AU2001277754A1 - Proline derivatives and use thereof as drugs - Google Patents

Proline derivatives and use thereof as drugs

Info

Publication number
AU2001277754A1
AU2001277754A1 AU2001277754A AU2001277754A AU2001277754A1 AU 2001277754 A1 AU2001277754 A1 AU 2001277754A1 AU 2001277754 A AU2001277754 A AU 2001277754A AU 2001277754 A AU2001277754 A AU 2001277754A AU 2001277754 A1 AU2001277754 A1 AU 2001277754A1
Authority
AU
Australia
Prior art keywords
drugs
proline derivatives
proline
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2001277754A
Other versions
AU2001277754B2 (en
Inventor
Fumihiko Akahoshi
Yoshiharu Hayashi
Hiroshi Kitajima
Hiroshi Sakashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Priority claimed from PCT/JP2001/006906 external-priority patent/WO2002014271A1/en
Publication of AU2001277754A1 publication Critical patent/AU2001277754A1/en
Application granted granted Critical
Publication of AU2001277754B2 publication Critical patent/AU2001277754B2/en
Assigned to MITSUBISHI TANABE PHARMA CORPORATION reassignment MITSUBISHI TANABE PHARMA CORPORATION Request to Amend Deed and Register Assignors: MITSUBISHI PHARMA CORPORATION
Assigned to MITSUBISHI TANABE PHARMA CORPORATION reassignment MITSUBISHI TANABE PHARMA CORPORATION Request to Amend Deed and Register Assignors: MITSUBISHI PHARMA CORPORATION
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

AU2001277754A 2000-08-10 2001-08-10 Proline derivatives and use thereof as drugs Expired AU2001277754B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2000243217 2000-08-10
JP2000-243217 2000-08-10
JP2000400296 2000-12-28
JP2000-400296 2000-12-28
PCT/JP2001/006906 WO2002014271A1 (en) 2000-08-10 2001-08-10 Proline derivatives and use thereof as drugs

Publications (2)

Publication Number Publication Date
AU2001277754A1 true AU2001277754A1 (en) 2002-05-23
AU2001277754B2 AU2001277754B2 (en) 2005-09-29

Family

ID=26597757

Family Applications (2)

Application Number Title Priority Date Filing Date
AU7775401A Pending AU7775401A (en) 2000-08-10 2001-08-10 Proline derivatives and use thereof as drugs
AU2001277754A Expired AU2001277754B2 (en) 2000-08-10 2001-08-10 Proline derivatives and use thereof as drugs

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU7775401A Pending AU7775401A (en) 2000-08-10 2001-08-10 Proline derivatives and use thereof as drugs

Country Status (17)

Country Link
US (3) US7074794B2 (en)
EP (3) EP1308439B1 (en)
JP (1) JP4101053B2 (en)
KR (1) KR100817378B1 (en)
CN (1) CN1186322C (en)
AT (3) ATE411285T1 (en)
AU (2) AU7775401A (en)
BR (1) BRPI0113146B8 (en)
CA (1) CA2418656C (en)
DE (2) DE60136188D1 (en)
DK (1) DK1308439T3 (en)
ES (2) ES2311534T3 (en)
HU (1) HU227882B1 (en)
NO (3) NO325449B1 (en)
NZ (1) NZ524618A (en)
PT (1) PT1308439E (en)
WO (1) WO2002014271A1 (en)

Families Citing this family (183)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900226B2 (en) 2000-09-06 2005-05-31 Hoffman-La Roche Inc. Neuropeptide Y antagonists
EA007485B1 (en) * 2001-02-24 2006-10-27 Берингер Ингельхайм Фарма Гмбх Унд Ко. Кг Xanthine derivative, method for their production, pharmaceutical composition based thereon and method for their preparation
ATE395912T1 (en) 2001-03-27 2008-06-15 Merck & Co Inc DIPEPTIDYLPEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
US20040259883A1 (en) * 2001-09-14 2004-12-23 Hiroshi Sakashita Thiazolidine derivative and medicinal use thereof
US7074798B2 (en) 2002-02-25 2006-07-11 Eisai Co., Ltd Xanthine derivative and DPPIV inhibitor
HUP0200849A2 (en) 2002-03-06 2004-08-30 Sanofi-Synthelabo N-aminoacetyl-pyrrolidine-2-carbonitrile derivatives, pharmaceutical compositions containing them and process for producing them
CN1678586A (en) 2002-06-27 2005-10-05 舍林股份公司 Substituted quinoline CCR5 receptor antagonists
TW200404796A (en) * 2002-08-19 2004-04-01 Ono Pharmaceutical Co Nitrogen-containing compound
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7495005B2 (en) * 2002-08-22 2009-02-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, their preparation and their use in pharmaceutical compositions
US7569574B2 (en) 2002-08-22 2009-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Purine derivatives, the preparation thereof and their use as pharmaceutical compositions
JP2006505570A (en) 2002-10-17 2006-02-16 アムジエン・インコーポレーテツド Benzimidazole derivatives and their use as vanilloid receptor ligands
US7482337B2 (en) 2002-11-08 2009-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
DE10254304A1 (en) 2002-11-21 2004-06-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg New xanthine derivatives, their production and their use as medicines
JP2005170792A (en) * 2002-11-22 2005-06-30 Mitsubishi Pharma Corp L-proline derivative and use of the same as medicine
UY28103A1 (en) * 2002-12-03 2004-06-30 Boehringer Ingelheim Pharma NEW IMIDAZO-PIRIDINONAS REPLACED, ITS PREPARATION AND ITS EMPLOYMENT AS MEDICATIONS
US7109192B2 (en) 2002-12-03 2006-09-19 Boehringer Ingelheim Pharma Gmbh & Co Kg Substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions
WO2004069828A1 (en) * 2003-02-04 2004-08-19 Mitsubishi Pharma Corporation Piperidine compound and medicinal use thereof
CL2004000409A1 (en) 2003-03-03 2005-01-07 Vertex Pharma COMPOUNDS DERIVED FROM 2- (REPLACED CILO) -1- (AMINO OR REPLACED OXI) -CHINAZOLINE, INHIBITORS OF IONIC SODIUM AND CALCIUM VOLTAGE DEPENDENTS; PHARMACEUTICAL COMPOSITION; AND USE OF THE COMPOUND IN THE TREATMENT OF ACUTE PAIN, CHRONIC, NEU
US7713983B2 (en) 2003-03-03 2010-05-11 Vertex Pharmaceuticals Incorporated Quinazolines useful as modulators of ion channels
US7687625B2 (en) 2003-03-25 2010-03-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2004092169A1 (en) * 2003-04-18 2004-10-28 Ono Pharmaceutical Co., Ltd. Spiropiperidine compound and medicinal use thereof
KR20120035203A (en) 2003-05-05 2012-04-13 프로비오드룩 아게 Use of effectors of glutaminyl and glutamate cyclases
CN1784220B (en) 2003-05-05 2011-08-03 前体生物药物股份公司 Use of effectors of glutaminyl and glutamate cyclases
EP1624874B1 (en) * 2003-05-14 2009-11-04 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
AU2003902946A0 (en) * 2003-06-12 2003-06-26 Fujisawa Pharmaceutical Co., Ltd. Dpp-iv inhibitor
US7566707B2 (en) 2003-06-18 2009-07-28 Boehringer Ingelheim International Gmbh Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
KR100730867B1 (en) 2003-06-20 2007-06-20 에프. 호프만-라 로슈 아게 Pyrido[2,1-a]isoquinoline derivatives as dpp-iv inhibitors
US7226941B2 (en) * 2003-06-30 2007-06-05 Hif Bio, Inc. Compound for treating angiogenesis
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
CN1867560A (en) * 2003-08-13 2006-11-22 武田药品工株式会社 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors
US7205409B2 (en) 2003-09-04 2007-04-17 Abbott Laboratories Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
JP2007505121A (en) 2003-09-08 2007-03-08 武田薬品工業株式会社 Dipeptidyl peptidase inhibitor
EP2289498A1 (en) 2003-10-15 2011-03-02 Probiodrug AG Use of inhibitors of glutaminyl clyclase
ZA200603165B (en) 2003-11-03 2007-07-25 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
KR20150028829A (en) 2003-11-17 2015-03-16 노파르티스 아게 Use of dipeptidyl peptidase iv inhibitors
DE10355304A1 (en) * 2003-11-27 2005-06-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel 8- (piperazin-1-yl) and 8 - ([1,4] diazepan-1-yl) xanthines, their preparation and their use as pharmaceuticals
AU2004303604B2 (en) * 2003-12-24 2011-03-24 Prosidion Limited Heterocyclic derivatives as GPCR receptor agonists
ES2940341T3 (en) 2004-01-20 2023-05-05 Novartis Ag Formulation and direct compression process
WO2005073186A1 (en) * 2004-01-29 2005-08-11 Ono Pharmaceutical Co., Ltd. Pyrrolidine derivatives
EP1712547B1 (en) * 2004-02-05 2011-12-14 Kyorin Pharmaceutical Co., Ltd. Bicycloester derivative
KR101099206B1 (en) 2004-02-05 2011-12-27 프로비오드룩 아게 Novel Inhibitors of Glutaminyl Cyclase
EP1717225A4 (en) * 2004-02-18 2009-10-21 Kyorin Seiyaku Kk Bicyclic amide derivatives
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004009039A1 (en) 2004-02-23 2005-09-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8- [3-Amino-piperidin-1-yl] xanthines, their preparation and use as pharmaceuticals
US7514571B2 (en) * 2004-02-27 2009-04-07 Kyorin Pharmaceutical Co., Ltd. Bicyclo derivative
US7348346B2 (en) 2004-03-08 2008-03-25 Abbott Laboratories Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7393847B2 (en) 2004-03-13 2008-07-01 Boehringer Ingleheim International Gmbh Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions
CN102079743B (en) 2004-03-15 2020-08-25 武田药品工业株式会社 Dipeptidyl peptidase inhibitors
US7179809B2 (en) * 2004-04-10 2007-02-20 Boehringer Ingelheim International Gmbh 2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions
US7439370B2 (en) 2004-05-10 2008-10-21 Boehringer Ingelheim International Gmbh Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides
UA83133C2 (en) * 2004-05-12 2008-06-10 Пфайзер Продактс Інк. Proline derivatives and their use as dipeptidyl peptidase iv inhibitors, pharmaceutical composition based thereon
PT1753748E (en) 2004-05-12 2009-08-28 Pfizer Prod Inc Proline derivatives and their use as dipeptidyl peptidase iv inhibitors
FR2870538B1 (en) * 2004-05-19 2006-07-14 Servier Lab NOVEL DERIVATIVES OF PYRROLIDINES AND THIAZOLIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP2008501714A (en) * 2004-06-04 2008-01-24 武田薬品工業株式会社 Dipeptidyl peptidase inhibitor
DE102004030502A1 (en) 2004-06-24 2006-01-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel imidazoles and triazoles, their preparation and use as medicines
WO2006008644A1 (en) * 2004-07-13 2006-01-26 Pfizer Products Inc. Antidiabetic compounds
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
ATE553077T1 (en) * 2004-07-23 2012-04-15 Nuada Llc PEPTIDATE INHIBITORS
TW200616968A (en) 2004-08-27 2006-06-01 Ono Pharmaceutical Co Compound having basic substituent and application thereof
US7928107B2 (en) 2004-09-02 2011-04-19 Vertex Pharmaceuticals Incorporated Quinazolines useful as modulators of ion channels
DE102004043944A1 (en) * 2004-09-11 2006-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel 8- (3-amino-piperidin-1-yl) -7- (but-2-ynyl) -xanthines, their preparation and their use as pharmaceuticals
DE102004044221A1 (en) * 2004-09-14 2006-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg New 3-methyl-7-butynyl xanthines, their preparation and their use as pharmaceuticals
FR2876688B1 (en) * 2004-10-14 2007-03-16 Aventis Pharma Sa NEW PRODUCT, PROCESS AND INTERMEDIATES FOR PREPARING AZETIDINE DERIVATIVES
DE102004054054A1 (en) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for preparing chiral 8- (3-amino-piperidin-1-yl) -xanthines
WO2006068978A2 (en) 2004-12-21 2006-06-29 Takeda Pharmaceutial Company Limited Dipeptidyl peptidase inhibitors
WO2006073167A1 (en) * 2005-01-07 2006-07-13 Ono Pharmaceutical Co., Ltd. Pyrrolidine derivatives
DOP2006000008A (en) * 2005-01-10 2006-08-31 Arena Pharm Inc COMBINED THERAPY FOR THE TREATMENT OF DIABETES AND RELATED AFFECTIONS AND FOR THE TREATMENT OF AFFECTIONS THAT IMPROVE THROUGH AN INCREASE IN THE BLOOD CONCENTRATION OF GLP-1
NZ561489A (en) * 2005-02-18 2010-10-29 Mitsubishi Tanabe Pharma Corp Salt of proline derivative, solvate thereof, and production method thereof
DE602006014531D1 (en) * 2005-03-03 2010-07-08 Janssen Pharmaceutica Nv SUBSTITUTED OXADIAZASPIRO-Ä5.5Ü-UNDECANON DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS
ES2350647T3 (en) 2005-03-08 2011-01-25 Janssen Pharmaceutica Nv DERIVATIVES OF DIAZA-ESPIRO- [4.4] -NONANO AS AN ANTHOGONIST OF NEUROQUININS (NK1).
EP1879881A2 (en) * 2005-04-14 2008-01-23 Bristol-Myers Squibb Company Inhibitors of 11-beta hydroxysteroid dehydrogenase type i
ZA200708179B (en) 2005-04-22 2009-12-30 Alantos Pharmaceuticals Holding Inc Dipeptidyl peptidase-IV inhibitors
ES2355156T3 (en) * 2005-04-26 2011-03-23 Mitsubishi Tanabe Pharma Corporation PROFILACTIC / THERAPEUTIC AGENT FOR LOMID METABOLISM ANOMALIES.
ES2390231T3 (en) * 2005-06-03 2012-11-07 Mitsubishi Tanabe Pharma Corporation Concomitant pharmaceutical agents and their use
CA2610022A1 (en) 2005-06-06 2006-12-14 Georgetown University Compositions and methods for lipo modeling
MY152185A (en) 2005-06-10 2014-08-29 Novartis Ag Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation
TW200738701A (en) * 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
DE102005035891A1 (en) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8- (3-amino-piperidin-1-yl) -xanthines, their preparation and their use as pharmaceuticals
WO2007029629A1 (en) * 2005-09-06 2007-03-15 Shionogi & Co., Ltd. Indolecarboxylic acid derivative having pgd2 receptor antagonistic activity
DK1942898T4 (en) 2005-09-14 2014-06-02 Takeda Pharmaceutical Dipeptidyl peptidase inhibitors for the treatment of diabetes
KR101368988B1 (en) 2005-09-16 2014-02-28 다케다 야쿠힌 고교 가부시키가이샤 Dipeptidyl peptidase inhibitors
ES2407115T3 (en) 2005-11-18 2013-06-11 Ono Pharmaceutical Co., Ltd. Compound containing a basic group and its use
GB0526291D0 (en) 2005-12-23 2006-02-01 Prosidion Ltd Therapeutic method
CA2645154C (en) * 2006-03-08 2011-11-29 Kyorin Pharmaceutical Co., Ltd. Method for producing aminoacetylpyrrolidinecarbonitrile derivative and production intermediate thereof
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
AU2007229492B2 (en) 2006-03-28 2011-11-03 High Point Pharmaceuticals, Llc Benzothiazoles having histamine H3 receptor activity
PE20071221A1 (en) 2006-04-11 2007-12-14 Arena Pharm Inc GPR119 RECEPTOR AGONISTS IN METHODS TO INCREASE BONE MASS AND TO TREAT OSTEOPOROSIS AND OTHER CONDITIONS CHARACTERIZED BY LOW BONE MASS, AND COMBINED THERAPY RELATED TO THESE AGONISTS
KR101281962B1 (en) * 2006-04-11 2013-07-08 아레나 파마슈티칼스, 인크. Methods of using GPR119 receptor to identify compounds useful for increasing bone mass in an individual
TW200815351A (en) * 2006-05-02 2008-04-01 Astrazeneca Ab Novel compounds
PE20110235A1 (en) 2006-05-04 2011-04-14 Boehringer Ingelheim Int PHARMACEUTICAL COMBINATIONS INCLUDING LINAGLIPTIN AND METMORPHINE
CA2810839A1 (en) 2006-05-04 2007-11-15 Boehringer Ingelheim International Gmbh A polymorphic form of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(r)-amino-piperidin-1-yl)-xanthine
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
US8618122B2 (en) 2006-05-16 2013-12-31 Ono Pharmaceutical Co., Ltd. Compound having acidic group which may be protected, and use thereof
EP2044020B1 (en) * 2006-06-16 2011-05-04 H. Lundbeck A/S Crystalline forms of 4- [2- (4-methylphenylsulfanyl) -phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
EP2057160A1 (en) 2006-08-08 2009-05-13 Boehringer Ingelheim International GmbH Pyrrolo [3, 2 -d]pyrimidines as dpp-iv inhibitors for the treatment of diabetes mellitus
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
JPWO2008114857A1 (en) * 2007-03-22 2010-07-08 杏林製薬株式会社 Process for producing aminoacetylpyrrolidinecarbonitrile derivative
AU2008233548B2 (en) 2007-04-03 2011-12-01 Mitsubishi Tanabe Pharma Corporation Combined use of dipeptidyl peptidase IV inhibitor compound and sweetener
CL2008003653A1 (en) * 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Use of a glucopyranosyl-derived sglt inhibitor and a selected dppiv inhibitor to treat diabetes; and pharmaceutical composition.
PE20091730A1 (en) 2008-04-03 2009-12-10 Boehringer Ingelheim Int FORMULATIONS INVOLVING A DPP4 INHIBITOR
EP2108960A1 (en) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
US8236792B2 (en) * 2008-05-23 2012-08-07 Janssen Pharmaceutica Nv Substituted pyrrolidine amides as modulators of the histamine H3 receptor
UY32030A (en) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "TREATMENT FOR DIABETES IN INAPPROPRIATE PATIENTS FOR THERAPY WITH METFORMIN"
BRPI0916997A2 (en) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh DPP-4 INHIBITOR AND ITS USE
CN102119139A (en) * 2008-08-07 2011-07-06 杏林制药株式会社 Process for production of bicyclo[2.2.2]octylamine derivative
KR20110044780A (en) * 2008-08-14 2011-04-29 교린 세이야꾸 가부시키 가이샤 Stabilized pharmaceutical composition
MX2011001525A (en) 2008-08-15 2011-03-29 Boehringer Ingelheim Int Purin derivatives for use in the treatment of fab-related diseases.
CN102149407A (en) 2008-09-10 2011-08-10 贝林格尔.英格海姆国际有限公司 Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN102264228A (en) 2008-10-22 2011-11-30 默沙东公司 Novel cyclic benzimidazole derivatives useful for anti-diabetic agents
US8329914B2 (en) 2008-10-31 2012-12-11 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
BRPI0923121A2 (en) 2008-12-23 2015-08-11 Boehringer Ingelheim Int Saline forms of organic compounds
AR074990A1 (en) 2009-01-07 2011-03-02 Boehringer Ingelheim Int TREATMENT OF DIABETES IN PATIENTS WITH AN INAPPROPRIATE GLUCEMIC CONTROL THROUGH METFORMIN THERAPY
TWI466672B (en) 2009-01-29 2015-01-01 Boehringer Ingelheim Int Treatment for diabetes in paediatric patients
EP2395988A2 (en) 2009-02-13 2011-12-21 Boehringer Ingelheim International GmbH Antidiabetic medications comprising a dpp-4 inhibitor (linagliptin) optionally in combination with other antidiabetics
KR20120003906A (en) 2009-03-27 2012-01-11 교린 세이야꾸 가부시키 가이샤 Matrix-type sustained release preparation containing basic additive
AR077642A1 (en) 2009-07-09 2011-09-14 Arena Pharm Inc METABOLISM MODULATORS AND THE TREATMENT OF DISORDERS RELATED TO THE SAME
CN107115530A (en) 2009-11-27 2017-09-01 勃林格殷格翰国际有限公司 Gene diabetes mellitus type utilizes the treatment of DPP IV inhibitor such as BI 1356
ES2596324T3 (en) 2009-12-18 2017-01-05 Mitsubishi Tanabe Pharma Corporation Preparation of teneligliptin with stabilized elution
WO2011106273A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
EP2547339A1 (en) 2010-03-18 2013-01-23 Boehringer Ingelheim International GmbH Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions
AU2011237775A1 (en) 2010-04-06 2012-11-22 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
GB201006166D0 (en) * 2010-04-14 2010-05-26 Prosidion Ltd Compounds for the treatment of metabolic disorders
KR101927068B1 (en) 2010-05-05 2018-12-10 베링거 인겔하임 인터내셔날 게엠베하 Sequential Combination Therapy by the Weight Reducing Treatment Followed by the DPP-4 Inhibitor
CN102971005A (en) 2010-06-24 2013-03-13 贝林格尔.英格海姆国际有限公司 Diabetes therapy
CN103539791B (en) 2010-09-22 2017-01-11 艾尼纳制药公司 Modulators of the GPR119 receptor and the treatment of disorders related thereto
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
US20130310396A1 (en) * 2011-01-19 2013-11-21 Hongwen Zhu Thiazolidine derivatives and their therapeutic use
CA2826649C (en) 2011-02-25 2016-07-26 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
US20140018371A1 (en) 2011-04-01 2014-01-16 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145361A1 (en) 2011-04-19 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
US20140038889A1 (en) 2011-04-22 2014-02-06 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145604A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
JP5863789B2 (en) * 2011-06-01 2016-02-17 田辺三菱製薬株式会社 Method for producing pyrazole derivative
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
EP3517539B1 (en) 2011-07-15 2022-12-14 Boehringer Ingelheim International GmbH Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
CN103420981A (en) * 2012-05-21 2013-12-04 中国医学科学院药物研究所 Substituted-pyrrolidinyl-contained thiomorpholine compounds
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US20140045746A1 (en) 2012-08-02 2014-02-13 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
RU2654069C2 (en) * 2012-08-31 2018-05-16 Гленмарк Фармасьютикалс Лимитед Process for preparation of teneligliptin
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
BR112015019836A2 (en) 2013-02-22 2017-07-18 Merck Sharp & Dohme compound, pharmaceutical composition, and use of a compound
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
JP6348568B2 (en) 2013-03-15 2018-06-27 モンサント テクノロジー エルエルシー N-, C-disubstituted azoles for nematode pest control
CN104177295B (en) * 2013-05-24 2016-08-17 南京华威医药科技开发有限公司 Preparation method for Ge Lieting key intermediate 1-(3-methyl isophthalic acid-phenyl-5-pyrazolyl) piperazine
CN104211685A (en) * 2013-05-29 2014-12-17 中国医学科学院药物研究所 Thiomorpholine compounds containing substituted pyrrole alkyl groups
CN103275010A (en) * 2013-05-30 2013-09-04 上海皓元生物医药科技有限公司 Preparation method of 1-(3-methyl-1-phenyl-1H-pyrazolyl-5-yl)piperazine
CN104230917B (en) * 2013-06-24 2017-04-05 南京华威医药科技开发有限公司 A kind of hydrate and its production method of proline derivative salt
WO2015019239A1 (en) 2013-08-06 2015-02-12 Ranbaxy Laboratories Limited Process for the preparation of 1-(3-methyl-1-phenyl-1h-pyrazol-5-yl)piperazine
WO2015019238A1 (en) 2013-08-06 2015-02-12 Ranbaxy Laboratories Limited Process for the preparation of n-protected (5s)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-one
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2015063709A1 (en) 2013-10-31 2015-05-07 Ranbaxy Laboratories Limited Process for the preparation of 1-(3-methyl-1-phenyl-1h-pyrazol-5-yl)piperazine
JP6615109B2 (en) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Medical use of DPP-4 inhibitors
CN105085359A (en) * 2014-05-07 2015-11-25 中国医学科学院药物研究所 Nitrogen-containing heterocyclic substituted pyrrolidine formyl thiomorpholin DPP-IV inhibitor
CN105085358A (en) * 2014-05-07 2015-11-25 中国医学科学院药物研究所 4-substituted pyrrolidine formyl thiomorpholine DPP-IV (Dipeptidyl Peptidase IV) inhibitor
WO2015173779A1 (en) 2014-05-16 2015-11-19 Micro Labs Limited Process for the preparation of teneligliptin and its novel intermediates
CN105294673B (en) * 2014-06-18 2018-04-13 四川科伦药物研究院有限公司 A kind of hydrobromic acid replaces the synthetic method of Ge Lieting
CN104496876A (en) * 2015-01-13 2015-04-08 佛山市赛维斯医药科技有限公司 Hydroxyl diamantane amide derivative, preparation method and use thereof
CN104529858A (en) * 2015-01-13 2015-04-22 佛山市赛维斯医药科技有限公司 Derivative with halogeneated and amides and preparation method and application thereof
CN104529856A (en) * 2015-01-13 2015-04-22 佛山市赛维斯医药科技有限公司 Nitro adamantine amide derivative and preparing method and application thereof
AU2016229982B2 (en) 2015-03-09 2020-06-18 Intekrin Therapeutics, Inc. Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
JP7011596B2 (en) * 2015-12-02 2022-02-10 アストライア セラピューティクス, エルエルシー Piperidinyl nociceptin receptor compound
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
CA3022202A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
EP3558298A4 (en) 2016-12-20 2020-08-05 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
WO2018162722A1 (en) 2017-03-09 2018-09-13 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Dpp-4 inhibitors for use in treating bone fractures
BR112019020485A2 (en) 2017-04-03 2020-05-12 Coherus Biosciences, Inc. PPARY AGONIST FOR TREATMENT OF PROGRESSIVE SUPRANUCLEAR PALSY
JP7450534B2 (en) * 2017-10-19 2024-03-15 帝人ファーマ株式会社 Benzimidazole derivatives and their uses
JP6985179B2 (en) * 2018-02-27 2021-12-22 田辺三菱製薬株式会社 Method for producing proline amide compound
CN108997308A (en) * 2018-07-09 2018-12-14 西藏大学 A kind of benzimidazoles derivative and its preparation method and application
KR102494848B1 (en) 2018-10-10 2023-02-02 주식회사 파마코스텍 Crystal form I of teneligliptin ditosylate dihydrate and preparation process thereof
KR20200127480A (en) 2019-05-02 2020-11-11 연성정밀화학(주) Crystalline Forms of Teneligliptin Edisylate and Process of Preparing the Same
US20240101549A1 (en) 2020-12-17 2024-03-28 Astrazeneca Ab N-(2-(4-cyanothiazolidin-3-yl)-2-oxoethyl)-quinoline-4-carboxamides
WO2023002011A1 (en) * 2021-07-23 2023-01-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) Gram-negative bacteria efflux pump inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111785A0 (en) * 1993-12-03 1995-01-24 Ferring Bv Dp-iv inhibitors and pharmaceutical compositions containing them
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
DE19823831A1 (en) * 1998-05-28 1999-12-02 Probiodrug Ges Fuer Arzneim New pharmaceutical use of isoleucyl thiazolidide and its salts
US6399629B1 (en) * 1998-06-01 2002-06-04 Microcide Pharmaceuticals, Inc. Efflux pump inhibitors
JP2000243217A (en) 1999-02-23 2000-09-08 Matsushita Electric Works Ltd Semiconductor diamond electron emitting element
EP1200422A2 (en) * 2000-02-05 2002-05-02 Vertex Pharmaceuticals Incorporated Pyrazole compositions useful as inhibitors of erk
US6495582B1 (en) * 2000-09-15 2002-12-17 Vertex Pharmaceuticals Incorporated Isoxazole compositions useful as inhibitors of ERK

Similar Documents

Publication Publication Date Title
AU2001277754A1 (en) Proline derivatives and use thereof as drugs
HUP0300746A3 (en) Proline derivatives and use thereof as drugs
AU2001277741A1 (en) 2-aminopyridine compounds and use thereof as drugs
AU2001264313A1 (en) Pyrazolopyridine compounds and use thereof as drugs
PT1296974E (en) 2-cyanopyrrolidine derivatives and their use as medicaments
AU2002225356A1 (en) Glucopyranosyloxypyrazole derivatives and use thereof in medicines
AU2001290257A1 (en) Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same
AU2001290257A2 (en) Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same
AU2002226486A1 (en) Novel c-glycoside derivatives and use thereof
AU2002306269A1 (en) N-arylphenylacetamide derivatives and pharmaceutical composition containing the same
AU8198901A (en) Novel heteroaryl derivatives and use thereof as medicaments
AU7240201A (en) Aza- and polyazanthranyl amides and their use as medicaments
AU2002226487A1 (en) Novel c-glycoside derivatives and use thereof
AU5326100A (en) Pharmaceutical compositions and methods for use
AU2001245316A1 (en) Naphtalene derivatives and their pharmaceutical use
AU2001289758A1 (en) Novel indole derivatives and their use as medicaments
AU8975801A (en) Novel indole derivatives and their use as medicaments
AU2002218502A1 (en) Lactam compounds and medicinal use thereof
AU2002308891A1 (en) Novel heterocyclic derivatives and medicinal use thereof
AU2001227084A1 (en) N-arylhydrazide compounds and use thereof as drugs
AU4432001A (en) Trityl-type compounds and their use
AU3192500A (en) Substituted proline derivatives and medicinal compositions containing the same
AU2001243601A1 (en) Caprolactam derivatives and uses thereof
AU2001284084A1 (en) Polyfluoroalkyltriazole derivatives, preparation and therapeutic use thereof
AU2002308105A1 (en) Benzoaxathiepin derivatives and their use as medicines