AU2002336172B2 - Bicyclic oxopyridine and oxopyrimidine derivatives - Google Patents
Bicyclic oxopyridine and oxopyrimidine derivatives Download PDFInfo
- Publication number
- AU2002336172B2 AU2002336172B2 AU2002336172A AU2002336172A AU2002336172B2 AU 2002336172 B2 AU2002336172 B2 AU 2002336172B2 AU 2002336172 A AU2002336172 A AU 2002336172A AU 2002336172 A AU2002336172 A AU 2002336172A AU 2002336172 B2 AU2002336172 B2 AU 2002336172B2
- Authority
- AU
- Australia
- Prior art keywords
- group
- oxo
- ethyl
- optionally substituted
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
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- Neurosurgery (AREA)
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- Hematology (AREA)
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- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0124848.3A GB0124848D0 (en) | 2001-10-16 | 2001-10-16 | Chemical compounds |
GB0124848.3 | 2001-10-16 | ||
PCT/GB2002/004680 WO2003033502A1 (en) | 2001-10-16 | 2002-10-16 | Bicyclic oxopyridine and oxopyrimidine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2002336172A1 AU2002336172A1 (en) | 2003-07-03 |
AU2002336172B2 true AU2002336172B2 (en) | 2007-09-13 |
Family
ID=9923964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002336172A Ceased AU2002336172B2 (en) | 2001-10-16 | 2002-10-16 | Bicyclic oxopyridine and oxopyrimidine derivatives |
Country Status (17)
Country | Link |
---|---|
US (1) | US7176215B2 (hu) |
EP (1) | EP1438313A1 (hu) |
JP (1) | JP2005505627A (hu) |
KR (1) | KR20040062565A (hu) |
CN (1) | CN1310921C (hu) |
AU (1) | AU2002336172B2 (hu) |
CA (1) | CA2462147A1 (hu) |
EA (1) | EA007957B1 (hu) |
GB (1) | GB0124848D0 (hu) |
HU (1) | HUP0401718A3 (hu) |
IL (1) | IL161384A0 (hu) |
MX (1) | MXPA04003450A (hu) |
NO (1) | NO20041975L (hu) |
NZ (1) | NZ532713A (hu) |
PL (1) | PL369867A1 (hu) |
WO (1) | WO2003033502A1 (hu) |
ZA (1) | ZA200402803B (hu) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
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GB0124934D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124939D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124933D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124938D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124941D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
NZ533865A (en) | 2002-02-12 | 2006-02-24 | Smithkline Beecham Corp | Nicotinamide derivates useful as p38 inhibitors |
GB0214268D0 (en) * | 2002-06-20 | 2002-07-31 | Celltech R&D Ltd | Chemical compounds |
GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
GB0218800D0 (en) * | 2002-08-13 | 2002-09-18 | Celltech R&D Ltd | Chemical compounds |
GB0222743D0 (en) * | 2002-10-01 | 2002-11-06 | Celltech R&D Ltd | Chemical compounds |
WO2004076450A1 (en) | 2003-02-27 | 2004-09-10 | J. Uriach Y Compañia S.A. | Pyrazolopyridine derivates |
GB0308185D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
ATE534649T1 (de) | 2003-05-15 | 2011-12-15 | Arqule Inc | Imidazothiazole und imidazoxazolderivative als inhibitoren von p38 |
US7119205B2 (en) * | 2003-05-16 | 2006-10-10 | Abbott Laboratories | Thienopyridones as AMPK activators for the treatment of diabetes and obesity |
CA2528603A1 (en) * | 2003-06-20 | 2004-12-29 | Celltech R & D Limited | Thienopyridone derivatives as kinase inhibitors |
AU2004249507A1 (en) * | 2003-06-20 | 2004-12-29 | Ucb Pharma S.A. | Process for preparing 3-aminothienopyridone derivatives |
EP1641804A1 (en) * | 2003-06-20 | 2006-04-05 | Celltech R & D Limited | Thienopyridone derivatives as kinase inhibitors |
CA2540881A1 (en) * | 2003-10-24 | 2005-05-12 | Celltech R & D Limited | Thieno-pyridinone derivatives as kinase inhibitors |
CA2548326A1 (en) * | 2003-12-23 | 2005-07-14 | Novartis Ag | Bicyclic heterocyclic p-38 kinase inhibitors |
GB0402138D0 (en) | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
GB0402140D0 (en) | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
GB0402137D0 (en) | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
GB0402143D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
US7829560B2 (en) | 2004-07-08 | 2010-11-09 | Arqule, Inc. | 1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase |
JP2008517064A (ja) | 2004-10-19 | 2008-05-22 | アークル インコーポレイテッド | P38mapキナーゼのイミダゾオキサゾールおよびイミダゾチアゾール阻害剤の合成 |
WO2006061642A1 (en) * | 2004-12-09 | 2006-06-15 | Xention Discovery Limited | Compounds |
DK1928454T3 (da) | 2005-05-10 | 2014-11-03 | Intermune Inc | Pyridonderivater til modulering af stress-aktiveret proteinkinasesystem |
GB0512429D0 (en) * | 2005-06-17 | 2005-07-27 | Smithkline Beecham Corp | Novel compound |
EP1960405A2 (en) * | 2005-11-23 | 2008-08-27 | Intermune, Inc. | Method of modulating stress-activated protein kinase system |
HUP0501168A3 (en) * | 2005-12-20 | 2007-10-29 | Richter Gedeon Nyrt | 2-(acyl, oxycarbonyl or aminocarbonyl)-3-phenyl-thieno[2,3-b]pyridines, process for their preparation, their use and pharmaceutical composition containing them |
WO2007072094A1 (en) * | 2005-12-20 | 2007-06-28 | Richter Gedeon Nyrt. | New compounds |
ES2301380B1 (es) | 2006-08-09 | 2009-06-08 | Laboratorios Almirall S.A. | Nuevos derivados de 1,7-naftiridina. |
ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
ES2329639B1 (es) | 2007-04-26 | 2010-09-23 | Laboratorios Almirall S.A. | Nuevos derivados de 4,8-difenilpoliazanaftaleno. |
BRPI0821349A2 (pt) * | 2007-12-21 | 2019-09-24 | Hoffmann La Roche | compostos antivirais heterocíclicos |
EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
EP2296653B1 (en) | 2008-06-03 | 2016-01-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
GB0915892D0 (en) * | 2009-09-10 | 2009-10-14 | Smithkline Beecham Corp | Compounds |
EP2322176A1 (en) | 2009-11-11 | 2011-05-18 | Almirall, S.A. | New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives |
EP2542240B1 (en) | 2010-03-01 | 2017-04-05 | Novadrug, LLC | Compositions and methods for treating viral diseases |
CN103957911A (zh) * | 2011-08-24 | 2014-07-30 | Novadrug有限责任公司 | 用于治疗病毒性疾病的组合物及方法 |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
EP3454897A4 (en) * | 2016-05-10 | 2020-01-15 | Georgia State University Research Foundation, Inc. | BICYCLIC CONDENSED PYRAZOLE DERIVATIVES FOR THE TREATMENT OF RSV |
CN116925045A (zh) * | 2020-12-15 | 2023-10-24 | 中国科学院上海药物研究所 | 甲状腺素受体β选择性激动剂化合物、其药物组合物和用途 |
Citations (1)
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WO1999064400A1 (en) * | 1998-06-12 | 1999-12-16 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF p38 |
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GR77945B (hu) * | 1982-03-30 | 1984-09-25 | Lepetit Spa | |
US5219864A (en) * | 1991-03-12 | 1993-06-15 | Kyowa Hakko Kogyo Co., Ltd. | Thienopyridine derivatives |
WO1994004504A1 (en) * | 1992-08-19 | 1994-03-03 | Otsuka Pharmaceutical Co., Ltd. | Apoptosis regulator |
JPH0776586A (ja) * | 1993-07-16 | 1995-03-20 | Yoshitomi Pharmaceut Ind Ltd | ピリジン化合物 |
DE4444815A1 (de) * | 1994-12-15 | 1996-06-20 | Merck Patent Gmbh | Thienopyridone |
JPH0959276A (ja) * | 1995-08-11 | 1997-03-04 | Kumiai Chem Ind Co Ltd | 縮合ヘテロ環誘導体及び除草剤 |
GB2350111A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives |
ES2235970T3 (es) * | 1999-10-19 | 2005-07-16 | MERCK & CO. INC. | Inhibidores de tirosina quinasa. |
EP1248624A4 (en) * | 1999-11-23 | 2003-01-22 | Smithkline Beecham Corp | 3,4-DIHYDRO- (1H) -CHIRAZOLINE-2-ONES AND THE USE THEREOF AS CSBP / P38 KINASE INHIBITORS |
AR030053A1 (es) * | 2000-03-02 | 2003-08-13 | Smithkline Beecham Corp | 1h-pirimido [4,5-d] pirimidin-2-onas y sales, composiciones farmaceuticas, uso para la fabricacion de un medicamento y procedimiento para producirlas |
AR030273A1 (es) * | 2000-03-10 | 2003-08-20 | Smithkline Beecham Corp | Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina |
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2001
- 2001-10-16 GB GBGB0124848.3A patent/GB0124848D0/en not_active Ceased
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2002
- 2002-10-16 CA CA002462147A patent/CA2462147A1/en not_active Abandoned
- 2002-10-16 EP EP02770072A patent/EP1438313A1/en not_active Withdrawn
- 2002-10-16 CN CNB02825094XA patent/CN1310921C/zh not_active Expired - Fee Related
- 2002-10-16 AU AU2002336172A patent/AU2002336172B2/en not_active Ceased
- 2002-10-16 IL IL16138402A patent/IL161384A0/xx unknown
- 2002-10-16 MX MXPA04003450A patent/MXPA04003450A/es not_active Application Discontinuation
- 2002-10-16 HU HU0401718A patent/HUP0401718A3/hu unknown
- 2002-10-16 JP JP2003536241A patent/JP2005505627A/ja not_active Abandoned
- 2002-10-16 US US10/492,466 patent/US7176215B2/en not_active Expired - Fee Related
- 2002-10-16 EA EA200400550A patent/EA007957B1/ru not_active IP Right Cessation
- 2002-10-16 WO PCT/GB2002/004680 patent/WO2003033502A1/en active IP Right Grant
- 2002-10-16 NZ NZ532713A patent/NZ532713A/en unknown
- 2002-10-16 PL PL02369867A patent/PL369867A1/xx not_active Application Discontinuation
- 2002-10-16 KR KR10-2004-7005544A patent/KR20040062565A/ko not_active Application Discontinuation
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2004
- 2004-04-13 ZA ZA200402803A patent/ZA200402803B/en unknown
- 2004-05-13 NO NO20041975A patent/NO20041975L/no not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1999064400A1 (en) * | 1998-06-12 | 1999-12-16 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF p38 |
Also Published As
Publication number | Publication date |
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US20040254200A1 (en) | 2004-12-16 |
WO2003033502A1 (en) | 2003-04-24 |
NZ532713A (en) | 2005-10-28 |
CN1604901A (zh) | 2005-04-06 |
EA200400550A1 (ru) | 2004-10-28 |
GB0124848D0 (en) | 2001-12-05 |
NO20041975D0 (no) | 2004-05-13 |
NO20041975L (no) | 2005-07-16 |
HUP0401718A2 (hu) | 2004-12-28 |
CA2462147A1 (en) | 2003-04-24 |
HUP0401718A3 (en) | 2008-07-28 |
KR20040062565A (ko) | 2004-07-07 |
MXPA04003450A (es) | 2004-07-16 |
PL369867A1 (en) | 2005-05-02 |
CN1310921C (zh) | 2007-04-18 |
EP1438313A1 (en) | 2004-07-21 |
US7176215B2 (en) | 2007-02-13 |
EA007957B1 (ru) | 2007-02-27 |
ZA200402803B (en) | 2006-06-28 |
JP2005505627A (ja) | 2005-02-24 |
IL161384A0 (en) | 2004-09-27 |
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