AU2002224851A1 - Generation and use of dendritic cells - Google Patents
Generation and use of dendritic cellsInfo
- Publication number
- AU2002224851A1 AU2002224851A1 AU2002224851A AU2485102A AU2002224851A1 AU 2002224851 A1 AU2002224851 A1 AU 2002224851A1 AU 2002224851 A AU2002224851 A AU 2002224851A AU 2485102 A AU2485102 A AU 2485102A AU 2002224851 A1 AU2002224851 A1 AU 2002224851A1
- Authority
- AU
- Australia
- Prior art keywords
- dendritic cells
- generation
- monocytes
- cd11c
- interferon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000004443 dendritic cell Anatomy 0.000 title abstract 2
- 210000001616 monocyte Anatomy 0.000 abstract 2
- 102100022297 Integrin alpha-X Human genes 0.000 abstract 1
- 102000002227 Interferon Type I Human genes 0.000 abstract 1
- 108010014726 Interferon Type I Proteins 0.000 abstract 1
- 108010002386 Interleukin-3 Proteins 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000035800 maturation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464436—Cytokines
- A61K39/464439—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464436—Cytokines
- A61K39/464441—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
- C12N2501/056—Immunostimulating oligonucleotides, e.g. CpG
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
Abstract
The present invention relates to an in vitro method for differentiation and maturation of isolated monocytes into IL3-R+CD11c+ myeloid dendritic cells consisting of incubating the monocytes with a combination of a type I interferon and IL-3.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00870273 | 2000-11-14 | ||
EP00870273 | 2000-11-14 | ||
PCT/EP2001/013189 WO2002040646A1 (en) | 2000-11-14 | 2001-11-14 | Generation and use of dendritic cells |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002224851A1 true AU2002224851A1 (en) | 2002-05-27 |
Family
ID=8175855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002224851A Abandoned AU2002224851A1 (en) | 2000-11-14 | 2001-11-14 | Generation and use of dendritic cells |
Country Status (7)
Country | Link |
---|---|
US (1) | US7405076B2 (en) |
EP (1) | EP1334177B1 (en) |
AT (1) | ATE287945T1 (en) |
AU (1) | AU2002224851A1 (en) |
DE (1) | DE60108661T2 (en) |
ES (1) | ES2234928T3 (en) |
WO (1) | WO2002040646A1 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10231655A1 (en) * | 2002-07-12 | 2004-02-26 | Blasticon Biotechnologische Forschung Gmbh | Graft acceptance-inducing cells of monocytic origin, as well as their production and use |
US20140170116A9 (en) * | 2002-08-22 | 2014-06-19 | Marc S. Penn | Method of treating ischemic disorders |
US20050271639A1 (en) * | 2002-08-22 | 2005-12-08 | Penn Marc S | Genetically engineered cells for therapeutic applications |
FR2848565B1 (en) | 2002-12-16 | 2007-04-06 | Ets Francais Du Sang | LINE OF GEN2.2 DENDRITIC CELLS |
CA2515369C (en) * | 2003-02-06 | 2015-03-31 | Cerus Corporation | Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the listeria, and methods of use thereof |
US7695725B2 (en) | 2003-02-06 | 2010-04-13 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
AU2004224425B2 (en) * | 2003-02-06 | 2010-06-24 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
US7842289B2 (en) * | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
US8513008B2 (en) * | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
KR101243577B1 (en) * | 2004-10-07 | 2013-03-20 | 아고스 쎄라퓨틱스, 인코포레이티드 | Mature dendritic cell compositions and methods for culturing same |
DE102007006736B4 (en) | 2007-02-07 | 2012-01-12 | Dagmar Briechle | In-vitro test kit for the animal-free determination of the sensitizing potential of a substance |
AU2008338525B2 (en) * | 2007-12-14 | 2015-04-02 | Juventas Therapeutics, Inc. | Compositions and methods of promoting wound healing |
US20090259160A1 (en) * | 2008-04-10 | 2009-10-15 | Therinject, Llc | System and composition for dendritic cell therapy using pharmacologically active microcarriers |
JP5856059B2 (en) | 2009-08-28 | 2016-02-09 | ザ クリーブランド クリニック ファウンデーション | SDF-1 delivery for treating ischemic tissue |
US20120237535A1 (en) | 2009-09-11 | 2012-09-20 | Proyecto De Biomedicina Cima, S.L. | Therapeutic Compositions For The Treatment of HPV-Induced Diseases |
WO2012142597A1 (en) * | 2011-04-15 | 2012-10-18 | The Regents Of The University Of California | A method for generating potent dendritic cells |
US9273284B2 (en) | 2011-04-19 | 2016-03-01 | The Regents Of The University Of California | Method for generating potent dendritic cells |
JPWO2021100828A1 (en) * | 2019-11-19 | 2021-05-27 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL89662A (en) * | 1989-03-19 | 1997-11-20 | Interpharm Lab Ltd Kiryat Weiz | Pharmaceutical compositions comprising interferon-beta |
US7659119B2 (en) * | 1996-02-12 | 2010-02-09 | Argos Therapeutics, Inc. | Method and compositions for obtaining mature dendritic cells |
WO1998053048A1 (en) * | 1997-05-21 | 1998-11-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods and compositions for making dendritic cells from expanded populations of monocytes and for activating t cells |
-
2001
- 2001-11-14 ES ES01994661T patent/ES2234928T3/en not_active Expired - Lifetime
- 2001-11-14 EP EP01994661A patent/EP1334177B1/en not_active Expired - Lifetime
- 2001-11-14 AT AT01994661T patent/ATE287945T1/en not_active IP Right Cessation
- 2001-11-14 WO PCT/EP2001/013189 patent/WO2002040646A1/en not_active Application Discontinuation
- 2001-11-14 US US10/416,434 patent/US7405076B2/en not_active Expired - Fee Related
- 2001-11-14 AU AU2002224851A patent/AU2002224851A1/en not_active Abandoned
- 2001-11-14 DE DE60108661T patent/DE60108661T2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2002040646A1 (en) | 2002-05-23 |
EP1334177A1 (en) | 2003-08-13 |
DE60108661T2 (en) | 2006-01-05 |
ATE287945T1 (en) | 2005-02-15 |
DE60108661D1 (en) | 2005-03-03 |
ES2234928T3 (en) | 2005-07-01 |
US20040037807A1 (en) | 2004-02-26 |
US7405076B2 (en) | 2008-07-29 |
EP1334177B1 (en) | 2005-01-26 |
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