AU2001278471A1 - Stable salts of o-acetylsalicyclic with basic amino acids - Google Patents

Stable salts of o-acetylsalicyclic with basic amino acids

Info

Publication number: AU2001278471A1
Authority: AU; Australia
Prior art keywords: acetylsalicyclic; amino acids; basic amino; stable salts; salts
Prior art date: 2000-07-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

AU2001278471A

Other versions

AU2001278471B2 (en

Inventor

Hubert Appolt

Gerhard Franckowiak

Wolfram Ledwoch

Gregor Leifker

Hans-Peter Wirges

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Bayer Schering Pharma AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-18

Filing date

2001-07-05

Publication date

2002-05-02

2000-07-18 Priority claimed from DE10034802A external-priority patent/DE10034802A1/en

2001-07-05 Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG

2002-05-02 Publication of AU2001278471A1 publication Critical patent/AU2001278471A1/en

2004-07-22 Application granted granted Critical

2004-07-22 Publication of AU2001278471B2 publication Critical patent/AU2001278471B2/en

2004-08-12 Assigned to BAYER HEALTHCARE AG reassignment BAYER HEALTHCARE AG Request for Assignment Assignors: BAYER ATKIENGESELLSCHAFT

2004-10-13 Priority to AU2004218728A priority Critical patent/AU2004218728B8/en

2009-05-14 Assigned to BAYER SCHERING PHARMA AKTIENGESELLSCHAFT reassignment BAYER SCHERING PHARMA AKTIENGESELLSCHAFT Request for Assignment Assignors: BAYER HEALTHCARE AG

2021-07-05 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

150000001413 amino acids Chemical class 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
239000011780 sodium chloride Substances 0.000 title 1

AU2001278471A 2000-07-18 2001-07-05 Stable salts of o-acetylsalicyclic with basic amino acids Ceased AU2001278471B2 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
AU2004218728A AU2004218728B8 (en)	2000-07-18	2004-10-13	Stable salts of O-acetylsalicyclic acid with basic amino acids

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10034802.5		2000-07-18
DE10034802A DE10034802A1 (en)	2000-07-18	2000-07-18	Stable salts of O-acetylsalicylic acid with basic amino acids
PCT/EP2001/007669 WO2002005782A2 (en)	2000-07-18	2001-07-05	Stable salts of o-acetylsalicyclic with basic amino acids

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2004218728A Division AU2004218728B8 (en)	2000-07-18	2004-10-13	Stable salts of O-acetylsalicyclic acid with basic amino acids

Publications (2)

Publication Number	Publication Date
AU2001278471A1 true AU2001278471A1 (en)	2002-05-02
AU2001278471B2 AU2001278471B2 (en)	2004-07-22

Family

ID=7649258

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AU2001278471A Ceased AU2001278471B2 (en)	2000-07-18	2001-07-05	Stable salts of o-acetylsalicyclic with basic amino acids
AU7847101A Pending AU7847101A (en)	2000-07-18	2001-07-05	Stable salts of o-acetylsalicyclic with basic amino acids

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AU7847101A Pending AU7847101A (en)	2000-07-18	2001-07-05	Stable salts of o-acetylsalicyclic with basic amino acids

Country Status (34)

Country	Link
US (2)	US6773724B2 (en)
EP (1)	EP1365737B1 (en)
JP (2)	JP2004507463A (en)
KR (1)	KR100773658B1 (en)
CN (1)	CN1205176C (en)
AR (1)	AR030305A1 (en)
AT (1)	ATE293589T1 (en)
AU (2)	AU2001278471B2 (en)
BR (1)	BR0112538A (en)
CA (1)	CA2416288C (en)
CR (1)	CR6888A (en)
CZ (1)	CZ300337B6 (en)
DE (2)	DE10034802A1 (en)
DK (1)	DK1365737T3 (en)
EC (1)	ECSP034437A (en)
ES (1)	ES2241849T3 (en)
GT (1)	GT200100134A (en)
HK (1)	HK1061811A1 (en)
HR (1)	HRP20030108B1 (en)
HU (1)	HUP0302053A3 (en)
IL (2)	IL153873A0 (en)
MX (1)	MXPA03000510A (en)
MY (1)	MY134521A (en)
NO (1)	NO20030222D0 (en)
PE (1)	PE20020267A1 (en)
PL (1)	PL204593B1 (en)
PT (1)	PT1365737E (en)
RS (1)	RS50329B (en)
SK (1)	SK286162B6 (en)
SV (1)	SV2002000557A (en)
TW (1)	TWI299729B (en)
UY (1)	UY26841A1 (en)
WO (1)	WO2002005782A2 (en)
ZA (1)	ZA200300469B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6346510B1 (en)	1995-10-23	2002-02-12	The Children's Medical Center Corporation	Therapeutic antiangiogenic endostatin compositions
DE10202019A1 (en) *	2002-01-18	2003-07-24	Bayer Ag	Pharmaceutical composition, useful in oral formulations for the treatment of e.g. rheumatism, neuralgia, migraine or myocardial infarction, comprises a free-flowing salt of acetylsalicylic acid and a basic amino acid
US8142810B2 (en)	2002-05-30	2012-03-27	The Procter & Gamble Company	Dietary method for modulating glucose metabolism and associated conditions and increasing longevity
DE60329167D1 (en) *	2003-05-16	2009-10-22	Cephalon France	Process for the preparation of modafinil
EP1778652A2 (en) *	2004-08-20	2007-05-02	EntreMed, Inc.	Compositions and methods comprising proteinase activated receptor antagonists
US20060166901A1 (en) *	2005-01-03	2006-07-27	Yu Ruey J	Compositions comprising O-acetylsalicyl derivatives of aminocarbohydrates and amino acids
DE102005025283A1 (en)	2005-06-02	2006-12-07	Bayer Healthcare Ag	Stable complex of salts of o-acetylsalicylic acid with basic amino acids and glycine
DE102005049293A1 (en) *	2005-10-15	2007-04-26	Bayer Healthcare Ag	Combination preparations of salts or o-acetylsalicylic acid
US20090221703A1 (en)	2006-07-09	2009-09-03	Chongxi Yu	High penetration composition and uses thereof
US20090238763A1 (en)	2006-07-09	2009-09-24	Chongxi Yu	High penetration compositions and uses thereof
JP5759672B2 (en)	2006-07-09	2015-08-05	テックフィールズバイオケムカンパニーリミテッド	Positively charged water-soluble prodrug of aspirin
AU2007354632B2 (en) *	2007-06-04	2014-06-26	Techfields Inc	Pro-drugs of NSAIAs with very high skin and membranes penetration rates and their new medicinal uses
DE102008004386A1 (en)	2008-01-14	2009-07-23	Activaero Gmbh	Use of an acetylsalicylic acid salt for the treatment of viral infections
CN101314029B (en) *	2008-06-18	2010-12-08	四川省农业科学院实验场	Acetylsalicylic peptide and preparation method thereof
US20100120727A1 (en) *	2008-11-12	2010-05-13	Kyphia Pharmaceuticals, Inc.	Eflornithine Prodrugs, Conjugates and Salts, and Methods of Use Thereof
MX362949B (en)	2008-12-04	2019-02-27	Yu Chongxi	High penetration compositions and their applications.
EA021588B1 (en) *	2009-06-25	2015-07-30	Тетра Сиа	Betain salts of acetylsalicylic acid
CN101633624B (en) *	2009-08-04	2013-05-01	蚌埠丰原医药科技发展有限公司	Preparation method of improved di-lysine-aspirin
FR2965261B1 (en) *	2009-09-30	2012-10-26	Holis Technologies	PROCESS FOR THE PREPARATION OF AN O-ACETYLSALICYLIC ACID SALT OF A BASIC AMINO ACID AND COMPOSITION OBTAINED THEREBY
FR2950625B1 (en) *	2009-09-30	2016-12-02	Holis Tech	PROCESS FOR PREPARING AN O-ACETYLSALICYL ACID SALT OF A BASIC AMINO ACID AND COMPOSITION OBTAINED
FR2973370B1 (en) *	2011-03-29	2013-05-03	Holis Technologies	LOW COST PROCESS FOR THE PREPARATION OF O-ACETYLSALICYCLIC ACID AND BASIC AMINO ACID
CN102503845A (en) *	2011-09-28	2012-06-20	广州普星药业有限公司	Preparation method of DL-lysine aspirin salt and application thereof
CA3189252A1 (en)	2012-05-16	2013-11-21	Techfields Pharma Co., Ltd.	High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions
CN102976962B (en) *	2012-11-20	2015-02-04	南京工业大学	L-ornithine-aspirin double salt and its preparation method and use
FR3021654B1 (en) *	2014-05-28	2016-06-24	Unither Pharmaceuticals	PROCESS FOR THE PREPARATION OF AN ACETYLSALICYLIC ACID SALT AND A BASIC AMINO ACID
JP7012725B2 (en) *	2016-12-23	2022-01-28	アスピエアーゲーエムベーハー	Improved synthesis of lysine glycine acetylsalicylate particles
CA3064012A1 (en)	2017-05-30	2018-12-06	Rhoshan Pharmaceuticals, Inc.	In-vial deposition of a stable, sterile and crystalline o-acetyl salicylic acid (aspirin)
WO2019026992A1 (en) *	2017-08-03	2019-02-07	参天製薬株式会社	Medicinal composition containing chlorhexidine
CN113105326A (en) *	2021-03-24	2021-07-13	海南卓华制药有限公司	Preparation method and application of aspirin lysine
CN114478287A (en) *	2021-12-31	2022-05-13	蚌埠丰原医药科技发展有限公司	Aspirin-lysine crystal form, preparation method and application
WO2023131645A1 (en)	2022-01-05	2023-07-13	Aspiair Gmbh	Improved synthesis of lysine acetylsalicylate · glycine particles

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2115060A1 (en) *	1970-11-26	1972-07-07	Metabio	Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin
ES388158A1 (en) *	1971-02-11	1974-03-16	Liade Sa Lab	Procedure for obtaining soluble salts from salicy acetyl acid. (Machine-translation by Google Translate, not legally binding)
JPS4856815A (en) *	1971-11-13	1973-08-09
JPS55127345A (en) *	1979-03-23	1980-10-02	Kyowa Hakko Kogyo Co Ltd	Preparation of acetylsalicylic acid salt
JPS5610110A (en) *	1979-07-06	1981-02-02	Green Cross Corp:The	Acetyl salicylate salt preparation for injection
JPS56113741A (en) *	1980-02-13	1981-09-07	Mitsui Toatsu Chem Inc	Preparation of crystal of acetylsalicylic acid salt
JPS5721345A (en) *	1980-07-15	1982-02-04	Mitsui Toatsu Chem Inc	Purification of acetylsalicylate salt
CS247688B1 (en) *	1984-12-22	1987-01-15	Evzen Kasafirek	Method of lysine salt with acetylsalicylid acid production
JPS632929A (en) *	1986-06-20	1988-01-07	Kao Corp	Acetylsalicylic acid drug preparation
EP0499142A3 (en) *	1991-02-09	1993-05-05	Hoechst Aktiengesellschaft	Potentiation of the antireactive-antiasthmatic effect of inhaled loop diuretics by inhaled non steroidal anti-flammatory drugs
DE4332093C2 (en) *	1993-09-22	1995-07-13	Lohmann Therapie Syst Lts	Transdermal therapeutic system with the active ingredient acetylsalicylic acid and process for its preparation

2000
- 2000-07-18 DE DE10034802A patent/DE10034802A1/en not_active Withdrawn
2001
- 2001-07-05 CN CNB018158811A patent/CN1205176C/en not_active Expired - Fee Related
- 2001-07-05 DE DE50105985T patent/DE50105985D1/en not_active Expired - Lifetime
- 2001-07-05 AU AU2001278471A patent/AU2001278471B2/en not_active Ceased
- 2001-07-05 SK SK67-2003A patent/SK286162B6/en not_active IP Right Cessation
- 2001-07-05 IL IL15387301A patent/IL153873A0/en unknown
- 2001-07-05 RS YUP-20/03A patent/RS50329B/en unknown
- 2001-07-05 EP EP01956511A patent/EP1365737B1/en not_active Expired - Lifetime
- 2001-07-05 WO PCT/EP2001/007669 patent/WO2002005782A2/en active IP Right Grant
- 2001-07-05 JP JP2002511715A patent/JP2004507463A/en active Pending
- 2001-07-05 DK DK01956511T patent/DK1365737T3/en active
- 2001-07-05 PL PL365648A patent/PL204593B1/en not_active IP Right Cessation
- 2001-07-05 AU AU7847101A patent/AU7847101A/en active Pending
- 2001-07-05 ES ES01956511T patent/ES2241849T3/en not_active Expired - Lifetime
- 2001-07-05 AT AT01956511T patent/ATE293589T1/en not_active IP Right Cessation
- 2001-07-05 KR KR1020037000713A patent/KR100773658B1/en not_active IP Right Cessation
- 2001-07-05 CZ CZ20030164A patent/CZ300337B6/en not_active IP Right Cessation
- 2001-07-05 BR BR0112538-9A patent/BR0112538A/en not_active IP Right Cessation
- 2001-07-05 MX MXPA03000510A patent/MXPA03000510A/en active IP Right Grant
- 2001-07-05 CA CA002416288A patent/CA2416288C/en not_active Expired - Fee Related
- 2001-07-05 PT PT01956511T patent/PT1365737E/en unknown
- 2001-07-05 HU HU0302053A patent/HUP0302053A3/en unknown
- 2001-07-11 GT GT200100134A patent/GT200100134A/en unknown
- 2001-07-16 MY MYPI20013365A patent/MY134521A/en unknown
- 2001-07-16 AR ARP010103378A patent/AR030305A1/en unknown
- 2001-07-16 TW TW090117276A patent/TWI299729B/en active
- 2001-07-16 UY UY26841A patent/UY26841A1/en not_active Application Discontinuation
- 2001-07-16 US US09/906,497 patent/US6773724B2/en not_active Expired - Lifetime
- 2001-07-17 PE PE2001000717A patent/PE20020267A1/en not_active Application Discontinuation
- 2001-07-17 SV SV2001000557A patent/SV2002000557A/en unknown
2003
- 2003-01-09 IL IL153873A patent/IL153873A/en not_active IP Right Cessation
- 2003-01-16 NO NO20030222A patent/NO20030222D0/en not_active Application Discontinuation
- 2003-01-17 EC EC2003004437A patent/ECSP034437A/en unknown
- 2003-01-17 ZA ZA200300469A patent/ZA200300469B/en unknown
- 2003-01-17 CR CR6888A patent/CR6888A/en unknown
- 2003-02-17 HR HR20030108A patent/HRP20030108B1/en not_active IP Right Cessation
2004
- 2004-07-07 HK HK04104934A patent/HK1061811A1/en not_active IP Right Cessation
- 2004-08-09 US US10/915,652 patent/US7449198B2/en not_active Expired - Fee Related
2012
- 2012-03-28 JP JP2012072662A patent/JP2012131824A/en active Pending

Publication	Publication Date	Title
AU2001278471A1 (en)	2002-05-02	Stable salts of o-acetylsalicyclic with basic amino acids
HK1061811A1 (en)	2004-10-08	Stable salts of o-acetylsalicyclic with basic amino acids
HUP0300299A3 (en)	2005-01-28	Composition comprising free amino acids
AU2001269503A1 (en)	2002-05-02	Amino alcohol derivatives
AU2002234645A1 (en)	2002-09-19	Amino dicarboxylic acid derivatives with pharmaceutical properties
GB0018828D0 (en)	2000-09-20	Alkyl Amino Acid Derivatives useful as pharmaceutical agents
AU2001260455A1 (en)	2001-12-03	Cyclic amino acid derivatives useful as pharmaceutical agents
AU2002224884A1 (en)	2002-06-18	Substituted anthranilic acids
AU2001267854A1 (en)	2002-03-28	Novel dicarboxylic acid derivatives
AU2002340470A1 (en)	2003-05-26	L-dopa ethyl ester salts and uses thereof
IL153166A0 (en)	2003-06-24	Beta-amino acid nitrile derivatives
AU2001268035A1 (en)	2001-10-03	Aqueous cleaning composition with controlled ph
AU2001273761A1 (en)	2002-01-14	Preparation of (r)-2-alkyl-3-phenylpropionic acids
AU2001280167A1 (en)	2002-03-13	Novel propenohydroxamic acid derivatives
IL153441A0 (en)	2003-07-06	Stable gabapentin having ph within a controlled range
AU6038601A (en)	2001-11-20	Amino acid derivatives and their use as medicines
AU2001235698A1 (en)	2001-11-08	Amino acid derivatives and use thereof as NEP, ACE and ECE inhibitors
AU5032501A (en)	2001-09-12	Use of cationic protein hydrolysates
AU3196200A (en)	2000-10-16	Beta-amino acid derivatives
AU2001235976A1 (en)	2002-07-01	An antidiabetic composition of amino acids
AU5029801A (en)	2001-09-03	Copolymers of allylphosphonium salts
AU2001236442A1 (en)	2001-07-24	Method for the purification of aryl sulfonic acids and salts
AU2001258543A1 (en)	2001-11-26	Branched amino acids
AU2001246541A1 (en)	2001-10-30	Novel alpha-sulfin- and alpha-sulfonamino acid amide derivatives
AU2003245571A1 (en)	2004-01-06	Preparation of protected amino acids