AR077642A1 - METABOLISM MODULATORS AND THE TREATMENT OF DISORDERS RELATED TO THE SAME - Google Patents

METABOLISM MODULATORS AND THE TREATMENT OF DISORDERS RELATED TO THE SAME

Info

Publication number
AR077642A1
AR077642A1 ARP100102446A ARP100102446A AR077642A1 AR 077642 A1 AR077642 A1 AR 077642A1 AR P100102446 A ARP100102446 A AR P100102446A AR P100102446 A ARP100102446 A AR P100102446A AR 077642 A1 AR077642 A1 AR 077642A1
Authority
AR
Argentina
Prior art keywords
disorders related
treatment
same
metabolism modulators
metabolism
Prior art date
Application number
ARP100102446A
Other languages
Spanish (es)
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of AR077642A1 publication Critical patent/AR077642A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Composicion farmacéutica de N-(2-fluoro-4-(metilsulfonil)fenil)-5-metil-6-(1-(5-metilpirazin-2-il)piperidin-4-iloxi)pirimidin-4-amina, utiles en el tratamiento de trastornos relacionados con GPR119, tales como trastornos relacionados con el metabolismo y complicaciones de los mismos, tales como la diabetes y la obesidad. Reivindicacion 1: Un compuesto seleccionado del compuesto de formula (1) y sales, solvatos e hidratos farmacéuticamente aceptables del mismo.Pharmaceutical composition of N- (2-fluoro-4- (methylsulfonyl) phenyl) -5-methyl-6- (1- (5-methylpyrazin-2-yl) piperidin-4-yloxy) pyrimidin-4-amine, useful in the treatment of disorders related to GPR119, such as disorders related to metabolism and complications thereof, such as diabetes and obesity. Claim 1: A compound selected from the compound of formula (1) and pharmaceutically acceptable salts, solvates and hydrates thereof.

ARP100102446A 2009-07-09 2010-07-07 METABOLISM MODULATORS AND THE TREATMENT OF DISORDERS RELATED TO THE SAME AR077642A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27050209P 2009-07-09 2009-07-09

Publications (1)

Publication Number Publication Date
AR077642A1 true AR077642A1 (en) 2011-09-14

Family

ID=42751753

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102446A AR077642A1 (en) 2009-07-09 2010-07-07 METABOLISM MODULATORS AND THE TREATMENT OF DISORDERS RELATED TO THE SAME

Country Status (3)

Country Link
AR (1) AR077642A1 (en)
TW (1) TW201105327A (en)
WO (1) WO2011005929A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG182004A1 (en) 2003-01-14 2012-07-30 Arena Pharm Inc 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
SG188548A1 (en) 2010-09-22 2013-04-30 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
CN103619334A (en) * 2011-01-19 2014-03-05 朱红文 Thiazolidine derivatives and therapeutic use thereof
EP2718279B1 (en) 2011-06-09 2016-08-10 Rhizen Pharmaceuticals SA Novel compounds as modulators of gpr-119
ES2759010T3 (en) 2012-06-12 2020-05-07 Chong Kun Dang Pharmaceutical Corp Piperidine derivatives as GPR119 agonists
CA2878625A1 (en) 2012-07-11 2014-01-16 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
US9096641B2 (en) 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists
PT3074384T (en) 2013-11-26 2019-07-10 Chong Kun Dang Pharmaceutical Corp Amide derivatives for gpr119 agonist
MX2017008925A (en) 2015-01-06 2017-10-11 Arena Pharm Inc Methods of treating conditions related to the s1p1 receptor.
KR102603199B1 (en) 2015-06-22 2023-11-16 아레나 파마슈티칼스, 인크. (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta for use in S1P1 receptor-related disorders [Ｂ]Indole-3-yl)crystalline L-arginine salt of acetic acid (Compound 1)
WO2018151873A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis

Family Cites Families (233)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD296075A5 (en) 1989-08-07 1991-11-21 Martin-Luther-Universitaet Halle-Wittenberg,De PROCESS FOR THE PREPARATION OF NEW INHIBITORS OF DIPEPTIDYL PEPTIDASE IV
WO1991016339A1 (en) 1990-04-14 1991-10-31 New England Medical Center Hospitals, Inc. Inhibitors of dipeptidyl-aminopeptidase type iv
DE69233671T2 (en) 1991-10-22 2007-10-18 New England Medical Center Hospitals, Inc., Boston Inhibitors of dipeptidyl aminopeptidase type IV
MX9206628A (en) 1991-11-22 1993-05-01 Boehringer Ingelheim Pharma PROLINABORONATE ESTER AND METHOD FOR ITS PREPARATION.
DE4208254A1 (en) * 1992-03-14 1993-09-16 Hoechst Ag SUBSTITUTED PYRIMIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A PEST CONTROL AND FUNGICIDE
IL111785A0 (en) 1993-12-03 1995-01-24 Ferring Bv Dp-iv inhibitors and pharmaceutical compositions containing them
US5543396A (en) 1994-04-28 1996-08-06 Georgia Tech Research Corp. Proline phosphonate derivatives
DE122010000020I1 (en) 1996-04-25 2010-07-08 Prosidion Ltd Method for lowering the blood glucose level in mammals
US20020006899A1 (en) 1998-10-06 2002-01-17 Pospisilik Andrew J. Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
JPH1081666A (en) 1996-06-12 1998-03-31 Ishihara Sangyo Kaisha Ltd Phthalimide derivative or salt thereof, its production and medicinal composition containing the same
AU4721897A (en) 1996-10-25 1998-05-22 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline derivatives
JPH10182613A (en) 1996-10-25 1998-07-07 Tanabe Seiyaku Co Ltd Tetraphydroisoquinoline derivative
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
US6100234A (en) 1997-05-07 2000-08-08 Tufts University Treatment of HIV
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
ES2285785T3 (en) 1997-09-29 2007-11-16 Point Therapeutics, Inc. STIMULATION OF IN VITRO HEMATOPOYETIC CELLS.
CA2310400C (en) 1997-11-18 2008-02-19 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Novel physiologically active substance sulphostin, process for producing the same, and use thereof
DE04029691T1 (en) 1998-02-02 2007-11-08 Trustees Of Tufts College, Medford Use of dipetidylpeptidase inhibitors to regulate glucose metabolism
AU770319C (en) 1998-05-04 2004-11-25 Point Therapeutics, Inc. Hematopoietic stimulation
DE19823831A1 (en) 1998-05-28 1999-12-02 Probiodrug Ges Fuer Arzneim New pharmaceutical use of isoleucyl thiazolidide and its salts
ES2189423T3 (en) 1998-06-05 2003-07-01 Point Therapeutics Inc BOROPROLINE CYCLING COMPOUNDS.
DE19828113A1 (en) 1998-06-24 2000-01-05 Probiodrug Ges Fuer Arzneim Prodrugs of Dipeptidyl Peptidase IV Inhibitors
DE19834591A1 (en) 1998-07-31 2000-02-03 Probiodrug Ges Fuer Arzneim Use of substances that decrease the activity of dipeptidyl peptidase IV to increase blood sugar levels, e.g. for treating hypoglycemia
AU5480199A (en) 1998-08-21 2000-03-14 Point Therapeutics, Inc. Regulation of substrate activity
US6410508B1 (en) 1998-10-07 2002-06-25 Med College Georgia Res Inst Glucose-dependent insulinotropic peptide for use as an osteotropic hormone
US6242422B1 (en) 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
EP2295572A1 (en) 1998-11-20 2011-03-16 Arena Pharmaceuticals, Inc. Human orphan G protein-coupled receptors
CO5150173A1 (en) 1998-12-10 2002-04-29 Novartis Ag COMPOUNDS N- (REPLACED GLYCLE) -2-DIPEPTIDYL-IV PEPTIDASE INHIBITING CYANOPIRROLIDINS (DPP-IV) WHICH ARE EFFECTIVE IN THE TREATMENT OF CONDITIONS MEDIATED BY DPP-IV INHIBITION
JP2000191616A (en) 1998-12-24 2000-07-11 Senju Pharmaceut Co Ltd New peptidylaldehyde derivative and medicine containing the same
GB9906714D0 (en) 1999-03-23 1999-05-19 Ferring Bv Compositions for improving fertility
GB9906715D0 (en) 1999-03-23 1999-05-19 Ferring Bv Compositions for promoting growth
JP4121215B2 (en) 1999-05-17 2008-07-23 財団法人微生物化学研究会 Sulfostin analog, and method for producing sulfostine and its analog
WO2000071135A1 (en) 1999-05-25 2000-11-30 Point Therapeutics, Inc. Anti-tumor comprising boroproline compounds
US6617340B1 (en) 1999-07-29 2003-09-09 Novartis Ag N-(substituted glycyl)-pyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
CA2390231A1 (en) 1999-11-12 2001-05-17 Paul Jackson Dipeptidyl peptidase iv inhibitors and methods of making and using dipeptidyl peptidase iv inhibitors
US6380398B2 (en) 2000-01-04 2002-04-30 Novo Nordisk A/S Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV
BRPI0107715B8 (en) 2000-01-21 2021-05-25 Novartis Ag pharmaceutical product comprising an inhibitor of dipeptidyl peptidase-iv and metformin, as well as uses of said pharmaceutical product and inhibitor of dipeptidyl peptidase-iv
JP2003520849A (en) 2000-01-24 2003-07-08 ノボ ノルディスク アクティーゼルスカブ N-substituted 2-cyanopyrroles and -pyrrolines which are inhibitors of the enzyme DPP-IV
US6395767B2 (en) 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
GB0010183D0 (en) 2000-04-26 2000-06-14 Ferring Bv Inhibitors of dipeptidyl peptidase IV
GB0010188D0 (en) 2000-04-26 2000-06-14 Ferring Bv Inhibitors of dipeptidyl peptidase IV
US6432969B1 (en) 2000-06-13 2002-08-13 Novartis Ag N-(substituted glycyl)-2 cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
TW583185B (en) 2000-06-13 2004-04-11 Novartis Ag N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same
GB0014969D0 (en) 2000-06-19 2000-08-09 Smithkline Beecham Plc Novel method of treatment
EP1301187B1 (en) 2000-07-04 2005-07-06 Novo Nordisk A/S Purine-2,6-diones which are inhibitors of the enzyme dipeptidyl peptidase iv (dpp-iv)
NZ524618A (en) 2000-08-10 2004-08-27 Mitsubishi Pharma Corp Proline derivatives and use thereof as drugs
JP4329291B2 (en) 2000-10-06 2009-09-09 田辺三菱製薬株式会社 Nitrogen-containing five-membered ring compounds
JP2004035574A (en) 2000-10-06 2004-02-05 Tanabe Seiyaku Co Ltd Aliphatic nitrogenous five-membered ring compound
NZ525630A (en) 2000-10-06 2004-10-29 Tanabe Seiyaku Co Nitrogen-containing 5-membered ring compound used as dipeptidylpeptidase IV (DPPIV) inhibitor
JP4329290B2 (en) 2000-10-06 2009-09-09 田辺三菱製薬株式会社 Aliphatic nitrogen-containing five-membered ring compounds
AUPR107800A0 (en) 2000-10-27 2000-11-23 University Of Sydney, The Peptide and nucleic acid molecule ii
TWI243162B (en) 2000-11-10 2005-11-11 Taisho Pharmaceutical Co Ltd Cyanopyrrolidine derivatives
AU2002218509A1 (en) 2000-12-01 2002-06-11 Yamanouchi Pharmaceutical Co..Ltd. Method of screening remedy for diabetes
JPWO2002051836A1 (en) 2000-12-27 2004-04-22 協和醗酵工業株式会社 Dipeptidyl peptidase-IV inhibitor
WO2002055088A1 (en) 2001-01-16 2002-07-18 Nippon Kayaku Kabushiki Kaisha Remedies for bone marrow suppression and infectious diseases and white blood cell count elevating agents
HUP0400058A2 (en) 2001-02-02 2004-04-28 Takeda Chemical Industries, Ltd. Fused heterocyclic compounds, pharmaceutical compositions containing them and their use
JP4213390B2 (en) 2001-02-02 2009-01-21 武田薬品工業株式会社 Fused heterocyclic compounds
SI1757606T1 (en) 2001-02-24 2009-10-31 Boehringer Ingelheim Pharma Xanthinderivatives for use as medical agents and the preparation thereof
JP2002265439A (en) 2001-03-08 2002-09-18 Mitsubishi Pharma Corp Cyanopyrrolidine derivative and its use for medicine
JP2004525929A (en) 2001-03-27 2004-08-26 メルク　エンド　カムパニー　インコーポレーテッド Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
FR2822826B1 (en) 2001-03-28 2003-05-09 Servier Lab NOVEL ALPHA-AMINO ACID SULPHONYL DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
GB0109146D0 (en) 2001-04-11 2001-05-30 Ferring Bv Treatment of type 2 diabetes
US6573287B2 (en) 2001-04-12 2003-06-03 Bristo-Myers Squibb Company 2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method
FR2824825B1 (en) 2001-05-15 2005-05-06 Servier Lab NOVEL ALPHA-AMINOACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US7098239B2 (en) 2001-06-20 2006-08-29 Merck & Co., Inc Dipeptidyl peptidase inhibitors for the treatment of diabetes
WO2003000181A2 (en) 2001-06-20 2003-01-03 Merck & Co., Inc. Dipeptidyl peptidase inhibitors for the treatment of diabetes
GB0115517D0 (en) 2001-06-25 2001-08-15 Ferring Bv Novel antidiabetic agents
US20030130199A1 (en) 2001-06-27 2003-07-10 Von Hoersten Stephan Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
US7132443B2 (en) 2001-06-27 2006-11-07 Smithklinebeecham Corporation Fluoropyrrolidines as dipeptidyl peptidase inhibitors
EP1399433B1 (en) 2001-06-27 2007-08-22 Smithkline Beecham Corporation Fluoropyrrolidines as dipeptidyl peptidase inhibitors
US7368421B2 (en) 2001-06-27 2008-05-06 Probiodrug Ag Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
CN1321682C (en) 2001-06-27 2007-06-20 前体生物药物股份有限公司 New dipeptidyl peptidase iv inhibitors and their uses as anti-cancer agents
EP1399469A2 (en) 2001-06-27 2004-03-24 Probiodrug AG Peptide structures useful for competitive modulation of dipeptidyl peptidase iv catalysis
US7196201B2 (en) 2001-06-27 2007-03-27 Smithkline Beecham Corporation Pyrrolidines as dipeptidyl peptidase inhibitors
DE10154689A1 (en) 2001-11-09 2003-05-22 Probiodrug Ag Substituted amino ketone compounds
US6869947B2 (en) 2001-07-03 2005-03-22 Novo Nordisk A/S Heterocyclic compounds that are inhibitors of the enzyme DPP-IV
JP2005502624A (en) 2001-07-03 2005-01-27 ノボ　ノルディスク　アクティーゼルスカブ Purine derivatives inhibiting DPP-IV for the treatment of diabetes
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
US6844316B2 (en) 2001-09-06 2005-01-18 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
DE10143840A1 (en) 2001-09-06 2003-03-27 Probiodrug Ag New acylated hydroxamates useful for the treatment of e.g. wound healing
TWI246510B (en) 2001-09-14 2006-01-01 Mitsubishi Pharma Corp Thiazolidine derivatives and pharmaceutical uses thereof
AU2002331311A1 (en) 2001-09-19 2003-04-01 Novo Nordisk A/S Heterocyclic compounds that are inhibitors of the enzyme dpp-iv
GB0125446D0 (en) 2001-10-23 2001-12-12 Ferring Bv Novel anti-diabetic agents
GB0125445D0 (en) 2001-10-23 2001-12-12 Ferring Bv Protease Inhibitors
US6861440B2 (en) 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
WO2003038123A2 (en) 2001-10-31 2003-05-08 Novartis Ag Methods to treat diabetes and related conditions based on polymorphisms in the tcf1 gene
US20030125304A1 (en) 2001-11-09 2003-07-03 Hans-Ulrich Demuth Substituted amino ketone compounds
US8410053B2 (en) 2001-11-26 2013-04-02 Trustees Of Tufts College Methods for treating autoimmune disorders, and reagents related thereto
WO2003045977A2 (en) 2001-11-26 2003-06-05 Trustees Of Tufts College Peptidomimetic Inhibitors of Post-Proline Cleaving Enzymes
AU2002360732A1 (en) 2001-12-26 2003-07-24 Guilford Pharmaceuticals Change inhibitors of dipeptidyl peptidase iv
US6727261B2 (en) 2001-12-27 2004-04-27 Hoffman-La Roche Inc. Pyrido[2,1-A]Isoquinoline derivatives
CA2475653A1 (en) 2002-02-08 2003-09-04 Idun Pharmaceuticals, Inc. (substituted)acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
ES2345096T3 (en) 2002-02-13 2010-09-15 F. Hoffmann-La Roche Ag NEW DERIVATIVES OF PIRIDINA AND PIRIMIDINA.
JP4216197B2 (en) 2002-02-13 2009-01-28 エフ．ホフマン−ラ ロシュ アーゲー New pyridine and quinoline derivatives
US6906074B2 (en) 2002-02-22 2005-06-14 Nippon Zoki Pharmaceutical Co., Ltd. 2-phenylpiperazine derivatives
DE60304911D1 (en) 2002-02-25 2006-06-08 Eisai Co Ltd Xanthine derivatives as DPP-IV inhibitors
JP2004043429A (en) 2002-02-25 2004-02-12 Eisai Co Ltd New xanthine derivative and dppiv inhibitor
CN1622941A (en) 2002-02-28 2005-06-01 普罗西迪恩有限公司 Glutaminyl based DPIV inhibitors
HUP0200849A2 (en) 2002-03-06 2004-08-30 Sanofi-Synthelabo N-aminoacetyl-pyrrolidine-2-carbonitrile derivatives, pharmaceutical compositions containing them and process for producing them
DE60322857D1 (en) 2002-03-25 2008-09-25 Nippon Kayaku Kk NEW ALPHA-AMINO-N- (DIAMINOPHOSPHINYL) LACTAM DERIVATIVE
AU2003225916A1 (en) 2002-03-25 2003-10-13 Merck & Co., Inc. Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
JP4329381B2 (en) 2002-04-04 2009-09-09 田辺三菱製薬株式会社 Pharmaceutical composition
JP4329382B2 (en) 2002-04-04 2009-09-09 田辺三菱製薬株式会社 Pharmaceutical composition
PL372814A1 (en) 2002-04-08 2005-08-08 Torrent Pharmaceuticals Ltd. Thiazolidine-4-carbonitriles and analogues and their use as dipeptidyl-peptidas inhibitors
JP2003300977A (en) 2002-04-10 2003-10-21 Sumitomo Pharmaceut Co Ltd Xanthine derivative
JP2004026820A (en) 2002-05-09 2004-01-29 Taisho Pharmaceut Co Ltd Dipeptidyl peptidase iv inhibitor
AU2003235913A1 (en) 2002-05-09 2003-11-11 Taisho Pharmaceutical Co., Ltd. Cyanopyrrolidine derivatives
JP2003327532A (en) 2002-05-10 2003-11-19 Takeda Chem Ind Ltd Peptidase inhibitor
GB0212412D0 (en) 2002-05-29 2002-07-10 Novartis Ag Combination of organic compounds
DK1513519T3 (en) 2002-06-03 2009-06-02 Novartis Ag Use of substituted cyanopyrrolidines for the treatment of hyperlipidemia
US6710040B1 (en) 2002-06-04 2004-03-23 Pfizer Inc. Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors
BR0311608A (en) 2002-06-04 2005-02-22 Pfizer Prod Inc Cyclically fluorinated amides as dipeptidyl peptidase iv inhibitors
AU2003233010A1 (en) 2002-06-04 2003-12-19 Pfizer Products Inc. Process for the preparation of 3,3,4,4-tetrafluoropyrrolidine and derivatives thereof
KR100985160B1 (en) 2002-06-06 2010-10-05 에자이 알앤드디 매니지먼트 가부시키가이샤 Novel condensed imidazole derivatives
HUP0202001A2 (en) 2002-06-14 2005-08-29 Sanofi-Aventis Azabicyclo-octane and nonane derivatives with ddp-iv inhibiting activity
AU2003243545A1 (en) 2002-06-14 2003-12-31 Amylin Pharmaceuticals, Inc. Prevention and/or treatment of inflammatory bowel disease using pyy or agonists thereof
JP2004026678A (en) 2002-06-24 2004-01-29 Microbial Chem Res Found Therapeutic agent for type 2 diabetes
WO2004004658A2 (en) 2002-07-09 2004-01-15 Point Therapeutics, Inc. Methods and compositions relating to isoleucine boroproline compounds
AU2003248259A1 (en) 2002-07-10 2004-02-02 Yamanouchi Pharmaceutical Co., Ltd. Novel azetidine derivative or salt thereof
US7208498B2 (en) 2002-07-15 2007-04-24 Merck & Co., Inc. Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
TW200401635A (en) 2002-07-23 2004-02-01 Yamanouchi Pharma Co Ltd 2-Cyano-4-fluoropyrrolidine derivative or salt thereof
ATE401311T1 (en) 2002-08-08 2008-08-15 Takeda Pharmaceutical CONDENSED HETEROCYCLIC COMPOUNDS AS PETIDASE INHIBITORS
JP4542757B2 (en) 2002-08-08 2010-09-15 武田薬品工業株式会社 Fused heterocyclic compounds
DE10238243A1 (en) 2002-08-21 2004-03-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg New 8-(3-amino-piperidin-1-yl)-xanthine derivatives are dipeptidylpeptidase-IV inhibitors useful for, e.g. treating diabetes mellitus, arthritis or obesity
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
CA2496249C (en) 2002-08-21 2012-01-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use of the same as medicaments
DE10238470A1 (en) 2002-08-22 2004-03-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg New xanthine derivatives, their production and their use as medicines
DE10238477A1 (en) 2002-08-22 2004-03-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg New purine derivatives, their production and their use as medicines
MXPA05002253A (en) 2002-08-29 2005-06-08 Taisho Pharma Co Ltd Benzenesulfonate of 4-fluoro-2-cyanopyrrolidine derivative.
NZ538567A (en) 2002-09-19 2007-04-27 Abbott Lab Pyrrolidine-2-carbonitrile derivatives and their pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
ES2291680T3 (en) 2002-10-07 2008-03-01 MERCK & CO., INC. BETA-AMINO HETEROCICLIC INHIBITING ANTIDIABETICS OF DIPEPTIDIL PEPTIDASA.
WO2004033455A2 (en) 2002-10-08 2004-04-22 Novo Nordisk A/S Hemisuccinate salts of heterocyclic dpp-iv inhibitors
AU2003298596B2 (en) 2002-10-18 2008-12-18 Merck Sharp & Dohme Corp. Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
EP1553937B1 (en) 2002-10-23 2010-06-02 Bristol-Myers Squibb Company Glycinenitrile-based inhibitors of dipeptidyl peptidase iv
WO2004041795A1 (en) 2002-10-30 2004-05-21 Guilford Pharmaceuticals Inc. Novel inhibitors of dipeptidyl peptidase iv
WO2004048379A1 (en) 2002-11-01 2004-06-10 Sumitomo Pharmaceuticals Co., Ltd. Xanthine compound
PL376822A1 (en) 2002-11-07 2006-01-09 Merck & Co., Inc. Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
DE10251927A1 (en) 2002-11-08 2004-05-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg New 1,7,8-trisubstituted xanthine derivatives, are dipeptidylpeptidase-IV inhibitors useful e.g. for treating diabetes mellitus type I or II, arthritis or obesity
US7482337B2 (en) 2002-11-08 2009-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
WO2004046106A1 (en) 2002-11-18 2004-06-03 Pfizer Products Inc. Dipeptidyl peptidase iv inhibiting fluorinated cyclic amides
UY28103A1 (en) 2002-12-03 2004-06-30 Boehringer Ingelheim Pharma NEW IMIDAZO-PIRIDINONAS REPLACED, ITS PREPARATION AND ITS EMPLOYMENT AS MEDICATIONS
DE10256264A1 (en) 2002-12-03 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg New trisubstituted dihydro-imidazo-pyridazinone or imidazo-pyridinone derivatives, useful as dipeptidylpeptidase-IV inhibitors for e.g. treating diabetes mellitus type I or II, arthritis or obesity
US7309714B2 (en) 2002-12-04 2007-12-18 Merck & Co., Inc. Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US7420079B2 (en) 2002-12-09 2008-09-02 Bristol-Myers Squibb Company Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof
DE60322944D1 (en) 2002-12-10 2008-09-25 Novartis Ag COMBINATIONS OF A DPP-IV INHIBITOR AND A PPAR-ALPHA AGONIST
AU2003297219A1 (en) 2002-12-20 2004-07-22 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
SG182004A1 (en) 2003-01-14 2012-07-30 Arena Pharm Inc 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
US7265128B2 (en) 2003-01-17 2007-09-04 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
JP2004244412A (en) 2003-01-20 2004-09-02 Kotobuki Seiyaku Kk 2-cyanopyrrolidine derivative having substituent at 4-position, method for producing the same, and medicament containing the same
KR100998796B1 (en) 2003-01-31 2010-12-06 가부시키가이샤산와카가쿠켄큐쇼 Compound inhibiting dipeptidyl peptidase IV
JP2006516573A (en) 2003-01-31 2006-07-06 メルク　エンド　カムパニー　インコーポレーテッド 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment and prevention of diabetes
WO2004071454A2 (en) 2003-02-13 2004-08-26 Guilford Pharmaceuticals Inc. Substituted azetidine compounds as inhibitors of dipeptidyl peptidase iv
CN1751038A (en) 2003-02-24 2006-03-22 艾尼纳制药公司 Substituted aryl and heteroaryl derivatives as modulators of glucose metabolism and the prophylaxis and treatment of disorders thereof
WO2004076433A1 (en) 2003-02-28 2004-09-10 Aic Dipeptidyl peptidase inhibitors
WO2004076434A1 (en) 2003-02-28 2004-09-10 Aic Dipeptidyl peptidase inhibitors
AR043515A1 (en) 2003-03-19 2005-08-03 Merck & Co Inc PROCEDURE TO PREPARE CHIRAL DERIVATIVES BETA AMINO ACIDS BY ASYMMETRIC HYDROGENATION
WO2004085661A2 (en) 2003-03-24 2004-10-07 Merck & Co., Inc Process to chiral beta-amino acid derivatives
US20040242566A1 (en) 2003-03-25 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
WO2004087650A2 (en) 2003-03-27 2004-10-14 Merck & Co. Inc. Process and intermediates for the preparation of beta-amino acid amide dipeptidyl peptidase-iv inhibitors
WO2004092128A1 (en) 2003-04-10 2004-10-28 Smithkline Beecham Corporation Anhydrous crystalline forms of (2s, 4s)-1-{(2r)-2-amino-3-‘4-methoxybenzyl)sulfonyl!-3-methylbutanoyl}-4-fluoropyrrolindine-2-carbonitrile
JPWO2004096806A1 (en) 2003-04-30 2006-07-13 大日本住友製薬株式会社 Condensed imidazole derivatives
US20040229848A1 (en) 2003-05-05 2004-11-18 Hans-Ulrich Demuth Glutaminyl based DP IV-inhibitors
EP1625122A1 (en) 2003-05-14 2006-02-15 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
EP1624874B1 (en) 2003-05-14 2009-11-04 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
EP1631680A2 (en) 2003-05-21 2006-03-08 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase iv (dpp4)
EP1631679A2 (en) 2003-05-21 2006-03-08 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase 7 (dpp7)
AU2003902828A0 (en) 2003-06-05 2003-06-26 Fujisawa Pharmaceutical Co., Ltd. Dpp-iv inhibitor
WO2004110375A2 (en) 2003-06-06 2004-12-23 Merck & Co., Inc. Combination therapy for the treatment of diabetes
WO2004110436A1 (en) 2003-06-06 2004-12-23 Merck & Co., Inc. Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
AU2003902946A0 (en) 2003-06-12 2003-06-26 Fujisawa Pharmaceutical Co., Ltd. Dpp-iv inhibitor
CA2527806A1 (en) 2003-06-17 2004-12-29 Merck & Co., Inc. Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
DE10327439A1 (en) 2003-06-18 2005-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel imidazopyridazinone and imidazopyridone derivatives, their production and their use as pharmaceuticals
CA2529443C (en) 2003-06-20 2012-06-05 F. Hoffmann-La Roche Ag Pyrido[2,1-a]-isoquinoline derivatives as dpp-iv inhibitors
ATE437876T1 (en) 2003-06-20 2009-08-15 Hoffmann La Roche HEXAHYDROPYRIDOISOCHINOLINES AS DPP-IV INHIBITORS
JO2625B1 (en) 2003-06-24 2011-11-01 ميرك شارب اند دوم كوربوريشن Phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor
JP2005023038A (en) 2003-07-04 2005-01-27 Taisho Pharmaceut Co Ltd Therapeutic agent for chronic renal disease
AR045047A1 (en) 2003-07-11 2005-10-12 Arena Pharm Inc ARILO AND HETEROARILO DERIVATIVES TRISUSTITUIDOS AS MODULATORS OF METABOLISM AND PROFILAXIS AND TREATMENT OF DISORDERS RELATED TO THEMSELVES
ATE411980T1 (en) 2003-07-21 2008-11-15 Smithkline Beecham Corp (2S,4S)-4-FLUORINE-1-Ä4-FLUORO-BETA-(4-FLUOROPHENYL) L-PHENYLALANYLÜ-2-PYRROLIDINECARBONITRILE-P-TOLUENESULFONIC ACID SALT AND ANHYDROUS CRYSTALLINE FORMS THEREOF
PE20050249A1 (en) 2003-07-25 2005-06-01 Aventis Pharma Gmbh NEW CYANOPYRROLIDES AND PROCEDURE FOR THEIR PREPARATION AS MEDICINES
DE10333935A1 (en) 2003-07-25 2005-02-24 Aventis Pharma Deutschland Gmbh New bicyclic cyano-heterocycles, process for their preparation and their use as pharmaceuticals
US7008957B2 (en) 2003-07-25 2006-03-07 Sanofi-Aventis Deutschland Gmbh Bicyclic cyanoheterocycles, process for their preparation and their use as medicaments
US7094800B2 (en) 2003-07-25 2006-08-22 Sanofi-Aventis Deutschland Gmbh Cyanopyrrolidides, process for their preparation and their use as medicaments
EP1651623B1 (en) 2003-07-31 2008-12-17 Merck & Co., Inc. Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
US6995183B2 (en) 2003-08-01 2006-02-07 Bristol Myers Squibb Company Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
WO2005019168A2 (en) 2003-08-20 2005-03-03 Pfizer Products Inc. Fluorinated lysine derivatives as dipeptidyl peptidase iv inhibitors
EP1662876A4 (en) 2003-09-02 2009-01-14 Merck & Co Inc Novel crystalline forms of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor
WO2005023762A1 (en) 2003-09-04 2005-03-17 Abbott Laboratories Pyrrolidine-2-carbonitrile derivatives and their use as inhibitors of dipeptidyl peptidase-iv (dpp-iv)
JP2007513058A (en) 2003-09-08 2007-05-24 武田薬品工業株式会社 Dipeptidyl peptidase inhibitor
JP2007505121A (en) 2003-09-08 2007-03-08 武田薬品工業株式会社 Dipeptidyl peptidase inhibitor
TW200530157A (en) 2003-09-09 2005-09-16 Japan Tobacco Inc Dipeptidyl peptidase iv inhibitor
EP1667524A4 (en) 2003-09-23 2009-01-14 Merck & Co Inc Novel crystalline form of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor
ATE534404T1 (en) 2003-10-03 2011-12-15 Takeda Pharmaceutical DIPEPTIDYLPEPTIDASE IV INHIBITORS FOR THE TREATMENT OF DIABETES PATIENTS WITH SECONDARY FAILURE DUE TO SULFONYL UREAS
WO2005033099A2 (en) 2003-10-03 2005-04-14 Glenmark Pharmaceuticals Ltd. Novel dipeptidyl peptidase iv inhibitors; processes for their preparation and compositions thereof
DE10348022A1 (en) 2003-10-15 2005-05-25 Imtm Gmbh New dipeptidyl peptidase IV inhibitors for the functional influence of different cells and for the treatment of immunological, inflammatory, neuronal and other diseases
DE10348044A1 (en) 2003-10-15 2005-05-19 Imtm Gmbh Dual alanyl aminopeptidase and dipeptidyl peptidase IV inhibitors for the functional influence of different cells and for the treatment of immunological, inflammatory, neuronal and other diseases
GB0324236D0 (en) 2003-10-16 2003-11-19 Astrazeneca Ab Chemical compounds
TW200519105A (en) 2003-10-20 2005-06-16 Lg Life Science Ltd Novel inhibitors of DPP-IV, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent
PE20050444A1 (en) 2003-10-31 2005-08-09 Takeda Pharmaceutical PYRIDINE COMPOUNDS AS PEPTIDASE INHIBITORS
US7238683B2 (en) 2003-11-04 2007-07-03 Merck & Co., Inc. Fused phenylalanine derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
KR20070054762A (en) 2003-11-12 2007-05-29 페노믹스 코포레이션 Heterocyclic boronic acid compounds
CN1905876B (en) 2003-11-17 2010-06-09 诺瓦提斯公司 Use of dipeptidyl peptidase IV inhibitors
WO2005058849A1 (en) 2003-12-15 2005-06-30 Glenmark Pharmaceuticals Ltd. New dipeptidyl peptidase in inhibitors; process for their preparation and compositions containing them
DE10360835A1 (en) 2003-12-23 2005-07-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg New bicyclic imidazole derivatives are dipeptidylpeptidase-IV inhibitors useful to treat e.g. arthritis, obesity, allograft transplantation and calcitonin-induced osteoporosis
WO2005072530A1 (en) 2004-01-16 2005-08-11 Merck & Co., Inc. Novel crystalline salts of a dipeptidyl peptidase-iv inhibitor
WO2005075426A1 (en) 2004-02-03 2005-08-18 Glenmark Pharmaceuticals Ltd. Novel dipeptidyl peptidase iv inhibitors; processes for their preparation and compositions thereof
CN101684089A (en) 2004-02-05 2010-03-31 杏林制药株式会社 bicycloester derivative
KR20060124712A (en) 2004-02-20 2006-12-05 노파르티스 아게 Dpp-iv inhibitors for treating neurodegeneration and cognitive disorders
JP2007526255A (en) 2004-02-23 2007-09-13 トラスティーズ オブ タフツ カレッジ Lactams as conformation-fixing peptidomimetic inhibitors
KR20130016435A (en) 2004-02-23 2013-02-14 트러스티즈 오브 터프츠 칼리지 Inhibitors of dipeptidylpeptidase iv
KR100844593B1 (en) 2004-03-09 2008-07-07 내셔날 헬스 리서치 인스티튜트 Pyrrolidine compounds
CN102127053A (en) 2004-03-15 2011-07-20 武田药品工业株式会社 Dipeptidyl peptidase inhibitors
GEP20084421B (en) 2004-05-12 2008-07-10 Pfizer Prod Inc Proline derivatives and their use as dipeptidyl peptidase iv inhibitors
DE102004038270A1 (en) 2004-08-06 2006-03-16 Sanofi-Aventis Deutschland Gmbh Substituted bicyclic 8-amino-xanthines, process for their preparation and their use as medicaments
NZ554515A (en) 2004-10-12 2009-12-24 Glenmark Pharmaceuticals Sa Novel dipeptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and process for their preparation
EP1829877A4 (en) 2004-12-24 2009-10-14 Dainippon Sumitomo Pharma Co Bicyclic pyrrole derivatives
DOP2006000008A (en) 2005-01-10 2006-08-31 Arena Pharm Inc COMBINED THERAPY FOR THE TREATMENT OF DIABETES AND RELATED AFFECTIONS AND FOR THE TREATMENT OF AFFECTIONS THAT IMPROVE THROUGH AN INCREASE IN THE BLOOD CONCENTRATION OF GLP-1
JP4208938B2 (en) 2005-02-18 2009-01-14 田辺三菱製薬株式会社 Salt of proline derivative, or solvate thereof, and method for producing the same
EP1888571A2 (en) 2005-03-22 2008-02-20 F. Hoffmann-Roche AG New salt and polymorphs of a dpp-iv inhibitor
ZA200708179B (en) 2005-04-22 2009-12-30 Alantos Pharmaceuticals Holding Inc Dipeptidyl peptidase-IV inhibitors
CA2611446A1 (en) 2005-06-09 2006-12-14 Banyu Pharmaceutical Co., Ltd. Npy y2 agonist for use as therapeutic agent for disease accompanied by diarrhea
RU2008107873A (en) 2005-08-04 2009-09-10 Новартис АГ (CH) NEW COMPOUNDS
NZ591609A (en) 2005-08-30 2012-10-26 Abbott Lab Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv)
TW200745079A (en) 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
ATE482947T1 (en) 2005-12-21 2010-10-15 Hoffmann La Roche NEW SALT AND POLYMORPH OF DPP-IV INHIBITOR
WO2007120689A2 (en) 2006-04-11 2007-10-25 Arena Pharmaceuticals, Inc. Methods of using gpr119 receptor to identify compounds useful for increasing bone mass in an individual
PE20071221A1 (en) 2006-04-11 2007-12-14 Arena Pharm Inc GPR119 RECEPTOR AGONISTS IN METHODS TO INCREASE BONE MASS AND TO TREAT OSTEOPOROSIS AND OTHER CONDITIONS CHARACTERIZED BY LOW BONE MASS, AND COMBINED THERAPY RELATED TO THESE AGONISTS
KR101541791B1 (en) 2006-05-04 2015-08-04 베링거 인겔하임 인터내셔날 게엠베하 Polymorphs
WO2007148185A2 (en) 2006-06-21 2007-12-27 Pfizer Products Inc. Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors
CL2007002499A1 (en) 2006-08-30 2008-03-14 Phenomix Corp SALES CITRATE AND TARTRATE OF COMPOUNDS DERIVED FROM PIRROLIDINILAMINOACETILPIRROLIDINBORONICO ACID, DPP-IV INHIBITORS; PREPARATION METHOD; SOLID FORM; PHARMACEUTICAL COMBINATION, USEFUL FOR THE TREATMENT OF DIABETES.
UA97817C2 (en) * 2006-12-06 2012-03-26 Глаксосмиткляйн Ллк Heterocyclic derivatives of 4-(methylsulfonyl)phenyl and use thereof
WO2008114857A1 (en) 2007-03-22 2008-09-25 Kyorin Pharmaceutical Co., Ltd. Method for producing aminoacetylpyrrolidinecarbonitrile derivative
TW200938200A (en) 2007-12-28 2009-09-16 Dainippon Sumitomo Pharma Co Methyl-substituted piperidine derivative
EP2146210A1 (en) 2008-04-07 2010-01-20 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY

Also Published As

Publication number Publication date
TW201105327A (en) 2011-02-16
WO2011005929A1 (en) 2011-01-13

Similar Documents

Publication Publication Date Title
AR077642A1 (en) METABOLISM MODULATORS AND THE TREATMENT OF DISORDERS RELATED TO THE SAME
ECSP088281A (en) METABOLISM MODULATORS AND TREATMENT OF METABOLIC DISORDERS
ECSP088747A (en) PIRAZOLES AS INHIBITORS OF THE 11-BETA-HSD1
MX2009012285A (en) Diacylglycerol acyltransferase inhibitors.
MX2013003034A (en) Piperidinyl-substituted lactams as gpr119 modulators.
ECSP099037A (en) METABOLISM MODULATORS AND TREATMENT OF METABOLIC DISORDERS
ATE442349T1 (en) DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
DE602007009420D1 (en) OXADIAZOL DERIVATIVES AS S1P1 RECEPTOR AGONISTS
UY32884A (en) 1-substituted-4- (5- (phenyl or heteroaryl) methoxy) -pyrimidin-2-yl) piperazines and piperidines
GT200800305A (en) METABOLISM MODULATORS AND TREATMENT OF METABOLIC DISORDERS
CR20140142A (en) VARIANTS OF THE FIBROBLAST GROWTH 21
CL2008003798A1 (en) Compounds derived from substituted aromatic heterobicycles, py3 kinase inhibitors; pharmaceutical composition; Useful in the treatment of cancer, melanomas, glioblastomas, among other diseases.
UA97817C2 (en) Heterocyclic derivatives of 4-(methylsulfonyl)phenyl and use thereof
MX2012011631A (en) Modulators of the gpr119 receptor and the treatment of disorders related thereto.
CL2010001496A1 (en) Compounds derived from (pyridin- or pyrimidin-) piperidine, gpr119 agonists; pharmaceutical composition; and its use for the treatment of type I diabetes, type II diabetes and related diseases such as metabolic syndrome, dyslipidemia and insulin resistance.
GEP20156348B (en) Aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators
CR20120642A (en) REPLACED READERS WITH PIPERIDINYL AS MODULATORS OF GPR119
MX2010009922A (en) Pyridazinone glucokinase activators.
BRPI0911035B8 (en) pyrrolidinone glycokinase activators
CL2010001159A1 (en) Compounds derived from 3,8-diazabicyclo [2.4.0] octane and 3,6-diazabicyclo [3.2.0] heptane disubstituted, orexin receptor modulators; pharmaceutical composition; Useful in the treatment of sleep disorders, metabolic disorders, among others.
NI200700169A (en) DERIVATIVES OF PYRIMIDINIL AND PYRIDINIL REPLACED AS MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED TO THE SAME.
GEP20156351B (en) Glucagon receptor modulator
GEP20146125B (en) Aminopyrimidines as syk inhibitors
ECSP088833A (en) INHIBITORS OF 11-BETA-HYDROXIESTEROID DEHYDROGENASE 1
MX2007012212A (en) Pyrazoles.

Legal Events

Date Code Title Description
FB Suspension of granting procedure