N-aroyl cyclic amine derivatives and their use as orxin receptor antagonist

Info

Publication number
AU2002352388A1
AU2002352388A1 AU2002352388A AU2002352388A AU2002352388A1 AU 2002352388 A1 AU2002352388 A1 AU 2002352388A1 AU 2002352388 A AU2002352388 A AU 2002352388A AU 2002352388 A AU2002352388 A AU 2002352388A AU 2002352388 A1 AU2002352388 A1 AU 2002352388A1
Authority
AU
Australia
Prior art keywords
orxin
receptor antagonist
cyclic amine
amine derivatives
aroyl cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002352388A
Inventor
Clive Leslie Branch
Amanda Johns
Christopher Norbert Johnson
Riccardo Novelli
Roderick Alan Porter
Rachel Elizabeth Anne Stead
Geoffrey Stemp
Kevin Thewlis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of AU2002352388A1 publication Critical patent/AU2002352388A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
AU2002352388A 2001-12-19 2002-12-13 N-aroyl cyclic amine derivatives and their use as orxin receptor antagonist Abandoned AU2002352388A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0130388.2 2001-12-19
GBGB0130388.2A GB0130388D0 (en) 2001-12-19 2001-12-19 Compounds
PCT/GB2002/005675 WO2003051871A1 (en) 2001-12-19 2002-12-13 N-aroyl cyclic amine derivatives and their use as orxin receptor antagonist

Publications (1)

Publication Number Publication Date
AU2002352388A1 true AU2002352388A1 (en) 2003-06-30

Family

ID=9927953

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002352388A Abandoned AU2002352388A1 (en) 2001-12-19 2002-12-13 N-aroyl cyclic amine derivatives and their use as orxin receptor antagonist

Country Status (3)

Country Link
AU (1) AU2002352388A1 (en)
GB (1) GB0130388D0 (en)
WO (1) WO2003051871A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0218326D0 (en) * 2002-08-07 2002-09-11 Glaxo Group Ltd Compounds
CA2498091C (en) 2002-10-11 2011-03-22 Actelion Pharmaceuticals Ltd. Sulfonylamino-acetic acid derivatives
ES2533389T3 (en) 2004-03-01 2015-04-09 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivatives substituted
US8143285B2 (en) 2005-09-06 2012-03-27 Shionogi & Co., Ltd. Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity
PL2152690T3 (en) 2007-05-23 2012-06-29 Merck Sharp & Dohme Pyridyl piperidine orexin receptor antagonists
CN102083796B (en) 2007-12-28 2013-06-05 埃科特莱茵药品有限公司 Trisubstituted 3,4-dihydro-1H-isoquinolin compound, process for its preparation, and its use
WO2017194548A1 (en) 2016-05-10 2017-11-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000047576A1 (en) * 1999-02-12 2000-08-17 Smithkline Beecham Plc Cinnamide derivatives as orexin-1 receptors antagonists
HU227811B1 (en) * 2000-03-14 2012-03-28 Actelion Pharmaceuticals Ltd 1,2,3,4-tetrahydroisquinoline derivatives, pharmaceutical compositions containing them and their preparation processes

Also Published As

Publication number Publication date
WO2003051871A1 (en) 2003-06-26
GB0130388D0 (en) 2002-02-06

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase