AU2001277285A1 - Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases - Google Patents

Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases

Info

Publication number
AU2001277285A1
AU2001277285A1 AU2001277285A AU7728501A AU2001277285A1 AU 2001277285 A1 AU2001277285 A1 AU 2001277285A1 AU 2001277285 A AU2001277285 A AU 2001277285A AU 7728501 A AU7728501 A AU 7728501A AU 2001277285 A1 AU2001277285 A1 AU 2001277285A1
Authority
AU
Australia
Prior art keywords
pyrazole
methods
pharmaceutical compositions
compositions containing
dependent kinases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001277285A
Inventor
Wesley Kwan Mung Chong
Rohit Kumar Duvadie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agouron Pharmaceuticals LLC
Original Assignee
Agouron Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals LLC filed Critical Agouron Pharmaceuticals LLC
Publication of AU2001277285A1 publication Critical patent/AU2001277285A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
AU2001277285A 2000-08-09 2001-07-31 Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases Abandoned AU2001277285A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22398900P 2000-08-09 2000-08-09
US60/223,989 2000-08-09
PCT/US2001/041466 WO2002012250A2 (en) 2000-08-09 2001-07-31 Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases

Publications (1)

Publication Number Publication Date
AU2001277285A1 true AU2001277285A1 (en) 2002-02-18

Family

ID=22838822

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001277285A Abandoned AU2001277285A1 (en) 2000-08-09 2001-07-31 Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclin-dependent kinases

Country Status (15)

Country Link
US (1) US6566363B2 (en)
EP (1) EP1307462A2 (en)
JP (1) JP2004505983A (en)
AR (1) AR032763A1 (en)
AU (1) AU2001277285A1 (en)
BR (1) BR0113139A (en)
CA (1) CA2411928A1 (en)
GT (1) GT200100162A (en)
HK (1) HK1052354A1 (en)
MX (1) MXPA03001189A (en)
MY (1) MY117667A (en)
PA (1) PA8524801A1 (en)
PE (1) PE20020304A1 (en)
UY (1) UY26877A1 (en)
WO (1) WO2002012250A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
JP2005523928A (en) * 2002-04-30 2005-08-11 アルコン，インコーポレイテッド Modulates, inhibits, or modulates the activity and / or expression of connective tissue growth factor (CTGF) as a unique means for both reducing intraocular pressure and treating glaucomatous retinopathy / optic neuropathy Drugs
EP1616568A3 (en) * 2002-04-30 2006-06-21 Alcon, Inc GSK-3 inhibitors and CDK inhibitors as anti-glaucoma agents
US6818663B2 (en) * 2002-05-17 2004-11-16 Hoffmann-La Roches Diaminothiazoles
EP1597256A1 (en) * 2003-02-21 2005-11-23 Pfizer Inc. N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors
AU2004313947B2 (en) * 2003-12-17 2011-03-31 Sgx Pharmaceuticals, Inc. Bicyclic pyrazolo-fused compounds as protein kinase modulators
TW200526224A (en) * 2003-12-22 2005-08-16 Alcon Inc Short form c-Maf transcription factor antagonists for treatment of glaucoma
JP2007531772A (en) 2004-03-31 2007-11-08 レキシコン・ジェネティクス・インコーポレーテッド Novel thiazolopyrazole and method of use thereof
US7211576B2 (en) 2004-04-20 2007-05-01 Hoffmann-La Roche Inc. Diaminothiazoles
FR2878442B1 (en) * 2004-11-29 2008-10-24 Aventis Pharma Sa THIENO (2,3-c) SUBSTITUTED PYRAZOLES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS CONTAINING SAME AND USE THEREOF
US20070173488A1 (en) * 2005-11-16 2007-07-26 Sgx Pharmaceuticals, Inc. Pyrazolothiazole Protein Kinase Modulators
PL2193133T3 (en) 2007-09-27 2016-01-29 Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii Imidazolothiadiazoles for use as protein kinase inhibitors
EP2373664B1 (en) 2008-12-19 2013-06-12 Nerviano Medical Sciences S.r.l. Bicyclic pyrazoles as protein kinase inhibitors
SI2414369T1 (en) * 2009-04-02 2015-12-31 Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii Imidazo(2,1-b)(1,3,4)thiadiazole derivatives
DE102009058280A1 (en) 2009-12-14 2011-06-16 Merck Patent Gmbh thiazole

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2429195A1 (en) * 1974-06-18 1976-02-05 Basf Ag 2-Amino-pyrazolo-(3,4-D)-thiazoles useful as dye inters - prepd. by ring-closing dehydrogenation of substd. pyrazolyl thioureas
US5625031A (en) 1994-02-08 1997-04-29 Bristol-Myers Squibb Company Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein
US5631156A (en) 1994-06-21 1997-05-20 The University Of Michigan DNA encoding and 18 KD CDK6 inhibiting protein
ATE262902T1 (en) * 1994-11-10 2004-04-15 Millennium Pharm Inc USE OF PYRAZOLE COMPOUNDS TO TREAT GLOMERULONEPHRITIS, CANCER, ATHEROSCLERosis OR RESTENOSIS
US5733920A (en) 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
US6495526B2 (en) 1996-01-23 2002-12-17 Gpc Biotech, Inc. Inhibitors of cell-cycle progression and uses related thereto
GB9608435D0 (en) 1996-04-24 1996-06-26 Celltech Therapeutics Ltd Chemical compounds
US5849733A (en) 1996-05-10 1998-12-15 Bristol-Myers Squibb Co. 2-thio or 2-oxo flavopiridol analogs
FR2752523B1 (en) * 1996-08-26 1998-10-02 Oreal KERATINIC FIBER DYEING COMPOSITIONS CONTAINING PYRAZOLO- (3,4-D) -THIAZOLES THEIR USE FOR DYEING AS COUPLERS, DYEING METHOD
GB9621757D0 (en) 1996-10-18 1996-12-11 Ciba Geigy Ag Phenyl-substituted bicyclic heterocyclyl derivatives and their use
EP0964864B1 (en) 1997-02-05 2008-04-09 Warner-Lambert Company LLC Pyrido 2,3-d pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation
CA2294244A1 (en) 1997-07-12 1999-01-21 Cancer Research Campaign Technology Limited Cyclin dependent kinase inhibiting purine derivatives
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
ES2206997T3 (en) * 1997-10-06 2004-05-16 ABBOTT GMBH & CO. KG DERIVATIVES OF INDENO (1,2-C) -, OF NAFTO (1,2-C), AND OF BENZO (6,7) CICLOEPTA (1,2-C) PIRAZOL.
ES2267873T3 (en) * 1997-10-27 2007-03-16 Agouron Pharmaceuticals, Inc. DERIVATIVES OF 4-AMINOTIAZOL, ITS PREPARATION AND USE AS INHIBITORS OF CYCLINE DEPENDENT KINASES.
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6479487B1 (en) 1998-02-26 2002-11-12 Aventis Pharmaceuticals Inc. 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
DK1056745T3 (en) 1998-02-26 2004-10-25 Aventis Pharma Inc 6,9-Disubstituted 2- [trans- (4-aminocyclohexyl) amino] purines
BR9909597A (en) * 1998-04-21 2001-10-02 Du Pont Pharm Co Compound, pharmaceutical composition and method of treating cancer and proliferative diseases
UA60365C2 (en) 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Isothiazole derivatives, a method for preparing thereof, a pharmaceutical composition and a method for treatment of hyperproliferative disease of mammal

Also Published As

Publication number Publication date
BR0113139A (en) 2003-06-24
WO2002012250B1 (en) 2002-11-21
PE20020304A1 (en) 2002-05-29
AR032763A1 (en) 2003-11-26
US6566363B2 (en) 2003-05-20
WO2002012250A3 (en) 2002-09-06
CA2411928A1 (en) 2002-02-14
WO2002012250A2 (en) 2002-02-14
HK1052354A1 (en) 2003-09-11
EP1307462A2 (en) 2003-05-07
US20020049215A1 (en) 2002-04-25
UY26877A1 (en) 2002-03-22
MY117667A (en) 2004-07-31
GT200100162A (en) 2002-05-16
MXPA03001189A (en) 2004-05-14
PA8524801A1 (en) 2002-04-25
JP2004505983A (en) 2004-02-26

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