AU2002235543A1 - Imidazolophthalazine derivatives as ligands for gabaa receptors - Google Patents

Imidazolophthalazine derivatives as ligands for gabaa receptors

Info

Publication number
AU2002235543A1
AU2002235543A1 AU2002235543A AU3554302A AU2002235543A1 AU 2002235543 A1 AU2002235543 A1 AU 2002235543A1 AU 2002235543 A AU2002235543 A AU 2002235543A AU 3554302 A AU3554302 A AU 3554302A AU 2002235543 A1 AU2002235543 A1 AU 2002235543A1
Authority
AU
Australia
Prior art keywords
imidazolophthalazine
ligands
derivatives
gabaa receptors
gabaa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002235543A
Inventor
William Robert Carling
Tamara Ladduwahetty
Angus Murray Macleod
Austin Reeve
Francine Sternfeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Publication of AU2002235543A1 publication Critical patent/AU2002235543A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2002235543A 2000-07-17 2001-07-13 Imidazolophthalazine derivatives as ligands for gabaa receptors Abandoned AU2002235543A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0017543.0A GB0017543D0 (en) 2000-07-17 2000-07-17 Therapeutic agents
GB0017543 2000-07-17
PCT/GB2001/003166 WO2002016363A1 (en) 2000-07-17 2001-07-13 Imidazolophthalazine derivatives as ligands for gabaa receptors

Publications (1)

Publication Number Publication Date
AU2002235543A1 true AU2002235543A1 (en) 2002-03-04

Family

ID=9895826

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002235543A Abandoned AU2002235543A1 (en) 2000-07-17 2001-07-13 Imidazolophthalazine derivatives as ligands for gabaa receptors

Country Status (5)

Country Link
US (1) US6946461B2 (en)
EP (1) EP1303518A1 (en)
AU (1) AU2002235543A1 (en)
GB (1) GB0017543D0 (en)
WO (1) WO2002016363A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0128499D0 (en) * 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
AU2006227300B2 (en) * 2005-03-21 2012-02-02 Eli Lilly And Company Imidazopyridazine compounds
WO2008072682A1 (en) * 2006-12-15 2008-06-19 Daiichi Sankyo Company, Limited Imidazo[1,2-b]pyridazine derivative
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CN107344939A (en) * 2016-05-06 2017-11-14 如东赛默罗生物科技有限公司 Imidazoles [2,1-a] phthalazine derivative, its preparation method, pharmaceutical composition and purposes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA753363B (en) * 1974-05-31 1976-05-26 Aspro Nicholas Ltd Benzazine derivatives
US6013799A (en) * 1993-03-03 2000-01-11 Neurogen Corporation Certain cycloalkyl imidazopyrimides, a new class of gaba brain receptor ligands
US6297235B1 (en) * 1997-08-28 2001-10-02 Merck Sharp & Dohme Ltd. Triazolopyridazine derivatives for treating anxiety and enhancing cognition
YU43800A (en) 1998-01-21 2002-12-10 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors

Also Published As

Publication number Publication date
US20030153562A1 (en) 2003-08-14
WO2002016363A1 (en) 2002-02-28
GB0017543D0 (en) 2000-09-06
US6946461B2 (en) 2005-09-20
EP1303518A1 (en) 2003-04-23

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