AU2001236605A1 - Indole and benzimidazole inhibitors of factor xa - Google Patents

Indole and benzimidazole inhibitors of factor xa

Info

Publication number
AU2001236605A1
AU2001236605A1 AU2001236605A AU3660501A AU2001236605A1 AU 2001236605 A1 AU2001236605 A1 AU 2001236605A1 AU 2001236605 A AU2001236605 A AU 2001236605A AU 3660501 A AU3660501 A AU 3660501A AU 2001236605 A1 AU2001236605 A1 AU 2001236605A1
Authority
AU
Australia
Prior art keywords
indole
factor
benzimidazole inhibitors
benzimidazole
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001236605A
Inventor
Robert Scarborough
Bing-Yan Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
COR Therapeutics Inc
Original Assignee
COR Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by COR Therapeutics Inc filed Critical COR Therapeutics Inc
Publication of AU2001236605A1 publication Critical patent/AU2001236605A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
AU2001236605A 2000-02-01 2001-02-01 Indole and benzimidazole inhibitors of factor xa Abandoned AU2001236605A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17939000P 2000-02-01 2000-02-01
US60179390 2000-02-01
US19173500P 2000-03-24 2000-03-24
US60191735 2000-03-24
PCT/US2001/003225 WO2001057020A1 (en) 2000-02-01 2001-02-01 INDOLE AND BENZIMIDAZOLE INHIBITORS OF FACTOR Xa

Publications (1)

Publication Number Publication Date
AU2001236605A1 true AU2001236605A1 (en) 2001-08-14

Family

ID=26875281

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001236605A Abandoned AU2001236605A1 (en) 2000-02-01 2001-02-01 Indole and benzimidazole inhibitors of factor xa

Country Status (4)

Country Link
US (1) US20020072530A1 (en)
EP (1) EP1255750A1 (en)
AU (1) AU2001236605A1 (en)
WO (1) WO2001057020A1 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003248549B2 (en) * 2002-05-24 2010-04-08 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof
AU2003298661B2 (en) * 2002-11-18 2007-05-10 Chemocentryx, Inc. Aryl sulfonamides
US7227035B2 (en) * 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
US20070021466A1 (en) * 2002-11-18 2007-01-25 Solomon Ungashe CCR2 inhibitors and methods of use thereof
US7420055B2 (en) * 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
US7129264B2 (en) 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
RU2006108791A (en) 2003-08-21 2006-07-27 Оси Фармасьютикалз, Инк. (Us) N-SUBSTITUTED PYRAZOLYLAMIDYLBENZIMIDAZOLYLES AS C-KIT INHIBITORS
MXPA06002018A (en) * 2003-08-21 2006-05-31 Osi Pharm Inc N-substituted benzimidazolyl c-kit inhibitors.
AU2004268950A1 (en) 2003-08-21 2005-03-10 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine-derivatives as c-kit inhibitors
US7442709B2 (en) 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
JP2008518905A (en) 2004-11-02 2008-06-05 ファイザー株式会社 Sulfonylbenzimidazole derivatives
JP4887368B2 (en) 2005-10-13 2012-02-29 スミスクライン ビーチャム コーポレーション New heterocyclic compounds
JP5275236B2 (en) 2006-09-29 2013-08-28 スミスクライン ビーチャム コーポレーション Substituted indole compounds
US7960567B2 (en) 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
US8183293B2 (en) 2007-12-19 2012-05-22 Amgen Inc. Phenyl acetic acid derivatives
MX337662B (en) 2010-10-06 2016-03-14 Glaxosmithkline Llc Benzimidazole derivatives as pi3 kinase inhibitors.
TWI501967B (en) 2010-12-16 2015-10-01 Janssen R&D Ireland Azaindoles as respiratory syncytial virus antiviral agents
TWI515187B (en) * 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 Indoles as respiratory syncytial virus antiviral agents
TWI527814B (en) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 Azabenzimidazoles as respiratory syncytial virus antiviral agents
CN103582632B (en) 2011-03-31 2015-08-19 拜耳知识产权有限责任公司 The benzoglyoxaline replaced
DK2864323T3 (en) 2012-06-15 2017-08-14 Janssen Sciences Ireland Uc 1,3-DIHYDRO-2H-BENZIMIDAZOLE-2 UNDERIVATIVES SUBSTITUTED BY HETEROCYCLES AS ANTIVIRUS AGENTS AGAINST RESPIRATORY SYNCYTIAL VIRUS
WO2014151380A1 (en) 2013-03-15 2014-09-25 Janssen Pharmaceutica Nv 1,2,6-substituted benzimidazoles as flap modulators
US9067917B2 (en) 2013-03-15 2015-06-30 Janssen Pharmaceutica Nv 1,2,5-substituted benzimidazoles as FLAP modulators
WO2017207340A1 (en) 2016-05-31 2017-12-07 Bayer Pharma Aktiengesellschaft Novel substituted benzimidazole, methods for the production thereof, pharmaceutical preparations containing same, and use thereof to produce medicaments
WO2018060174A1 (en) 2016-09-29 2018-04-05 Bayer Pharma Aktiengesellschaft Substituted benzimidazoles, pharmaceutical preparations containing same, and use of same to produce drugs
WO2018060072A1 (en) 2016-09-29 2018-04-05 Bayer Pharma Aktiengesellschaft New substituted benzimidazoles, methods for the production of same, pharmaceutical preparations containing same, and use of same to produce drugs
WO2023283425A1 (en) 2021-07-09 2023-01-12 Plexium, Inc. Aryl compounds and pharmaceutical compositions that modulate ikzf2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3928177A1 (en) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K BENZIMIDAZOLE, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
US5849759A (en) * 1995-12-08 1998-12-15 Berlex Laboratories, Inc. Naphthyl-substituted benzimidazole derivatives as anti-coagulants
EP1017682A4 (en) * 1997-09-26 2000-11-08 Merck & Co Inc Novel angiogenesis inhibitors

Also Published As

Publication number Publication date
EP1255750A1 (en) 2002-11-13
WO2001057020A1 (en) 2001-08-09
US20020072530A1 (en) 2002-06-13

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