AU2001270070A1 - Nitrosated and nitrosylated taxanes, compositions and methods of use - Google Patents

Nitrosated and nitrosylated taxanes, compositions and methods of use

Info

Publication number
AU2001270070A1
AU2001270070A1 AU2001270070A AU2001270070A AU2001270070A1 AU 2001270070 A1 AU2001270070 A1 AU 2001270070A1 AU 2001270070 A AU2001270070 A AU 2001270070A AU 2001270070 A AU2001270070 A AU 2001270070A AU 2001270070 A1 AU2001270070 A1 AU 2001270070A1
Authority
AU
Australia
Prior art keywords
nitrosated
compositions
methods
nitrosylated taxanes
nitrosylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2001270070A
Other versions
AU2001270070B2 (en
Inventor
David S Garvey
L. Gordon Letts
Chia-En Lin
Stewart K. Richardson
Tiansheng Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nitromed Inc
Original Assignee
Nitromed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitromed Inc filed Critical Nitromed Inc
Priority claimed from PCT/US2001/019939 external-priority patent/WO2001098286A1/en
Publication of AU2001270070A1 publication Critical patent/AU2001270070A1/en
Application granted granted Critical
Publication of AU2001270070B2 publication Critical patent/AU2001270070B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

AU2001270070A 2000-06-22 2001-06-22 Nitrosated and nitrosylated taxanes, compositions and methods of use Ceased AU2001270070B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21329400P 2000-06-22 2000-06-22
US60/213,294 2000-06-22
US22609000P 2000-08-18 2000-08-18
US60/226,090 2000-08-18
PCT/US2001/019939 WO2001098286A1 (en) 2000-06-22 2001-06-22 Nitrosated and nitrosylated taxanes, compositions and methods of use

Publications (2)

Publication Number Publication Date
AU2001270070A1 true AU2001270070A1 (en) 2002-03-21
AU2001270070B2 AU2001270070B2 (en) 2006-03-16

Family

ID=26907932

Family Applications (2)

Application Number Title Priority Date Filing Date
AU7007001A Pending AU7007001A (en) 2000-06-22 2001-06-22 Nitrosated and nitrosylated taxanes, compositions and methods of use
AU2001270070A Ceased AU2001270070B2 (en) 2000-06-22 2001-06-22 Nitrosated and nitrosylated taxanes, compositions and methods of use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU7007001A Pending AU7007001A (en) 2000-06-22 2001-06-22 Nitrosated and nitrosylated taxanes, compositions and methods of use

Country Status (7)

Country Link
US (2) US6656966B2 (en)
EP (1) EP1301500B1 (en)
JP (1) JP2004501143A (en)
AU (2) AU7007001A (en)
CA (1) CA2410632A1 (en)
DE (1) DE60131537T2 (en)
WO (1) WO2001098286A1 (en)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1118325E (en) * 1993-07-29 2006-05-31 Us Health USES OF PACLITAXEL AND ITS DERIVATIVES IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF RESTENOSE
US20030040790A1 (en) 1998-04-15 2003-02-27 Furst Joseph G. Stent coating
US7967855B2 (en) 1998-07-27 2011-06-28 Icon Interventional Systems, Inc. Coated medical device
US8070796B2 (en) 1998-07-27 2011-12-06 Icon Interventional Systems, Inc. Thrombosis inhibiting graft
US7678391B2 (en) * 2000-04-26 2010-03-16 Queen's University At Kingston Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
US20050142217A1 (en) * 2000-04-26 2005-06-30 Adams Michael A. Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
AU5022101A (en) 2000-04-26 2001-11-07 Univ Kingston Formulations and methods of using nitric oxide mimetics against a malignant cellphenotype
CA2424029C (en) 2000-09-29 2008-01-29 Cordis Corporation Coated medical devices
US6627602B2 (en) * 2001-11-13 2003-09-30 Duke University Preventing desensitization of receptors
US20040110691A1 (en) * 2001-11-13 2004-06-10 Stamler Jonathan S. Thiol reactive agents as a therapeutic modality
AU2006252204B2 (en) * 2001-12-06 2010-07-08 Duke University Prevention of Flap Necrosis in Plastic Surgery
AU2002254931A1 (en) * 2002-03-07 2003-09-16 Universite Catholique De Louvain Method for diagnosing and treating predisposition for accelerated autosomal dominant polycystic kidney disease
CA2480832A1 (en) * 2002-04-05 2003-10-23 Nitromed, Inc. Nitric oxide donors, compositions and methods of use
EP1496951B1 (en) 2002-04-24 2006-06-14 Insense Limited Wound dressings comprising an oxidoreductase enzyme in hydrated condition
US20040038947A1 (en) 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
US8016881B2 (en) 2002-07-31 2011-09-13 Icon Interventional Systems, Inc. Sutures and surgical staples for anastamoses, wound closures, and surgical closures
US6936639B2 (en) * 2002-08-21 2005-08-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxyl progenitors in the treatment of heart failure
KR20120104412A (en) 2002-09-06 2012-09-20 인설트 테라페틱스, 인코퍼레이티드 Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
US20050009931A1 (en) * 2003-03-20 2005-01-13 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20050004098A1 (en) * 2003-03-20 2005-01-06 Britten Nancy Jean Dispersible formulation of an anti-inflammatory agent
US20040214753A1 (en) * 2003-03-20 2004-10-28 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
RU2325189C2 (en) * 2003-03-20 2008-05-27 Фармация Корпорейшн Method and pharmaceutical composition for antiphlogistic agent delivery
ITMI20030743A1 (en) * 2003-04-11 2004-10-12 Biopeg Ltd POLYETHYLENGLYCULATED DERIVATIVES THAT RELEASE NITRIC OXIDE.
US7972616B2 (en) * 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
US20050038498A1 (en) * 2003-04-17 2005-02-17 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7803574B2 (en) * 2003-05-05 2010-09-28 Nanosys, Inc. Medical device applications of nanostructured surfaces
GB0313217D0 (en) 2003-06-09 2003-07-16 Insense Ltd Improvements in or relating to skin dressings
EP1668008A4 (en) * 2003-08-28 2009-02-25 Nitromed Inc Nitrosated ad nitrosylated diuretic compouds, compositions and methods of use
MXPA06007378A (en) * 2003-12-23 2007-01-26 Musc Found For Res Dev Methods and compositions for the prevention and treatment of inflammatory diseases or conditions.
US7211108B2 (en) 2004-01-23 2007-05-01 Icon Medical Corp. Vascular grafts with amphiphilic block copolymer coatings
WO2005114194A1 (en) * 2004-05-21 2005-12-01 Mds Inc. Doing Business Through Its Mds Pharma Services Division Method of quantifying the cell-binding properties of a medical device
ATE493973T1 (en) 2004-06-04 2011-01-15 Teva Pharma PHARMACEUTICAL COMPOSITION CONTAINING IRBESARTAN
US20060039950A1 (en) * 2004-08-23 2006-02-23 Zhengrong Zhou Multi-functional biocompatible coatings for intravascular devices
WO2006024491A1 (en) * 2004-08-30 2006-03-09 Interstitial Therapeutics Methods and compositions for the treatment of cell proliferation
US9107899B2 (en) 2005-03-03 2015-08-18 Icon Medical Corporation Metal alloys for medical devices
US7540995B2 (en) 2005-03-03 2009-06-02 Icon Medical Corp. Process for forming an improved metal alloy stent
WO2006110197A2 (en) 2005-03-03 2006-10-19 Icon Medical Corp. Polymer biodegradable medical device
US20060222592A1 (en) * 2005-04-05 2006-10-05 Clemens Burda Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications
US20090298795A1 (en) * 2005-06-23 2009-12-03 The Johns Hopins University Thiol-Sensitive Positive Inotropes
WO2007005758A2 (en) * 2005-06-30 2007-01-11 Mc3, Inc. Methods , compositions and devices for promoting angiogenesis
CN101252880A (en) * 2005-09-02 2008-08-27 宝洁公司 Methods for retail measurement of skin moisture content
US7566308B2 (en) * 2005-10-13 2009-07-28 Cardiac Pacemakers, Inc. Method and apparatus for pulmonary artery pressure signal isolation
WO2007058190A1 (en) * 2005-11-16 2007-05-24 Tokai University Educational System Controlled drug release composition and drug releasing medical device
US20080051702A1 (en) * 2006-08-24 2008-02-28 Herrmann Robert A Therapeutic agent delivery for the treatment of asthma via implantable and insertable medical devices
WO2008086490A2 (en) * 2007-01-11 2008-07-17 Robert Lamar Bjork, Jr Multiple drug-eluting coronary artery stent for percutaneous coronary artery intervention
US9339593B2 (en) * 2007-01-11 2016-05-17 Robert L. Bjork, JR. Drug-eluting coronary artery stent coated with anti-platelet-derived growth factor antibodies overlaying extracellular matrix proteins with an outer coating of anti-inflammatory (calcineurin inhibitor) and/or anti-proliferatives
JP2010516625A (en) 2007-01-24 2010-05-20 インサート セラピューティクス, インコーポレイテッド Polymer-drug conjugates with tether groups for controlled drug delivery
KR100904207B1 (en) 2007-06-01 2009-06-25 (주) 태웅메디칼 Coating agent for drug releasing stent, manufacturing method thereof and drug releasing stent coated with the coating agent
WO2009036368A2 (en) 2007-09-14 2009-03-19 Nitto Denko Corporation Drug carriers
US8319002B2 (en) * 2007-12-06 2012-11-27 Nanosys, Inc. Nanostructure-enhanced platelet binding and hemostatic structures
US8304595B2 (en) 2007-12-06 2012-11-06 Nanosys, Inc. Resorbable nanoenhanced hemostatic structures and bandage materials
WO2010005687A1 (en) * 2008-06-12 2010-01-14 University Of Alabama Huntsville Compositions comprising nitric oxide or nitric oxide donors for the treatment of neurodegenerative diseases or trauma
EP2320728A4 (en) * 2008-07-21 2013-03-13 Osiris Therapeutics Inc Taxane compounds for treating eye disease
US20110319987A1 (en) 2009-05-20 2011-12-29 Arsenal Medical Medical implant
US9309347B2 (en) 2009-05-20 2016-04-12 Biomedical, Inc. Bioresorbable thermoset polyester/urethane elastomers
US8888840B2 (en) * 2009-05-20 2014-11-18 Boston Scientific Scimed, Inc. Drug eluting medical implant
US8992601B2 (en) 2009-05-20 2015-03-31 480 Biomedical, Inc. Medical implants
AU2010249558A1 (en) * 2009-05-20 2011-12-08 Arsenal Medical, Inc. Medical implant
US9265633B2 (en) 2009-05-20 2016-02-23 480 Biomedical, Inc. Drug-eluting medical implants
US8372133B2 (en) 2009-10-05 2013-02-12 480 Biomedical, Inc. Polymeric implant delivery system
US20110160200A1 (en) * 2009-11-23 2011-06-30 Cardioxyl Pharmaceuticals, Inc. Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension
EP2509942A2 (en) * 2009-12-07 2012-10-17 Johns Hopkins University Bis-acylated hydroxylamine derivatives
MX2012006349A (en) * 2009-12-07 2012-10-03 Cardioxyl Pharmaceuticals Inc N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives.
WO2011082164A1 (en) 2009-12-28 2011-07-07 Colorado State University Research Foundation Modular biocompatible materials for medical devices and uses thereof
US8398916B2 (en) 2010-03-04 2013-03-19 Icon Medical Corp. Method for forming a tubular medical device
US9034355B2 (en) 2011-02-24 2015-05-19 Colorado State University Research Foundation Materials for modulating biological responses and methods of making
JP2015505557A (en) * 2012-01-31 2015-02-23 セルリアン・ファーマ・インコーポレイテッド Polymers based on cyclodextrins for therapeutic delivery
WO2014046671A1 (en) * 2012-09-21 2014-03-27 Michigan Technological University No-releasing polymers and uses thereof
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
BR112016030273A8 (en) 2014-06-24 2021-05-18 Icon Medical Corp medical device and method of forming said device
BR112018005200A2 (en) 2015-09-16 2018-10-09 Dfb Soria Llc release of drug nanoparticles and methods of using them
WO2017151548A1 (en) 2016-03-04 2017-09-08 Mirus Llc Stent device for spinal fusion
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
CN110636833A (en) 2017-03-15 2019-12-31 Dfb索里亚有限责任公司 Topical therapy using taxane nanoparticles for the treatment of skin malignancies
US11883807B2 (en) 2017-04-11 2024-01-30 Colorado State University Research Foundation Functionalization of metal-organic frameworks
WO2019178024A1 (en) 2018-03-16 2019-09-19 Dfb Soria, Llc Topical therapy for the treatment of cervical intraepithelial neoplasia (cin) and cervical cancer using nanoparticles of taxanes

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666884A (en) 1984-04-10 1987-05-19 New England Deaconess Hospital Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
US4885173A (en) 1985-05-01 1989-12-05 University Of Utah Methods and compositions for noninvasive dose-to-effect administration of drugs with cardiovascular or renal vascular activities
US5157049A (en) 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4900719A (en) 1988-08-05 1990-02-13 The Ohio State University Nitrosothiols as hypotensive agents
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
CA2081896A1 (en) 1990-06-15 1991-12-16 James E. Shapland Drug delivery apparatus and method
US6028205A (en) 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
US5284865A (en) 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5399726A (en) 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5998656A (en) 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US5990325A (en) 1993-03-05 1999-11-23 Florida State University Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5407816A (en) 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
US5278192A (en) 1992-07-02 1994-01-11 The Research Foundation Of State University Of New York Method of vasodilator therapy for treating a patient with a condition
FR2698871B1 (en) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa New taxoids, their preparation and the pharmaceutical compositions containing them.
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
IL108316A (en) 1993-01-15 2006-10-31 Univ Florida State C10 taxane derivatives and pharmaceutical compositions containing them
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
EP1260507A1 (en) 1993-02-05 2002-11-27 Bryn Mawr College Synthesis of taxol, analogs and intermediates with variable A-nng side chains
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US5945452A (en) 1993-06-11 1999-08-31 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production or activity
US5861168A (en) 1993-06-11 1999-01-19 The Board Of Trustees Of The Leland Stanford Junior University Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury
DK0982301T3 (en) 1993-06-11 2003-12-08 Upjohn Co Delta 6,7-taxols antineoplastic use and pharmaceutical compositions containing them
US5428070A (en) 1993-06-11 1995-06-27 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity
US5852058A (en) 1993-06-11 1998-12-22 The Board Of Trustees Of The Leland Stanford Junior University Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
PT1118325E (en) * 1993-07-29 2006-05-31 Us Health USES OF PACLITAXEL AND ITS DERIVATIVES IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF RESTENOSE
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
IL127598A (en) 1994-01-28 2003-04-10 Upjohn Co Process for preparing isotaxol analogs
US5482925A (en) 1994-03-17 1996-01-09 Comedicus Incorporated Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents
MX9700026A (en) 1994-06-28 1997-04-30 Upjohn Co 7-ether-taxol analogs, antineoplastic use and pharmaceutical compositions containing them.
US5629433A (en) 1994-07-18 1997-05-13 Hauser, Inc. Selective process for the deacylation and deacetylation of taxol and taxanes
WO1996011008A1 (en) 1994-10-06 1996-04-18 New York University Administration of a 27-hydroxycholesterol or prodrug thereof as an anti-cancer agent
US6100411A (en) 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
EP0738265A1 (en) 1994-11-04 1996-10-23 PHARMACIA S.p.A. Taxane derivatives
GB9423868D0 (en) 1994-11-25 1995-01-11 Wellcome Found Compounds for use in medicine
CA2206119C (en) 1994-12-12 2008-05-13 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain, inflammation and spasm
US5679807A (en) 1995-01-30 1997-10-21 Hauser, Inc. Preparation of taxol and docetaxel through primary amines
US6063407A (en) 1995-02-16 2000-05-16 The General Hospital Corporation Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US5665077A (en) 1995-04-24 1997-09-09 Nitrosci Pharmaceuticals Llc Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
AU716005B2 (en) 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
KR100401220B1 (en) 1995-09-12 2004-03-20 더 리포좀 컴퍼니, 인코퍼레이티드 Hydrophobic taxane derivatives that promote hydrolysis
CA2231837A1 (en) * 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
WO1997019938A1 (en) 1995-11-29 1997-06-05 Consejo Superior Investigaciones Cientificas Fluorescent derivatives of paclitaxel and docetaxel with antineoplastic activity, method for producing them and their applications
US5760072A (en) 1995-12-29 1998-06-02 Pharmachemie B.V. Paclitaxel prodrugs, method for preparation as well as their use in selective chemotherapy
US5951458A (en) 1996-02-29 1999-09-14 Scimed Life Systems, Inc. Local application of oxidizing agents to prevent restenosis
US5688977A (en) 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
NZ332234A (en) 1996-03-12 2000-06-23 Pg Txl Company Lp Water soluble paclitaxel prodrugs formed by conjugating paclitaxel or docetaxel with a polyglutamic acid polymer and use for treating cancer
WO1997044026A1 (en) * 1996-05-22 1997-11-27 Neuromedica, Inc. Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere
US5919815A (en) 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
AU3572397A (en) 1996-07-02 1998-01-21 Bristol-Myers Squibb Company Ortho-ester analogs of paclitaxel
US5797887A (en) 1996-08-27 1998-08-25 Novovasc Llc Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
IT1295694B1 (en) 1996-11-14 1999-05-27 Nicox Sa NITROXIS DERIVATIVES FOR THE PREPARATION OF MEDICATIONS WITH ANTI-THROMBINIC ACTIVITY
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US5977386A (en) 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US6017935A (en) 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
DE19718339A1 (en) 1997-04-30 1998-11-12 Schering Ag Polymer coated stents, processes for their manufacture and their use for restenosis prophylaxis
KR100428634B1 (en) 1997-07-11 2004-11-03 주식회사 코오롱 Method for preparation taxol using fungus showing improved taxol producing activity
JPH1192468A (en) 1997-09-17 1999-04-06 Yakult Honsha Co Ltd New taxane derivative
AU9596698A (en) 1997-10-15 1999-05-03 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
US5994444A (en) 1997-10-16 1999-11-30 Medtronic, Inc. Polymeric material that releases nitric oxide
US20020164374A1 (en) 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
US6150537A (en) 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
WO1999055317A2 (en) 1998-04-30 1999-11-04 The Johns Hopkins University Treatment of advanced decompensated heart failure with nitric oxide donors
PT1082316E (en) 1998-05-01 2004-11-30 Napro Biotherapeutics Inc PROCESSES AND INTERMEDIARIES FOR PACLITAXEL SYNTHESIS FROM C-7, C-10-DI-CBZ-BACATIN III
US5981564A (en) 1998-07-01 1999-11-09 Universite Laval Water-soluble derivatives of paclitaxel, method for producing same and uses thereof
US5916913A (en) 1998-08-03 1999-06-29 Joseph; Hazel L. Inhibition of wound contraction with paclitaxel, colchicine and penicillamine
ES2179526T3 (en) 1998-08-21 2003-01-16 Pharmachemie Bv ANALOGS AND PROFARMACOS OF PACLITAXEL SOLUBLES IN WATER.
US6017948A (en) 1998-10-30 2000-01-25 Supergen, Inc. Water-miscible pharmaceutical compositions
US6071952A (en) 1998-12-02 2000-06-06 Mylan Pharmaceuticals, Inc. Stabilized injectable pharmaceutical compositions containing taxoid anti-neoplastic agents
IT1311923B1 (en) 1999-04-13 2002-03-20 Nicox Sa PHARMACEUTICAL COMPOUNDS.
IT1311921B1 (en) 1999-04-13 2002-03-20 Nicox Sa PHARMACEUTICAL COMPOUNDS.
IT1311924B1 (en) 1999-04-13 2002-03-20 Nicox Sa PHARMACEUTICAL COMPOUNDS.
WO2001010344A1 (en) 1999-08-04 2001-02-15 C.R. Bard, Inc. Nitric oxide releasing medical devices
IT1314184B1 (en) 1999-08-12 2002-12-06 Nicox Sa PHARMACEUTICAL COMPOSITIONS FOR THE THERAPY OF STRESS-OXIDATIVE CONDITIONS

Similar Documents

Publication Publication Date Title
AU2001270070A1 (en) Nitrosated and nitrosylated taxanes, compositions and methods of use
AU7007001A (en) Nitrosated and nitrosylated taxanes, compositions and methods of use
IL150368A0 (en) Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use
AU2003293529A1 (en) Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
AU2003291668A1 (en) Sacrificial compositions, methods of use thereof, and methods of decomposition thereof
AU4841700A (en) Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
AU2002357119A1 (en) Mitocidal compositions and methods
AU2001281989A1 (en) Novel heteroaryl derivatives and use thereof as anti-tumour agents
AU2003259735A1 (en) Small-mer compositions and methods of use
AU3713600A (en) Nitrosated and nitrosylated prostaglandins, compositions and metods of use
AU2003299441A1 (en) Nf-hev compositions and methods of use
AU2001261194A1 (en) Novel members of the lysyl oxidases family of amine oxidases related applications
AU2002357748A1 (en) Osteopontin-related compositions and methods
AU2002251140A1 (en) Chemical derivatives and their use as anti-telomerase agent
AU2756301A (en) Compositions comprising genome segments and methods of using the same
AUPR446801A0 (en) Novel compositions and uses therefor
AU5179800A (en) Mycolactone and related compounds, compositions and methods of use
AU2002361023A1 (en) Stabilizer composition, production and use thereof
AU2001238091A1 (en) Tgf-beta therapeutics, compositions and methods of use
AU2002359869A1 (en) Pak5-related compositions and methods
AU2003238034A1 (en) Novel use of imidazotriazinones
AU2001258330A1 (en) New uses of imidazolylmethyl-pyridines
AU2002229859A1 (en) Chemical derivatives and their use as anti-telomerase agent
AU2002319505A1 (en) Hair extension kits
AU2001249940A1 (en) Aminoflavone compounds, compositions, and methods of use thereof