AU2001218841A1 - Glycerophosphoinositol derivatives as modulators of cytosolic a2 phospholipase - Google Patents

Glycerophosphoinositol derivatives as modulators of cytosolic a2 phospholipase

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Publication number
AU2001218841A1
AU2001218841A1 AU2001218841A AU1884101A AU2001218841A1 AU 2001218841 A1 AU2001218841 A1 AU 2001218841A1 AU 2001218841 A AU2001218841 A AU 2001218841A AU 1884101 A AU1884101 A AU 1884101A AU 2001218841 A1 AU2001218841 A1 AU 2001218841A1
Authority
AU
Australia
Prior art keywords
modulators
derivatives
glycerophosphoinositol
cytosolic
phospholipase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001218841A
Inventor
Giovanna Bonvento
Daniela Corda
Renzo Dal Monte
Roberto Dal Toso
Gabriele Marcolongo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IRB Istituto di Ricerche Biotecnologiche SpA
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IRB Istituto di Ricerche Biotecnologiche SpA
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Publication date
Application filed by IRB Istituto di Ricerche Biotecnologiche SpA filed Critical IRB Istituto di Ricerche Biotecnologiche SpA
Publication of AU2001218841A1 publication Critical patent/AU2001218841A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/177—Esters of thiophosphoric acids with cycloaliphatic alcohols

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)

Abstract

Optionally O-substituted glycero-phosphoinositol derivatives, their analogues and their salts wherein the substitutents: R'1, R'2, R2, R3, R4, R5, R6 have the described meaning, their synthesis and their pharmacological effect as modulators of the activation or over-stimulation of cPLA2.
AU2001218841A 2000-11-07 2000-11-07 Glycerophosphoinositol derivatives as modulators of cytosolic a2 phospholipase Abandoned AU2001218841A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT2000/000447 WO2002038575A1 (en) 2000-11-07 2000-11-07 Glycerophosphoinositol derivatives as modulators of cytosolic a2 phospholipase

Publications (1)

Publication Number Publication Date
AU2001218841A1 true AU2001218841A1 (en) 2002-05-21

Family

ID=11133577

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001218841A Abandoned AU2001218841A1 (en) 2000-11-07 2000-11-07 Glycerophosphoinositol derivatives as modulators of cytosolic a2 phospholipase

Country Status (11)

Country Link
US (1) US7625883B1 (en)
EP (1) EP1332149B1 (en)
JP (1) JP2004513176A (en)
CN (1) CN1300155C (en)
AT (1) ATE308548T1 (en)
AU (1) AU2001218841A1 (en)
CA (1) CA2427352C (en)
DE (1) DE60023758T2 (en)
ES (1) ES2252079T3 (en)
IL (2) IL155619A0 (en)
WO (1) WO2002038575A1 (en)

Families Citing this family (16)

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AUPS282602A0 (en) * 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
WO2006006161A2 (en) * 2004-07-09 2006-01-19 Vascular Biogenics Ltd. Improved process for the preparation of oxidized phospholipids
GB0510463D0 (en) * 2005-05-23 2005-06-29 Britania Pharmaceuticals Ltd Improvements in or relating to organic materials
CN101505763A (en) * 2006-06-09 2009-08-12 鹿特丹伊拉斯姆斯大学医疗中心 Modulation of the immune system by inositol phospholipids
BRPI0807972A2 (en) 2007-01-24 2014-06-10 Glaxo Group Ltd PHARMACEUTICAL COMPOSITIONS UNDERSTANDING 3,5-DIAMINO-6- (2,3-DICHLOPHENYL) -L, 2,4-TRIAZINE OR R (-) - 2,4-DIAMINO-5- (2,3-DICHLOROPHENYL) -6- FLUOROMETILPIRIM IDINA AND ONE NK1
CN101951921A (en) * 2007-09-17 2011-01-19 比奥尼里斯有限责任公司 Be used for the treatment of cachectic ways and means
JP5420848B2 (en) * 2008-02-28 2014-02-19 株式会社コーセー Whitening agent and skin external preparation for whitening
JP2009269851A (en) * 2008-05-07 2009-11-19 Nikko Chemical Co Ltd Inhibitor of prostaglandin e2 production and its utilization
WO2012158591A1 (en) * 2011-05-18 2012-11-22 The Research Foundation Of State University Of New York Anti-blepharitis products and methods
JP5670858B2 (en) * 2011-10-14 2015-02-18 イ．エルレ．ビ．イスティトゥト ディ リチェルケ ビオテクノロジケ ソチエタ ペル アツィオニ Glycerophosphoinositol derivatives as modulators of cytosolic phospholipases
ITRM20120473A1 (en) * 2012-10-04 2014-04-05 Consiglio Nazionale Ricerche USE OF GLYCEROPHOSPHOINOSITOLS FOR THE TREATMENT OF SEPTIC SHOCK
JP5701371B2 (en) 2012-12-28 2015-04-15 花王株式会社 Sphingomyelin containing supplements
RU2580280C2 (en) * 2014-07-08 2016-04-10 Общество с ограниченной ответственностью "НИТРОЗДРАВ" Composition for local application for reduction or relief of pain syndrome
KR20170086019A (en) * 2014-09-24 2017-07-25 이스티튜토 프로필라티코 이 파르마씨유티코 칸디올리 & 씨. 에스.피.에이. Compositions useful for the prevention and/or treatment of infections and inflammations
CN104447856A (en) * 2014-12-11 2015-03-25 河南省农科院农副产品加工研究所 Preparation method of glycerol phosphatidylinositol
IT202200010199A1 (en) * 2022-05-17 2023-11-17 Plantarei Biotech S R L GLYCEROPHOSPHOINOSITOL IN THE PREVENTION AND TREATMENT OF COVID-19 INFECTIONS AND METHOD FOR ITS OBTAINMENT

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DE2659048A1 (en) * 1976-12-27 1978-07-06 Nattermann A & Cie Inositol phosphatide ester derivs. - with antilipaemic, anti-atherosclerotic, platelet aggregation reducing and peripheral blood flow increasing activity
FR2517310A1 (en) 1981-11-27 1983-06-03 Unilever Nv Salts of alpha glycero phosphatide ester(s) - skin treatment agents to reduce dryness and peeling
US4585762A (en) 1982-07-30 1986-04-29 Fujisawa Pharmaceutical Co., Ltd. Phospholipid derivatives, processes for use thereof and pharmaceutical composition of the same
US4997761A (en) * 1987-10-06 1991-03-05 Houston Biotechnology Incorporated Phosphatidyl treatment of viral disease
IT1239474B (en) 1989-10-27 1993-11-02 Depha Team Srl PHARMACEUTICAL COMPOSITIONS BASED ON L-ALPHA-GLYCEROPHOSPHORYL-D-MYO- INOXITOL OR ITS ALKALINE OR ALKALINE-EARTH SALTS FOR THERAPY OF PERIPHERAL NEROPATHIES OF DYSMETABOLIC OR TOXIC ORIGIN, AND FUNCTIONAL ORBANIC BASE
IT1238683B (en) * 1990-02-09 1993-09-01 Istituto Chemioterapico PROCEDURE FOR THE PREPARATION OF L-A-GLYCYLPHOSFORIL-D-MYOINOSITOL AND ITS SALTS FROM RAW OR PARTIALLY PURIFIED PHOSPHATIDES
IT1247093B (en) 1991-01-22 1994-12-12 Flarer S R L Ora Castellini S SALINE DERIVATIVES OF GLYCERYL PHOSPHORYL MYINOSITOL FOR THERAPEUTIC ACTIVITY, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
US5464754A (en) 1993-08-17 1995-11-07 The Regents Of The University Of California Assay and substrate for arachidonoyl-specific phospholipase A2
US5478857A (en) * 1993-12-23 1995-12-26 Eli Lilly And Company Use of PLA2 inhibitors as treatment for alzheimer's disease
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US6801860B1 (en) * 1999-02-15 2004-10-05 Genetics Institute, Llc Crystal structure of cPLA2 and methods of identifying agonists and antagonists using same
SE532388C2 (en) * 2008-03-14 2010-01-12 Tetra Laval Holdings & Finance Packaging laminates and containers with two separate gas barrier layers and method for their preparation

Also Published As

Publication number Publication date
CA2427352A1 (en) 2002-05-16
CN1455779A (en) 2003-11-12
CN1300155C (en) 2007-02-14
JP2004513176A (en) 2004-04-30
WO2002038575A1 (en) 2002-05-16
DE60023758D1 (en) 2005-12-08
ES2252079T3 (en) 2006-05-16
EP1332149A1 (en) 2003-08-06
IL155619A (en) 2010-06-30
DE60023758T2 (en) 2006-12-07
EP1332149B1 (en) 2005-11-02
IL155619A0 (en) 2003-11-23
CA2427352C (en) 2010-10-12
US7625883B1 (en) 2009-12-01
ATE308548T1 (en) 2005-11-15

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