AU2001242484A1 - Polyphosphazene derivatives - Google Patents

Polyphosphazene derivatives

Info

Publication number
AU2001242484A1
AU2001242484A1 AU2001242484A AU4248401A AU2001242484A1 AU 2001242484 A1 AU2001242484 A1 AU 2001242484A1 AU 2001242484 A AU2001242484 A AU 2001242484A AU 4248401 A AU4248401 A AU 4248401A AU 2001242484 A1 AU2001242484 A1 AU 2001242484A1
Authority
AU
Australia
Prior art keywords
medical device
polyphosphazene derivatives
coating
polyphosphazene
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001242484A
Inventor
Michael Grunze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celonova Biosciences Germany GmbH
Original Assignee
Polyzenix GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyzenix GmbH filed Critical Polyzenix GmbH
Publication of AU2001242484A1 publication Critical patent/AU2001242484A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06Use of macromolecular materials
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L85/00Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers
    • C08L85/02Compositions of macromolecular compounds obtained by reactions forming a linkage in the main chain of the macromolecule containing atoms other than silicon, sulfur, nitrogen, oxygen and carbon; Compositions of derivatives of such polymers containing phosphorus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08Materials for coatings
    • A61L29/085Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06Use of macromolecular materials
    • A61L33/068Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G79/00Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
    • C08G79/02Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
    • C08G79/025Polyphosphazenes

Abstract

The present invention relates to polyphosphazene derivatives and their use, having excellent biocompatible properties and imparting bacterial resistance to a coating of an article such as a medical device. In particular, the coating is applied on at least part of a surface of e.g. said medical device and can be used for preventing and/or reducing an inflammatory response upon application of said medical device to a patient.
AU2001242484A 2000-03-18 2001-03-19 Polyphosphazene derivatives Abandoned AU2001242484A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10013639 2000-03-18
DE10013639 2000-03-18
PCT/EP2001/003108 WO2001070296A1 (en) 2000-03-18 2001-03-19 Polyphosphazene derivatives

Publications (1)

Publication Number Publication Date
AU2001242484A1 true AU2001242484A1 (en) 2001-10-03

Family

ID=7635541

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001242484A Abandoned AU2001242484A1 (en) 2000-03-18 2001-03-19 Polyphosphazene derivatives

Country Status (13)

Country Link
US (1) US20030099683A1 (en)
EP (2) EP1265653B1 (en)
JP (1) JP3716344B2 (en)
KR (1) KR100572168B1 (en)
CN (1) CN1211130C (en)
AT (2) ATE302810T1 (en)
AU (1) AU2001242484A1 (en)
CA (1) CA2402949C (en)
DE (2) DE60103620T2 (en)
DK (1) DK1312635T3 (en)
ES (2) ES2222352T3 (en)
HK (1) HK1055910A1 (en)
WO (1) WO2001070296A1 (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7265199B2 (en) 2000-04-11 2007-09-04 Celonova Biosciences Germany Gmbh Poly-tri-fluoro-ethoxypolyphosphazene coverings and films
US20090004240A1 (en) * 2000-08-11 2009-01-01 Celonova Biosciences, Inc. Implants with a phosphazene-containing coating
EP1179353A1 (en) * 2000-08-11 2002-02-13 B. Braun Melsungen Ag Antithrombogenic implants with coating of polyphosphazenes and a pharmacologically active agent
US20080228284A1 (en) * 2001-01-11 2008-09-18 Celonova Biosciences, Inc. Specific Polyphosphazene-Containing Three-Dimensional Bone Support Implants and Methods for Their Use
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
DE10202467A1 (en) * 2002-01-23 2003-07-24 Polyzenix Gmbh Device, useful as an artificial implant, comprises a substrate based on nitinol having at least a partial coating of a phosphazene polymer.
DE10100961B4 (en) 2001-01-11 2005-08-04 Polyzenix Gmbh Body-compatible material and substrate coated with this material for the cultivation of cells and artificial organic implants constructed or grown from cells
DE10113971A1 (en) * 2001-03-22 2002-10-24 Polyzenix Gmbh Process for coating plastic surfaces with bis-poly-trifluoroethoxy-polyphosphazene and derivatives
PT1432380E (en) 2001-08-17 2007-01-31 Polyzenix Gmbh Device based on nitinol with a polyphosphazene coating
EP1534352B1 (en) * 2002-07-05 2008-09-10 CeloNova BioSciences Germany GmbH Implant for transport and release for pharmacologically active agents as well as a process for producing the same
US20080138433A1 (en) * 2002-07-05 2008-06-12 Celonova Biosciences, Inc. Vasodilator eluting blood storage and administration devices with a specific polyphosphazene coating and methods for their manufacture and use
US20080138792A1 (en) * 2002-07-05 2008-06-12 Celonova Biosciences, Inc. Vasodilator eluting medical devices with a specific polyphosphazene coating and methods for their manufacture and use
KR20050120665A (en) * 2003-03-26 2005-12-22 폴리제닉스 게엠베하 Coated dental implants
US11426355B2 (en) 2004-10-25 2022-08-30 Varian Medical Systems, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20210299056A9 (en) * 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
ATE503465T1 (en) * 2004-10-25 2011-04-15 Celonova Biosciences Germany Gmbh LOADABLE POLYPHOSPHAZENE-CONTAINING PARTICLES FOR THERAPEUTIC AND/OR DIAGNOSTIC APPLICATIONS AND PRODUCTION AND USE METHODS THEREOF
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
JP2008536978A (en) * 2005-04-15 2008-09-11 パラレル ソリューションズ,インク. Biodegradable polyphosphazenes containing pyrrolidone side groups
US7959940B2 (en) 2006-05-30 2011-06-14 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical devices
US7842737B2 (en) * 2006-09-29 2010-11-30 Abbott Cardiovascular Systems Inc. Polymer blend-bioceramic composite implantable medical devices
CA2690462A1 (en) * 2006-10-10 2008-04-17 Celonova Biosciences, Inc. Compositions and devices comprising silicone and specific polyphosphazenes
ES2378905T3 (en) * 2006-10-10 2012-04-19 Celonova Biosciences, Inc. Bioprotics heart valve with polyphosphazene
US20080188932A1 (en) * 2007-02-07 2008-08-07 Harrup Mason K Coated medical implants, methods of coating medical implants, and methods of coating materials
US8425591B1 (en) 2007-06-11 2013-04-23 Abbott Cardiovascular Systems Inc. Methods of forming polymer-bioceramic composite medical devices with bioceramic particles
US20090016935A1 (en) * 2007-07-09 2009-01-15 Andrianov Alexander K Coating formulations including polyphosphazene polyelectrolytes and biologically active agents and asperities coated with such formulations
WO2009008988A1 (en) * 2007-07-09 2009-01-15 Apogee Technology, Inc. Immunostimulating polyphosphazene compounds for intradermal immunization
BRPI0721916A2 (en) * 2007-07-25 2015-05-05 Celonova Biosciences Inc Color-coded polymeric particles sized for therapeutic and / or diagnostic applications and methods of preparation and use thereof
WO2009054854A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
WO2009058134A1 (en) * 2007-10-30 2009-05-07 Celonova Biosciences, Inc. Loadable polymeric particles for marking or masking individuals and methods of preparing and using the same
WO2009110858A2 (en) * 2007-10-31 2009-09-11 Celonova Biosciences, Inc. Vasodilator eluting dynamic blood handling devices with a specific polyphosphazene coating and methods for their manufacture and use
CN102176868A (en) * 2008-02-11 2011-09-07 西洛诺瓦生物科学公司 Tissue-fastening articles and devices, and related methods
CN101249287B (en) * 2008-04-08 2010-08-04 张玉霄 Blood vessel support for curing coronary heart disease
US20110093057A1 (en) * 2009-10-16 2011-04-21 Confluent Surgical, Inc. Mitigating Thrombus Formation On Medical Devices By Influencing pH Microenvironment Near The Surface
DE102012016590A1 (en) 2012-08-14 2014-02-20 Gmbu E.V., Fachsektion Dresden Bacteria-repellent coating for bacteria-repellent finishing of e.g. biliary stents, has material produced by dissolving or dispersing cholesterol and/or cholesterol compound in fluid, and joint formed between coating and substrate materials
DE102013006185A1 (en) 2013-04-04 2014-10-09 Gmbu E.V., Fachsektion Dresden Bacteria repellent material and method of manufacture
DE102013013908A1 (en) 2013-08-12 2015-02-12 Gmbu E.V., Fachsektion Dresden Bacteria-repellent coating and method of manufacture
DE102014103972A1 (en) * 2014-03-24 2015-09-24 Christian Lutz Method for producing an implant for osteosynthesis
ES2555827B1 (en) 2014-07-04 2016-10-13 Javier GIL MUR Procedure for the application of an antibacterial protection in a dental implant, and dental implant obtained
KR101940862B1 (en) * 2016-11-14 2019-04-11 주식회사 포스코 Composite resin composition for steel sheet of fuel tank, coated steel sheet using the same and method for manufacturing the coated steel sheet
EP3735193A1 (en) 2018-01-03 2020-11-11 GLW, Inc. Hybrid cannulated orthopedic screws
EP3740145A1 (en) 2018-01-15 2020-11-25 GLW, Inc. Hybrid intramedullary rods
US11628000B2 (en) 2019-03-18 2023-04-18 Glw, Inc. Hybrid bone plate

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4311736A (en) * 1979-03-19 1982-01-19 The Kendall Company Article having organo-phosphonitrile rubber coating bonded to natural or synthetic rubber and method of making
US4341844A (en) * 1979-10-25 1982-07-27 The Kendall Company Article having organo-phosphonitrile rubber coating bonded to natural or synthetic rubber and method of making
US4318947A (en) * 1979-12-26 1982-03-09 The Kendall Company Polymer coating and curing process for catheters
US4424395A (en) * 1982-03-11 1984-01-03 The Dow Chemical Company Carbamates of biphenyls
US4451647A (en) * 1982-06-21 1984-05-29 Research Corporation Heparinized polyorganophosphazenes
US4480642A (en) * 1982-07-26 1984-11-06 Health Products Research, Inc. Dilation device for the cervix
JPS6038307A (en) * 1983-08-11 1985-02-27 Nippon Daigaku Composite material for plugging
US4911691A (en) * 1984-09-21 1990-03-27 Menlo Care, Inc. Assembly for adminstering IV solution
US4883699A (en) * 1984-09-21 1989-11-28 Menlo Care, Inc. Polymeric article having high tensile energy to break when hydrated
US4592755A (en) * 1985-06-11 1986-06-03 Ethyl Corporation Mammary implant
US4798876A (en) * 1985-11-12 1989-01-17 Tyndale Plains-Hunter Ltd. Hydrophilic polyurethane composition
US4880622A (en) * 1986-05-20 1989-11-14 Research Corporation Technologies, Inc. Water-soluble phosphazene polymers having pharmacological applications
FR2679466B1 (en) * 1991-07-25 1994-04-15 Ceramique Technique FILTRATION MEMBRANE AND MANUFACTURING METHOD.
CA2118520C (en) * 1992-04-24 1999-08-10 Dirkjan Bakker Devices for preventing tissue adhesion
JPH0782279A (en) * 1993-05-15 1995-03-28 Nippon Univ Polymerization curable phosphazene compound for dental use
ATE154757T1 (en) * 1993-07-19 1997-07-15 Angiotech Pharm Inc ANTI-ANGIogenic AGENTS AND METHODS OF USE THEREOF
US5788979A (en) * 1994-07-22 1998-08-04 Inflow Dynamics Inc. Biodegradable coating with inhibitory properties for application to biocompatible materials
US5548060A (en) * 1994-08-08 1996-08-20 Penn State Research Foundation, Inc. Sulfonation of polyphosphazenes
DE19613048C2 (en) * 1995-03-30 1997-12-18 Michael Prof Dr Grunze Artificial implants with antithrombogenic properties and processes for their production
US5914388A (en) * 1995-04-26 1999-06-22 The Penn State Research Foundation Synthesis polyphosphazenes with controlled molecular weight and polydisperity
AU716005B2 (en) * 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
US6007573A (en) * 1996-09-18 1999-12-28 Microtherapeutics, Inc. Intracranial stent and method of use
US5980972A (en) * 1996-12-20 1999-11-09 Schneider (Usa) Inc Method of applying drug-release coatings
US5814704A (en) * 1997-03-04 1998-09-29 Virus Research Institute, Inc. Recovery of polyphosphazene polyacids or acids salts thereof
US20030153985A1 (en) * 1997-04-26 2003-08-14 Lee Yong Chan Medical implant
US6077916A (en) * 1997-06-04 2000-06-20 The Penn State Research Foundation Biodegradable mixtures of polyphoshazene and other polymers
DE19743373A1 (en) * 1997-09-30 1999-04-15 Univ Heidelberg · 3 ·· 2 · P-polyphosphazene
US20010029351A1 (en) * 1998-04-16 2001-10-11 Robert Falotico Drug combinations and delivery devices for the prevention and treatment of vascular disease
US6254634B1 (en) * 1998-06-10 2001-07-03 Surmodics, Inc. Coating compositions
US5997301A (en) * 1998-10-20 1999-12-07 Linden; Lars Ake Treatment of tooth surfaces and substances therefor
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6203551B1 (en) * 1999-10-04 2001-03-20 Advanced Cardiovascular Systems, Inc. Chamber for applying therapeutic substances to an implant device
KR100315630B1 (en) * 1999-11-17 2001-12-12 박호군 Biodegradable and thermosensitive polyphosphazenes and their preparation method
US6447835B1 (en) * 2000-02-15 2002-09-10 Scimed Life Systems, Inc. Method of coating polymeric tubes used in medical devices
US20020005206A1 (en) * 2000-05-19 2002-01-17 Robert Falotico Antiproliferative drug and delivery device
US20020051730A1 (en) * 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
CA2424029C (en) * 2000-09-29 2008-01-29 Cordis Corporation Coated medical devices
US20020111590A1 (en) * 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
US7261735B2 (en) * 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
US7195640B2 (en) * 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US20030065377A1 (en) * 2001-09-28 2003-04-03 Davila Luis A. Coated medical devices
US6887270B2 (en) * 2002-02-08 2005-05-03 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation

Also Published As

Publication number Publication date
ATE302810T1 (en) 2005-09-15
ES2222352T3 (en) 2005-02-01
CN1418116A (en) 2003-05-14
EP1265653B1 (en) 2004-06-02
DE60112950D1 (en) 2005-09-29
CA2402949C (en) 2009-09-08
WO2001070296A1 (en) 2001-09-27
DE60112950T2 (en) 2006-05-18
EP1312635A2 (en) 2003-05-21
ATE268189T1 (en) 2004-06-15
EP1265653A1 (en) 2002-12-18
EP1312635B1 (en) 2005-08-24
CA2402949A1 (en) 2001-09-27
JP3716344B2 (en) 2005-11-16
DK1312635T3 (en) 2005-10-17
EP1312635A3 (en) 2003-05-28
ES2246431T3 (en) 2006-02-16
DE60103620D1 (en) 2004-07-08
CN1211130C (en) 2005-07-20
JP2003527215A (en) 2003-09-16
DE60103620T2 (en) 2005-06-16
KR20030020869A (en) 2003-03-10
US20030099683A1 (en) 2003-05-29
KR100572168B1 (en) 2006-04-19
HK1055910A1 (en) 2004-01-30

Similar Documents

Publication Publication Date Title
AU2001242484A1 (en) Polyphosphazene derivatives
BE2011C037I2 (en)
AU775126C (en) Substituted oxazolidinones and their use in the field of blood coagulation
WO2003087303A3 (en) Tissue composites and uses thereof
AU2002360517A1 (en) Respiratory infection prevention and treatment with terpene-containing compositions
WO2002100455A3 (en) Use of ozone for the prevention of infection caused by medical devices
ATE467650T1 (en) BIOLOGICALLY ACTIVE BLOCK COPOLYMERS AND ARTICLES COATED THEREWITH
AU2001293553A1 (en) Phosphatidylserine-carrying apoptosis-mimicking bodies and the use thereof in medical treatment
AU6339599A (en) Quinoline derivatives and their use as antibacterial agents
AU2002345544A1 (en) Method of immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications
AU2003251787A1 (en) Polymerized and modified rapamycins and their use in coating medical prostheses
WO1997040072A3 (en) Adam proteins and uses thereof
AU4439401A (en) Methods and apparatus usable with or applicable to the use of the internet
AU2001283285A1 (en) Antimicrobial composition and methods of use in the treatment of disease
ATE458509T1 (en) THREE-ARM BIOLOGICALLY ACTIVE COPOLYMERS AND COATED IMPLANTABLE ARTICLES
AU2000255628A1 (en) Formulation comprising thymol useful in the treatment of drug resistant bacterial infections
AU7935500A (en) Suture material
FI931204A (en) NYA, SAOSOM LIPOOXIGENASINHIBITORER VERKANDE AMINOBENSOSULTAMDERIVAT
AU645032B2 (en) Method of coating a substrate with an ambient temperature- drying aqueous elastomeric composition and the use of such compositions in or as elastomeric coating compositions
WO1998053850A3 (en) Compositions and means for the treatment of burns and other cutaneous traumas
AU4511201A (en) Compositions and methods for the induction and treatment of retinal detachments
DK1157688T3 (en) Antibacterial aqueous ophthalmic formulations with ofloxacin and chitosan
AU2001246754A1 (en) Central venous line catheter and method of preparing the same for the use
AU4015195A (en) Polymeric peel-off coating compositions and methods of use thereof
AU2001293105A1 (en) Polymeric peel-off coating compositions and method of use thereof