AU2001279808A1 - Novel radiotherapeutic formulations containing 224ra and a method for their production - Google Patents

Novel radiotherapeutic formulations containing 224ra and a method for their production

Info

Publication number
AU2001279808A1
AU2001279808A1 AU2001279808A AU7980801A AU2001279808A1 AU 2001279808 A1 AU2001279808 A1 AU 2001279808A1 AU 2001279808 A AU2001279808 A AU 2001279808A AU 7980801 A AU7980801 A AU 7980801A AU 2001279808 A1 AU2001279808 A1 AU 2001279808A1
Authority
AU
Australia
Prior art keywords
production
formulations containing
radiotherapeutic formulations
radionuclides
centrifugation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001279808A
Inventor
Rolf Daniels
Uwe Schwarz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Altmann Therapie GmbH and Co
Original Assignee
Altmann Therapie GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altmann Therapie GmbH and Co filed Critical Altmann Therapie GmbH and Co
Publication of AU2001279808A1 publication Critical patent/AU2001279808A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to novel radiotherapeutic formulations containing 224Ra and methods for their production. The invention discloses, in particular, radiotherapeutic formulations comprising at least one salt of the isotope 224Ra, which are characterized in that the content of other radionuclides, in particular, the respective content of certain longeval radionuclides does not exceed a specific numerical value in mBq/g. The invention also relates to a method for producing radiotherapeutic formulations of this type, which is characterized by the following steps: after at least one centrifugation of an aqueous suspension of the compound 228Th(OH)4 and optionally after the resuspension of the raw sediment obtained in said centrifugation, the precipitated 228Th(OH)4 sediment is separated. The supernatant solution of a 224Ra salt that has been obtained is subsequently subjected to sterile filtration and is then made up to the required dose. Finally, said solution is sterilized and bottled in ampoules in a manner known per se.
AU2001279808A 2000-08-21 2001-08-07 Novel radiotherapeutic formulations containing 224ra and a method for their production Abandoned AU2001279808A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10040771 2000-08-21
DE10040771A DE10040771A1 (en) 2000-08-21 2000-08-21 Novel, 224Ra-containing radiotherapeutically effective formulations and methods for their preparation
PCT/EP2001/009121 WO2002015943A2 (en) 2000-08-21 2001-08-07 Novel radiotherapeutic formulations containing 224ra and a method for their production

Publications (1)

Publication Number Publication Date
AU2001279808A1 true AU2001279808A1 (en) 2002-03-04

Family

ID=7653114

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001279808A Abandoned AU2001279808A1 (en) 2000-08-21 2001-08-07 Novel radiotherapeutic formulations containing 224ra and a method for their production

Country Status (8)

Country Link
US (1) US7887782B2 (en)
EP (1) EP1311303B1 (en)
AT (1) ATE364405T1 (en)
AU (1) AU2001279808A1 (en)
DE (2) DE10040771A1 (en)
DK (1) DK1311303T3 (en)
ES (1) ES2288973T3 (en)
WO (1) WO2002015943A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004004787A2 (en) * 2002-07-05 2004-01-15 Universite Libre De Bruxelles - Hopital Erasme Method and device for dispensing individual doses of a radiopharmaceutical solution
FR2913970B1 (en) * 2007-03-19 2009-06-12 Cogema PRODUCTION OF THORIUM 228 FROM NATURAL THORIUM SALT
RU2513206C1 (en) * 2012-10-30 2014-04-20 Леонид Асхатович Мазитов Method of separating thorium-228 and radium-224
EP3474904A1 (en) 2016-06-24 2019-05-01 Sciencons AS Preparation of 212pb labeled monoclonal antibodies
US10636536B1 (en) * 2017-02-13 2020-04-28 Radtran Llc Systems and methods for preparing tailored radioactive isotope solutions
EP3563875A1 (en) * 2018-05-04 2019-11-06 Ceské vysoké ucení technické v Praze Radium for radionuclide therapy, in combination with calcium metabolism affecting treatment
DE102021109246B3 (en) * 2021-04-13 2022-06-09 ITM Isotope Technologies Munich SE Radiopharmaceuticals to different ARTs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993538A (en) * 1976-01-27 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Production of high purity radiothallium
US4663129A (en) * 1985-01-30 1987-05-05 The United States Of America As Represented By The United States Department Of Energy Isotopic generator for bismuth-212 and lead-212 from radium
US4859431A (en) * 1986-11-10 1989-08-22 The Curators Of The University Of Missouri Rhenium generator system and its preparation and use
EP0746761A4 (en) * 1993-03-12 1997-02-26 Akzo America Inc Process for stripping radon-220 from radioactive isotope mixture
US5854968A (en) * 1997-06-09 1998-12-29 Arch Development Corporation Process and apparatus for the production of BI-213 cations

Also Published As

Publication number Publication date
ES2288973T3 (en) 2008-02-01
WO2002015943A3 (en) 2002-06-20
US7887782B2 (en) 2011-02-15
DE10040771A1 (en) 2002-03-14
ATE364405T1 (en) 2007-07-15
DK1311303T3 (en) 2007-10-15
WO2002015943A2 (en) 2002-02-28
DE50112630D1 (en) 2007-07-26
US20040028606A1 (en) 2004-02-12
EP1311303A2 (en) 2003-05-21
EP1311303B1 (en) 2007-06-13

Similar Documents

Publication Publication Date Title
PL347472A1 (en) Process for purifying human papillomavirus virus-like particles
AU2002351349A8 (en) Radioactive ion
AU2001279808A1 (en) Novel radiotherapeutic formulations containing 224ra and a method for their production
AU6095198A (en) Novel method for the isolation of polysaccharides
AU2001213184A1 (en) A process of producing polyphenolic adhesive proteins and proteins produced in accordance with the process
DE69907232D1 (en) ZEOLITES AND METHOD FOR THEIR PRODUCTION
IL150234A0 (en) Methods and compositions for the manufacture of ophthalmic lenses
ES8609312A1 (en) Method of treating liver diseases using pure silibinin
DE3462904D1 (en) Process for improving mechanical properties of epoxy resins by addition of cobalt ions
HK1054403A1 (en) Deodorized colorant of brassicaceae plant
DE69522436D1 (en) METHOD FOR PRODUCING ETHYL ALCOHOL
WO2008113792A3 (en) Production of thorium 228 starting from a natural thorium salt
HUT76450A (en) Process for clarifying vinasse
MY127111A (en) Process for producing a purified aqueous hydrogen peroxide solution
EP0316996A3 (en) Method for preparing textile treatment compositions
WO1990013632A1 (en) Process for cleaning enzyme liquid concentrates
YU57695A (en) (R)-ENANTIOMER DERIVATA DIHIDRO-2,3-BENZODIAZEPINA
US2985561A (en) Process for the producing of a substance which causes leucocytosis
ATE341562T1 (en) METHOD FOR PREPARING LH-RH DERIVATIVES
US3368867A (en) Chromatographic purification of influenza virus with brushite modified by autoclaving
CN107412318A (en) A kind of efficiency reduces the method for glycyrrhizic acid and enoxolone in liquorice flavonoids compound
TW200503777A (en) Process for producing liposome suspensions and products containing liposome suspensions produced thereby
KR930012805A (en) How to Make Glucan
NZ511028A (en) Process for the isolation of milk proteins
HUT51128A (en) Process for producing composition for reanimating, improving and strangthening growth of hair